00
Correct
00
Incorrect
00 : 00 : 00
Session Time
00 : 00
Average Question Time ( Secs)
Retry this test Dashboard

  • Question 1 - The ENaC Transporter occurs in which part of the renal tubule? ...

    Correct

    • The ENaC Transporter occurs in which part of the renal tubule?

      Your Answer: Collecting duct

      Explanation:

      The epithelial sodium channel (ENaC) is a membrane-bound ion channel that is selectively permeable to Na+ ions. It is involved primarily in the reabsorption of sodium ions at the collecting ducts of the kidney’s nephrons.

    • This question is part of the following fields:

      • Medicine
      • Renal
      2.2
      Seconds

  • Question 2 - The premotor cortex is: ...

    Correct

    • The premotor cortex is:

      Your Answer: Brodmann area 6

      Explanation:

      A Brodmann area in the brain is defined by cytoarchitecture, histology and organization of cells:Primary Sensory 3,1,2Primary Motor 4Premotor 6Primary Visual 17Primary Auditory 41Brocas 44

    • This question is part of the following fields:

      • Medicine
      • Neurology
      2.1
      Seconds

  • Question 3 - Where does the SA node develop? ...

    Correct

    • Where does the SA node develop?

      Your Answer: From structures on the right side of the embryo.

      Explanation:

      The SA node develops from the right side of the embryo and the AV node from the left. This is the reason why in adults the right vagus supplies the SA node and the left vagus supplies the AV node.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      3.3
      Seconds

  • Question 4 - Which one of the following is true about bone marrow? ...

    Correct

    • Which one of the following is true about bone marrow?

      Your Answer: At birth the bone marrow is entirely red marrow and is converted to yellow marrow with age

      Explanation:

      The two types of bone marrow are red marrow, which consists mainly of hematopoietic tissue, and yellow marrow, which is mainly made up of fat cells. Red blood cells, platelets, and most white blood cells arise in red marrow. Both types of bone marrow contain numerous blood vessels and capillaries. At birth, all bone marrow is red. With age, more and more of it is converted to the yellow type; only around half of adult bone marrow is red.

    • This question is part of the following fields:

      • Haematology
      • Medicine
      6.6
      Seconds

  • Question 5 - Which glucose transporter is responsible for the uptake of dietary glucose from the...

    Correct

    • Which glucose transporter is responsible for the uptake of dietary glucose from the gut?

      Your Answer: SGLT1

      Explanation:

      SGLT 1 is responsible for the uptake of glucose via secondary active transport from the small intestine and the renal tubules.

    • This question is part of the following fields:

      • Gastrointestinal
      • Medicine
      3.4
      Seconds

  • Question 6 - The channel that coalesces the small pancreatic duct radicles before joining the common...

    Correct

    • The channel that coalesces the small pancreatic duct radicles before joining the common bile duct is known as the:

      Your Answer: Duct of Wirsung

      Explanation:

      The small ducts from the pancreas coalesce into a single duct known as the pancreatic duct or the duct of Wirsung. It usually joins the bile duct at the ampulla of Vater before entering the duodenum.

    • This question is part of the following fields:

      • Gastrointestinal
      • Medicine
      3.1
      Seconds

  • Question 7 - Which of the following drugs requires plasma level monitoring? ...

    Correct

    • Which of the following drugs requires plasma level monitoring?

      Your Answer: Vancomycin

      Explanation:

      All patients require plasma-vancomycin measurement (after 3 or 4 doses if renal function normal, earlier if renal impairment). There is a risk of nephrotoxicity including renal failure, interstitial nephritis and ototoxicity.

    • This question is part of the following fields:

      • Medicine
      • Pharmacology
      1.4
      Seconds

  • Question 8 - Among the following which is the beneficial effect of nitro-glycerine? ...

    Correct

    • Among the following which is the beneficial effect of nitro-glycerine?

      Your Answer: Dilation of systemic veins

      Explanation:

      Dilation of systemic veins is a beneficial effect of nitro-glycerine.Administration of nitro-glycerine results in the dilation of systemic veins and decrease of myocardial wall tension and oxygen demand. Dilatation of systemic veins can cause reduced systemic vascular resistance leading to reduced cardiac workload thus reducing anginal symptoms secondary to demand ischemia.This is accompanied by vasodilation of large and medium-sized coronary arteries with increased coronary blood flow to the sub endocardium.

    • This question is part of the following fields:

      • Medicine
      • Pharmacology
      5.8
      Seconds

  • Question 9 - Cholinergic neurons that pass into a retrograde direction activate neurons that release: ...

    Correct

    • Cholinergic neurons that pass into a retrograde direction activate neurons that release:

      Your Answer: Substance P and acetyl choline

      Explanation:

      Serotonin activates sensory neurons that activate the myenteric plexus. Cholinergic neurons passing in a retrograde direction in the myenteric plexus activate neurons that release substance P and acetylcholine, causing smooth muscle contraction.

    • This question is part of the following fields:

      • Gastrointestinal
      • Medicine
      6
      Seconds

  • Question 10 - Myocyte action potentials – Choose the false statement: ...

    Correct

    • Myocyte action potentials – Choose the false statement:

      Your Answer: Repolarisation is due to net k+ influx

      Explanation:

      Final repolarization (phase 3) to the resting membrane potential (phase 4) is due to closure of the Ca2+ channels and a slow, delayed increase of K+ efflux through various types of K+ channels.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      6.3
      Seconds

  • Question 11 - The growth promoting protein anabolic effects of insulin are mediated by: ...

    Correct

    • The growth promoting protein anabolic effects of insulin are mediated by:

      Your Answer: Phosphatidylinositol 3-kinase

      Explanation:

      Phosphatidylinositol 3-kinase or PI-3Ks are a group of enzymes which are involved in a number of different cellular functions. PI-3Ks interact with insulin and the insulin receptor substrate, regulating glucose uptake. They are an important element in the insulin signalling pathway.

    • This question is part of the following fields:

      • Endocrinology
      • Medicine
      3.5
      Seconds

  • Question 12 - Which of the following can trigger parietal cell secretion? ...

    Correct

    • Which of the following can trigger parietal cell secretion?

      Your Answer: Gastrin

      Explanation:

      The three agonists of parietal cell secretion are gastrin, acetylcholine and histamine. Parietal cells are responsible for the secretion of HCl and intrinsic factor.

    • This question is part of the following fields:

      • Gastrointestinal
      • Medicine
      3.1
      Seconds

  • Question 13 - A 71-year-old woman residing in a nursing home for a couple of years...

    Correct

    • A 71-year-old woman residing in a nursing home for a couple of years complains of drooling of saliva and sudden difficulty in swallowing while eating. She is a known hypertensive on treatment. What would be your next step?

      Your Answer: Endoscopy

      Explanation:

      Dysphagia or difficulty in swallowing. Endoscopy allows for visual examination of the oesophagus and is indicated in patients with dysphagia to determine the underlying aetiology, exclude malignant and premalignant conditions, assess the need for therapy, and perform therapy including dilation.

    • This question is part of the following fields:

      • Geriatrics
      • Medicine
      2.8
      Seconds

  • Question 14 - Which of the following statements is true regarding chromosomes? ...

    Correct

    • Which of the following statements is true regarding chromosomes?

      Your Answer: All are true

      Explanation:

      All of the above mentioned statements are true regarding chromosomes.

    • This question is part of the following fields:

      • Genetics
      • Medicine
      4.4
      Seconds

  • Question 15 - Endotoxin ...

    Correct

    • Endotoxin

      Your Answer: Composed of Lipid A in liposaccharide in cell wall

      Explanation:

      Lipopolysaccharides (LPS), also known as lipoglycans and endotoxins, are large molecules consisting of a lipid (lipid A) and a polysaccharide composed of O-antigen, outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria, and elicit strong immune responses in animals.

    • This question is part of the following fields:

      • Infectious Diseases
      • Medicine
      7
      Seconds

  • Question 16 - A 75 year old man was brought to the clinic by his wife...

    Correct

    • A 75 year old man was brought to the clinic by his wife because lately he has lost interest in activities he previously enjoyed. His wife is worried and claims he's generally withdrawn. What would exclude depression in favour of dementia?

      Your Answer: Urinary incontinence

      Explanation:

      Urinary incontinence is not a usual symptom of depression. A depressed patient is usually capable of maintaining control of his body sphincters. In dementia, however, urinary incontinence is an important and late symptom of the disease, non-related to any urinary tract pathology. It is rather related to the cognitive impairment caused by dementia.

    • This question is part of the following fields:

      • Geriatrics
      • Medicine
      3.2
      Seconds

  • Question 17 - Which of the following statements is true of the beta- lactams: ...

    Correct

    • Which of the following statements is true of the beta- lactams:

      Your Answer: Co-amoxiclav is more likely to cause obstructive jaundice than amoxicillin

      Explanation:

      β-lactam antibiotics are a class of broad-spectrum antibiotics, consisting of all antibiotic agents that contain a β-lactam ring in their molecular structures. This includes penicillin derivatives (penams), cephalosporins (cephems), monobactams, and carbapenems. Most β-lactam antibiotics work by inhibiting cell wall biosynthesis in the bacterial organism and are the most widely used group of antibiotics. Bacteria often develop resistance to β-lactam antibiotics by synthesizing a β-lactamase, an enzyme that attacks the β-lactam ring. To overcome this resistance, β-lactam antibiotics are often given with β-lactamase inhibitors such as clavulanic acid. Immunologically mediated adverse reactions to any β-lactam antibiotic may occur in up to 10% of patients receiving that agent (a small fraction of which are truly IgE-mediated allergic reactions). Rarely, cholestatic jaundice has been associated with Co-amoxiclav (amoxicillin/clavulanic acid). The reaction may occur up to several weeks after treatment has stopped, and usually takes weeks to resolve. It is more frequent in men, older people, and those who have taken long courses of treatment; the estimated overall incidence is one in 100,000 exposures.

    • This question is part of the following fields:

      • Infectious Diseases
      • Medicine
      4.3
      Seconds

  • Question 18 - Cross-bridges between actin and myosin filaments contain: ...

    Correct

    • Cross-bridges between actin and myosin filaments contain:

      Your Answer: Calcium ions

      Explanation:

      At rest troponin I is bound to actin and tropomyosin and covers the site where the myosin head interacts with actin. When calcium enters into the muscle, it binds with troponin C and causes a structural change in troponin I which moves out of the myosin binding site and causes the cross bridges between the actin and myosin filaments to occur.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      4
      Seconds

  • Question 19 - What is the function of the BK channel on the vascular smooth muscle...

    Correct

    • What is the function of the BK channel on the vascular smooth muscle membrane?

      Your Answer: Massive K+ efflux, increasing membrane potential, and shutting off the voltage gated Ca2+ channel

      Explanation:

      BK channels, also known as large-conductance calcium-activated potassium channels, play a critical role in regulating vascular smooth muscle tone. When BK channels open, they allow a large efflux of potassium ions (K+) out of the cell. This efflux of K+ causes the membrane potential to become more negative (hyperpolarization), which in turn leads to the closure of voltage-gated calcium channels. The closure of these calcium channels reduces the influx of calcium ions (Ca2+) into the smooth muscle cells, resulting in decreased intracellular calcium levels and subsequent relaxation of the smooth muscle.

      Thus, BK channels promote smooth muscle relaxation by hyperpolarizing the membrane and reducing the activity of voltage-gated Ca2+ channels.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      10.2
      Seconds

  • Question 20 - A 28 year old female with a history of psoriatic arthritis would most...

    Correct

    • A 28 year old female with a history of psoriatic arthritis would most likely have which of the following hand conditions?

      Your Answer: Nail dystrophy

      Explanation:

      Nail dystrophy (pitting of nails, onycholysis, subungual hyperkeratosis), dactylitis, sausage shaped fingers are most commonly seen with psoriatic arthropathy. There is asymmetric joint involvement most commonly distal interphalangeal joints. Uveitis and sacroiliitis may also occur. Arthritis mutilans may occur but is very rare. Cutaneous lesions may or may not develop. When they do, its usually much after the symptoms of arthritis.

    • This question is part of the following fields:

      • Connective Tissue
      • Medicine
      2.9
      Seconds

  • Question 21 - The structure of haemoglobin A in adults includes ...

    Correct

    • The structure of haemoglobin A in adults includes

      Your Answer: Haem, globin polypeptide chains α and β

      Explanation:

      Haemoglobin A (HbA), also known as adult haemoglobin or α2β2, is the most common human haemoglobin tetramer, comprising over 97% of the total red blood cell haemoglobin. It consists of two alpha chains and two beta chains.

    • This question is part of the following fields:

      • Haematology
      • Medicine
      1.4
      Seconds

  • Question 22 - The following are Gram-negative cocci: ...

    Correct

    • The following are Gram-negative cocci:

      Your Answer: Neisseria

      Explanation:

      Gram-negative cocci include the four types that cause a sexually transmitted disease (Neisseria gonorrhoeae), a meningitis (Neisseria meningitidis), and respiratory symptoms (Moraxella catarrhalis, Haemophilus influenzae).

    • This question is part of the following fields:

      • Infectious Diseases
      • Medicine
      1.5
      Seconds

  • Question 23 - A 40-year-old patient under treatment for gout gave a history of progressive weakness...

    Correct

    • A 40-year-old patient under treatment for gout gave a history of progressive weakness of his limbs over 2 months. He noticed that it was particularly difficult for him to get up from the toilet seat and to get out of his car. He also felt some tingling and numbness of his toes at night, which was distressing. He was taking several medications which included Ibuprofen, perindopril, colchicine, vitamin supplements, and indapamide.On examination his pulse was 85/min, blood pressure was 140/90 mmHg and fundi revealed arteriovenous nipping. He had proximal lower limb weakness of 4/5 and absent ankle reflexes. Plantar reflexes were upgoing on both sides. His serum creatinine phosphokinase level was normal.What is the most likely diagnosis?

      Your Answer: Colchicine toxicity

      Explanation:

      The given clinical scenario is suggestive of myo-neuropathy and is most likely to be caused by colchicine toxicity. It gives rise to subacute proximal muscle weakness and on occasions can lead to an acute necrotizing myopathy. Creatine phosphokinase may be normal or may be elevated.Weakness resolves when the drug is discontinued but the neuropathic features remain.Death is usually a result of respiratory depression and cardiovascular collapse.Treatment is symptomatic and supportive, and the treatment for colchicine poisoning includes lavage and measures to prevent shock.

    • This question is part of the following fields:

      • Medicine
      • Pharmacology
      2.6
      Seconds

  • Question 24 - Direct conduction from the atrium to the ventricles is prevented by: ...

    Correct

    • Direct conduction from the atrium to the ventricles is prevented by:

      Your Answer: Annulus fibrosus

      Explanation:

      The annulus fibrosus disconnects the syncytium complex. The atria are rapidly activated however the activation peters out when the insulating layer-the annulus fibrosus-is reached.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      2.1
      Seconds

  • Question 25 - Normally the portal venous pressure is about: ...

    Correct

    • Normally the portal venous pressure is about:

      Your Answer: 5mmhg

      Explanation:

      Under normal physiological conditions, the pressure in the portal vein, which carries blood from the gastrointestinal tract and spleen to the liver, typically ranges around 5-10 mmHg. Pressures significantly higher than this range can indicate portal hypertension, which can be associated with liver diseases such as cirrhosis.

    • This question is part of the following fields:

      • Gastrointestinal
      • Medicine
      1.2
      Seconds

  • Question 26 - The net effect of active Vitamin D on calcium and phosphate homeostasis is?...

    Correct

    • The net effect of active Vitamin D on calcium and phosphate homeostasis is?

      Your Answer: Increase in Ca, increase in phosphate

      Explanation:

      Bone and its metabolism are regulated by several hormones, amongst which is vitamin D. It is heavily involved in the metabolism and homeostasis of calcium and phosphate through several processes. Vitamin D works in the intestine, kidney, bone and parathyroid glands to maintain levels of calcium and phosphate, promoting its absorption, bone resorption, and proper functioning of the parathyroid to maintain adequate serum calcium levels.

    • This question is part of the following fields:

      • Endocrinology
      • Medicine
      4.4
      Seconds

  • Question 27 - The ependyma fuse with which of the following to from the choroid plexus?...

    Correct

    • The ependyma fuse with which of the following to from the choroid plexus?

      Your Answer: Tela choroidea

      Explanation:

      The choroid plexus produces the cerebrospinal fluid (CSF) in the ventricles of the brain. It consists of modified ependymal cells. Tela choroidea is a region of pia mater of the meninges and underlying ependyma that’s a part of the choroid plexus. It is a very thin layer of the connective tissue of pia mater that overlies and covers the ependyma.

    • This question is part of the following fields:

      • Medicine
      • Neurology
      2.9
      Seconds

  • Question 28 - The actions of dihydrotestosterone in male reproductive physiology include: ...

    Correct

    • The actions of dihydrotestosterone in male reproductive physiology include:

      Your Answer: Development of external genitalia in utero and at puberty

      Explanation:

      Dihydrotestosterone mediates the differentiation of the urogenital sinus and genital tubercles, leading to the fusion of the urethral and labial folds; thus, it leads to the development of external genitalia in the male.

    • This question is part of the following fields:

      • Endocrinology
      • Medicine
      3.9
      Seconds

  • Question 29 - A 22 year old man who has recently returned from a trip to...

    Correct

    • A 22 year old man who has recently returned from a trip to Far East presents with sore eyes and symmetrical joint pain in his knees, ankles and feet. Labs reveal an elevated ESR. The synovial fluid aspirate is sterile and has a high neutrophil count. What is the most likely diagnosis?

      Your Answer: Reactive arthropathy

      Explanation:

      Reactive arthritis, (formerly known as Reiter’s syndrome), is an autoimmune condition that occurs after a bacterial infection of the gastrointestinal or urinary tract. It is categorized as a seronegative spondylarthritis because of its association with HLA-B27. Reactive arthritis primarily affects young men and usually presents with musculoskeletal or extra‑articular symptoms. The characteristic triad consists of arthritis, conjunctivitis, and urethritis. Symmetric lower limb arthropathy and a sterile joint aspirate points towards reactive arthropathy.

    • This question is part of the following fields:

      • Connective Tissue
      • Medicine
      2
      Seconds

  • Question 30 - The pontine tegmentum as part of the midbrain, contains which cranial nerve nuclei?...

    Correct

    • The pontine tegmentum as part of the midbrain, contains which cranial nerve nuclei?

      Your Answer: CN 5 to 8

      Explanation:

      The pontine tegmentum also known as dorsal pons is located within the brain stem. Several cranial nerve nuclei are located in the pontine tegmentum. The nuclei of CN V, CN VI, CN VII and CNVIII are located in the pontine tegmentum.

    • This question is part of the following fields:

      • Medicine
      • Neurology
      1.4
      Seconds

SESSION STATS - PERFORMANCE PER SPECIALTY

Medicine (30/30) 100%
Renal (1/1) 100%
Neurology (3/3) 100%
Cardiovascular (5/5) 100%
Haematology (2/2) 100%
Gastrointestinal (5/5) 100%
Pharmacology (3/3) 100%
Endocrinology (3/3) 100%
Geriatrics (2/2) 100%
Genetics (1/1) 100%
Infectious Diseases (3/3) 100%
Connective Tissue (2/2) 100%
Passmed
Retry this test Dashboard