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  • Question 1 - Generalized vasoconstrictors include: ...

    Correct

    • Generalized vasoconstrictors include:

      Your Answer: Norepinephrine, endothelin, angiotensin ii

      Explanation:

      Vasopressin, angiotensin II, adrenaline and endothelin are generalized vasoconstrictors.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      11.1
      Seconds

  • Question 2 - When is the blood pressure at its lowest during pregnancy? ...

    Incorrect

    • When is the blood pressure at its lowest during pregnancy?

      Your Answer: Third trimester

      Correct Answer: Second trimester

      Explanation:

      It is lowest during the second trimester.

      Previous studies have reported changes in blood pressure (BP) throughout pregnancy, and it was generally accepted that in clinically healthy pregnant women, BP falls gradually at first trimester, reaching the lowest around 22–24 weeks, rising again from 28 weeks, and reaching preconception levels by 36 weeks of gestation

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      6.5
      Seconds

  • Question 3 - Which heart sounds are matched correctly? ...

    Correct

    • Which heart sounds are matched correctly?

      Your Answer: All of the above

      Explanation:

      In healthy adults, there are two normal heart sounds often described as a lub and a dub (or dup), that occur in sequence with each heartbeat. These are the first heart sound (S1) and second heart sound (S2), produced by the closing of the atrioventricular valves and semilunar valves, respectively. In addition to these normal sounds, a variety of other sounds may be present including heart murmurs, adventitious sounds, and gallop rhythms S3 and S4. S3 is thought to be caused by the oscillation of blood back and forth between the walls of the ventricles initiated by blood rushing in from the atria. The reason the third heart sound does not occur until the middle third of diastole is probably that during the early part of diastole, the ventricles are not filled sufficiently to create enough tension for reverberation. S4 when audible in an adult is called a presystolic gallop or atrial gallop. This gallop is produced by the sound of blood being forced into a stiff or hypertrophic ventricle.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      13.8
      Seconds

  • Question 4 - Which of the following suggests the presence of mitral regurgitation as well as...

    Correct

    • Which of the following suggests the presence of mitral regurgitation as well as mitral stenosis?

      Your Answer: Displaced apex beat

      Explanation:

      Mitral stenosis on its own does not lead to left ventricular dilatation and hence a displaced apex beat. Thus a displaced apex beat is suggestive of mixed mitral disease. The other options occur in mitral stenosis.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      7.7
      Seconds

  • Question 5 - Closure of the tricuspid valve is marked by which of the following features...

    Correct

    • Closure of the tricuspid valve is marked by which of the following features of the jugular venous waveform?

      Your Answer: c wave

      Explanation:

      The jugular venous pressure (JVP) classically has three upward deflections and two downward deflections. The upward deflections are the a (atrial contraction), c (ventricular contraction and resulting bulging of tricuspid into the right atrium during isovolumetric systole) and v = venous filling. The downward deflections of the wave are the x (the atrium relaxes and the tricuspid valve moves downward) and the y descent (filling of ventricle after tricuspid opening).

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      27.8
      Seconds

  • Question 6 - Where are the baroreceptors of the great arteries located? ...

    Correct

    • Where are the baroreceptors of the great arteries located?

      Your Answer: In the adventitia

      Explanation:

      Arterial baroreceptors are located in the aortic arch and carotid sinuses, and are formed by small nerve endings present in the adventitia of these vessels.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      11.6
      Seconds

  • Question 7 - Where would one normally find venous valves? ...

    Correct

    • Where would one normally find venous valves?

      Your Answer: Saphenous vein

      Explanation:

      The intima of the limb veins is folded at intervals to form venous valves that prevent retrograde flow. There are no valves present in the very small veins, the great veins, or the veins in the brain and viscera.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      18.2
      Seconds

  • Question 8 - Troponin I is inhibited by calcium binding to: ...

    Correct

    • Troponin I is inhibited by calcium binding to:

      Your Answer: Troponin c

      Explanation:

      At rest troponin I is bound to actin and tropomyosin and covers the site where the myosin head interacts with actin. When calcium enters into the muscle, it binds with troponin C and cause a structural change in troponin I which moves out of the myosin binding site and causes the cross bridges between the actin and myosin filaments to occur.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      6.5
      Seconds

  • Question 9 - The following determines the strength of contraction ...

    Correct

    • The following determines the strength of contraction

      Your Answer: Plateau phase

      Explanation:

      The plateau phase which follows is unique to myocytes and results from a small, but sustained inward calcium current through L-type calcium channels lasting 200-400 ms. This calcium influx is caused by a combined increase in permeability of the cell and especially the sarcolemmal membranes to calcium. This plateau (or refractory) phase in myocyte action potential prevents early reactivation of the myocytes and directly determines the strength of contraction

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      8.5
      Seconds

  • Question 10 - What is the function of the BK channel on the vascular smooth muscle...

    Correct

    • What is the function of the BK channel on the vascular smooth muscle membrane?

      Your Answer: Massive K+ efflux, increasing membrane potential, and shutting off the voltage gated Ca2+ channel

      Explanation:

      BK channels, also known as large-conductance calcium-activated potassium channels, play a critical role in regulating vascular smooth muscle tone. When BK channels open, they allow a large efflux of potassium ions (K+) out of the cell. This efflux of K+ causes the membrane potential to become more negative (hyperpolarization), which in turn leads to the closure of voltage-gated calcium channels. The closure of these calcium channels reduces the influx of calcium ions (Ca2+) into the smooth muscle cells, resulting in decreased intracellular calcium levels and subsequent relaxation of the smooth muscle.

      Thus, BK channels promote smooth muscle relaxation by hyperpolarizing the membrane and reducing the activity of voltage-gated Ca2+ channels.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      18.7
      Seconds

  • Question 11 - Which of the following pairs are correct concerning arteriolar tone? ...

    Incorrect

    • Which of the following pairs are correct concerning arteriolar tone?

      Your Answer: Neural control: vasoconstriction activated by sympathetic nerves

      Correct Answer: Hormonal control: catecholamines affect the adrenergic receptors of the vascular smooth muscle

      Explanation:

      Catecholamines released from the adrenal medulla act on the noradrenergic receptors of the vascular smooth muscles. In the skeletal muscles and liver it causes vasodilation whilst it causes vasoconstriction in the rest of the blood vessels of the body.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      26.2
      Seconds

  • Question 12 - Which one of the following ECG findings is least associated with digoxin use?...

    Correct

    • Which one of the following ECG findings is least associated with digoxin use?

      Your Answer: Prolonged QT interval

      Explanation:

      Digoxin ECG features:•    ST depression (‘reverse tick’)•    flattened/inverted T waves•  Prolonged PR interval•    short QT interval•    arrhythmias e.g. AV block, bradycardia, ventricular tachycardia or fibrillation (for example paroxysmal atrial tachycardia with A-V block – so-called PAT with block) is said to be pathognomonic (i.e. diagnostic) of digoxin toxicity.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      16.5
      Seconds

  • Question 13 - Coronary blood flow occurs in? ...

    Correct

    • Coronary blood flow occurs in?

      Your Answer: Diastole

      Explanation:

      Coronary arteries are unique in that they fill during diastole, when not occluded by valve cusps nor compressed by myocardial contraction).

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      4.7
      Seconds

  • Question 14 - The ability of the SA node cells to allow ionic flow through channels...

    Incorrect

    • The ability of the SA node cells to allow ionic flow through channels activated in a hyperpolarized state is known as:

      Your Answer: Pace maker current

      Correct Answer: Pace maker potential

      Explanation:

      Rhythmically discharging cells have a membrane potential that, after each impulse, declines to the firing level. Thus this prepotential or Pacemaker potential triggers the next impulse. The inherent leakiness of the sinus nodal fibers to Na+ and Ca2+ causes their self excitation.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      40.3
      Seconds

  • Question 15 - The function of ATP in cardiac muscle contraction includes: ...

    Incorrect

    • The function of ATP in cardiac muscle contraction includes:

      Your Answer: Cross linkage of actin and myosin

      Correct Answer: Binding to myosin after the power stroke to allow uncoupling of actin and myosin

      Explanation:

      After calcium binds to the troponin C, there is a conformational change in the structure of troponin I and tropomyosin, which moves out of the way and frees the site where myosin can bind to actin. This results in the formation of the cross linkage of the actin and myosin giving rise to the power stroke in the contraction phase. This occurs with the release of ADP. When ATP combines to this complex it breaks and the cycle repeats itself.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      68
      Seconds

  • Question 16 - Relaxation of the cardiac muscle at the actin-myosin cross bridges is initiated by...

    Correct

    • Relaxation of the cardiac muscle at the actin-myosin cross bridges is initiated by binding of which molecule to the exposed site on the myosin.

      Your Answer: ATP

      Explanation:

      A crossbridge is a myosin projection, consisting of two myosin heads, that extends from the thick filaments. Each myosin head has two binding sites: one for ATP and another for actin. The binding of ATP to a myosin head detaches myosin from actin, thereby allowing myosin to bind to another actin molecule. Once attached, the ATP is hydrolysed by myosin, which uses the released energy to move into the cocked position whereby it binds weakly to a part of the actin binding site.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      58
      Seconds

  • Question 17 - Which one of the following is a cause of a soft second heart...

    Incorrect

    • Which one of the following is a cause of a soft second heart sound?

      Your Answer: Aortic regurgitation

      Correct Answer: Aortic stenosis

      Explanation:

      Second heart sound (S2) forms the dub of lub-dub and is composed of components A2 and P2. •    loud: hypertension•    soft: AS•    fixed split: physiological split (normally occurs during inhalation), right bundle branch block, pulmonary stenosis, and atrial septal defect.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      132.5
      Seconds

  • Question 18 - Myocardial oxygen consumption is increased by: ...

    Correct

    • Myocardial oxygen consumption is increased by:

      Your Answer: An increase in after load

      Explanation:

      Cardiac oxygen consumption is directly related to the amount of tension that develops in the ventricles. It is increased by an increased size of heart, increased afterload, increased contractility and increased heart rate.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      7.9
      Seconds

  • Question 19 - Impulse conduction through the AV node is slow and depends on the action...

    Correct

    • Impulse conduction through the AV node is slow and depends on the action potential produced by which of the following.

      Your Answer: Calcium flux

      Explanation:

      The action potentials in the SA and AV nodes are largely due to Ca2+, with no contribution by Na+ influx.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      25.1
      Seconds

  • Question 20 - The following is true of the sinus node: ...

    Correct

    • The following is true of the sinus node:

      Your Answer: It generates impulses automatically & at a quicker rate than other cardiac cells

      Explanation:

      The SA node exhibits automaticity. It generates the impulses to which the heart beats. It fires at a faster speed than the rest of the nervous components of the heart i.e. the AV nodes, purkinje fibers. This is the reason when the SA node fails the heart beats to the rhythm of the AV node.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      34.6
      Seconds

  • Question 21 - The interventricular septum is supplied anteriorly by the? ...

    Incorrect

    • The interventricular septum is supplied anteriorly by the?

      Your Answer: Right main coronary artery

      Correct Answer: Left anterior descending artery

      Explanation:

      The anterior interventricular artery or left anterior descending artery supplies the anterior 2/3rds of the interventricular septum.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      6.7
      Seconds

  • Question 22 - Myocardial fibers have a resting membrane potential of approximately: ...

    Correct

    • Myocardial fibers have a resting membrane potential of approximately:

      Your Answer: -90mv

      Explanation:

      The resting membrane potential of the mammalian heart is about -90 mv.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      5.6
      Seconds

  • Question 23 - Concerning coronary arteries, what is the net effect of B2 stimulation on the...

    Incorrect

    • Concerning coronary arteries, what is the net effect of B2 stimulation on the heart (e.g. Running athlete)?

      Your Answer: Vasodilation directly

      Correct Answer: Vasodilation via production of metabolites

      Explanation:

      The coronary arterioles contain α-adrenergic receptors, which cause vasoconstriction, and β-adrenergic receptors, which cause vasodilation. Activity in the noradrenergic nerves to the heart and injections of norepinephrine cause coronary vasodilation. However, norepinephrine also increases the heart rate and the force of cardiac contraction, and the vasodilation is due to production of vasodilator metabolites in the myocardium secondary to the increase in its activity. As exercise has the same effect as sympathetic stimulation, it will result in vasodilation.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      43.1
      Seconds

  • Question 24 - The process by which depolarization of the muscle fiber initiates contraction is called?...

    Correct

    • The process by which depolarization of the muscle fiber initiates contraction is called?

      Your Answer: Action potential

      Explanation:

      This process is known as an action potential. Upon generation of an action potential when depolarization reaches threshold, it spreads throughout the muscle fiber, resulting in generation of an excitation-contraction coupling leading to contraction of the muscle.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      22.9
      Seconds

  • Question 25 - The branche(s) of the left coronary artery include: ...

    Correct

    • The branche(s) of the left coronary artery include:

      Your Answer: Left circumflex artery & anterior interventricular artery

      Explanation:

      The left main coronary divides into branches:

      1. The left anterior descending artery branches off the left coronary artery and supplies blood to the front of the left side of the heart.

      2. The circumflex artery branches off the left coronary artery and encircles the heart muscle.

      The anterior interventricular artery is otherwise known as the anterior descending branch. The posterior descending artery comes from Right coronary artery.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      12.2
      Seconds

  • Question 26 - Myocyte action potentials – Choose the false statement: ...

    Correct

    • Myocyte action potentials – Choose the false statement:

      Your Answer: Repolarisation is due to net k+ influx

      Explanation:

      Final repolarization (phase 3) to the resting membrane potential (phase 4) is due to closure of the Ca2+ channels and a slow, delayed increase of K+ efflux through various types of K+ channels.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      39.2
      Seconds

  • Question 27 - Coronary arteries arise from? ...

    Incorrect

    • Coronary arteries arise from?

      Your Answer: Ascending aorta

      Correct Answer: None of the above

      Explanation:

      Coronary arteries arise from the sinuses behind 2 of the cusps of the aortic valve at the root of aorta.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      30.1
      Seconds

  • Question 28 - Which of the following supplies the AV node? ...

    Incorrect

    • Which of the following supplies the AV node?

      Your Answer: Left anterior descending

      Correct Answer: Right coronary artery

      Explanation:

      The AV node is supplied by the right coronary artery near the origin of the posterior IV artery.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      9.4
      Seconds

  • Question 29 - The SA and AV nodes are usually supplied by which artery? ...

    Correct

    • The SA and AV nodes are usually supplied by which artery?

      Your Answer: Right coronary artery

      Explanation:

      The right coronary artery supplies the right atrium, right ventricle, SA and AV nodes.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      4.5
      Seconds

  • Question 30 - The bradycardia that occurs in patients with raised intracranial pressure is a result...

    Correct

    • The bradycardia that occurs in patients with raised intracranial pressure is a result of the?

      Your Answer: Cushing reflex

      Explanation:

      When intracranial pressure is increased, the blood supply to RVLM neurons is compromised. This results in an increase in their discharge as a result of hypoxia and hypercapnia. The resultant rise in systemic arterial pressure (Cushing reflex) tends to restore the blood flow to the medulla.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      4.2
      Seconds

SESSION STATS - PERFORMANCE PER SPECIALTY

Cardiovascular (21/30) 70%
Medicine (21/30) 70%
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