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  • Question 1 - Endothelial cells produce the following substance(s): ...

    Correct

    • Endothelial cells produce the following substance(s):

      Your Answer: All of the above

      Explanation:

      Endothelial cells produce thromboxane, prostacyclins, nitric oxides, endothelins, IL-1 and TNF.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      3
      Seconds
  • Question 2 - The following can cause steatorrhea except ...

    Correct

    • The following can cause steatorrhea except

      Your Answer: Diseases that destroy the endocrine portion of the pancreas

      Explanation:

      Dietary fats and lipids are usually efficiently digested and over 90% absorbed. Impaired digestion or absorption can result in fatty stools. Possible causes include exocrine (not endocrine) pancreatic insufficiency, with poor digestion from lack of lipases, loss of bile salts, which reduces micelle formation, and small intestinal disease producing malabsorption. Various other causes including certain medicines that block fat absorption, or indigestible or excess oil/fat in diet.

    • This question is part of the following fields:

      • Gastrointestinal
      • Medicine
      2.8
      Seconds
  • Question 3 - The functional unit of the liver is called? ...

    Correct

    • The functional unit of the liver is called?

      Your Answer: Acini

      Explanation:

      From a metabolic perspective, the functional unit is the hepatic acinus (terminal acinus), each of which is centred on the line connecting two portal triads and extends outwards to the two adjacent central veins. The periportal zone I is nearest to the entering vascular supply and receives the most oxygenated blood, making it least sensitive to ischemic injury while making it very susceptible to viral hepatitis. Conversely, the centrilobular zone III has the poorest oxygenation, and will be most affected during a time of ischemia.

    • This question is part of the following fields:

      • Hepatobiliary
      • Medicine
      2.6
      Seconds
  • Question 4 - Although variable, branches of which artery most often supply the SA and AV...

    Correct

    • Although variable, branches of which artery most often supply the SA and AV nodes?

      Your Answer: Right coronary artery

      Explanation:

      The RCA (right coronary artery) supplies the SA and the AV nodes along with the postero-basal wall of the left ventricle, posterior one third of the inferior vena cava, right ventricle and the posteromedial papillary muscle in the left ventricle.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      2.8
      Seconds
  • Question 5 - Which of the following structures of the cardiac conduction system is located in...

    Correct

    • Which of the following structures of the cardiac conduction system is located in the right posterior portion of the interatrial septum?

      Your Answer: AV node

      Explanation:

      AV node is located at the right posterior portion of the interatrial septum.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      6.8
      Seconds
  • Question 6 - As assessed by immunocytochemistry and electron microscopy, the anterior pituitary gland contains how...

    Correct

    • As assessed by immunocytochemistry and electron microscopy, the anterior pituitary gland contains how many different types of cells?

      Your Answer: 5

      Explanation:

      The pituitary is divided into three sections

      -the anterior lobe which constitute the majority of the pituitary mass and is composed primarily of five hormone-producing cell types (thyrotropes, lactotropes, corticotropes, somatotropes and gonadotropes) each secreting thyrotropin, prolactin, ACTH, growth hormone and gonadotropins (FSH and LH) respectively.

      There is also a sixth cell type in the anterior lobe -the non-endocrine, agranular, folliculostellate cells.

      The intermediate lobe produces melanocyte-stimulating hormone and endorphins, whereas the posterior lobe secretes anti-diuretic hormone (vasopressin) and oxytocin.

    • This question is part of the following fields:

      • Endocrinology
      • Medicine
      3.5
      Seconds
  • Question 7 - The Afferent neuron that supplies all sensory elements of the muscle spindle is...

    Correct

    • The Afferent neuron that supplies all sensory elements of the muscle spindle is what type of sensory neuron?

      Your Answer: Ia

      Explanation:

      Muscle spindle is supplied by both sensory and motor nerves. Sensory supply is Type Ia fibers whereas motor supply is gamma motor neurone.

    • This question is part of the following fields:

      • Medicine
      • Neurology
      3.1
      Seconds
  • Question 8 - Which part of the ECG represents ventricular repolarisation? ...

    Correct

    • Which part of the ECG represents ventricular repolarisation?

      Your Answer: T wave

      Explanation:

      Ventricular repolarisation is denoted by the T wave.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      2.1
      Seconds
  • Question 9 - An 80-year-old woman with advanced COPD has been admitted to the medicine ward...

    Correct

    • An 80-year-old woman with advanced COPD has been admitted to the medicine ward in an unconscious state. She appears to have an acute lower respiratory tract infection. After consulting with an anaesthesiologist it was concluded that she was not a candidate for intensive care unit admission and thus, a decision was made to start the patient on doxapram therapy. Which of the following best fits the characteristics of doxapram?

      Your Answer: It is contraindicated in hyperthyroidism

      Explanation:

      The two statements that fit the characteristics of doxapram are, epilepsy is a contraindication for doxapram use and concurrent use with theophylline may increase agitation.Doxapram is a central respiratory stimulant. In clinical practice, doxapram is usually used for patients who have an acute exacerbation of chronic obstructive pulmonary disease (COPD) who are unsuitable for admission to the intensive therapy unit for ventilatory support. Doxapram infusion may buy an extra 24 h to allow for recovery.Contraindications include: ischaemic heart disease, epilepsy, cerebral oedema, acute stroke, asthma, hypertension, hyperthyroidism, and pheochromocytoma. The infusion may worsen agitation and dyspnoea and lead to hypertension, nausea, vomiting and urinary retention.Drug interactions:Concomitant administration of doxapram and aminophylline (theophylline) can cause increased skeletal muscle activity, agitation, and hyperactivity.

    • This question is part of the following fields:

      • Medicine
      • Pharmacology
      3.4
      Seconds
  • Question 10 - The end- diastolic ventricular volume is about? ...

    Correct

    • The end- diastolic ventricular volume is about?

      Your Answer: 130 ml

      Explanation:

      The end diastolic volume in a healthy individual is about 130 ml.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      2.3
      Seconds
  • Question 11 - Which of the following skin conditions is not associated with diabetes mellitus? ...

    Correct

    • Which of the following skin conditions is not associated with diabetes mellitus?

      Your Answer: Sweet's syndrome

      Explanation:

      Diabetic dermadromes constitute a group of cutaneous conditions commonly seen in people with diabetes with longstanding disease. Conditions included in this group are:- Acral dry gangrene- Carotenosis- Diabetic dermopathy- Diabetic bulla- Diabetic cheiroarthropathy- Malum perforans- Necrobiosis lipoidica- Limited joint mobility- Scleroderma- Waxy skin is observed in roughly 50%. Sweet’s syndrome is also known as acute febrile neutrophilic dermatosis has a strong association with acute myeloid leukaemia. It is not associated with diabetes mellitus.

    • This question is part of the following fields:

      • Dermatology
      • Medicine
      7.5
      Seconds
  • Question 12 - The amount of a substance taken up by an organ (or whole body)...

    Correct

    • The amount of a substance taken up by an organ (or whole body) per unit time is = (the arterial level - the venous level) * the blood flow. This statement describes?

      Your Answer: The Fick principle

      Explanation:

      The essence of the Fick principle is that blood flow to an organ can be calculated using a marker substance if the following information is known:- Amount of marker substance taken up by the organ per unit time- Concentration of marker substance in arterial blood supplying the organ- Concentration of marker substance in venous blood leaving the organ

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      3.4
      Seconds
  • Question 13 - Where is Basic Electrical rhythm initiated ...

    Correct

    • Where is Basic Electrical rhythm initiated

      Your Answer: Interstitial cells of cajal

      Explanation:

      The interstitial cells of Cajal are specialized pacemaker cells located in the wall of the stomach, small intestine, and large intestine. These cells are connected to the smooth muscle via gap junctions and the myenteric plexus. The cell membranes of the pacemaker cells undergo a rhythmic depolarization and repolarization from -65mV to -45mV. This rhythm of depolarization-repolarization of the cell membrane creates a slow wave known as a basic electrical rhythm (BER), and it is transmitted to the smooth muscle cells.

    • This question is part of the following fields:

      • Gastrointestinal
      • Medicine
      4.7
      Seconds
  • Question 14 - Calcium needed for cardiac muscle contraction is made available during which phase of...

    Correct

    • Calcium needed for cardiac muscle contraction is made available during which phase of the action potential?

      Your Answer: 2

      Explanation:

      It is made available during the plateau phase of the action potential i.e. phase 2. During the plateau phase of the action potential, Calcium from the extracellular fluid enters through the L type of calcium channels. This entry triggers the release of more calcium from the sarcoplasmic reticulum via the ryanodine receptors.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      3.9
      Seconds
  • Question 15 - A 28 year old female with a history of psoriatic arthritis would most...

    Correct

    • A 28 year old female with a history of psoriatic arthritis would most likely have which of the following hand conditions?

      Your Answer: Nail dystrophy

      Explanation:

      Nail dystrophy (pitting of nails, onycholysis, subungual hyperkeratosis), dactylitis, sausage shaped fingers are most commonly seen with psoriatic arthropathy. There is asymmetric joint involvement most commonly distal interphalangeal joints. Uveitis and sacroiliitis may also occur. Arthritis mutilans may occur but is very rare. Cutaneous lesions may or may not develop. When they do, its usually much after the symptoms of arthritis.

    • This question is part of the following fields:

      • Connective Tissue
      • Medicine
      4.7
      Seconds
  • Question 16 - The cells that secrete HCL are found in which part of the stomach?...

    Incorrect

    • The cells that secrete HCL are found in which part of the stomach?

      Your Answer: Antrum

      Correct Answer: Body

      Explanation:

      The stomach can be divided in to different regions. Cardia, fundus, body, antrum and pylorus from proximal end to distal end respectively. Different cell types are distributed accordingly among the regions of the stomach. Cells that secret HCl in the gastric mucosa are known as parietal cells and are abundant in the gastric body region. They have receptors for acetylcholine stimulated via the vagus nerve, histamine receptors and gastrin receptors which stimulate gastric acid secretion. G cells that secret gastrin are abundant in the antrum.

    • This question is part of the following fields:

      • Gastrointestinal
      • Medicine
      3.3
      Seconds
  • Question 17 - Which two ducts form the ampulla of Vater? ...

    Correct

    • Which two ducts form the ampulla of Vater?

      Your Answer: The common bile duct and the pancreatic duct of Wirsung

      Explanation:

      The ampulla of Vater, also known as the hepatopancreatic ampulla or the hepatopancreatic duct, is formed by the union of the pancreatic duct and the common bile duct. The ampulla is specifically located at the major duodenal papilla.

    • This question is part of the following fields:

      • Gastrointestinal
      • Medicine
      2.8
      Seconds
  • Question 18 - Absorption of protein antigens i.e. bacterial and viral proteins takes place in the:...

    Correct

    • Absorption of protein antigens i.e. bacterial and viral proteins takes place in the:

      Your Answer: Microfold cells (m cells) of the intestine

      Explanation:

      M cells are specialized epithelial cells. They have a high capacity of transcytosis of microorganisms and macromolecules. They rapidly uptake antigens and present them to immune cells associated with the gut. In contrast to absorptive enterocytes, M cells do not exert direct defence mechanisms to antigens and pathogens in the intestinal cavity. Crypts of Lieberkühn are located mainly in the small intestine and large intestine and the main function is to replenish epithelial cells and to secrete intestinal enzymatic juice as well as mucous. Brunner’s glands empty into intestinal glands and their main function is to secrete mucin and to form a protective mucus layer on the duodenal epithelial cells to protect it from acidic chyme coming from the stomach. Islets of Langerhans are located in the pancreas and secrets insulin mainly. Mucosa associated lymphoid tissue plays a role in inducing immune response after presentation of antigens.

    • This question is part of the following fields:

      • Gastrointestinal
      • Medicine
      4.4
      Seconds
  • Question 19 - What is the main function of vitamin E? ...

    Correct

    • What is the main function of vitamin E?

      Your Answer: It is an antioxidant

      Explanation:

      Vitamin E has many biological functions, the antioxidant function being the best known. Other functions include enzymatic activities, gene expression, and neurological function(s).

    • This question is part of the following fields:

      • Haematology
      • Medicine
      2.3
      Seconds
  • Question 20 - A 51-year-old real estate agent takes hydrocortisone 20mg in the mornings and 5mg...

    Correct

    • A 51-year-old real estate agent takes hydrocortisone 20mg in the mornings and 5mg at night for Addison’s disease. The endocrinology consultant would like her to take prednisolone instead. What dose of prednisolone should be started?

      Your Answer: 7 mg

      Explanation:

      1mg Prednisolone = 4mg hydrocortisone, so the actual equivalent daily dose is 7mg.

    • This question is part of the following fields:

      • Medicine
      • Pharmacology
      2.1
      Seconds
  • Question 21 - Regarding the cardiac muscle striations as viewed under the microscope, which areas are...

    Correct

    • Regarding the cardiac muscle striations as viewed under the microscope, which areas are dark?

      Your Answer: A band and z line

      Explanation:

      Dark bands: a, h. Dark line: z. Clear band: i, m

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      4.8
      Seconds
  • Question 22 - Where are the principal cells found in the kidney? ...

    Correct

    • Where are the principal cells found in the kidney?

      Your Answer: Collecting ducts

      Explanation:

      A kidney collecting duct cell can be of two different cell types:Principal cellsIntercalated cells

    • This question is part of the following fields:

      • Medicine
      • Renal
      3.8
      Seconds
  • Question 23 - A 22 year old man is being evaluated for chronic lower backache. Which...

    Correct

    • A 22 year old man is being evaluated for chronic lower backache. Which of the following would most strongly point towards the diagnosis of ankylosing spondylitis?

      Your Answer: Reduced lateral flexion of the lumbar spine

      Explanation:

      Ankylosing spondylitis (spondylarthritis) is a chronic inflammatory disease of the axial skeleton that leads to partial or even complete fusion and rigidity of the spine. Males are disproportionately affected and upwards of 90% of patients are positive for the HLA-B27 genotype, which predisposes to the disease. The most characteristic early finding is pain and stiffness in the neck and lower back, caused by inflammation of the vertebral column and the sacroiliac joints. The pain typically improves with activity and is especially prominent at night. Other articular findings include tenderness to percussion and displacement of the sacroiliac joints (Mennell’s sign), as well as limited spine mobility, which can progress to restrictive pulmonary disease. The most common extra-articular manifestation is acute, unilateral anterior uveitis. Diagnosis is primarily based on symptoms and x-ray of the sacroiliac joints, with HLA-B27 testing and MRI reserved for inconclusive cases. There is no curative treatment, but regular physiotherapy can slow progression of the disease. Additionally, NSAIDs and/or tumour necrosis factor-α inhibitors may improve symptoms. In severe cases, surgery may be considered to improve quality of life. The spine adopts a bamboo shape, not lordosis. The pain usually improves as the day progresses. leg raise test causes pain in cases of meningitis etc not in this case.

    • This question is part of the following fields:

      • Connective Tissue
      • Medicine
      3
      Seconds
  • Question 24 - During strenuous exercise the PO2 of mixed venous blood is: ...

    Correct

    • During strenuous exercise the PO2 of mixed venous blood is:

      Your Answer: 25 mmHg

      Explanation:

      During strenuous exercise the PO2 of mixed venous blood is less than 30 mmHg.

    • This question is part of the following fields:

      • Medicine
      • Respiratory
      7.8
      Seconds
  • Question 25 - High titre of which of the following antibodies is not considered diagnostic for...

    Correct

    • High titre of which of the following antibodies is not considered diagnostic for the mentioned disease?

      Your Answer: Rheumatoid factor in rheumatoid arthritis (RA)

      Explanation:

      Diagnosis of RA is mainly based on clinical features (e.g., morning stiffness, symmetrical joint swelling) and laboratory tests (e.g., anti-CCP). Rheumatoid factor is not very specific for this disease and hence has low reliability. X-ray findings (e.g., soft tissue swelling or joint space narrowing) occur late in the disease and are therefore not typically used for diagnosis.

    • This question is part of the following fields:

      • Connective Tissue
      • Medicine
      2.9
      Seconds
  • Question 26 - The blood supply to the liver is by ...

    Correct

    • The blood supply to the liver is by

      Your Answer: Hepatic artery and hepatic portal vein

      Explanation:

      The liver receives a dual blood supply from the hepatic portal vein and hepatic arteries. The hepatic portal vein delivers approximately 75% of the liver’s blood supply, and carries venous blood drained from the spleen, gastrointestinal tract, and its associated organs. The hepatic arteries supply arterial blood to the liver, accounting for the remaining quarter of its blood flow.

    • This question is part of the following fields:

      • Gastrointestinal
      • Medicine
      2.7
      Seconds
  • Question 27 - Which of the following limits the duration of inspiration and increases respiratory rate?...

    Correct

    • Which of the following limits the duration of inspiration and increases respiratory rate?

      Your Answer: Pneumotaxic centre

      Explanation:

      The mechanism of control of ventilation is an interplay of multiple regions in the brain. The medullary respiratory centre sets the basic rhythm of breathing and the pons modifies the output of the medullary centres. There are two pontine centres: apneustic and pneumotaxic.

      The pnuemotaxic centre controls inspiratory time. Increased signals to this area increases respiratory rate. The dorsal respiratory group (DRG) integrates input from the stretch receptors and the chemoreceptors in the periphery and is composed mainly of inspiratory neurons. The DRG controls the basic rhythm of breathing by triggering inspiratory impulses. The ventral respiratory group (VRG) generates breathing rhythm and integrates data coming into the medulla and contains both inspiratory and expiratory neurons. They are primarily active in exercise and stress.

    • This question is part of the following fields:

      • Medicine
      • Respiratory
      3.8
      Seconds
  • Question 28 - What is the isolated effect of B2 stimulation on the coronaries? ...

    Correct

    • What is the isolated effect of B2 stimulation on the coronaries?

      Your Answer: Vasodilatation

      Explanation:

      Norepinephrine and epinephrine are agonists for all adrenergic receptor subtypes, although with varying affinities. Based on their physiology and pharmacology, adrenergic receptors have been divided into two principal types: alpha and beta. These types have been further differentiated into alpha-1, alpha-2, b1, and b2 receptors.

      Alpha-1 Receptors are located on postsynaptic cells in smooth muscle and elicit vasoconstriction.

      Alpha-2 receptors are localized on presynaptic membranes of postganglionic nerve terminals that synthesize norepinephrine. When activated by catecholamines, alpha-2 receptors act as negative feedback controllers, inhibiting further norepinephrine release.

      Activation of myocardial b1 receptors stimulates the rate and strength of cardiac contraction, and consequently increases cardiac output. b1 Receptor activation also stimulates renin release from the kidney. Another class of antihypertensive agents acts by inhibiting b1 receptors.

      Activation of b2 receptors by epinephrine relaxes vascular smooth muscle and results in vasodilation.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      2.5
      Seconds
  • Question 29 - Which of the following is true for P 53: ...

    Correct

    • Which of the following is true for P 53:

      Your Answer: It is induced by ‘broken’ DNA

      Explanation:

      All of the above mentioned statements are true regarding tumour suppressor genes.

    • This question is part of the following fields:

      • Genetics
      • Medicine
      4
      Seconds
  • Question 30 - Choose the correct statement regarding trabecular bone: ...

    Correct

    • Choose the correct statement regarding trabecular bone:

      Your Answer: All of the options are correct

      Explanation:

      Trabecular, spongy or cancellous bone. It is located inside the cortical bone and makes up around 20% of all bone in the body. It is made of spicules or plates with a high surface to volume ratio, where many cells sit on the surface of the end plates. It receives its nutrients from the extracellular fluid (ECF), exchanging about 10 mmol of calcium every 24 hours.

    • This question is part of the following fields:

      • Endocrinology
      • Medicine
      3
      Seconds
  • Question 31 - A 30-year-old female presents with a 4-day history of diarrhoea and vomiting. She...

    Correct

    • A 30-year-old female presents with a 4-day history of diarrhoea and vomiting. She has been unable to keep fluids down for 4 days and has been treated with metoclopramide. She develops a dystonic reaction. What is the most appropriate treatment for this woman?

      Your Answer: Benztropine

      Explanation:

      Acute dystonic reactions (extrapyramidal symptoms) such as spasmodic torticollis, trismus, and oculogyric crises can occur following the administration of metoclopramide or stemetil and thus, neither is recommended for the treatment of nausea in young women.

      Such reactions respond well to treatment with benztropine or procyclidine.

      – Benztropine: It is an anticholinergic medication with significant CNS penetration. A single dose of benztropine 1 to 2 mg IV followed by 1 to 2 mg p.o twice a day for up to 7 days to prevent a recurrence. Subsequently, both the offending agent and those from the same group should be avoided.

      – Alternatively, diphenhydramine can be used intravenously (up to a dose of 50mg) or intramuscularly followed by p.o therapy every 6 hours for 1 to 2 to prevent a recurrence.- Second-line therapy with IV benzodiazepines is reserved for those patients who do not respond to anticholinergics.

    • This question is part of the following fields:

      • Medicine
      • Pharmacology
      3.8
      Seconds
  • Question 32 - What is the normal portal venous pressure? ...

    Correct

    • What is the normal portal venous pressure?

      Your Answer: 6 mm hg

      Explanation:

      Portal venous pressure is the blood pressure in the hepatic portal vein, and is normally between 5-10 mmHg

    • This question is part of the following fields:

      • Hepatobiliary
      • Medicine
      2.9
      Seconds
  • Question 33 - Which of the following isoforms of Nitric oxide synthase (NOS) is found in...

    Correct

    • Which of the following isoforms of Nitric oxide synthase (NOS) is found in endothelial cells?

      Your Answer: Nos 3

      Explanation:

      There are only 3 isoforms:NOS 1: found in nervous systemNOS 2: in macrophages and other immune cellsNOS 3: In endothelial cells

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      2.2
      Seconds
  • Question 34 - One of the cells of the bone marrow that are responsible for forming...

    Correct

    • One of the cells of the bone marrow that are responsible for forming the various forms of differentiated blood cells are called?

      Your Answer: Hematopoietic stem cell

      Explanation:

      Hematopoietic stem cells (HSCs) or hemocytoblasts are the stem cells that give rise to all the other blood cells through the process of haematopoiesis. They are derived from mesoderm and located in the red bone marrow, which is contained in the core of most bones.

    • This question is part of the following fields:

      • Haematology
      • Medicine
      4.4
      Seconds
  • Question 35 - Where in the body would you find Kupffer cells? ...

    Correct

    • Where in the body would you find Kupffer cells?

      Your Answer: Liver

      Explanation:

      Kupffer cells are hepatic macrophages. They are responsible for 80% of the phagocytic activity in the liver.

    • This question is part of the following fields:

      • Immunology
      • Medicine
      2.3
      Seconds
  • Question 36 - Which part of the cerebellum is primarily responsible for interacting with the motor...

    Correct

    • Which part of the cerebellum is primarily responsible for interacting with the motor cortex and planning and programming movements?

      Your Answer: Cerebrocerebellum

      Explanation:

      The cerebrocerebellum is the largest functional subdivision of the cerebellum, comprising of the lateral hemispheres and the dentate nuclei. It is involved in the planning and timing of movements, and in the cognitive functions of the cerebellum.

    • This question is part of the following fields:

      • Medicine
      • Neurology
      2.7
      Seconds
  • Question 37 - Wernicke’s area: ...

    Correct

    • Wernicke’s area:

      Your Answer: Is concerned with comprehension of auditory and visual information

      Explanation:

      Wernicke’s area is located in the categorical hemisphere or left hemisphere in about 95% of right handed individuals and 60% of left handed individuals. It is involved in the comprehension or understanding of written and spoken language. In contrast Broca’s area is involved in production of language.

    • This question is part of the following fields:

      • Medicine
      • Neurology
      7.1
      Seconds
  • Question 38 - When 2 nucleotide chains of DNA bind together, thymine is bound to: ...

    Correct

    • When 2 nucleotide chains of DNA bind together, thymine is bound to:

      Your Answer: Adenine

      Explanation:

      As a general rule in the structure of DNA, thymine always binds to adenine with two hydrogen bonds, cytosine always binds to guanine with three hydrogen bonds and vice versa. However In the structure of RNA the only difference is that adenine binds to uracil instead of thymine. But thymine will always bind to adenine.

    • This question is part of the following fields:

      • Genetics
      • Medicine
      1.8
      Seconds
  • Question 39 - Which enzyme deficiency can lead to ammonia intoxication? ...

    Correct

    • Which enzyme deficiency can lead to ammonia intoxication?

      Your Answer: Ornithine transcarbamylase

      Explanation:

      Ornithine transcarbamylase deficiency also known as OTC deficiency is the most common urea cycle disorder in humans. Ornithine transcarbamylase, the defective enzyme in this disorder is the final enzyme in the proximal portion of the urea cycle, responsible for converting carbamoyl phosphate and ornithine into citrulline. OTC deficiency is inherited in an X-linked recessive manner, meaning males are more commonly affected than females.

    • This question is part of the following fields:

      • Medicine
      • Metabolism
      2.9
      Seconds
  • Question 40 - Where does protein digestion begin? ...

    Correct

    • Where does protein digestion begin?

      Your Answer: Stomach

      Explanation:

      Digestion typically begins in the stomach when pepsinogen is converted to pepsin by the action of hydrochloric acid, and continued by trypsin and chymotrypsin in the small intestine.

    • This question is part of the following fields:

      • Gastrointestinal
      • Medicine
      3.5
      Seconds
  • Question 41 - Which of the following initiates migrating motor complex ...

    Correct

    • Which of the following initiates migrating motor complex

      Your Answer: Motilin

      Explanation:

      Migrating motor complexes (MMC) are thought to be partially regulated by motilin, which is initiated in the stomach as a response to vagal stimulation, and does not directly depend on extrinsic nerves.

    • This question is part of the following fields:

      • Gastrointestinal
      • Medicine
      3.1
      Seconds
  • Question 42 - From which of the following can niacin be synthesized in humans ...

    Correct

    • From which of the following can niacin be synthesized in humans

      Your Answer: Tryptophan

      Explanation:

      Niacin, is also known as vitamin B3. The liver can synthesize niacin from the essential amino acid tryptophan, requiring 60 mg of tryptophan to make one mg of niacin.

    • This question is part of the following fields:

      • Haematology
      • Medicine
      4.5
      Seconds
  • Question 43 - Which one of the following is least associated with photosensitivity? ...

    Correct

    • Which one of the following is least associated with photosensitivity?

      Your Answer: Acute intermittent porphyria

      Explanation:

      Sunlight, especially its ultraviolet radiation component, can cause increased or additional types of damage in predisposed individuals, such as those taking certain phototoxic drugs, or those with certain conditions associated with photosensitivity, including:- Psoriasis- Atopic eczema- Erythema multiforme- Seborrheic dermatitis- Autoimmune bullous diseases (immunobullous diseases)- Mycosis fungoides- Smith–Lemli–Opitz syndrome- Porphyria cutanea tardaAlso, many conditions are aggravated by strong light, including:- Systemic lupus erythematosus- Sjögren’s syndrome- Sinear Usher syndrome- Rosacea- Dermatomyositis- Darier’s disease- Kindler-Weary syndromeAcute intermittent porphyria (AIP) belongs to the group inborn errors of metabolism and most patients with AIP are not light sensitive.

    • This question is part of the following fields:

      • Dermatology
      • Medicine
      5.3
      Seconds
  • Question 44 - Preload: ...

    Correct

    • Preload:

      Your Answer: Is the degree to which the myocardium is stretched before is contracts

      Explanation:

      Preload is end diastolic volume. It is the degree to which the heart muscle fiber is stretched when it fills up completely just before the heart contracts.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      2.6
      Seconds
  • Question 45 - Which one of the following have not been shown to improve mortality in...

    Correct

    • Which one of the following have not been shown to improve mortality in patients with chronic heart failure?

      Your Answer: Furosemide

      Explanation:

      A number of drugs have been shown to improve mortality in patients with chronic heart failure:

      • ACE inhibitors (SAVE, SOLVD, CONSENSUS)
      • spironolactone (RALES)
      • beta-blockers (CIBIS)
      • hydralazine with nitrates (VHEFT-1)

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      4.1
      Seconds
  • Question 46 - Which one of the following antibiotics is safest to use in pregnancy? ...

    Correct

    • Which one of the following antibiotics is safest to use in pregnancy?

      Your Answer: Erythromycin

      Explanation:

      Antibiotics that should be avoided in pregnancy are included in the mnemonic: Countless SAFe Moms Take Really Good Care -Clarithromycin, Sulphonamides, Aminoglycosides, Fluoroquinolones, Metronidazole, Tetracyclines, Ribavirin, Griseofulvin, Chloramphenicol

    • This question is part of the following fields:

      • Medicine
      • Pharmacology
      4.2
      Seconds
  • Question 47 - Of the daily production of CSF, the vast majority is produced in the:...

    Correct

    • Of the daily production of CSF, the vast majority is produced in the:

      Your Answer: Choroid plexus

      Explanation:

      About 80% of CSF is produced by the choroid plexus. It is also produced by a single layer of column shaped ependymal cells.

    • This question is part of the following fields:

      • Medicine
      • Neurology
      2.3
      Seconds
  • Question 48 - Mean intra pleural pressure at rest with inspiration can reach: ...

    Correct

    • Mean intra pleural pressure at rest with inspiration can reach:

      Your Answer: -6 mmHg

      Explanation:

      It is a negative pressure as it is lower than the atmospheric pressure. It can start from -2.5 and reach around -6 mmHg

    • This question is part of the following fields:

      • Medicine
      • Respiratory
      3
      Seconds
  • Question 49 - A 50-year-old male was under treatment for bipolar disease. He was brought to...

    Correct

    • A 50-year-old male was under treatment for bipolar disease. He was brought to the emergency department as he had become increasingly confused over the past two days. He had vomiting and diarrhoea. He was also consuming and passing a lot of water.On examination, he was disoriented. He had vertical nystagmus and was ataxic.What two investigations are likely to lead to the correct diagnosis?

      Your Answer: Desmopressin test and serum lithium level

      Explanation:

      Desmopressin test (done to differentiate nephrogenic diabetes insipidus from central diabetes insipidus), and serum lithium levels can together confirm a diagnosis of lithium-induced nephrogenic diabetes insipidus.Bipolar disease is most often managed with mood stabilizers like lithium. This patient develops gastrointestinal symptoms followed by an acute confusional state associated with polyuria and polydipsia. These symptoms are suggestive of diabetes insipidus.In a case where these symptoms occur in a bipolar patient under treatment, lithium-induced nephrogenic diabetes insipidus should be considered as the most probable cause.Lithium intoxication can present with symptoms of nausea, vomiting, mental dullness, action tremor, weakness, ataxia, slurred speech, blurred vision, dizziness, especially vertical nystagmus and stupor or coma. Diffuse myoclonic twitching and nephrogenic diabetes insipidus can also occur. Such a clinical syndrome occurs above the serum level of lithium of 1.5–2.0 mEq/L.Management: – Correcting electrolyte abnormalities in patients with acute disease is critical and often life-saving.- Treatment should be initiated with parenteral fluids to replete hypovolemia (normal saline at 200-250 mL/h), followed by administration of hypotonic fluid (0.5% normal saline). – On the restoration of the volume status of the patient forced diuresis should be initiated by the administration of parenteral furosemide or bumetanide accompanied by continued intravenous hypotonic fluid administration to maintain volume status.- Polyuria is managed with hydrochlorothiazide combined with amiloride, acetazolamide.

    • This question is part of the following fields:

      • Medicine
      • Pharmacology
      3
      Seconds
  • Question 50 - Which is primarily responsible for the conversion of T4 to T3 in the...

    Correct

    • Which is primarily responsible for the conversion of T4 to T3 in the periphery?

      Your Answer: Deiodinase 1

      Explanation:

      Type 1 iodothyronine deiodinase, also known simply as deiodinase 1, is an enzyme which can produce both triiodothyronine (active form) or inactivate metabolites from T4. It is responsible for almost 80% of the conversion of peripheral T4 to T3. Iodothyronine deiodinases are not to be confused with iodotyrosine deiodinases, which are also part of the deiodinase enzymes.

    • This question is part of the following fields:

      • Endocrinology
      • Medicine
      3.7
      Seconds

SESSION STATS - PERFORMANCE PER SPECIALTY

Cardiovascular (12/12) 100%
Medicine (49/50) 98%
Gastrointestinal (7/8) 88%
Hepatobiliary (2/2) 100%
Endocrinology (3/3) 100%
Neurology (4/4) 100%
Pharmacology (5/5) 100%
Dermatology (2/2) 100%
Connective Tissue (3/3) 100%
Haematology (3/3) 100%
Renal (1/1) 100%
Respiratory (3/3) 100%
Genetics (2/2) 100%
Immunology (1/1) 100%
Metabolism (1/1) 100%
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