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  • Question 1 - Dietary starch is mainly: ...

    Incorrect

    • Dietary starch is mainly:

      Your Answer: Amylose

      Correct Answer: Amylopectin

      Explanation:

      Dietary starch consists of two types of molecules: the linear and helical amylose and the branched amylopectin. Starch generally contains 20 to 25% amylose and 75 to 80% amylopectin by weight but depends in the plant. Glycogen, the glucose store of animals, is a more branched version of amylopectin.

    • This question is part of the following fields:

      • Gastrointestinal
      • Medicine
      7.5
      Seconds
  • Question 2 - What is the mechanism of action of sumatriptan? ...

    Incorrect

    • What is the mechanism of action of sumatriptan?

      Your Answer: 5-HT3 agonist

      Correct Answer: 5-HT1 agonist

      Explanation:

      Triptans are specific 5-HT1 agonists used in the acute treatment of migraine. They are generally used as first-line therapy in combination with an NSAID or paracetamol.

      Sumatriptan acts as an agonist on 5-HT1B/1D receptors by inducing vasoconstriction in the basilar artery and blood vessels within the dura mater. The drug reduces peripheral nociception either by selective cranial vasoconstriction or by affecting trigeminovascular nerves.

    • This question is part of the following fields:

      • Medicine
      • Pharmacology
      5.8
      Seconds
  • Question 3 - Where does the SA node develop? ...

    Incorrect

    • Where does the SA node develop?

      Your Answer: From structures on the left side of the embryo

      Correct Answer: From structures on the right side of the embryo.

      Explanation:

      The SA node develops from the right side of the embryo and the AV node from the left. This is the reason why in adults the right vagus supplies the SA node and the left vagus supplies the AV node.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      6.2
      Seconds
  • Question 4 - Which of the following pairs are correct concerning arteriolar tone? ...

    Correct

    • Which of the following pairs are correct concerning arteriolar tone?

      Your Answer: Hormonal control: catecholamines affect the adrenergic receptors of the vascular smooth muscle

      Explanation:

      Catecholamines released from the adrenal medulla act on the noradrenergic receptors of the vascular smooth muscles. In the skeletal muscles and liver it causes vasodilation whilst it causes vasoconstriction in the rest of the blood vessels of the body.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      41.5
      Seconds
  • Question 5 - Which of the following features is least commonly seen in Gitelman’s syndrome? ...

    Incorrect

    • Which of the following features is least commonly seen in Gitelman’s syndrome?

      Your Answer: Hypocalciuria

      Correct Answer: Hypertension

      Explanation:

      Gitelman syndrome is an autosomal recessive kidney disorder characterized by hypokalaemia metabolic alkalosis with hypocalciuria, and hypomagnesemia. In contrast to patients with Gordon’s syndrome, those suffering from Gitelman’s syndrome are generally normotensive or hypotensive.

    • This question is part of the following fields:

      • Endocrinology
      • Medicine
      5.4
      Seconds
  • Question 6 - Among the following which is the beneficial effect of nitro-glycerine? ...

    Correct

    • Among the following which is the beneficial effect of nitro-glycerine?

      Your Answer: Dilation of systemic veins

      Explanation:

      Dilation of systemic veins is a beneficial effect of nitro-glycerine.Administration of nitro-glycerine results in the dilation of systemic veins and decrease of myocardial wall tension and oxygen demand. Dilatation of systemic veins can cause reduced systemic vascular resistance leading to reduced cardiac workload thus reducing anginal symptoms secondary to demand ischemia.This is accompanied by vasodilation of large and medium-sized coronary arteries with increased coronary blood flow to the sub endocardium.

    • This question is part of the following fields:

      • Medicine
      • Pharmacology
      20.3
      Seconds
  • Question 7 - Which of the following correctly describes stages in the formation of CSF? ...

    Incorrect

    • Which of the following correctly describes stages in the formation of CSF?

      Your Answer: Passive filtration of plasma

      Correct Answer: All of the above

      Explanation:

      All the above are true for the formation of CSF

    • This question is part of the following fields:

      • Medicine
      • Neurology
      15.4
      Seconds
  • Question 8 - Which area in the GIT lacks Basic Electrical Rhythm? ...

    Correct

    • Which area in the GIT lacks Basic Electrical Rhythm?

      Your Answer: Oesophagus

      Explanation:

      The basal or basic electrical rhythm acts to coordinate peristalsis and are initiated in the interstitial cells of Cajal, specialized pacemaker cells located in the wall of the stomach, below the oesophagus.

    • This question is part of the following fields:

      • Gastrointestinal
      • Medicine
      12.6
      Seconds
  • Question 9 - There is a measure of dispersion of a set of data from its...

    Correct

    • There is a measure of dispersion of a set of data from its mean. Which of following is the best term which can describe the above?

      Your Answer: Standard deviation (root mean square deviation)

      Explanation:

      Standard deviation is defined as the measure of dispersion of a set of data from its mean. It measures the absolute variability of a distribution; the higher the dispersion or variability, the greater is the standard deviation and greater will be the magnitude of the deviation of the value from their mean.

    • This question is part of the following fields:

      • Medicine
      • Research Skills
      12.6
      Seconds
  • Question 10 - The effects of β1 stimulation include the following ...

    Incorrect

    • The effects of β1 stimulation include the following

      Your Answer: Only a and b are correct

      Correct Answer: Increased strength of contraction

      Explanation:

      β1 stimulation include the phosphorylation of L type Ca++ channels and phospholamban and increased Ca++ influx from myocytes.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      9
      Seconds
  • Question 11 - An important hormone controlling the differentiation of monocytes to osteoclasts, by inhibiting the...

    Incorrect

    • An important hormone controlling the differentiation of monocytes to osteoclasts, by inhibiting the RANKL/ RANK interaction is called?

      Your Answer: Rank – inhibitor

      Correct Answer: Osteoprotegerin

      Explanation:

      Osteoprotegerin, also known as osteoclastogenesis inhibitory factor (OCIF) is a glycoprotein that acts as a cytokine receptor. It works as a decoy receptor for the receptor activator of nuclear factor-kappaB ligand (RANKL)/osteoclast differentiation factor, thus inhibiting the differentiation of osteoclasts, which are capable of resorbing bone. Osteoprotegerin has been proposed as a therapeutic agent for osteoporosis.

    • This question is part of the following fields:

      • Endocrinology
      • Medicine
      20.7
      Seconds
  • Question 12 - Which of the following would be the most appropriate treatment (leaving out the...

    Incorrect

    • Which of the following would be the most appropriate treatment (leaving out the current NICE guidelines) for a 29 year old man with erythrodermic psoriasis and arthritis mutilans involving several digits of both hands?

      Your Answer: Prednisolone

      Correct Answer: Etanercept

      Explanation:

      TNF-alpha inhibitors are known to ameliorate the symptoms and disease activity of Arthritis mutilans (a rare and severe form of psoriatic arthritis), by disabling the cytokines that are involved in inflammation and joint destruction. From the mentioned choices, this would be the most effective option. Methotrexate is the most commonly used DMARD, followed by sulfasalazine used in mild to moderate forms of psoriatic arthritis but has not shown much efficacy in arthritis mutilans. Phototherapy, narrowband UVB light therapy can be very effective in clearing skin lesions.

    • This question is part of the following fields:

      • Connective Tissue
      • Medicine
      25.9
      Seconds
  • Question 13 - When 2 nucleotide chains of DNA bind together, thymine is bound to: ...

    Incorrect

    • When 2 nucleotide chains of DNA bind together, thymine is bound to:

      Your Answer: Guanine

      Correct Answer: Adenine

      Explanation:

      As a general rule in the structure of DNA, thymine always binds to adenine with two hydrogen bonds, cytosine always binds to guanine with three hydrogen bonds and vice versa. However In the structure of RNA the only difference is that adenine binds to uracil instead of thymine. But thymine will always bind to adenine.

    • This question is part of the following fields:

      • Genetics
      • Medicine
      12.9
      Seconds
  • Question 14 - Which statement is correct about the clinical state of methemoglobinemia? ...

    Incorrect

    • Which statement is correct about the clinical state of methemoglobinemia?

      Your Answer: It is due to carbon monoxide reacting with haemoglobin.

      Correct Answer: May arise due to a hereditary deficiency of NADH.

      Explanation:

      Methaemoglobin is a form of haemoglobin that contains ferric [Fe3+] iron and has a decreased ability to bind oxygen. Spontaneously formed methaemoglobin is normally reduced by protective enzyme systems, e.g., NADH methaemoglobin reductase, hence a deficiency of NADH may result in increased levels of methaemoglobin

    • This question is part of the following fields:

      • Haematology
      • Medicine
      9.2
      Seconds
  • Question 15 - In blistering dermatological disorders e.g.. Pemphigus, which junctions are attacked by autoantibodies? ...

    Correct

    • In blistering dermatological disorders e.g.. Pemphigus, which junctions are attacked by autoantibodies?

      Your Answer: Desmosomes

      Explanation:

      Pemphigus is an autoimmune disease caused by antibodies directed against both desmoglein 1 and desmoglein 3 present in desmosomes. Loss of desmosomes results in loss of cohesion between keratinocytes in the epidermis, and a disruption of the barrier function served by intact skin. The process is classified as a type II hypersensitivity reaction

    • This question is part of the following fields:

      • Cell Biology
      • Medicine
      5.8
      Seconds
  • Question 16 - The following cells replicate without shortening their telomeres because they express telomerase. ...

    Incorrect

    • The following cells replicate without shortening their telomeres because they express telomerase.

      Your Answer: Red blood cells

      Correct Answer: Germ cells

      Explanation:

      Telomerase activity is seen in germ cells and is absent in somatic cells. Telomeres prevent the chromosomes from shortening and prevent the coding portion of the DNA from being lost, thus allowing the cell to replicate indefinitely. During replication telomeres may be lost resulting in cell death.

    • This question is part of the following fields:

      • Genetics
      • Medicine
      8
      Seconds
  • Question 17 - Where is the major site of purine synthesis? ...

    Correct

    • Where is the major site of purine synthesis?

      Your Answer: Liver

      Explanation:

      The major site of purine synthesis is in the liver. Purines are biologically synthesized as nucleotides and in particular as ribotides.

    • This question is part of the following fields:

      • Medicine
      • Metabolism
      11
      Seconds
  • Question 18 - Number of cases that are infected at a specific point in time ...

    Correct

    • Number of cases that are infected at a specific point in time

      Your Answer: Prevalence

      Explanation:

      Prevalence in epidemiology is the proportion of a population found to have a condition (typically a disease or a risk factor such as smoking or seat-belt use). It is arrived at by comparing the number of people found to have the condition with the total number of people studied, and is usually expressed as a fraction, as a percentage or as the number of cases per 10,000 or 100,000 people. Point prevalence is the proportion of a population that has the condition at a specific point in time. Period prevalence is the proportion of a population that has the condition at some time during a given period (e.g., 12 month prevalence), and includes people who already have the condition at the start of the study period as well as those who acquire it during that period. Lifetime prevalence (LTP) is the proportion of a population that at some point in their life (up to the time of assessment) have experienced the condition

    • This question is part of the following fields:

      • Infectious Diseases
      • Medicine
      5.9
      Seconds
  • Question 19 - The following can cause steatorrhea except ...

    Correct

    • The following can cause steatorrhea except

      Your Answer: Diseases that destroy the endocrine portion of the pancreas

      Explanation:

      Dietary fats and lipids are usually efficiently digested and over 90% absorbed. Impaired digestion or absorption can result in fatty stools. Possible causes include exocrine (not endocrine) pancreatic insufficiency, with poor digestion from lack of lipases, loss of bile salts, which reduces micelle formation, and small intestinal disease producing malabsorption. Various other causes including certain medicines that block fat absorption, or indigestible or excess oil/fat in diet.

    • This question is part of the following fields:

      • Gastrointestinal
      • Medicine
      11.6
      Seconds
  • Question 20 - Telomerase is active in all of the following cells, except: ...

    Incorrect

    • Telomerase is active in all of the following cells, except:

      Your Answer: Germ cells

      Correct Answer: Certain liver cells

      Explanation:

      Telomerase is an enzyme that adds repetitive nucleotide sequences to the ends of chromosomes (telomeres), preventing their shortening during cell division. Telomerase activity is crucial for cells that divide frequently and need to maintain their telomere length for continued proliferation. These include:

      • Stem cells: They have high telomerase activity to maintain their long-term proliferative capacity.
      • Germ cells: These cells also have active telomerase to ensure the stability of genetic material across generations.
      • Certain white blood cells: Some immune cells, particularly those that need to proliferate in response to infection, show telomerase activity.
      • Certain cancer cells: Many cancer cells reactivate telomerase, which contributes to their uncontrolled growth and immortality.

      However, most somatic cells, including certain liver cells, do not exhibit significant telomerase activity. While some liver cells might show low levels of telomerase activity during regeneration, it is not generally active in normal, differentiated liver cells.

    • This question is part of the following fields:

      • Genetics
      • Medicine
      3.7
      Seconds
  • Question 21 - Where would one normally find venous valves? ...

    Correct

    • Where would one normally find venous valves?

      Your Answer: Saphenous vein

      Explanation:

      The intima of the limb veins is folded at intervals to form venous valves that prevent retrograde flow. There are no valves present in the very small veins, the great veins, or the veins in the brain and viscera.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      10.4
      Seconds
  • Question 22 - G cells release which of the following substances ...

    Correct

    • G cells release which of the following substances

      Your Answer: Gastrin

      Explanation:

      The G cell is a type of cell in the stomach and duodenum that secretes gastrin. It works in conjunction with gastric chief cells and parietal cells. G cells are found deep within the pyloric glands of the stomach antrum, and occasionally in the pancreas and duodenum. Gastrin-releasing peptide, as well as the presence of amino acids in the stomach, stimulates the release of gastrin from the G cells. Gastrin stimulates enterochromaffin-like cells to secrete histamine. Gastrin also targets parietal cells by increasing the amount of histamine and the direct stimulation by gastrin, causing the parietal cells to increase HCl secretion in the stomach.

    • This question is part of the following fields:

      • Gastrointestinal
      • Medicine
      5.5
      Seconds
  • Question 23 - In which area is depolarization initiated? ...

    Correct

    • In which area is depolarization initiated?

      Your Answer: SA node

      Explanation:

      SA node is the pacemaker of the heart. It determines the rate of contractions. It is the place where depolarization is initiated. It exhibits phase 4 depolarization or automaticity. Electrical impulses then spread to the AV node, purkinje fibers, bundle of his and the ventricular muscles.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      3.4
      Seconds
  • Question 24 - Which of the following conditions does not influence the cardiac output? ...

    Incorrect

    • Which of the following conditions does not influence the cardiac output?

      Your Answer: Eating

      Correct Answer: Sleep

      Explanation:

      Sleep has no effect on the cardiac output.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      11.6
      Seconds
  • Question 25 - The conversion of haem to bilirubin is catalysed by which of these enzymes?...

    Correct

    • The conversion of haem to bilirubin is catalysed by which of these enzymes?

      Your Answer: Biliverdin reductase

      Explanation:

      Bilirubin is created by the activity of biliverdin reductase on biliverdin, a green tetrapyrrolic bile pigment that is also a product of haem catabolism.

    • This question is part of the following fields:

      • Hepatobiliary
      • Medicine
      10.7
      Seconds
  • Question 26 - Which of the following is the most common clinical feature of carbon monoxide...

    Incorrect

    • Which of the following is the most common clinical feature of carbon monoxide poisoning?

      Your Answer: Cherry red skin

      Correct Answer: Headache

      Explanation:

      Carbon monoxide (CO) poisoning:It is considered as the great imitator of other diseases as the patients present with a myriad of symptoms. The carbon monoxide diffuses rapidly across the pulmonary capillary membrane binding to the haem molecule with a very high affinity (240 times that of oxygen) forming carboxy-haemoglobin (COHb). Non-smokers have a baseline COHb of ,3% while smokers have a baseline COHb of 10-15%.Clinical features of carbon monoxide toxicity:Headache: 90% of cases (most common clinical feature)Nausea and vomiting: 50%Vertigo: 50%Confusion: 30%Subjective weakness: 20%Severe toxicity: ‘pink’ skin and mucosa, hyperpyrexia, arrhythmias, extrapyramidal features, coma, deathCherry red skin is a sign of severe toxicity and is usually a post-mortem finding.Management• 100% oxygen• Hyperbaric oxygen therapy (HBOT)The use of Hyperbaric oxygen therapy (HBOT) for treatment mild to moderate CO poisoning is not routine.The selection criteria for HBOT in cases of CO poisoning include:• COHb levels > 20-25%• COHb levels > 20% in pregnant patient • Loss of consciousness• Severe metabolic acidosis (pH <7.1)• Evidence of end-organ ischemia (e.g., ECG changes, chest pain, or altered mental status)

    • This question is part of the following fields:

      • Medicine
      • Pharmacology
      4.2
      Seconds
  • Question 27 - What percentage of blood to the liver is supplied by hepatic artery? ...

    Correct

    • What percentage of blood to the liver is supplied by hepatic artery?

      Your Answer: 25%

      Explanation:

      The liver receives a dual blood supply from the hepatic portal vein and hepatic arteries. The hepatic portal vein delivers approximately 75% of the liver’s blood supply, and carries venous blood drained from the spleen, gastrointestinal tract, and its associated organs. The hepatic arteries supply arterial blood to the liver, accounting for the remaining quarter of its blood flow.

    • This question is part of the following fields:

      • Gastrointestinal
      • Medicine
      4
      Seconds
  • Question 28 - Activation of the cool receptor (CMR-1), causes: ...

    Incorrect

    • Activation of the cool receptor (CMR-1), causes:

      Your Answer: Efflux of Ca++

      Correct Answer: Influx of Ca++ & Na+

      Explanation:

      Cold and Menthol receptor 1 (CMR1) is a protein that in humans is encoded by TRPM8 gene. It is an ion channel which upon activation causes the influx of Na+ and Ca++ ions into the cell that leads to the depolarization and generation of an action potential.

    • This question is part of the following fields:

      • Medicine
      • Neurology
      2.8
      Seconds
  • Question 29 - The main efferent input of the posterior pituitary gland comes from: ...

    Incorrect

    • The main efferent input of the posterior pituitary gland comes from:

      Your Answer: Paracrine hormones secreted from the hypothalamus via pituitary portal veins

      Correct Answer: Paracrine hormones secreted from the hypothalamus via axons.

      Explanation:

      The posterior pituitary or neurohypophysis consists of a collection of axonal projections emerging from the hypothalamus. It releases hormones directly from these axonal endings into circulation; these hormones are oxytocin and vasopressin.

    • This question is part of the following fields:

      • Endocrinology
      • Medicine
      13.5
      Seconds
  • Question 30 - Which of the following has the shortest duration: ...

    Correct

    • Which of the following has the shortest duration:

      Your Answer: Atrial systole

      Explanation:

      Atrial systole: 0.1s

      Atrial diastole: around 0.4s

      Ventricular diastole: 0.4-0.53s

      Ventricular systole: 0.27s

      PR interval: 0.12-0.2 s

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      14
      Seconds
  • Question 31 - Which of the following statements is most suitable to describe necrosis? ...

    Incorrect

    • Which of the following statements is most suitable to describe necrosis?

      Your Answer: Shrinking of cytoplasm and condensation of nucleus.

      Correct Answer: Significant inflammatory response

      Explanation:

      Necrosis is the death of most or all of the cells in an organ or tissue due to disease, injury, or failure of the blood supply. Cellular death due to necrosis does not follow the (regulated) apoptotic signal transduction pathway, but rather various receptors are activated, and result in the loss of cell membrane integrity and an uncontrolled release of products of cell death into the extracellular space. This initiates in the surrounding tissue an inflammatory response which attracts leukocytes and nearby phagocytes which eliminate the dead cells by phagocytosis.

    • This question is part of the following fields:

      • Cell Biology
      • Medicine
      10.3
      Seconds
  • Question 32 - Which of the following conditions is least likely to exhibit the Koebner phenomenon?...

    Incorrect

    • Which of the following conditions is least likely to exhibit the Koebner phenomenon?

      Your Answer: Pityriasis rubra

      Correct Answer: Lupus vulgaris

      Explanation:

      The Koebner phenomenon refers to skin lesions appearing on lines of trauma, exposure to a causative agents including: molluscum contagiosum, warts and toxicodendron dermatitis or secondary to scratching rather than an infective or chemical cause include vitiligo, psoriasis, lichen planus, lichen nitidus, pityriasis rubra pilaris, and keratosis follicularis (Darier disease).

    • This question is part of the following fields:

      • Dermatology
      • Medicine
      6.9
      Seconds
  • Question 33 - Iron absorption occurs primarily in which part of the GIT? ...

    Incorrect

    • Iron absorption occurs primarily in which part of the GIT?

      Your Answer: Terminal ileum

      Correct Answer: Duodenum

      Explanation:

      Like most mineral nutrients, the majority of the iron absorbed from digested food or supplements is absorbed in the duodenum by enterocytes of the duodenal lining.

    • This question is part of the following fields:

      • Haematology
      • Medicine
      3.3
      Seconds
  • Question 34 - Which is primarily responsible for the conversion of T4 to T3 in the...

    Incorrect

    • Which is primarily responsible for the conversion of T4 to T3 in the periphery?

      Your Answer: Iodotyrosine deiodinase

      Correct Answer: Deiodinase 1

      Explanation:

      Type 1 iodothyronine deiodinase, also known simply as deiodinase 1, is an enzyme which can produce both triiodothyronine (active form) or inactivate metabolites from T4. It is responsible for almost 80% of the conversion of peripheral T4 to T3. Iodothyronine deiodinases are not to be confused with iodotyrosine deiodinases, which are also part of the deiodinase enzymes.

    • This question is part of the following fields:

      • Endocrinology
      • Medicine
      4.6
      Seconds
  • Question 35 - In addition to its role in digestion and absorption of fats, bile: ...

    Correct

    • In addition to its role in digestion and absorption of fats, bile:

      Your Answer: Is the major excretory route for lipid-soluble waste products

      Explanation:

      The end product of haem metabolism is bilirubin and jaundice is caused by increased bilirubin levels in the blood. Gallstones are mainly caused by cholesterol and bile pigments. Bile is the main route of excretion for lipid soluble waste products whereas urine is the main route of excretion of water soluble waste products.

    • This question is part of the following fields:

      • Gastrointestinal
      • Medicine
      21.2
      Seconds
  • Question 36 - Regarding bronchial innervation which of the following is correct: ...

    Incorrect

    • Regarding bronchial innervation which of the following is correct:

      Your Answer: Beta 2 receptors mediate bronchoconstriction

      Correct Answer: Alpha 1 receptors increase bronchial constriction

      Explanation:

      Stimulation of β2 receptors results in smooth muscle relaxation and bronchodilation. α1 receptors cause smooth muscle contraction in the bronchioles although minor to the β2 effects.

    • This question is part of the following fields:

      • Medicine
      • Respiratory
      17.1
      Seconds
  • Question 37 - Which statement is correct? ...

    Correct

    • Which statement is correct?

      Your Answer: MtDNA principally encodes for proteins that are involved in oxidative phosphorylation for the production of ATP in the cell.

      Explanation:

      Mitochondria have no nucleus instead they contain their own free floating circular genome (MtDNA), which encodes 13 different subunits of proteins involved in oxidative phosphorylation. The remainder of the mitochondrial proteins are nuclear encoded, synthesized in the cytoplasm, and transported into the mitochondria.

    • This question is part of the following fields:

      • Genetics
      • Medicine
      18.6
      Seconds
  • Question 38 - Which of the following isoforms of Nitric oxide synthase (NOS) is found in...

    Incorrect

    • Which of the following isoforms of Nitric oxide synthase (NOS) is found in endothelial cells?

      Your Answer: Nos 1

      Correct Answer: Nos 3

      Explanation:

      There are only 3 isoforms:NOS 1: found in nervous systemNOS 2: in macrophages and other immune cellsNOS 3: In endothelial cells

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      4.5
      Seconds
  • Question 39 - Which one of the following is necessary to activate plasminogen to plasmin? ...

    Incorrect

    • Which one of the following is necessary to activate plasminogen to plasmin?

      Your Answer: Factor Va

      Correct Answer: tPA

      Explanation:

      In circulation, plasminogen adopts a closed, activation resistant conformation. Upon binding to clots, or to the cell surface, plasminogen adopts an open form that can be converted into active plasmin by a variety of enzymes, including tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), kallikrein, and factor XII (Hageman factor).

    • This question is part of the following fields:

      • Haematology
      • Medicine
      6.6
      Seconds
  • Question 40 - Regarding taste threshold and intensity discrimination: ...

    Incorrect

    • Regarding taste threshold and intensity discrimination:

      Your Answer: 50% change in concentration of substance tasted is necessary before an intensity difference can be detected

      Correct Answer: 30% change in concentration of substance tasted is necessary before an intensity difference can be detected

      Explanation:

      The ability of humans to differentiate differences in intensity of taste is poor. A 30% change in the concentration of the substance being tasted is required before an intensity difference is perceived.

    • This question is part of the following fields:

      • Medicine
      • Neurology
      25
      Seconds
  • Question 41 - The endothelium of the sinusoids has the following important function: ...

    Correct

    • The endothelium of the sinusoids has the following important function:

      Your Answer: Highly fenestrated, large subendothelial spaces, many macrophages

      Explanation:

      Substances absorbed in the intestines reach the liver via the portal vein and contain toxic substances that needs to be detoxified in hepatocytes. Thus, hepatic sinusoids are fenestrated and contain large spaces which allows passage of substances freely. These fenestrations are rich in Kupffer cells which are macrophages.

    • This question is part of the following fields:

      • Hepatobiliary
      • Medicine
      16.6
      Seconds
  • Question 42 - In most somatic cells telomeres progressively shorten as: ...

    Correct

    • In most somatic cells telomeres progressively shorten as:

      Your Answer: The cell divides

      Explanation:

      Telomere length shortens with age. Progressive shortening of telomeres leads to senescence, apoptosis, or oncogenic transformation of somatic cells, affecting the health and lifespan of an individual. Telomeres prevent the chromosomes from shortening and prevent the coding portion of the DNA from being lost, thus allowing the cell to replicate indefinitely. During replication telomeres may be lost resulting in cell death.

    • This question is part of the following fields:

      • Genetics
      • Medicine
      15.1
      Seconds
  • Question 43 - Which of the following is true with regard to the acini? ...

    Incorrect

    • Which of the following is true with regard to the acini?

      Your Answer: Zone 1 is the most susceptible to anoxic stimuli

      Correct Answer: The central zone (Zone III) is the least oxygenated

      Explanation:

      The acini are divided into zone I (periportal), zone II (transition zone), and zone III (pericentral). Cells located close to the portal triad or peripheral zone which consist of an arteriole from the hepatic artery are the most oxygenated cells. Cells in the central zone (III) are least oxygenated and mainly receive blood supply from the central vein which is a branch of hepatic vein.

    • This question is part of the following fields:

      • Gastrointestinal
      • Medicine
      8.4
      Seconds
  • Question 44 - Which of the following enzymes are involved in Phase I drug metabolism? ...

    Incorrect

    • Which of the following enzymes are involved in Phase I drug metabolism?

      Your Answer: Succinic dehydrogenase

      Correct Answer: Alcohol dehydrogenase

      Explanation:

      Drug metabolism can be broadly classified into:Phase I (functionalization) reactions: also termed non-synthetic reactions, they include oxidation, reduction, hydrolysis, cyclization and de-cyclization. The most common and vital reactions are oxidation reactions. (Of the given enzymes only Alcohol dehydrogenase is involved in phase I drug metabolism. Succinate dehydrogenase, is a vital enzyme involved in the Kreb’s cycle and the mitochondrial electron transport chain). They are mainly catalysed by Cytochrome P-450 enzyme.Phase II (conjugation) reactions: occur following phase I reactions, they include reactions: glucuronidation and sulphate conjugation, etc. They are mostly catalysed by UDP-glucuronosyltransferase enzyme. Other phase II enzymes include: sulfotransferases, N-acetyltransferases, glutathione S-transferases and methyltransferases.

    • This question is part of the following fields:

      • Medicine
      • Pharmacology
      11.4
      Seconds
  • Question 45 - The process where by DNA fragments are separated by size and charge is...

    Incorrect

    • The process where by DNA fragments are separated by size and charge is called:

      Your Answer: Northern blotting

      Correct Answer: Gel electrophoresis

      Explanation:

      Fragments of DNA of varying length can be separated on the basis of their charge and their size by a process called gel electrophoresis. Because DNA contains negatively charged phosphate groups, it will migrate in an electric field toward the positive electrode. Shorter chains migrate more rapidly through the pores of the gel, and thus separation depends on length. DNA bands in the gel can be visualized by various techniques including staining with dyes and autoradiography.

    • This question is part of the following fields:

      • Genetics
      • Medicine
      5.4
      Seconds
  • Question 46 - Which of the following is not true regarding mitochondrial chromosome disorders? ...

    Incorrect

    • Which of the following is not true regarding mitochondrial chromosome disorders?

      Your Answer: Retinal degeneration, diabetes mellitus and some forms of hearing loss are some of the other disease attributed to mitochondrial chromosome defects

      Correct Answer: Because mitochondrial chromosomes have no introns in their genes, any point mutation has a low likelihood of having an effect.

      Explanation:

      Any point mutation in any part of the mitochondrial DNA will lead to a mutated mitochondria and will likewise have its ill effect on the body.

    • This question is part of the following fields:

      • Genetics
      • Medicine
      15.9
      Seconds
  • Question 47 - The formation of superoxide is catalysed by which enzyme? ...

    Incorrect

    • The formation of superoxide is catalysed by which enzyme?

      Your Answer: Oxide reductase

      Correct Answer: NADPH oxidase

      Explanation:

      Superoxide is biologically toxic and is deployed by the immune system to kill invading microorganisms. In phagocytes, superoxide is produced in large quantities by the enzyme NADPH oxidase for use in oxygen-dependent killing mechanisms of invading pathogens.

    • This question is part of the following fields:

      • Cell Biology
      • Medicine
      7.8
      Seconds
  • Question 48 - The branche(s) of the left coronary artery include: ...

    Incorrect

    • The branche(s) of the left coronary artery include:

      Your Answer: Anterior interventricular artery

      Correct Answer: Left circumflex artery & anterior interventricular artery

      Explanation:

      The left main coronary divides into branches:

      1. The left anterior descending artery branches off the left coronary artery and supplies blood to the front of the left side of the heart.

      2. The circumflex artery branches off the left coronary artery and encircles the heart muscle.

      The anterior interventricular artery is otherwise known as the anterior descending branch. The posterior descending artery comes from Right coronary artery.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      9.1
      Seconds
  • Question 49 - In which of the following are the enzymatic mechanisms for producing aldosterone found?...

    Incorrect

    • In which of the following are the enzymatic mechanisms for producing aldosterone found?

      Your Answer: Zona reticularis

      Correct Answer: Zona glomerulosa

      Explanation:

      The zona glomerulosa is the outermost layer of the adrenal gland. In it, aldosterone is secreted as a response to an increase in potassium levels, decreased blood flow, or renin. This secretion is regulated by the renin-angiotensin system.

    • This question is part of the following fields:

      • Endocrinology
      • Medicine
      3.7
      Seconds
  • Question 50 - The following is true in relation to coronary venous drainage? ...

    Correct

    • The following is true in relation to coronary venous drainage?

      Your Answer: Most venous return ultimately drains into right atrium via the coronary sinus

      Explanation:

      Most of the venous blood returns to the heart via the coronary sinus and the anterior cardiac veins. Apart from these there are other vessels that drain directly into the heart chambers

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      19.1
      Seconds

SESSION STATS - PERFORMANCE PER SPECIALTY

Gastrointestinal (5/7) 71%
Medicine (19/50) 38%
Pharmacology (1/4) 25%
Cardiovascular (5/10) 50%
Endocrinology (0/5) 0%
Neurology (0/3) 0%
Research Skills (1/1) 100%
Connective Tissue (0/1) 0%
Genetics (2/7) 29%
Haematology (0/3) 0%
Cell Biology (1/3) 33%
Metabolism (1/1) 100%
Infectious Diseases (1/1) 100%
Hepatobiliary (2/2) 100%
Dermatology (0/1) 0%
Respiratory (0/1) 0%
Passmed