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  • Question 1 - The postextrasystolic potentiation of myocardial contractility is due to: ...

    Correct

    • The postextrasystolic potentiation of myocardial contractility is due to:

      Your Answer: Increase in intracellular Ca2+

      Explanation:

      The postextrasystolic potentiation of myocardial contractility Is not due to ventricular filling. It occurs in isolated locations in the heart and is due to increase availability of intracellular calcium.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      5.1
      Seconds
  • Question 2 - Which of the following would be a contraindication to thrombolysis? ...

    Correct

    • Which of the following would be a contraindication to thrombolysis?

      Your Answer: Intracranial neoplasm

      Explanation:

      Absolute contraindications to thrombolysis include:

      • Previous intracranial bleeding at any time
      • Stroke in less than 6 months
      • Closed head or facial trauma within 3 months
      • Suspected aortic dissection
      • Ischemic stroke within 3 months (except in ischemic stroke within 3 hours time)
      • Active bleeding diathesis
      • Uncontrolled high blood pressure (>180 systolic or >100 diastolic)
      • Known structural cerebral vascular lesion
      • Arterio-venous malformations
      • Thrombocytopenia
      • Known coagulation disorders
      • Aneurysm
      • Brain tumours
      • Pericardial effusion
      • Septic embolus

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      4.3
      Seconds
  • Question 3 - B1 adrenergic stimulation produces: ...

    Incorrect

    • B1 adrenergic stimulation produces:

      Your Answer: Decrease in cAMP

      Correct Answer: Increase in calcium cytosolic concentration

      Explanation:

      Norepinephrine secreted by the sympathetic endings binds to B1 receptors, and the resulting increase in intracellular cAMP facilitates the opening of L channels, increasing Ica and the rapidity of the depolarization phase of the impulse and activates PKA which leads to phosphorylation of the voltage-gated Ca2+ channels, causing them to spend more time in the open state.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      19.9
      Seconds
  • Question 4 - Which of the following supplies the AV node? ...

    Correct

    • Which of the following supplies the AV node?

      Your Answer: Right coronary artery

      Explanation:

      The AV node is supplied by the right coronary artery near the origin of the posterior IV artery.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      3.8
      Seconds
  • Question 5 - The following is true in relation to coronary venous drainage? ...

    Correct

    • The following is true in relation to coronary venous drainage?

      Your Answer: Most venous return ultimately drains into right atrium via the coronary sinus

      Explanation:

      Most of the venous blood returns to the heart via the coronary sinus and the anterior cardiac veins. Apart from these there are other vessels that drain directly into the heart chambers

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      12
      Seconds
  • Question 6 - In the cardiac cycle, all of the following are true except: ...

    Incorrect

    • In the cardiac cycle, all of the following are true except:

      Your Answer: The left ventricular volume is maximal at the end of atrial systole

      Correct Answer: Mitral valve is closed by contraction of papillary muscles

      Explanation:

      Mitral valve is closed by contraction of papillary muscles: This statement is incorrect. The mitral valve closes due to the pressure difference between the left ventricle and the left atrium at the onset of ventricular systole. The papillary muscles contract to prevent prolapse of the valve into the atrium but do not cause the valve to close.

      The left ventricular volume is maximal at the end of atrial systole: This statement is true. At the end of atrial systole, the atria have pushed the remaining blood into the ventricles, making the ventricular volume maximal (end-diastolic volume).

      The left ventricular pressure is maximal just before the aortic valve opens: This statement is true. Left ventricular pressure peaks just before the aortic valve opens, as the ventricle contracts to overcome the pressure in the aorta.

      The ejection fraction is about 55%: This statement is true. The ejection fraction, which is the percentage of blood ejected from the ventricles with each contraction, is typically around 55%.

      The ‘a’ wave is due to atrial systole: This statement is true. The ‘a’ wave on the venous pressure curve corresponds to atrial systole, reflecting the increased pressure from atrial contraction.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      28.8
      Seconds
  • Question 7 - Which coronary artery supplies the right atria? ...

    Correct

    • Which coronary artery supplies the right atria?

      Your Answer: Right coronary

      Explanation:

      The left coronary artery distributes blood to the left side of the heart, the left atrium and ventricle, and the interventricular septum. The circumflex artery arises from the left coronary artery and follows the coronary sulcus to the left. Eventually, it will fuse with the small branches of the right coronary artery. The right coronary artery proceeds along the coronary sulcus and distributes blood to the right atrium, portions of both ventricles, and the heart conduction system.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      4.1
      Seconds
  • Question 8 - The triangle with the heart at its centre, using limb leads is called:...

    Correct

    • The triangle with the heart at its centre, using limb leads is called:

      Your Answer: Einthoven

      Explanation:

      The Einthoven triangle is formed by placing the limb leads on both the arms and on the left leg with the heart in the centre.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      5.7
      Seconds
  • Question 9 - Which of the following is a method for measurement of cardiac output? ...

    Correct

    • Which of the following is a method for measurement of cardiac output?

      Your Answer: Indicator dilution method

      Explanation:

      There are two methods of calculating the cardiac output in humans other than doppler with echocardiography: The direct Fick’s method and the indicator dilution method. In the indicator dilution technique, a known amount of a substance such as a dye or, more commonly, a radioactive isotope is injected into an arm vein and the concentration of the indicator in serial samples of arterial blood is determined. The output of the heart is equal to the amount of indicator injected divided by its average concentration in arterial blood after a single circulation through the heart.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      3.9
      Seconds
  • Question 10 - Digoxin causes: ...

    Incorrect

    • Digoxin causes:

      Your Answer: Na/k ATPase stimulation

      Correct Answer: Increase in cytosolic calcium concentration

      Explanation:

      Digoxin is a positive inotrope which inhibits NA/K ATPase, increases cardiac contractility and can cause hypokalaemia.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      7.8
      Seconds
  • Question 11 - Coronary flow is reduced during ...

    Correct

    • Coronary flow is reduced during

      Your Answer: Tachycardia

      Explanation:

      Maximum amount of blood flow in the coronary arteries occur during diastole. When the heart rate increases which is also called tachycardia the duration of diastole decreases. Hence the amount of blood flow to the cardiac muscle also decreases.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      9.6
      Seconds
  • Question 12 - The AV Node: ...

    Correct

    • The AV Node:

      Your Answer: It decelerates impulses passing to the ventricles

      Explanation:

      The action potentials in the sinoatrial (SA) and atrioventricular (AV) nodes are largely due to Ca2+, with no contribution by Na+ influx. The depolarization continues to conduct slowly through the atrioventricular (AV) node. The AV node is located in the right posterior portion of the interatrial septum. This is small and bean-shaped. The atrial conductive system is organized so that the cardiac impulse does not travel from the atria into the ventricles too rapidly; this delay allows the atria to empty before ventricular contraction begins. It is the AV node and its adjacent conductive fibers that delay this transmission into the ventricles. Conduction through the AV Node is represented on the ECG by the PR interval.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      13.2
      Seconds
  • Question 13 - Which of the following regulates the calcium release channels? ...

    Incorrect

    • Which of the following regulates the calcium release channels?

      Your Answer: Phospholambin

      Correct Answer: Calstabin 2

      Explanation:

      Ca2+ is released from the SR through a Ca2+ release channel, a cardiac isoform of the ryanodine receptor (RyR2), which controls intracytoplasmic [Ca2+] and, as in vascular smooth-muscle cells, leads to the local changes in intracellular [Ca2+] called calcium sparks. A number of regulatory proteins, including calstabin 2, inhibit RyR2 and, thereby, the release of Ca2+ from the SR.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      5.5
      Seconds
  • Question 14 - Which of the following antiarrhythmic drugs may be used in the treatment of...

    Incorrect

    • Which of the following antiarrhythmic drugs may be used in the treatment of long QT syndrome?

      Your Answer: Amiodarone

      Correct Answer: Atenolol

      Explanation:

      Beta-blockers are the mainstay of treatment in long QT syndrome. Implantable cardioverter-defibrillators are the most effective treatment in genotypes with a high risk of recurrence.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      11.4
      Seconds
  • Question 15 - Which of the following is NOT an effect of a positive inotropic agent...

    Incorrect

    • Which of the following is NOT an effect of a positive inotropic agent on the heart?

      Your Answer: It increases the initial velocity of muscle shortening at all loads

      Correct Answer: It decreases the rate of rise in ventricular blood pressure during systole

      Explanation:

      Inotropic agents increase the contractility of the heart as well as the rate of rise in ventricular blood pressure during systole, generating a greater pressure and increasing the stroke volume e.g. like catecholamines do.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      22.9
      Seconds
  • Question 16 - Which factor produced by the endothelium is responsible for the regulation of vascular...

    Incorrect

    • Which factor produced by the endothelium is responsible for the regulation of vascular cell growth?

      Your Answer:

      Correct Answer: Vascular endothelial growth factor (VEGF)

      Explanation:

      VEGF is produced by the endothelial cells and is the major growth factor responsible for causing vasculogenesis. Some isoforms of this growth factor also have a prominent role in formation of lymphatic vessels.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 17 - The steps of cardiac cycle in sequence are: ...

    Incorrect

    • The steps of cardiac cycle in sequence are:

      Your Answer:

      Correct Answer: Isovolumic contraction, ejection, isovolumic relaxation, passive ventricular filling, active ventricular filling.

      Explanation:

      The cardiac cycle refers to a complete heartbeat from its generation to the beginning of the next beat, and so includes the diastole, the systole, and the intervening pause.1st stage: diastole, or passive filling is when the semilunar valves (the pulmonary valve and the aortic valve) close, the atrioventricular (AV) valves (the mitral valve and the tricuspid valve) open, and the whole heart is relaxed. 2nd stage: atrial systole, is when the atrium contracts, and blood flows from atrium to the ventricle (active filling).3rd stage: isovolumic contraction is when the ventricles begin to contract, the AV and semilunar valves close, and there is no change in volume. 4th stage: ventricular ejection, is when the ventricles are contracting and emptying, and the semilunar valves are open. 5th stage: isovolumic relaxation time, pressure decreases, no blood enters the ventricles, the ventricles stop contracting and begin to relax, and the semilunar valves close due to the pressure of blood in the aorta.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 18 - In which organ will you find extremely porous sinusoidal capillaries, with discontinuous endothelium?...

    Incorrect

    • In which organ will you find extremely porous sinusoidal capillaries, with discontinuous endothelium?

      Your Answer:

      Correct Answer: Liver

      Explanation:

      The liver is the organ which contains sinusoidal capillaries with discontinuous endothelium. The brain, lungs and the intestine all contain continuous capillaries, however the kidney contains fenestrated capillaries to aid in filtration.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 19 - Coronary arteries fill up during ...

    Incorrect

    • Coronary arteries fill up during

      Your Answer:

      Correct Answer: Diastole

      Explanation:

      During contraction of the ventricular myocardium (systole), the subendocardial coronary vessels (the vessels that enter the myocardium) are compressed due to the high ventricular pressures. This compression results in momentary retrograde blood flow (i.e., blood flows backward toward the aorta) which further inhibits perfusion of myocardium during systole. However, the epicardial coronary vessels (the vessels that run along the outer surface of the heart) remain open. Because of this, blood flow in the sub endocardium stops during ventricular contraction. As a result, most myocardial perfusion occurs during heart relaxation (diastole) when the subendocardial coronary vessels are open and under lower pressure.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 20 - What is troponin? ...

    Incorrect

    • What is troponin?

      Your Answer:

      Correct Answer: A component of thin filaments

      Explanation:

      Skeletal muscle cytoplasmic proteins include myosin and actin (also known as thick and thin filaments, respectively) which are arranged in a repeating unit called a sarcomere. Troponin is a component of thin filaments (along with tropomyosin), and is the protein to which calcium binds.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 21 - In the Fick‘s method of measuring cardiac output, the arterial oxygen content can...

    Incorrect

    • In the Fick‘s method of measuring cardiac output, the arterial oxygen content can be measured in a sample obtained from

      Your Answer:

      Correct Answer: The pulmonary vein

      Explanation:

      In Fick’s original method, the following variables are measured:VO2, oxygen consumption in ml of pure gaseous oxygen per minute. This may be measured using a spirometer within a closed rebreathing circuit incorporating a CO2 absorberCa, the oxygen concentration of blood taken from the pulmonary vein (representing oxygenated blood)Cv, the oxygen concentration of blood from an intravenous cannula (representing deoxygenated blood)From these values, we know that:VO2 = (CO x Ca) – (CO x Cv)where CO = Cardiac Output, Ca = Oxygen concentration of arterial blood and Cv = Oxygen concentration of mixed venous blood.This allows us to sayCO = VO2/{Ca – Cv}and hence calculate cardiac output.Note that (Ca – Cv) is also known as the arteriovenous oxygen difference.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 22 - If both the noradrenergic and the cholinergic systems are blocked in the heart,...

    Incorrect

    • If both the noradrenergic and the cholinergic systems are blocked in the heart, the rate will be approximately:

      Your Answer:

      Correct Answer: 100/min

      Explanation:

      The normal heart beat is about 70/min. This is due to a predominant parasympathetic activity. If sympathetic activity was unopposed the heart rate would have been 150/min. When both the noradrenergic and cholinergic systems are blocked the heart rate is 100/min. This is the normal firing rate of the SA node.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 23 - Which part of the ECG represents ventricular repolarisation? ...

    Incorrect

    • Which part of the ECG represents ventricular repolarisation?

      Your Answer:

      Correct Answer: T wave

      Explanation:

      Ventricular repolarisation is denoted by the T wave.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 24 - Myocardium requires more oxygen to expel blood in: ...

    Incorrect

    • Myocardium requires more oxygen to expel blood in:

      Your Answer:

      Correct Answer: A stenotic aortic valve

      Explanation:

      In aortic valve stenosis, increased ventricular pressure Is needed to expel the blood into the aorta. Increased pressure means increased contractility hence increase O2 consumption by the heart muscles.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 25 - What is the function of the BK channel on the vascular smooth muscle...

    Incorrect

    • What is the function of the BK channel on the vascular smooth muscle membrane?

      Your Answer:

      Correct Answer: Massive K+ efflux, increasing membrane potential, and shutting off the voltage gated Ca2+ channel

      Explanation:

      BK channels, also known as large-conductance calcium-activated potassium channels, play a critical role in regulating vascular smooth muscle tone. When BK channels open, they allow a large efflux of potassium ions (K+) out of the cell. This efflux of K+ causes the membrane potential to become more negative (hyperpolarization), which in turn leads to the closure of voltage-gated calcium channels. The closure of these calcium channels reduces the influx of calcium ions (Ca2+) into the smooth muscle cells, resulting in decreased intracellular calcium levels and subsequent relaxation of the smooth muscle.

      Thus, BK channels promote smooth muscle relaxation by hyperpolarizing the membrane and reducing the activity of voltage-gated Ca2+ channels.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 26 - The following contributes to the rate of depolarization? ...

    Incorrect

    • The following contributes to the rate of depolarization?

      Your Answer:

      Correct Answer: All of the options given

      Explanation:

      Depolarization occurs due to impulses generated by the SA node. As the heart beats to the rhythm of the SA node, certain factors will effect the rate of depolarization. All the mentioned options effect the rate of depolarization.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 27 - The following products of the vascular endothelium produce vasodilation except: ...

    Incorrect

    • The following products of the vascular endothelium produce vasodilation except:

      Your Answer:

      Correct Answer: Endothelin

      Explanation:

      Endothelin: This is incorrect in the context of vasodilation. Endothelin is actually a potent vasoconstrictor produced by the endothelium, leading to the narrowing of blood vessels and increased blood pressure.

      Nitrous oxide (Nitric oxide): This is correct for vasodilation. Nitric oxide is a powerful vasodilator produced by the endothelium, which helps relax and widen blood vessels.

      Prostacyclin: This is correct for vasodilation. Prostacyclin (PGI2) is a vasodilator and inhibits platelet aggregation, helping to maintain blood flow and reduce clot formation.

      Endothelial-derived hyperpolarizing factor (EDHF): This is correct for vasodilation. EDHF causes vasodilation by hyperpolarizing the smooth muscle cells of blood vessels.

      Vascular endothelial growth factor (VEGF): This is correct for vasodilation. VEGF primarily promotes the growth of new blood vessels but also has vasodilatory effects through nitric oxide production.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 28 - How many molecules of myosin attach to actin at any given time? ...

    Incorrect

    • How many molecules of myosin attach to actin at any given time?

      Your Answer:

      Correct Answer: 1

      Explanation:

      1 molecule of myosin binds to actin at any give time.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 29 - Regarding blood supply to the heart; ...

    Incorrect

    • Regarding blood supply to the heart;

      Your Answer:

      Correct Answer: Coronary arteries fill as the heart relaxes

      Explanation:

      The heart muscles acts like the skeletal muscle in the fact that it also compress the vessels during contraction. As the pressure in the ventricle is slightly greater than in the aorta the coronary vessels collapse during systole. Blood flows through them during the diastole phase of contraction.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 30 - The basic unit of contraction in myocytes is: ...

    Incorrect

    • The basic unit of contraction in myocytes is:

      Your Answer:

      Correct Answer: Sarcomere

      Explanation:

      Sarcomere is the organelle where calcium is stored to be released during contraction of the muscle. It is the basic unit of contraction in striated muscle fibers. As myocytes are also striated muscles, sarcomeres also forms the basic unit of contraction. The impulses travel along the membrane and via its interaction with the dihydropyridine receptors it releases the stored calcium.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 31 - Activation of nitric oxide synthesis by endothelial cells is triggered by: ...

    Incorrect

    • Activation of nitric oxide synthesis by endothelial cells is triggered by:

      Your Answer:

      Correct Answer: All of the above

      Explanation:

      Acetylcholine, histamine, bradykinin, vasoactive intestinal peptide (VIP) and shear stress on the endothelial cells causing the release of NO. NO is formed from arginine and causes vasodilatation of the blood vessels.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 32 - The positive inotropic effect of digoxin is due to? ...

    Incorrect

    • The positive inotropic effect of digoxin is due to?

      Your Answer:

      Correct Answer: Inhibition of the sodium potassium ATPase in the myocardium

      Explanation:

      Digitalis compounds are potent inhibitors of cellular Na+/K+-ATPase. This ion transport system moves sodium ions out of the cell and brings potassium ions into the cell. By inhibiting the Na+/K+-ATPase, cardiac glycosides cause the intracellular sodium concentration to increase. This then leads to an accumulation of intracellular calcium via the Na+/Ca++ exchange system. In the heart, increased intracellular calcium causes more calcium to be released by the sarcoplasmic reticulum, thereby making more calcium available to bind to troponin-C, which increases contractility (inotropy).

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 33 - The principle by which the energy of contraction is proportional to the initial...

    Incorrect

    • The principle by which the energy of contraction is proportional to the initial length of cardiac muscle fiber is known as:

      Your Answer:

      Correct Answer: Starling’s law

      Explanation:

      The Frank starling relationship describes that an increase in the venous return or the end diastolic volume will cause an increase in the stroke volume/ preload and also cardiac output. It stems from the fact that increase venous return will increase the stretch on the ventricular muscle fibers. The sarcomere will stretch a considerable length that is needed for maximum contraction and increased development of tension in the muscle fiber. The greater the venous return the greater the cardiac output. This relation is directly proportional.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 34 - Which of the following causes the closure of the ductus arteriosus during birth?...

    Incorrect

    • Which of the following causes the closure of the ductus arteriosus during birth?

      Your Answer:

      Correct Answer: Reduced levels of prostaglandins

      Explanation:

      Ductus arteriosus is kept open by the prostaglandin E2 which is a vasodilator. At birth the high levels of cyclooxygenase blocks the production of prostaglandins which results in the closure of the ductus arteriosus.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 35 - The effects of β1 stimulation include the following ...

    Incorrect

    • The effects of β1 stimulation include the following

      Your Answer:

      Correct Answer: Increased strength of contraction

      Explanation:

      β1 stimulation include the phosphorylation of L type Ca++ channels and phospholamban and increased Ca++ influx from myocytes.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 36 - Which factors increase the end-diastolic volume? ...

    Incorrect

    • Which factors increase the end-diastolic volume?

      Your Answer:

      Correct Answer: Constriction of veins

      Explanation:

      End diastolic volume is also known as preload. It is the amount of blood the heart contracts against. Constriction of veins will decrease venous pooling and increase venous return, hence increasing the end diastolic volume. Standing will increase venous pooling hence decreasing venous return and end diastolic volume. Raised intrapericardial pressure will also decrease venous return and hence end diastolic volume.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 37 - Which of the following does not lower ventricular rate in atrial fibrillation? ...

    Incorrect

    • Which of the following does not lower ventricular rate in atrial fibrillation?

      Your Answer:

      Correct Answer: Adrenaline

      Explanation:

      Adrenaline is a sympathetic neurotransmitter which increases the heart rate. During atrial fibrillation the atria is contracting at more than 200 beats/min. Acetylcholine is a parasympathetic neurotransmitter decreasing the heart rate. Digital also depresses the conduction at the AV conduction. Vagal discharge and occulocardiac reflux decrease the heart rate and convert the tachycardia into normal sinus rhythm.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 38 - What is the main reason for checking the urea and electrolytes prior to...

    Incorrect

    • What is the main reason for checking the urea and electrolytes prior to commencing a patient on amiodarone?

      Your Answer:

      Correct Answer: To detect hypokalaemia

      Explanation:

      All antiarrhythmic drugs have the potential to cause arrhythmias. Coexistent hypokalaemia significantly increases this risk.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 39 - The isoforms of nitric oxide synthase which are found in the nervous system...

    Incorrect

    • The isoforms of nitric oxide synthase which are found in the nervous system (NOS1) and endothelial cells (NOS3) are activated by agents that increase which of the following intracellular electrolytes?

      Your Answer:

      Correct Answer: Ca

      Explanation:

      Synthesis of nitric oxide is stimulated by activation of the NMDA receptors by certain agents. This leads to opening of the Calcium channels and an influx of calcium into the cell. This will activate the nitric oxide synthase. Nitric oxide is produced on demand.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 40 - Pacemaker cells in the SA node and the AV node are connected by?...

    Incorrect

    • Pacemaker cells in the SA node and the AV node are connected by?

      Your Answer:

      Correct Answer: Gap junctions

      Explanation:

      Gap junctions allows for rapid propagation of the action potential from one cell to the other. The cells of the heart are connected by gap junctions.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 41 - Activation of baroreceptor reflex involves: ...

    Incorrect

    • Activation of baroreceptor reflex involves:

      Your Answer:

      Correct Answer: Short term regulation of systemic blood pressure

      Explanation:

      Baroreceptors are found in the heart and the blood vessels. They are the carotid sinus and the aortic arch receptors and respond to the minute to minute change in the blood pressure i.e. a change in the pulsatile pressure and not to a change in the mean arterial pressure. If the pulse pressure decreases, the rate of firing of the receptors decreases, stimulating an increase in the heart rate and blood pressure. Mechanisms that regulate the long term blood pressure control include the renin-angiotensin-aldosterone mechanism.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 42 - The a-wave is created by: ...

    Incorrect

    • The a-wave is created by:

      Your Answer:

      Correct Answer: Regurgitation of some blood to the great veins when the atria contracts in atrial systole

      Explanation:

      The a-wave created on the venous pulse curve occurs as a result of atrial systole. Due to the pressure build-up in the atria, it causes a back pressure in the vena cava. This pressure is exerted on the valve and this back pressure is what causes a slight increase in the venous pressure.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 43 - Which of the following are responsible for the 4th heart sound? ...

    Incorrect

    • Which of the following are responsible for the 4th heart sound?

      Your Answer:

      Correct Answer: Ventricular hypertrophy

      Explanation:

      The fourth heart sound is not normally audible in a normal adult. It occurs as a consequence of ventricular hypertrophy. It is caused by filling of the ventricle in atrial systole.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 44 - Angina pectoris develops when blood through the coronary artery becomes: ...

    Incorrect

    • Angina pectoris develops when blood through the coronary artery becomes:

      Your Answer:

      Correct Answer: Restricted, limiting blood blow

      Explanation:

      Angina pectoris develops when stenosis ( >70%) of the artery occurs as a result of formation of an atherosclerotic plaque. This leads to a decrease in the O2 carried to the thickened heart muscle by the blood, leading to the characteristic chest pain associated with angina pectoris.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 45 - Concerning coronary arteries, what is the net effect of B2 stimulation on the...

    Incorrect

    • Concerning coronary arteries, what is the net effect of B2 stimulation on the heart (e.g. Running athlete)?

      Your Answer:

      Correct Answer: Vasodilation via production of metabolites

      Explanation:

      The coronary arterioles contain α-adrenergic receptors, which cause vasoconstriction, and β-adrenergic receptors, which cause vasodilation. Activity in the noradrenergic nerves to the heart and injections of norepinephrine cause coronary vasodilation. However, norepinephrine also increases the heart rate and the force of cardiac contraction, and the vasodilation is due to production of vasodilator metabolites in the myocardium secondary to the increase in its activity. As exercise has the same effect as sympathetic stimulation, it will result in vasodilation.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 46 - The coronary sinus drains into the: ...

    Incorrect

    • The coronary sinus drains into the:

      Your Answer:

      Correct Answer: Right atrium

      Explanation:

      The coronary sinus drains into the right atrium. Most of the venous blood returns to the heart via the coronary sinus and the anterior cardiac veins. Apart from these there are other vessels that drain directly into the heart chambers.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 47 - Normal stroke volume is about: ...

    Incorrect

    • Normal stroke volume is about:

      Your Answer:

      Correct Answer: 70 ml

      Explanation:

      Stroke volume is the amount of blood that is pumped from the heart into the aorta. It is typically 70 ml.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 48 - The coronary arteries supply which part of the heart’s subendocardial region exclusively in...

    Incorrect

    • The coronary arteries supply which part of the heart’s subendocardial region exclusively in diastole?

      Your Answer:

      Correct Answer: Left ventricle

      Explanation:

      It is only during diastole that the blood flows to the subendocardial portion of the left ventricle, as the heart muscle relaxes and the coronary arteries regain their patency.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 49 - Arterioles stemming from the coronary artery can also empty into the heart directly...

    Incorrect

    • Arterioles stemming from the coronary artery can also empty into the heart directly via the:

      Your Answer:

      Correct Answer: Arteriosinusoidal vessels

      Explanation:

      Most of the venous blood returns to the heart via the coronary sinus and the anterior cardiac veins. Apart from these there are other vessels that drain directly into the heart chambers. They include arteriosinusoidal vessels, which connect the arterioles to the heart chambers. The thebesian veins drain the capillaries into the chambers and the arterioluminal vessels drain small arteries directly into the chambers.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds
  • Question 50 - Where does the SA node develop? ...

    Incorrect

    • Where does the SA node develop?

      Your Answer:

      Correct Answer: From structures on the right side of the embryo.

      Explanation:

      The SA node develops from the right side of the embryo and the AV node from the left. This is the reason why in adults the right vagus supplies the SA node and the left vagus supplies the AV node.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      0
      Seconds

SESSION STATS - PERFORMANCE PER SPECIALTY

Cardiovascular (9/15) 60%
Medicine (9/15) 60%
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