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  • Question 1 - Regarding Gene Knockout Mouse Models, all are true except: ...

    Correct

    • Regarding Gene Knockout Mouse Models, all are true except:

      Your Answer: In knockout mouse models a gene is turned on through targeted mutation

      Explanation:

      In knockout mouse models, a gene is not turned on but rather turned off or “knocked out” through targeted mutation. This involves disrupting or deleting the gene to study the effects of its loss of function. Knockout models are crucial for understanding the roles of specific genes, particularly those with unknown functions.

      The other statements are true:

      • Knockout models are important in studying the roles of sequenced genes with unknown function.
      • RFLP (Restriction Fragment Length Polymorphisms) can be subcategorized as SLP (single locus probe) and MLP (multi locus probe).
      • RFLP analysis is slow and cumbersome and is now largely obsolete, having been replaced by more efficient techniques.
      • Sequence changes involved in RFLP can be analyzed more quickly by PCR (Polymerase Chain Reaction).

    • This question is part of the following fields:

      • Genetics
      • Medicine
      70.5
      Seconds

  • Question 2 - When one of the two copies of the autosomes has a mutation and...

    Incorrect

    • When one of the two copies of the autosomes has a mutation and the protein produced by the normal form of the gene cannot compensate. The affected individual has an:

      Your Answer: Autosomal recessive disorder

      Correct Answer: Autosomal dominant disorder

      Explanation:

      An autosomal dominant trait will be expressed no matter the consequence. If one chromosome has a mutation the other will not be able to compensate for the mutation hence the protein formed will be mutated and will not function properly.

    • This question is part of the following fields:

      • Genetics
      • Medicine
      9.7
      Seconds

  • Question 3 - In which phase do chromosomes in the nucleus become condensed into well-defined chromosomes?...

    Incorrect

    • In which phase do chromosomes in the nucleus become condensed into well-defined chromosomes?

      Your Answer: Anaphase

      Correct Answer: Metaphase

      Explanation:

      Prophase begins when the nucleus envelope disintegrates and the chromosomes start to condense. The chromosomes consist of two sister chromatids that are joined at a constriction known as centromere. When the cell reaches the metaphase the chromosomes are completely condensed and ready to align on the equatorial plate

    • This question is part of the following fields:

      • Genetics
      • Medicine
      9.3
      Seconds

  • Question 4 - When during the cell cycle does DNA replication occur? ...

    Incorrect

    • When during the cell cycle does DNA replication occur?

      Your Answer: Cytokinesis

      Correct Answer: S phase

      Explanation:

      The S phase is known as the synthesis phase. During this phase DNA will begin to replicated, as well as the synthesis of the centrosomes and associated proteins.

    • This question is part of the following fields:

      • Genetics
      • Medicine
      10.7
      Seconds

  • Question 5 - During which phase of the cell cycle does transcription of DNA synthesis molecules...

    Incorrect

    • During which phase of the cell cycle does transcription of DNA synthesis molecules occur?

      Your Answer: G0

      Correct Answer: S

      Explanation:

      DNA synthesis occurs in the S phase of the cell cycle. In the G1 phase the cell prepares to divide. In G2 the cellular organelles divide and in the M phase mitosis occur. In the G0 phase the cell becomes quiescent and does not divide further.

      Interphase is composed of G1 phase (cell growth), followed by S phase (DNA synthesis), followed by G2 phase (cell growth). At the end of interphase comes the mitotic phase, which is made up of mitosis and cytokinesis and leads to the formation of two daughter cells.

    • This question is part of the following fields:

      • Genetics
      • Medicine
      22.3
      Seconds

  • Question 6 - Which statement is correct? ...

    Correct

    • Which statement is correct?

      Your Answer: MtDNA principally encodes for proteins that are involved in oxidative phosphorylation for the production of ATP in the cell.

      Explanation:

      Mitochondria have no nucleus instead they contain their own free floating circular genome (MtDNA), which encodes 13 different subunits of proteins involved in oxidative phosphorylation. The remainder of the mitochondrial proteins are nuclear encoded, synthesized in the cytoplasm, and transported into the mitochondria.

    • This question is part of the following fields:

      • Genetics
      • Medicine
      9.1
      Seconds

  • Question 7 - Normal parents have a child with a recessive condition, Tay Sachs. The chance...

    Incorrect

    • Normal parents have a child with a recessive condition, Tay Sachs. The chance of them having a normal child is?

      Your Answer: 67%

      Correct Answer: 75%

      Explanation:

      The chance for normal parents having a child with a recessive disease is 1:4 or 25%. As both the parents are heterozygous for this condition. They have a 3:4 chance of having a normal child or 75%.

    • This question is part of the following fields:

      • Genetics
      • Medicine
      10.3
      Seconds

  • Question 8 - In most somatic cells telomeres progressively shorten as: ...

    Incorrect

    • In most somatic cells telomeres progressively shorten as:

      Your Answer: The cell ages

      Correct Answer: The cell divides

      Explanation:

      Telomerase activity is seen in germ cells and is absent in somatic cells. A somatic cell is any biological cell forming the body of an organism, other than a gamete, germ cell, gametocyte or undifferentiated stem cell. i.e. liver cells. Telomeres prevent the chromosomes from shortening and prevent the coding portion of the DNA from being lost, thus allowing the cell to replicate indefinitely. During replication telomeres may be lost resulting in cell death.

    • This question is part of the following fields:

      • Genetics
      • Medicine
      43.6
      Seconds

  • Question 9 - The enzyme responsible for Telomeres to maintain their length after cell division is...

    Incorrect

    • The enzyme responsible for Telomeres to maintain their length after cell division is called:

      Your Answer: Telomere reconstructing enzyme

      Correct Answer: Telomerase reverse transcriptase

      Explanation:

      Telomeres are non-coding DNA consisting of repetitive nucleotide sequences plus proteins that are found at the end of the linear chromosomes. They maintain the integrity of the chromosomes and prevent their shortening.

    • This question is part of the following fields:

      • Genetics
      • Medicine
      12.4
      Seconds

  • Question 10 - Southern Blotting and DNA probes: ...

    Incorrect

    • Southern Blotting and DNA probes:

      Your Answer: Gene probes can be labelled with radioactive isotopes e.g. 32 p

      Correct Answer: DNA fragments are separated by gel electrophoresis and transferred onto membrane sheets in southern blotting

      Explanation:

      A Southern blot is a method used in molecular biology for detection of a specific DNA sequence in DNA samples. Southern blotting combines transfer of electrophoresis-separated DNA fragments to a filter membrane and subsequent fragment detection by probe hybridization. The other forms of blotting involve the use of RNA and proteins.

    • This question is part of the following fields:

      • Genetics
      • Medicine
      27
      Seconds

SESSION STATS - PERFORMANCE PER SPECIALTY

Genetics (7/10) 70%
Medicine (7/10) 70%
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