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  • Question 1 - A 30-year-old male with a known allergy to natural latex rubber presents with...

    Correct

    • A 30-year-old male with a known allergy to natural latex rubber presents with an allergic reaction to a food he has just eaten.

      Which ONE of these foods is most likely to cause an associated hypersensitivity in him?

      Your Answer: Banana

      Explanation:

      About one third of patients with allergy to natural latex rubber (NRL) have an associated allergy to some plant-derived foods. It is known as the latex-fruit syndrome and occurs commonly with consumption of fresh fruits. Banana and avocado are the most implicated fruits but it can also be seen with tomato, kiwi and chestnut.

    • This question is part of the following fields:

      • General Pathology
      • Pathology
      8.2
      Seconds
  • Question 2 - You are reviewing a patient with hypocalcaemia secondary to hypoparathyroidism. Parathyroid hormone (PTH)...

    Correct

    • You are reviewing a patient with hypocalcaemia secondary to hypoparathyroidism. Parathyroid hormone (PTH) acts to increased calcium reabsorption at which of the following sites in the nephron:

      Your Answer: Distal convoluted tubule

      Explanation:

      Parathyroid hormone (PTH) is a peptide hormone synthesised by the chief cells of the parathyroid glands, located immediately behind the thyroid gland. PTH is primarily released in response to decreasing plasma [Ca2+] concentration. PTH acts to increase plasma calcium levels and decrease plasma phosphate levels.
      Parathyroid hormone (PTH) acts to increase calcium reabsorption in the distal tubule of the nephron (by activating Ca2+entry channels in the apical membrane and the Ca2+ATPase pump in the basolateral membrane) and increase phosphate excretion by inhibiting reabsorption in the proximal tubule of the nephron.

    • This question is part of the following fields:

      • Endocrine
      • Physiology
      12.1
      Seconds
  • Question 3 - A 30-year-old man present to the ED with abdominal pain, nausea and vomiting....

    Correct

    • A 30-year-old man present to the ED with abdominal pain, nausea and vomiting. It has been present for the past two days.

      Which of the following statements regarding diarrhoea and vomiting is true?

      Your Answer: E.Coli can cause diarrhoea and renal failure

      Explanation:

      Escherichia coli strain 0157 causes enterohaemorrhagic diarrhoea and can lead to renal failure, haemolytic anaemia and thrombocytopenia.

      Norwalk virus is an RNA virus.

      Although transmission of rotavirus is primarily through the faeco-oral route, airborne spread has been seen in some cases.

      Cryptosporidium are protozoa with acid fast walls and are resistant to both chlorine treatment and conventional filtering methods.

      There is no therapy effective in treating cryptosporidium diarrhoea as the protozoa is not susceptible to antibiotics.

    • This question is part of the following fields:

      • Microbiology
      • Specific Pathogen Groups
      32.7
      Seconds
  • Question 4 - An elderly female has a bacterial infection and you are asked to prescribe...

    Correct

    • An elderly female has a bacterial infection and you are asked to prescribe an antibiotic to her. This antibiotic is a nucleic acid synthesis inhibitor.

      Which of the following antimicrobial drugs will be prescribed to this patient?

      Your Answer: Metronidazole

      Explanation:

      Metronidazole and the other 5-nitroimidazole agents inhibit nucleic acid synthesis by forming toxic free radical metabolites in the bacterial cell that damage DNA.

      Vancomycin inhibits cell wall peptidoglycan formation by binding the D-Ala-D-Ala portion of cell wall precursors.

      Erythromycin inhibits protein synthesis and blocks translocation by binding to the 23S rRNA of the 50S ribosomal subunit.

      Chloramphenicol blocks peptidyl transferase at 50S ribosomal subunit.

      Gentamicin, an aminoglycoside antibiotic, acts by binding to the 30S subunit of the bacterial ribosome inhibiting the binding of aminoacyl-tRNA and thus preventing initiation of protein synthesis.

      An overview of the different mechanisms of action of the various types of antimicrobial agents is shown below:
      1. Inhibition of cell wall synthesis
      – Penicillins
      – Cephalosporins
      – Vancomycin
      2. Disruption of cell membrane function
      – Polymyxins
      – Nystatin
      – Amphotericin B
      3. Inhibition of protein synthesis
      – Macrolides
      – Aminoglycosides
      – Tetracyclines
      – Chloramphenicol
      4. Inhibition of nucleic acid synthesis
      – Quinolones
      – Trimethoprim
      – 5-nitroimidazoles
      – Rifampicin
      5. Anti-metabolic activity
      – Sulphonamides
      – Isoniazid

    • This question is part of the following fields:

      • Infections
      • Pharmacology
      24.3
      Seconds
  • Question 5 - An 18-year-old patient was brought to the ER after falling off of his...

    Correct

    • An 18-year-old patient was brought to the ER after falling off of his skateboard. He is unable to flex the distal interphalangeal joint of his index finger. You suspect that he suffers from a supracondylar fracture. Which of the following conditions would confirm supracondylar fracture?

      Your Answer: Inability to oppose the thumb

      Explanation:

      A supracondylar fracture is a fracture that occurs through the thin section of the distal humerus above the growth plate.

      A supracondylar fracture is most usually associated with median nerve injury. A medial nerve damage causes paralysis of the thenar muscles, as well as loss of thumb opposition.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      48.1
      Seconds
  • Question 6 - Which of the following is NOT a common side effect of diazepam: ...

    Correct

    • Which of the following is NOT a common side effect of diazepam:

      Your Answer: Bradycardia

      Explanation:

      Adverse effects include:
      Drowsiness and lightheadedness
      Confusion and ataxia (especially in the elderly), amnesia, muscle weakness
      Headache, vertigo, tremor, dysarthria, hypotension, decreased libido, erectile dysfunction, gynaecomastia, urinary retention
      Paradoxical effects such as talkativeness, excitement, irritability, aggression, anti-social behaviour, and suicidal ideation
      Withdrawal symptoms, for example anxiety, depression, anorexia, impaired concentration, insomnia, abdominal cramps, palpitations, tremor, tinnitus and perceptual disturbances
      Tolerance and dependence (people who use benzodiazepines longer term can develop tolerance and eventual dependence)

    • This question is part of the following fields:

      • Anaesthesia
      • Pharmacology
      19.5
      Seconds
  • Question 7 - Which extraocular muscle is entrapped in a patient with a blowout fracture? ...

    Incorrect

    • Which extraocular muscle is entrapped in a patient with a blowout fracture?

      Your Answer: Medial rectus

      Correct Answer: Inferior rectus

      Explanation:

      A blowout fracture is an isolated fracture of the orbital walls without compromise of the orbital rims. The common mechanisms are falls, high-velocity ball-related sports, traffic accidents, and interpersonal violence.

      The frontal, ethmoidal, sphenoid, zygomatic, and lacrimal bones form the bony structures of the orbit. Medially, the maxillary and the lacrimal bone form the lacrimal fossa. Together with the lamina papyracea of the ethmoid bone, they form the medial wall. The sphenoid bone forms the posterior wall and houses the orbital canal. Lateral to the orbital canal lies the superior orbital fissure housing cranial nerves III, IV, V, and VI. The zygomatic bone forms the lateral wall. Superior and inferior borders are the frontal and maxillary bones. Located around the globe of the eye and attached to it are 6 extraocular muscles; the 4 rectus muscles and the superior and inferior oblique muscles. The fat and connective tissue around the globe help to reduce the pressure exerted by the extraocular muscles.

      The goal of treatment is to restore aesthetics and physiological function. The problem with orbital blowout fractures is that the volume of the orbit can be increased, resulting in enophthalmos and hypoglobus. In addition, the orbital tissue and inferior rectus muscle can become trapped by the bony fragments leading to diplopia, limitation of gaze, and tethering. Finally, the orbital injury can lead to retinal oedema, hyphema, and significant loss of vision.

      While some cases may be managed with conservative care, others may require some type of surgical intervention.

    • This question is part of the following fields:

      • Anatomy
      • Head And Neck
      26.1
      Seconds
  • Question 8 - A 25 year old man has sustained a fracture to the surgical neck...

    Correct

    • A 25 year old man has sustained a fracture to the surgical neck of the humerus after falling from his bike. Examination suggests an axillary nerve injury. The clinical features expected to be seen in this patient are:

      Your Answer: Weakness of shoulder abduction

      Explanation:

      Axillary nerve injury results in:
      1. weakness of arm abduction (paralysis of deltoid),
      2. weakness of lateral rotation of the arm (paralysis of teres minor)
      3. loss of sensation over the regimental badge area.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      22.8
      Seconds
  • Question 9 - Regarding bile, which of the following statements is CORRECT: ...

    Correct

    • Regarding bile, which of the following statements is CORRECT:

      Your Answer: Bile passes into the duodenum through the ampulla of Vater.

      Explanation:

      Bile is synthesised in the liver. Bile functions to eliminate endogenous and exogenous substances from the liver, to neutralise gastric acid in the small intestine, and to emulsify fats in the small intestine and facilitate their digestion and absorption. Bile is stored and concentrated in the gallbladder. Bile passes out of the gallbladder via the cystic duct. Bile passes into the duodenum through the ampulla of Vater regulated by the sphincter of Oddi.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      33.7
      Seconds
  • Question 10 - Leukaemia has been diagnosed in a 6-year-old child on your list. He comes...

    Correct

    • Leukaemia has been diagnosed in a 6-year-old child on your list. He comes to the ER with a complication related to this diagnosis.

      Which type of leukaemia do you think this is?

      Your Answer: Acute lymphoblastic leukaemia

      Explanation:

      Acute lymphoblastic leukaemia (ALL) is the most common childhood cancer that primarily affects children. ALL is most common between the ages of 2 and 4, and it is uncommon in adults.

    • This question is part of the following fields:

      • Haematology
      • Pathology
      12.1
      Seconds
  • Question 11 - One of your patients is in resuscitation and is suffering from kidney failure....

    Correct

    • One of your patients is in resuscitation and is suffering from kidney failure. The intensive care outreach team arrives to assess them and determines that a dopamine infusion is necessary.

      Dopamine primarily acts on which of the following receptors at low doses?

      Your Answer: Dopamine receptors

      Explanation:

      Dopamine is a catecholamine that occurs naturally and is used to treat low cardiac output, septic shock, and renal failure. It is both adrenaline and noradrenaline’s immediate precursor.

      Dopamine acts on D1 and D2 dopamine receptors in the renal, mesenteric, and coronary beds at low doses (1-5 g/kg/min). Dopamine causes a significant decrease in renal vascular resistance and an increase in renal blood flow at these doses. Within this dose range, it is also involved in central modulation of behaviour and movement.

      Dopamine stimulates beta- and alpha-adrenergic receptors directly and indirectly at higher doses. Beta-stimulation predominates at a rate of 5-10 g/kg/min, resulting in a positive inotropic effect that increases cardiac output and coronary blood flow. Alpha-stimulation predominates at infusion rates greater than 15 g/kg/min, resulting in peripheral vasoconstriction and an increase in venous return and systolic blood pressure.

      Below is a summary of the mechanisms and effects of various inotropic agents:
      Inotrope
      Mechanism
      Effects
      Adrenaline (epinephrine)
      Beta-1 and -2 agonist at increasing doses;
      Alpha-agonist at high doses
      Increased cardiac output;
      Vasoconstriction at higher doses
      Noradrenaline (norepinephrine)
      Mainly alpha-agonist;
      Beta-1 and -2 agonist at increasing doses
      Vasoconstriction;
      Some increased cardiac output
      Dopamine
      Dopamine agonist at low doses;
      Beta-1 and -2 agonist at increasing doses;
      Alpha-agonist at high doses
      Increased cardiac output;
      Vasoconstriction at higher doses
      Dobutamine
      Mainly beta-1 agonist
      Increased cardiac output

    • This question is part of the following fields:

      • Cardiovascular Pharmacology
      • Pharmacology
      48.5
      Seconds
  • Question 12 - Which of the following is NOT a side effect of phenytoin: ...

    Correct

    • Which of the following is NOT a side effect of phenytoin:

      Your Answer: Ototoxicity

      Explanation:

      Adverse effects of phenytoin include:
      Nausea and vomiting
      Drowsiness, lethargy, and loss of concentration
      Headache, dizziness, tremor, nystagmus and ataxia
      Gum enlargement or overgrowth
      Coarsening of facial features, acne and hirsutism
      Skin rashes
      Blood disorders

    • This question is part of the following fields:

      • Central Nervous System
      • Pharmacology
      18.8
      Seconds
  • Question 13 - A patient suffers a stab wound to the neck. The entry point of...

    Correct

    • A patient suffers a stab wound to the neck. The entry point of the blade is situated within the posterior triangle of the neck.
      Which of the following muscles is LEAST likely to be involved? Select ONE answer only.

      Your Answer: Sternohyoid

      Explanation:

      The anterior triangle is the triangular area of the neck found anteriorly to the sternocleidomastoid muscle. It is formed by the anterior border of sternocleidomastoid laterally, the median line of the neck medially and by the inferior border of the mandible superiorly. The apex of the anterior triangle extends towards the manubrium sterni. The anterior triangle contains:
      Muscles: thyrohyoid, sternothyroid, sternohyoid muscles
      Organs: thyroid gland, parathyroid glands, larynx, trachea, esophagus, submandibular gland, caudal part of the parotid gland
      Arteries: superior and inferior thyroid, common carotid, external carotid, internal carotid artery (and sinus), facial, submental, lingual arteries
      Veins: anterior jugular veins, internal jugular, common facial, lingual, superior thyroid, middle thyroid veins, facial vein, submental vein, lingual veins
      Nerves: vagus nerve (CN X), hypoglossal nerve (CN XII), part of sympathetic trunk, mylohyoid nerve

      The posterior triangle is a triangular area found posteriorly to the sternocleidomastoid muscle. It has three borders; anterior, posterior and inferior borders. The anterior border is the posterior margin of the sternocleidomastoid muscle. The posterior border is the anterior margin of the trapezius muscle, while the inferior border is the middle one-third of the clavicle. The investing layer of deep cervical fascia and integument forms the roof of the space, while the floor is covered with the prevertebral fascia along with levator scapulae, splenius capitis and the scalene muscles. The inferior belly of omohyoid subdivides the posterior triangle into a small supraclavicular, and a large occipital, triangle.
      Contents:
      Vessels: the third part of the subclavian artery, suprascapular and transverse cervical branches of the thyrocervical trunk, external jugular vein, lymph nodes
      Nerves: accessory nerve (CN XI), the trunks of the brachial plexus, fibers of the cervical plexus

    • This question is part of the following fields:

      • Anatomy
      • Head And Neck
      46.6
      Seconds
  • Question 14 - Streptococcus pneumoniae is commonly implicated in all of the following infectious diseases EXCEPT...

    Correct

    • Streptococcus pneumoniae is commonly implicated in all of the following infectious diseases EXCEPT for:

      Your Answer: Impetigo

      Explanation:

      Impetigo is a highly contagious infection of the superficial epidermis that most commonly affects young children but can occur in any age group. In children it is the most common bacterial skin infection and it is the third most common skin disease overall, behind dermatitis and viral warts.
      The commonest causative organism is Staphylococcus aureus. Streptococcus pyogenesis the second commonest and causes fewer cases, either alone or in combination withS. aureus.The streptococcal form tends to be commoner in warmer, more humid climates. (Hirschmann JV. Impetigo: etiology and therapy. Curr Clin Top Infect Dis. 2002;22:42–51.)
      Impetigo is most commonly spread by direct person-to-person contact, and can spread rapidly through families and school classes. It can also, less commonly, be spread by indirect contact.
      There are two main forms of impetigo:
      Non-bullous impetigo – lesions usually start as tiny pustules or vesicles that evolve rapidly into honey-crusted plaques that tend to be under 2 cm in diameter. These can be itchy but are rarely painful.
      Bullous impetigo – lesions have a thin roof and tend to rupture spontaneously. This type is more likely to be painful and may be associated with systemic upset.

    • This question is part of the following fields:

      • Microbiology
      • Pathogens
      20.8
      Seconds
  • Question 15 - Regarding the resting membrane potential, which of the following statements is CORRECT: ...

    Incorrect

    • Regarding the resting membrane potential, which of the following statements is CORRECT:

      Your Answer: The resting membrane potential is primarily determined by the Na + equilibrium potential.

      Correct Answer: The resting cell membrane is more permeable to K + ions than to Na + ions.

      Explanation:

      A membrane potential is a property of all cell membranes, but the ability to generate an action potential is only a property of excitable tissues. The resting membrane is more permeable to K+and Cl-than to other ions (and relatively impermeable to Na+); therefore the resting membrane potential is primarily determined by the K+equilibrium potential. At rest the inside of the cell is negative relative to the outside. In most neurones the resting potential has a value of approximately -70 mV.

    • This question is part of the following fields:

      • Basic Cellular
      • Physiology
      35.5
      Seconds
  • Question 16 - A mother has serious concerns about vaccinating her child. She has read about...

    Correct

    • A mother has serious concerns about vaccinating her child. She has read about many contraindications and risks in the papers and would like to discuss them with you.

      One of these is a valid contraindication to vaccination.

      Your Answer: None of the other options

      Explanation:

      The options listed in this question are not true contraindications to vaccination. Therefore, the correct answer is ‘none of the other options’.
      The contraindications to vaccination are:
      Confirmed anaphylactic reaction to a previous dose of the vaccine or a vaccine containing the same antigens.
      A confirmed anaphylactic reaction to another component in the vaccine.

    • This question is part of the following fields:

      • Microbiology
      • Principles Of Microbiology
      22.2
      Seconds
  • Question 17 - What is the pathophysiology of a phaeochromocytoma: ...

    Correct

    • What is the pathophysiology of a phaeochromocytoma:

      Your Answer: Catecholamine-secreting tumour

      Explanation:

      Phaeochromocytomas are catecholamine-secreting tumours which occur in about 0.1% of patients with hypertension. In about 90% of cases they arise from the adrenal medulla. The remaining 10%, which arise from extra-adrenal chromaffin tissue, are termed paragangliomas. Common presenting symptoms include one or more of headache, sweating, pallor and palpitations. Less commonly, patients describe anxiety, panic attacks and pyrexia. Hypertension, whether sustained or episodic, is present in at least 90% of patients. Left untreated phaeochromocytoma can occasionally lead to hypertensive crisis, encephalopathy, hyperglycaemia, pulmonary oedema, cardiac arrhythmias, or even death.

    • This question is part of the following fields:

      • Endocrine
      • Physiology
      11.5
      Seconds
  • Question 18 - A 13-year-old male presents to the Emergency Department with a heavy nosebleed. His...

    Correct

    • A 13-year-old male presents to the Emergency Department with a heavy nosebleed. His medical record shows that he was diagnosed with Haemophilia B as a child.

      What is the mode of inheritance of this disease?

      Your Answer: X-linked recessive

      Explanation:

      Deficiency of Factor IX causes Haemophilia B, and like the other Haemophilia’s, it has an X-linked recessive pattern of inheritance, affecting males born to carrier mothers.

      Haemophilia B is the second commonest form of haemophilia and is rarer than haemophilia A. Haemophilia B is similar to haemophilia A but is less severe. You can distinguish the two disorders by specific coagulation factor assays.

      The incidence of Haemophilia B is one-fifth of that of haemophilia A.

      In laboratory findings, you get prolonged APTT, normal PT and low factor IX for Haemophilia B.

      There is also a variation called Leyden, in which factor IX levels are below 1% until puberty, when they rise, potentially reaching as high as 40-60% of normal. This is thought to be due to the effects of testosterone at puberty.

    • This question is part of the following fields:

      • Haematology
      • Pathology
      24.8
      Seconds
  • Question 19 - An elderly man with chronic heart and lung disease develops Legionnaires' disease. Which...

    Correct

    • An elderly man with chronic heart and lung disease develops Legionnaires' disease. Which of the following clinical features is NOT typical of Legionnaires' disease:

      Your Answer: Confusion

      Explanation:

      Legionella pneumophilais a Gram negative bacterium that is found in natural water supplies and in the soil, transmitted predominantly via inhalation of aerosols generated from contaminated water (direct person-to-person spread of infected patients does not occur). It is the cause of Legionnaires’ disease. Outbreaks of Legionnaires’ disease have been linked to poorly maintained air conditioning systems, whirlpool spas and hot tubs.

      The clinical features of the pneumonic form of Legionnaires’ disease include:
      Mild flu-like prodrome for 1-3 days
      Cough (usually non-productive and occurs in approximately 90%)
      Pleuritic chest pain
      Haemoptysis
      Headache
      Nausea, vomiting and diarrhoea
      Anorexia

      Legionella pneumophilainfections can be successfully treated with macrolide antibiotics, such as erythromycin, or quinolones, such as ciprofloxacin. Tetracyclines, such as doxycycline, can also be used.

      The syndrome of inappropriate antidiuretic hormone secretion (SIADH) can occur with Legionnaires’ disease and will result in hyponatraemia as is seen in this case.
      Legionella pneumophilainfections are resistant to amoxicillin but can be successfully treated with macrolide antibiotics, such as erythromycin, or quinolones, such as ciprofloxacin. Tetracyclines, such as doxycycline, can also be used. The majority of cases of Legionnaires’ disease are caused by Legionella pneumophila, however many other species of Legionella have been identified.
      Legionella longbeachae is another less commonly encountered species that has also been implicated in outbreaks. It is predominantly found in soil and potting compost, and has caused outbreaks of Pontiac fever, the non-respiratory and less severe variant of Legionnaires’ disease.

    • This question is part of the following fields:

      • Microbiology
      • Pathogens
      62.1
      Seconds
  • Question 20 - The ECG of a patient presenting with a history of intermittent palpitations has...

    Correct

    • The ECG of a patient presenting with a history of intermittent palpitations has a prolonged QT interval.

      Which of these can cause prolongation of the QT interval on the ECG?

      Your Answer: Hypomagnesaemia

      Explanation:

      The causes of a prolonged QT interval include:

      Hypomagnesaemia
      Hypothermia
      Hypokalaemia
      Hypocalcaemia
      Hypothyroidism
      Jervell-Lange-Nielsen syndrome (autosomal dominant)
      Romano Ward syndrome (autosomal recessive)
      Ischaemic heart disease
      Mitral valve prolapse
      Rheumatic carditis
      Erythromycin
      Amiodarone
      Quinidine
      Tricyclic antidepressants
      Terfenadine
      Methadone
      Procainamide
      Sotalol

    • This question is part of the following fields:

      • Cardiovascular Physiology
      • Physiology
      16.5
      Seconds
  • Question 21 - A 70-year-old man presents with right-sided hemiplegia and loss of joint position sense,...

    Incorrect

    • A 70-year-old man presents with right-sided hemiplegia and loss of joint position sense, vibratory sense, and discriminatory touch. Upon further physical examination, it was observed that her tongue deviates to the left-hand side. An MRI and CT scan was ordered and results showed that he was suffering a left-sided stroke.

      Which of the following is considered the best diagnosis for the case presented above?

      Your Answer: Lateral medullary syndrome

      Correct Answer: Medial medullary syndrome

      Explanation:

      Medial medullary syndrome is a form of stroke that affects the medial medulla of the brain. It is caused by a lesion in the medial part of the medulla, which is due to an infraction of vertebral arteries and/or paramedian branches of the anterior spinal artery.

      It is characterized by contralateral paralysis of the upper and lower limb of the body, a contralateral decrease in proprioception, vibration, and/or fine touch sensation, paresthesias or less commonly dysesthesias in the contralateral trunk and lower limb, and loss of position and vibration sense with proprioceptive dysfunction. Ipsilateral deviation of the tongue due to ipsilateral hypoglossal nerve damage can also be seen.

    • This question is part of the following fields:

      • Anatomy
      • Central Nervous System
      227.3
      Seconds
  • Question 22 - A patient diagnosed with cranial nerve palsy exhibits asymmetrical movement of the palate,...

    Correct

    • A patient diagnosed with cranial nerve palsy exhibits asymmetrical movement of the palate, nasal regurgitation of food, and nasal quality to the voice.

      Which of the following cranial nerves is most likely responsible for the aforementioned features?

      Your Answer: Vagus nerve

      Explanation:

      The vagus nerve, ‘the wanderer’, contains motor fibres (to the palate and vocal cords), sensory components (posterior and floor of external acoustic meatus) and visceral afferent and efferent fibres.

      Palatal weakness can cause nasal speech and nasal regurgitation of food. The palate moves asymmetrically when the patient says ‘ahh’. Recurrent nerve palsy results in hoarseness, loss of volume and ‘bovine cough’.

    • This question is part of the following fields:

      • Anatomy
      • Central Nervous System
      50.6
      Seconds
  • Question 23 - Which of the following is caused by an alpha-1 antitrypsin deficiency? ...

    Correct

    • Which of the following is caused by an alpha-1 antitrypsin deficiency?

      Your Answer: Early onset emphysema

      Explanation:

      Mucus contains chemicals such as alpha-1-antitrypsin, lysozyme, and IgA that protect the airway from pathogens and damaging proteases released from dead bacteria and immune cells. Early-onset emphysema results from a genetic deficit of alpha-1-antitrypsin, which is caused by unregulated protease activity in the lungs, which results in the degradation of elastin in the alveoli.

    • This question is part of the following fields:

      • Physiology
      • Respiratory
      18.4
      Seconds
  • Question 24 - Which of the following is NOT a typical feature of a lesion to...

    Correct

    • Which of the following is NOT a typical feature of a lesion to the vestibulocochlear nerve:

      Your Answer: Hyperacusis

      Explanation:

      Hyperacusis is increased acuity of hearing with hypersensitivity to low tones resulting from paralysis of the stapedius muscle, innervated by the facial nerve. General sensation to the face and to the anterior two-thirds of the tongue is carried by the divisions of the trigeminal nerve (although taste to the anterior two-thirds of the tongue is supplied by the facial nerve). Eye movements are mediated by the oculomotor, trochlear and abducens nerve. Ptosis results from paralysis of the levator palpebrae superioris, innervated by the oculomotor nerve, or the superior tarsal muscle, innervated by the sympathetic chain.

    • This question is part of the following fields:

      • Anatomy
      • Cranial Nerve Lesions
      48.4
      Seconds
  • Question 25 - Myocardial contractility is best correlated with the intracellular concentration of: ...

    Correct

    • Myocardial contractility is best correlated with the intracellular concentration of:

      Your Answer: Ca2+

      Explanation:

      Contractility of myocardial cells depends on the intracellular [Ca2+], which is regulated by Ca2+entry across the cell membrane during the plateau of the action potential and by Ca2+uptake into and release from the sarcoplasmic reticulum (SR).

    • This question is part of the following fields:

      • Cardiovascular
      • Physiology
      10.6
      Seconds
  • Question 26 - A patient with diplopia is found to have eye deviation downwards and outwards....

    Correct

    • A patient with diplopia is found to have eye deviation downwards and outwards. The likely nerves that are affected are:

      Your Answer: Oculomotor nerve

      Explanation:

      The results of an oculomotor (CN III) nerve palsy are a depressed and abducted (down and out) eye, ptosis, diplopia, and a fixed and dilated pupil.

    • This question is part of the following fields:

      • Anatomy
      • Cranial Nerve Lesions
      7.9
      Seconds
  • Question 27 - Streptococcus pyogenes is commonly implicated in all of the following infective diseases EXCEPT for:...

    Correct

    • Streptococcus pyogenes is commonly implicated in all of the following infective diseases EXCEPT for:

      Your Answer: Gas gangrene

      Explanation:

      Gas gangrene is a life-threatening infection caused by toxin-producing Clostridium species, primarily Clostridium perfringens, and characterised by rapidly progressive muscle necrosis, gas production and sepsis.
      Gas gangrene is not a notifiable disease.

    • This question is part of the following fields:

      • Microbiology
      • Pathogens
      17.5
      Seconds
  • Question 28 - Regarding bronchiolitis, which of the following statements is CORRECT: ...

    Correct

    • Regarding bronchiolitis, which of the following statements is CORRECT:

      Your Answer: Chest x-ray may show hyperinflation and increased peribronchial markings.

      Explanation:

      Acute bronchiolitis is caused most commonly by respiratory syncytial virus, occurring mostly in children aged 6 months to 2 years. Children with bronchiolitis are febrile and tachypnoeic with a dry cough and difficulty feeding. Examination may reveal chest hyperinflation, respiratory distress, wheezing and fine end-inspiratory crepitations. Chest x-ray may show hyperinflation and increased peribronchial markings (although CXR should only performed if there is diagnostic uncertainty or an atypical course). Treatment is usually supportive, aerosolized ribavirin is reserved for severely ill or immunocompromised patients.

    • This question is part of the following fields:

      • Microbiology
      • Pathogens
      34.6
      Seconds
  • Question 29 - Herpes simplex virus is transmitted most commonly through which of the following routes:...

    Correct

    • Herpes simplex virus is transmitted most commonly through which of the following routes:

      Your Answer: Direct contact spread

      Explanation:

      Herpes simplex virus is the most common cause of infective encephalitis and has a predilection for the temporal lobes. Herpes simplex is transmitted through direct contact. It invades skin locally producing skin vesicles by its cytolytic activity.

    • This question is part of the following fields:

      • Microbiology
      • Pathogens
      48
      Seconds
  • Question 30 - In adults in the United Kingdom, which of the following pathogens is the...

    Correct

    • In adults in the United Kingdom, which of the following pathogens is the most likely cause of viral infectious gastroenteritis:

      Your Answer: Norovirus

      Explanation:

      Norovirus is the most common viral cause of epidemic gastroenteritis worldwide; it is also a common cause of endemic diarrhoea in community settings. In the United Kingdom, norovirus has become the most common cause of gastroenteritis in adults and children since the introduction of rotavirus vaccination.

    • This question is part of the following fields:

      • Microbiology
      • Pathogens
      19.8
      Seconds

SESSION STATS - PERFORMANCE PER SPECIALTY

General Pathology (1/1) 100%
Pathology (3/3) 100%
Endocrine (2/2) 100%
Physiology (6/7) 86%
Microbiology (8/8) 100%
Specific Pathogen Groups (1/1) 100%
Infections (1/1) 100%
Pharmacology (4/4) 100%
Anatomy (6/8) 75%
Upper Limb (2/2) 100%
Anaesthesia (1/1) 100%
Head And Neck (1/2) 50%
Gastrointestinal (1/1) 100%
Haematology (2/2) 100%
Cardiovascular Pharmacology (1/1) 100%
Central Nervous System (2/3) 67%
Pathogens (6/6) 100%
Basic Cellular (0/1) 0%
Principles Of Microbiology (1/1) 100%
Cardiovascular Physiology (1/1) 100%
Respiratory (1/1) 100%
Cranial Nerve Lesions (2/2) 100%
Cardiovascular (1/1) 100%
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