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Question 1
Correct
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Regarding fibrinolytics, which of the following statements is INCORRECT:
Your Answer: Fibrinolytic drugs act as thrombolytics by directly degrading the fibrin mesh and so breaking up thrombi.
Explanation:Fibrinolytic drugs act as thrombolytics by activating plasminogen to form plasmin, which degrades fibrin and so breaks up thrombi.
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This question is part of the following fields:
- Cardiovascular
- Pharmacology
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Question 2
Incorrect
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A young patient presents with the features of an easily recognisable infectious disease.
Which of the following infectious diseases typically has an incubation period of less than 1 week? Select ONE answer only.Your Answer: Measles
Correct Answer: Cholera
Explanation:Cholera has an incubation period of 12 hours to 6 days.
Other infectious disease that have an incubation period of less than 1 week include:
Staphylococcal enteritis (1-6 hours)
Salmonella enteritis (12-24 hours)
Botulism (18-36 hours)
Gas gangrene (6 hours to 4 days)
Scarlet fever (1-4 days)
Diphtheria (2-5 days)
Gonorrhoea (3-5 days)
Yellow fever (3-6 days)
Meningococcaemia (1-7 days)
Brucellosis has an incubation period of 7-21 days.
Measles has an incubation period of 14-18 days.
Falciparum malaria usually has an incubation period of 7-14 days. The other forms of malaria have a longer incubation period of 12-40 days.
Rubella has an incubation period of 14-21 days. -
This question is part of the following fields:
- Microbiology
- Specific Pathogen Groups
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Question 3
Incorrect
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Which of the following is NOT a feature characteristic of intravascular haemolysis:
Your Answer: Haemoglobinuria
Correct Answer: Bilirubinuria
Explanation:Features of intravascular haemolysis include:haemoglobinaemia, methaemalbuminaemia, haemoglobinuria (dark urine) and haemosiderinuria
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This question is part of the following fields:
- Haematology
- Pathology
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Question 4
Incorrect
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A 67-year-old man with chronic breathlessness is sent for a lung function test.
Which statement concerning lung function testing is true?Your Answer: Spirometry is a good predictor of quality of life in COPD
Correct Answer: In restrictive lung disease, the FEV 1 /FVC ratio is usually >0.7
Explanation:In restrictive lung disease, the FEV1/FVC ratio is usually >0.7%.
In obstructive lung disease, FEV1 is reduced to <80% of normal and FVC is usually reduced. The FEV1/FVC ratio is reduced to <0.7. Airflow obstruction is defined in the NICE guidelines as:
Mild airflow obstruction = an FEV 1 of >80% in the presence of symptoms
Moderate airflow obstruction = FEV 1 of 50-79%
Severe airflow obstruction = FEV 1 of 30-49%
Very severe airflow obstruction = FEV1<30%. Spirometry is a poor predictor of quality of life in COPD. However, it can be used as part of the assessment of severity of COPD. -
This question is part of the following fields:
- Physiology
- Respiratory Physiology
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Question 5
Correct
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A 7-year old boy is referred to the Paediatrics Department due to slurred speech. Upon further examination, the attending physician noted the presence of dysdiadochokinesia, intention tremors, and nystagmus. An MRI is taken, which revealed a brain tumour.
Which of the following options is the most probable diagnosis given the clinical features of the patient?Your Answer: Astrocytoma of cerebellum
Explanation:Pilocytic astrocytoma (PCA), previously known as cystic cerebellar astrocytoma or juvenile pilocytic astrocytoma, was first described in 1931 by Harvey Cushing, based on a case series of cerebellar astrocytomas; though he never used these terms but rather described a spongioblastoma. They are low-grade, and usually well-circumscribed tumours, which tend to occur in young patients. By the World Health Organization (WHO) classification of central nervous system tumours, they are considered grade I gliomas and have a good prognosis.
PCA most commonly occurs in the cerebellum but can also occur in the optic pathway, hypothalamus, and brainstem. They can also occur in the cerebral hemispheres, although this tends to be the case in young adults. Presentation and treatment vary for PCA in other locations. Glial cells include astrocytes, oligodendrocytes, ependymal cells, and microglia. Astrocytic tumours arise from astrocytes and are the most common tumour of glial origin. The WHO 2016 categorized these tumours as either diffuse gliomas or other astrocytic tumours. Diffuse gliomas include grade II and III diffuse astrocytomas, grade IV glioblastoma, and diffuse gliomas of childhood. The other astrocytic tumours group include PCA, pleomorphic xanthoastrocytoma, subependymal giant cell astrocytoma, and anaplastic pleomorphic xanthoastrocytoma.
PCA can present with symptoms secondary to the posterior fossa mass effect. This may include obstructive hydrocephalus, with resultant headache, nausea and vomiting, and papilledema. If hydrocephalus occurs before the fusion of the cranial sutures (<18-months-of-age), then an increase in head circumference will likely occur. Lesions of the cerebellar hemisphere result in peripheral ataxia, dysmetria, intention tremor, nystagmus, and dysarthria. In contrast, lesions of the vermis cause a broad-based gait, truncal ataxia, and titubation. Posterior fossa lesions can also cause cranial nerve palsies. Diplopia may occur due to abducens palsy from the stretching of the nerve. They may also have blurred vision due to papilledema. Seizures are rare with posterior fossa lesions.
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This question is part of the following fields:
- Anatomy
- Central Nervous System
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Question 6
Incorrect
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In a ward round, you come across a patient's treatment chart prescribed an antibiotic to fight his infection. This antibiotic disrupts cell membrane function.
Which of the following antimicrobial drugs is prescribed to this patient?Your Answer: Vancomycin
Correct Answer: Nystatin
Explanation:Nystatin binds ergosterol (unique to the fungi cell membrane) and forms membrane pores that allow K+ leakage, acidification, and subsequent death of the fungus.
Vancomycin inhibits cell wall peptidoglycan formation by binding the D-Ala-D-Ala portion of cell wall precursors.
Flucloxacillin inhibits the synthesis of bacterial cell walls. It inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell wall of Gram-positive bacteria.
Trimethoprim inhibits bacterial dihydrofolate reductase.
Isoniazid decreases the synthesis of mycolic acids in mycobacteria.
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This question is part of the following fields:
- Infections
- Pharmacology
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Question 7
Incorrect
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After a work-related accident, a 33-year old male is taken to the emergency room with difficulty in adduction and flexion of his left arm at the glenohumeral joint. The attending physician is suspects involvement of the coracobrachialis muscle.
The nerve injured in the case above is?Your Answer:
Correct Answer: The musculocutaneous nerve
Explanation:The coracobrachialis muscle is innervated by the musculocutaneous nerve (C5-C7) a branch of the lateral cord of the brachial plexus.
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This question is part of the following fields:
- Anatomy
- Upper Limb
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Question 8
Incorrect
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Fusidic acid is primarily indicated for infections caused by which of the following microorganisms:
Your Answer:
Correct Answer: Staphylococcal infections
Explanation:Fusidic acid is a narrow spectrum antibiotic used for staphylococcal infections, primarily topically for minor staphylococcal skin (impetigo) or eye infection. It is sometimes used orally for penicillin-resistant staphylococcal infection, including osteomyelitis or endocarditis, in combination with other antibacterials.
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This question is part of the following fields:
- Infections
- Pharmacology
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Question 9
Incorrect
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Which of the following statements about lithium treatment is FALSE:
Your Answer:
Correct Answer: Concomitant treatment with NSAIDs decreases serum-lithium concentration.
Explanation:Lithium levels are raised by NSAIDs because renal clearance is reduced. Lithium is a small ion (74 Daltons) with no protein or tissue binding and is therefore amenable to haemodialysis. Lithium is freely distributed throughout total body water with a volume of distribution between 0.6 to 0.9 L/kg, although the volume may be smaller in the elderly, who have less lean body mass and less total body water. Steady-state serum levels are typically reached within five days at the usual oral dose of 1200 to 1800 mg/day. The half-life for lithium is approximately 18 hours in adults and 36 hours in the elderly.
Lithium is excreted almost entirely by the kidneys and is handled in a manner similar to sodium. Lithium is freely filtered but over 60 percent is then reabsorbed by the proximal tubules. -
This question is part of the following fields:
- Central Nervous System
- Pharmacology
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Question 10
Incorrect
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Injury to which nerve can lead to weakness or paralysis of the brachialis muscle?
Your Answer:
Correct Answer: The musculocutaneous nerve
Explanation:The brachialis muscle is a prime flexor of the forearm at the elbow joint. It is fusiform in shape and located in the anterior (flexor) compartment of the arm, deep to the biceps brachii. The brachialis is a broad muscle, with its broadest part located in the middle rather than at either of its extremities. It is sometimes divided into two parts, and may fuse with the fibres of the biceps brachii, coracobrachialis, or pronator teres muscles. It also functions to form part of the floor of the cubital fossa.
The brachialis is primarily supplied by the musculocutaneous nerve (C5, C6). In addition, a small lateral portion of the muscle is innervated by the radial nerve (C7).
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This question is part of the following fields:
- Anatomy
- Upper Limb
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Question 11
Incorrect
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A 20-year-old female presents with painful wrist following a fall while skating. X-rays shows fracture of the ulna.
The initial phase of bone healing is?
Your Answer:
Correct Answer: Haematoma at the fracture site
Explanation:Haemorrhage occurs into the fracture site from the ruptured vessels in the bone marrow and those supplying the periosteum immediately after fracture. This hematoma formation is the first phase of bone healing.
The 4 stages of bone healing are:
Haematoma at the fracture site (provides a framework for healing)
Callus formation
Lamellar bone formation
Remodelling -
This question is part of the following fields:
- General Pathology
- Pathology
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Question 12
Incorrect
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Osteoclasts are a type of bone cell that are critical in the maintenance, repair and remodelling of bones.
Which of the following inhibits osteoclast activity? Select ONE answer only.Your Answer:
Correct Answer: Calcitonin
Explanation:Osteoclasts are a type of bone cell that breaks down bone tissue. This is a critical function in the maintenance, repair and remodelling of bones. The osteoclast disassembles and digests the composite of hydrated protein and minerals at a molecular level by secreting acid and collagenase. This process is known as bone resorption and also helps to regulate the plasma calcium concentration.
Osteoclastic activity is controlled by a number of hormones:
1,25-dihydroxycholecalciferol increases osteoclastic activity
Parathyroid hormone increases osteoclastic activity
Calcitonin inhibits osteoclastic activity
Bisphosphonates are a class of drug that slow down and prevent bone damage. They are osteoclast inhibitors. -
This question is part of the following fields:
- Endocrine Physiology
- Physiology
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Question 13
Incorrect
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Which of the following lifestyle changes is not likely to improve symptoms of gastro-oesophageal reflux disease (GORD):
Your Answer:
Correct Answer: Lowering the head of the bed
Explanation:The following approaches have some benefit in adult patients with reflux:
Weight loss or weight management for individuals who are overweight
Head of bed elevation is important for individuals with nocturnal or laryngeal symptoms, but its value for other situations is unclear.
The following lifestyle approaches also are used frequently. There is some evidence that these lifestyle changes improve laboratory measures of reflux (such as lower oesophageal sphincter pressure).
Dietary modification – A practical approach is to avoid a core group of reflux-inducing foods, including chocolate, peppermint, and alcohol, which may reduce lower oesophageal sphincter pressure. Acidic beverages, including colas with caffeine and orange juice also may exacerbate symptoms.
Avoiding the supine position soon after eating.
Promotion of salivation by either chewing gum or using oral lozenges. Salivation neutralizes refluxed acid, thereby increasing the rate of oesophageal acid clearance.
Avoidance of tobacco (including passive exposure to tobacco smoke) and alcohol. Nicotine and alcohol reduce lower oesophageal sphincter pressure, and smoking also diminishes salivation. -
This question is part of the following fields:
- Gastrointestinal
- Pharmacology
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Question 14
Incorrect
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A fracture on which of the following structures is associated with a posterior elbow dislocation?
Your Answer:
Correct Answer: Radial head
Explanation:Fracture dislocations of the elbow appear extremely complex, and identification of the basic injury patterns can facilitate management. The simplest pattern of elbow fracture dislocation is posterior dislocation of the elbow with fracture of the radial head. Addition of a coronoid fracture, no matter how small, to elbow dislocation and radial head fracture is called the terrible triad of the elbow.
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This question is part of the following fields:
- Anatomy
- Upper Limb
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Question 15
Incorrect
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Regarding box and whisker plots, which of the following statements is true?
Your Answer:
Correct Answer: 25% of the values lie below the lower quartile
Explanation:A box and whisker plot is defined as a graphical method of displaying variation in a set of data. In most cases, a histogram analysis provides a sufficient display, but a box and whisker plot can provide additional detail while allowing multiple sets of data to be displayed in the same graph.
The procedure to develop a box and whisker plot comes from the five statistics below:
(1) Minimum value: The smallest value in the data set
(2) Second quartile: The value below which the lower 25% of the data are contained
(3) Median value: The middle number in a range of numbers
(4) Third quartile: The value above which the upper 25% of the data are contained
(5) Maximum value: The largest value in the data set
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This question is part of the following fields:
- Evidence Based Medicine
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Question 16
Incorrect
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In patients requiring oxygen, who are at risk of hypercapnic respiratory failure, oxygen saturations should be maintained at:
Your Answer:
Correct Answer: 88 - 92%
Explanation:A lower target of 88 – 92% oxygen saturation is indicated for patients at risk of hypercapnic respiratory failure e.g. patients with COPD. Until blood gases can be measured, initial oxygen should be given using a controlled concentration of 28% or less, titrated towards the SpO2 of 88 – 92%. The aim is to provide the patient with enough oxygen to achieve an acceptable arterial oxygen tension without worsening carbon dioxide retention and respiratory acidosis.
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This question is part of the following fields:
- Pharmacology
- Respiratory
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Question 17
Incorrect
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A 34-year-old man presented to the emergency room after being involved in a road traffic accident. Upon observation and examination, it was noted that he was hypotensive and has muffled heart sounds. It was suspected that he has pericardial effusion, so an emergency pericardiocentesis was to be performed.
In performing pericardiocentesis for suspected pericardial effusion, which of the following anatomical sites are at risk of being punctured?Your Answer:
Correct Answer: 1 cm below the left xiphocostal angle
Explanation:Pericardiocentesis is a procedure done to remove fluid build-up in the sac around the heart known as the pericardium. The pericardium can be tapped from almost any reasonable location on the chest wall. However, for the usual blind pericardiocentesis, the subxiphoid approach is preferred. Ideally, 2-D echocardiography is used to guide needle insertion and the subsequent path of the needle/catheter.
In the subxiphoid approach, the needle is inserted 1 cm inferior to the left xiphocostal angle with an angle of 30 degrees from the patient’s chest with a direction towards the left mid-clavicle.
The fingers may sense a distinct give when the needle penetrates the parietal pericardium. Successful removal of fluid confirms the needle’s position.
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This question is part of the following fields:
- Abdomen And Pelvis
- Anatomy
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Question 18
Incorrect
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How does aspirin mediate its antiplatelet effect:
Your Answer:
Correct Answer: It irreversibly inhibits cyclo-oxygenase
Explanation:Aspirin irreversibly inhibits cyclooxygenase and blocks the platelet production of thromboxane A2 (TXA2), thus inhibiting platelet aggregation.
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This question is part of the following fields:
- Haematology
- Pathology
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Question 19
Incorrect
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Regarding the management of diabetic ketoacidosis (DKA), insulin should initially be given:
Your Answer:
Correct Answer: At a concentration of 1 unit/mL at a fixed rate of 0.1 units/kg/hour
Explanation:An intravenous insulin infusion should be started at a concentration of 1 unit/mL, at a fixed rate of 0.1 units/kg/hour. Established subcutaneous long-acting insulin therapy should be continued concomitantly. Blood ketone and blood glucose concentrations should be checked hourly and the insulin infusion rate adjusted accordingly. Blood ketone concentration should fall by at least 0.5 mmol/litre/hour and blood glucose concentration should fall by at least 3 mmol/litre/hour.
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This question is part of the following fields:
- Endocrine
- Pharmacology
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Question 20
Incorrect
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What is the most common application of Nitrates?
Your Answer:
Correct Answer: Angina
Explanation:In patients with exertional stable angina, nitrates improve exercise tolerance, time to onset of angina, and ST-segment depression during exercise testing. In combination with beta-blockers or calcium channel blockers, nitrates produce greater anti-anginal and anti-ischemic effects.
While they act as vasodilators, coronary vasodilators, and modest arteriolar dilators, the primary anti ischemic effect of nitrates is to decrease myocardial oxygen demand by producing systemic vasodilation more than coronary vasodilation. This systemic vasodilation reduces left ventricular systolic wall stress. -
This question is part of the following fields:
- Cardiovascular
- Pharmacology
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Question 21
Incorrect
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Which of the following describes the pulse pressure:
Your Answer:
Correct Answer: Systolic - diastolic pressure
Explanation:During systole, the pressure in the left ventricle increases and blood is ejected into the aorta. The rise in pressure stretches the elastic walls of the aorta and large arteries and drives blood flow. Systolic pressure is the maximum arterial pressure during systole. During diastole, arterial blood flow is partly maintained by elastic recoil of the walls of large arteries. The minimum pressure reached before the next systole is the diastolic pressure. The difference between the systolic and diastolic pressure is the pulse pressure.
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This question is part of the following fields:
- Cardiovascular
- Physiology
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Question 22
Incorrect
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In the extrinsic pathway of the coagulation cascade, the tenase complex is:
Your Answer:
Correct Answer: Factor VIIa-tissue factor complex
Explanation:The extrinsic pathway for initiating the formation of prothrombin activator begins with a traumatized vascular wall or traumatized extravascular tissues that come in contact with the blood. Exposed and activated by vascular injury, with plasma factor VII. The extrinsic tenase complex, factor VIIa-tissue factor complex, activates factor X to factor Xa.
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This question is part of the following fields:
- Basic Cellular
- Physiology
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Question 23
Incorrect
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Gastric emptying is increased by all of the following EXCEPT for:
Your Answer:
Correct Answer: Secretin
Explanation:Gastric emptying is increased by:
Distension of the pyloric antrum
A fall in the pH of chyme in the stomach
Parasympathetic stimulation (via vagus)
Gastrin
The hormones secretin, cholecystokinin and gastric inhibitory polypeptide (GIP) inhibit gastric emptying. -
This question is part of the following fields:
- Gastrointestinal
- Physiology
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Question 24
Incorrect
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One of the following statements about acute lymphoblastic leukaemia(ALL) is true.
Your Answer:
Correct Answer: It is classified using the FAB classification
Explanation:ALL affects children predominantly.
The CNS is commonly involved in ALL.
The Philadelphia chromosome is present in 25% of adult ALL and 5% of childhood ALL cases.
The cure rate in children is approximately 80% in children and 50% in adults.
ALL is classified into 3 groups using the French-American-British (FAB) classification:
ALL-L1: small uniform cells
ALL-L2: large varied cells
ALL-L3: large varied cells with vacuoles. -
This question is part of the following fields:
- Haematology
- Pathology
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Question 25
Incorrect
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Renal potassium excretion is promoted by all but which one of the following:
Your Answer:
Correct Answer: Increased intracellular magnesium
Explanation:Aldosterone: A rise in [K+] in the extracellular fluid of the adrenal cortex directly stimulates aldosterone release. Aldosterone promotes the synthesis of Na+/K+ATPases and the insertion of more Na+/K+ATPases into the basolateral membrane, and also stimulates apical sodium and potassium channel activity, overall acting to increase sodium reabsorption and potassium secretion.
pH changes: Potassium secretion is reduced in acute acidosis and increased in acute alkalosis. A higher pH increases the apical K+channel activity and the basolateral Na+/K+ATPase activity – both changes that promote K+secretion.
Flow rates: Increased flow rates in the collecting duct reduce K+concentration in the lumen and therefore enhance K+secretion. Increased flow also activates BK potassium channels, and ENaC channels which promote potassium secretion and sodium reabsorption respectively.
Sodium delivery: Decreased Na+delivery to the collecting ducts results in less Na+reabsorption and hence a reduced gradient for K+secretion.
Magnesium: Intracellular magnesium can bind and block K+channels inhibiting K+secretion into the tubules. Therefore magnesium deficiency reduces this inhibitory effect and so allows more potassium to be secreted into tubules and can cause hypokalaemia. -
This question is part of the following fields:
- Physiology
- Renal
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Question 26
Incorrect
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Reed-Sternberg cells are characteristic of which of the following malignancies:
Your Answer:
Correct Answer: Hodgkin lymphoma
Explanation:Lymphomas are a group of diseases caused by malignant lymphocytes that accumulate in lymph nodes and other lymphoid tissue and cause the characteristic clinical feature of lymphadenopathy. The major subdivision of lymphomas is into Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) and this is based on the histological presence of Reed-Sternberg cells present in HL. Hodgkin lymphoma can present at any age but is rare in children and has a peak incidence in young adults. There is an almost 2 : 1 male predominance. Most patients present with painless, asymmetrical, firm and discrete enlargement of superficial lymph nodes. Cervical nodes are involved in 60-70% of cases, axillary nodes in 10-15% and inguinal nodes in 6-12%. Modest splenomegaly occurs during the course of the disease in 50% of patients; the liver may also be enlarged. Bone marrow failure involvement is unusual in early disease. The prognosis depends on age, stage and histology, but overall approximately 85% of patients are cured. Alcohol‐induced pain and pruritus are two well‐known but rare symptoms in HL.
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This question is part of the following fields:
- Haematology
- Pathology
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Question 27
Incorrect
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A patient suffers an injury to the nerve that innervates piriformis.
The piriformis muscle is innervated by which of the following nerves? Select ONE answer only.Your Answer:
Correct Answer: Nerve to piriformis
Explanation:Piriformis is innervated by the nerve to piriformis, which is a direct branch from the sacral plexus (S1 and S2).
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This question is part of the following fields:
- Anatomy
- Lower Limb
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Question 28
Incorrect
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An 18-year-old patient was brought to the ER after falling off of his skateboard. He is unable to flex the distal interphalangeal joint of his index finger. You suspect that he suffers from a supracondylar fracture. Which of the following conditions would confirm supracondylar fracture?
Your Answer:
Correct Answer: Inability to oppose the thumb
Explanation:A supracondylar fracture is a fracture that occurs through the thin section of the distal humerus above the growth plate.
A supracondylar fracture is most usually associated with median nerve injury. A medial nerve damage causes paralysis of the thenar muscles, as well as loss of thumb opposition.
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This question is part of the following fields:
- Anatomy
- Upper Limb
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Question 29
Incorrect
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You see a 63-year-old man with a history of melaena and epigastric discomfort. For a few months, he's been taking aspirin.
Which of the following statements about aspirin's mechanism of action is correct?Your Answer:
Correct Answer: It inhibits both COX-1 and COX-2 at medium to high doses (500-5000 mg per day)
Explanation:Aspirin inhibits cyclo-oxygenase irreversibly by covalently acetylating the cyclo-oxygenase active site in both COX-1 and COX-2. The production of prostaglandin and thromboxane is reduced as a result. As a result, platelet activation and aggregation are reduced. A single dose of aspirin has a half-life of 7-10 days, which is the time it takes for the bone marrow to produce new platelets.
Aspirin only inhibits COX-1, the enzyme that produces thromboxane A2, at low doses (75 mg per day), and thus has a primarily anti-thrombotic effect.
Aspirin inhibits both COX-1 and COX-2 at medium to high doses (500-5000 mg per day). COX-2 is involved in the production of prostaglandins, so it has an anti-inflammatory effect at these concentrations.
Aspirin, when used as an antipyretic for a viral illness in children, can cause Reye’s syndrome. Reye’s syndrome is a potentially fatal liver disease that causes encephalopathy and liver failure.
The inability of aspirin to reduce platelet production of thromboxane A2, and thus platelet activation and aggregation, is known as aspirin resistance. Although the exact frequency and mechanism of aspirin resistance are unknown, it is thought to affect about 1% of users. Women are more likely than men to experience this phenomenon.
According to new research, taking aspirin on a regular basis lowers the risk of colorectal cancer. It may also protect against cancers of the breast, bladder, prostate, and lungs.
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This question is part of the following fields:
- CNS Pharmacology
- Pharmacology
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Question 30
Incorrect
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Which of the following nerves is responsible for the symptoms of a patient who presented with ophthalmic herpes zoster and a few vesicles on the nose?
Your Answer:
Correct Answer: Trigeminal nerve
Explanation:Hutchinson sign relates to involvement of the tip of the nose from facial herpes zoster. It implies involvement of the external nasal branch of the nasociliary nerve which is a branch of the ophthalmic division of the trigeminal nerve.
The nasociliary branch of the trigeminal nerve innervates the apex and lateral aspect of the nose, as well as the cornea. Therefore, lesions on the side or tip of the nose should raise suspicion of ocular involvement.
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This question is part of the following fields:
- Anatomy
- Head And Neck
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