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  • Question 1 - Normal stroke volume is about: ...

    Correct

    • Normal stroke volume is about:

      Your Answer: 70 ml

      Explanation:

      Stroke volume is the amount of blood that is pumped from the heart into the aorta. It is typically 70 ml.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      24.4
      Seconds

  • Question 2 - Select the correct statement regarding the 4th heart sound, it? ...

    Correct

    • Select the correct statement regarding the 4th heart sound, it?

      Your Answer: Can be heard in atrial systole.

      Explanation:

      The fourth heart sound is not normally audible in a normal adult. It occurs as a consequence of ventricular hypertrophy. It is caused by filling of the ventricle by atrial systole.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      32.7
      Seconds

  • Question 3 - Which of the following components regulate cardiac output? ...

    Correct

    • Which of the following components regulate cardiac output?

      Your Answer: All of the above

      Explanation:

      Cardiac output is regulated by the autonomic nervous system with sympathetic nerves having a positive chronotropic and inotropic effect and parasympathetic nerves having the opposite effect. An increase in preload will increase cardiac output likewise an afterload increase will also increase cardiac output.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      8.5
      Seconds

  • Question 4 - The most resistant area in the brain to hypoxia is: ...

    Correct

    • The most resistant area in the brain to hypoxia is:

      Your Answer: Brain stem

      Explanation:

      The structures in the brainstem are more resistant to hypoxia than the cerebral cortex and the rest of the brain structures.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      2.2
      Seconds

  • Question 5 - In Starling’s law of the heart, the decrease in tension developed by muscle...

    Correct

    • In Starling’s law of the heart, the decrease in tension developed by muscle contraction at high degrees of stretch is due to:

      Your Answer: Disruption of myocardial fibers

      Explanation:

      Starling law states that the force of contraction is directly proportional to the preload. When the heart muscle is stretched beyond its limit the tension that is developed decreases, this is not due to loss of formation of effective myosin and actin cross bridges. The heart muscles despite being fully stretched is never stretched to this point. The reason for this decreased tension is physical disruption of the myocardial fibers.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      41.5
      Seconds

  • Question 6 - Which of the following normally has a slow depolarizing “prepotential”? ...

    Correct

    • Which of the following normally has a slow depolarizing “prepotential”?

      Your Answer: Sinoatrial node

      Explanation:

      There are 2 main types of action potentials (AP) in the heart, the slow response and the fast response:The slow response is initiated by the slow calcium-sodium channels, found in the SA node (which is the natural pacemaker of the heart) and the conduction fibers of the AV node.The fast response occurs in the atrial and ventricles muscle cells and the purkinje fibers.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      38.5
      Seconds

  • Question 7 - Closure of the tricuspid valve is marked by which of the following features...

    Correct

    • Closure of the tricuspid valve is marked by which of the following features of the jugular venous waveform?

      Your Answer: c wave

      Explanation:

      The jugular venous pressure (JVP) classically has three upward deflections and two downward deflections. The upward deflections are the a (atrial contraction), c (ventricular contraction and resulting bulging of tricuspid into the right atrium during isovolumetric systole) and v = venous filling. The downward deflections of the wave are the x (the atrium relaxes and the tricuspid valve moves downward) and the y descent (filling of ventricle after tricuspid opening).

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      19.5
      Seconds

  • Question 8 - Calcium induced calcium release occurs in the sarcoplasmic reticulum by activation of which...

    Correct

    • Calcium induced calcium release occurs in the sarcoplasmic reticulum by activation of which receptors

      Your Answer: Ryanodine receptors

      Explanation:

      Calcium-induced calcium release (CICR) describes a biological process whereby calcium is able to activate calcium release from intracellular Ca2+ stores (e.g., endoplasmic reticulum or sarcoplasmic reticulum). CICR occurs when the resulting Ca2+ influx activates ryanodine receptors on the SR membrane, which causes more Ca2+ to be released into the cytosol.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      9.7
      Seconds

  • Question 9 - Which of the following is first to rise following myocardial infarction? ...

    Incorrect

    • Which of the following is first to rise following myocardial infarction?

      Your Answer: Troponin I

      Correct Answer: Myoglobin

      Explanation:

      Myoglobin, is a sensitive indicator of muscle injury and is first to rise following MI within two hours but is nonspecific.Troponin and CK-MB both begin to rise approximately three hours after MI. The cardiac troponins T and I which are released within 4–6 hours of an attack of MI and remain elevated for up to 2 weeks, have nearly complete tissue specificity and are now the preferred markers for assessing myocardial damage.Lactate dehydrogenase (LDH) begins to rise approximately 12 hours after MI.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      7.1
      Seconds

  • Question 10 - Which structure forms the major part of the sternocostal surface of the heart?...

    Correct

    • Which structure forms the major part of the sternocostal surface of the heart?

      Your Answer: Right ventricle

      Explanation:

      The anterior (sternocostal) surface is formed mainly by the right ventricle.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      6.5
      Seconds

  • Question 11 - Activation of nitric oxide synthesis by endothelial cells is triggered by: ...

    Incorrect

    • Activation of nitric oxide synthesis by endothelial cells is triggered by:

      Your Answer: Bradykinin

      Correct Answer: All of the above

      Explanation:

      Acetylcholine, histamine, bradykinin, vasoactive intestinal peptide (VIP) and shear stress on the endothelial cells causing the release of NO. NO is formed from arginine and causes vasodilatation of the blood vessels.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      24.3
      Seconds

  • Question 12 - Nitric oxide triggers vascular smooth muscle contraction through activation of which enzyme? ...

    Correct

    • Nitric oxide triggers vascular smooth muscle contraction through activation of which enzyme?

      Your Answer: Guanylyl cyclase

      Explanation:

      Impaired production or excess catabolism of NO impairs this endothelium-dependent vasodilator function and may contribute to excessive vasoconstriction under various pathological situations.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      4.3
      Seconds

  • Question 13 - The following are examples of the functions of the vascular endothelium except: ...

    Correct

    • The following are examples of the functions of the vascular endothelium except:

      Your Answer: Tumour suppression

      Explanation:

      Vascular endothelium has many important functions including regulation of vascular tone, molecular exchange between blood and tissue compartments, hemostasis and signaling for the immune regulation and inflammation. Depending on specific tissue needs and local stresses, endothelial cells are capable of evoking either antithrombotic or prothrombotic events. Tumor suppression is related to genes, or anti-oncogenes, that regulate a cell during cell division and replication.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      16.9
      Seconds

  • Question 14 - Which of the following intercellular connections is important in endothelial barrier function? ...

    Correct

    • Which of the following intercellular connections is important in endothelial barrier function?

      Your Answer: Tight junctions

      Explanation:

      Tight junctions surround the apical margins of the epithelial cells such as in the intestinal mucosa and the choroid plexus. They are also important to the endothelial barrier function. They are made up of ridges that adhere to each other strongly at the cell junction, obliterating the space completely between the cells.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      6.4
      Seconds

  • Question 15 - Which of the following does not contribute to increased stroke volume during exercise?...

    Correct

    • Which of the following does not contribute to increased stroke volume during exercise?

      Your Answer: Increased length of filling time during diastole

      Explanation:

      Prolonged aerobic exercise training may also increase stroke volume, which frequently results in a lower (resting) heart rate. Reduced heart rate prolongs ventricular diastole (filling), increasing end-diastolic volume, and ultimately allowing more blood to be ejected.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      84.5
      Seconds

  • Question 16 - The interventricular septum is supplied anteriorly by the? ...

    Correct

    • The interventricular septum is supplied anteriorly by the?

      Your Answer: Left anterior descending artery

      Explanation:

      The anterior interventricular artery or left anterior descending artery supplies the anterior 2/3rds of the interventricular septum.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      13
      Seconds

  • Question 17 - Cholinergic vagal supply to the SA and AV nodes results in slowing of...

    Correct

    • Cholinergic vagal supply to the SA and AV nodes results in slowing of the heart rate via:

      Your Answer: M2 muscarinic receptors

      Explanation:

      M2 muscarinic receptors are the receptors for the parasympathetic system to the SA and the AV node.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      7.7
      Seconds

  • Question 18 - The Plateau phase in myocyte action potentials does all of the following except:...

    Correct

    • The Plateau phase in myocyte action potentials does all of the following except:

      Your Answer: It allows early reactivation of the myocytes

      Explanation:

      The presence of the plateau in the action potential causes ventricular contraction to last as much as 15 times longer in cardiac muscle as in skeletal muscle. The plateau phase which follows is unique to myocytes and results from a small, but sustained inward calcium current through L-type calcium channels lasting 200-400 ms. This calcium influx is caused by a combined increase in permeability of the cell and especially the sarcolemmal membranes to calcium. This plateau (refractory) phase prevents early reactivation of the myocytes and directly determines the strength of contraction.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      84.2
      Seconds

  • Question 19 - Which one of the following ECG findings is least associated with digoxin use?...

    Correct

    • Which one of the following ECG findings is least associated with digoxin use?

      Your Answer: Prolonged QT interval

      Explanation:

      Digoxin ECG features:•    ST depression (‘reverse tick’)•    flattened/inverted T waves•  Prolonged PR interval•    short QT interval•    arrhythmias e.g. AV block, bradycardia, ventricular tachycardia or fibrillation (for example paroxysmal atrial tachycardia with A-V block – so-called PAT with block) is said to be pathognomonic (i.e. diagnostic) of digoxin toxicity.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      63.2
      Seconds

  • Question 20 - Ventricular depolarization plus ventricular repolarization is shown by the _____ interval ...

    Correct

    • Ventricular depolarization plus ventricular repolarization is shown by the _____ interval

      Your Answer: QT

      Explanation:

      The QT interval represents ventricular depolarization as well as ventricular repolarization.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      8.3
      Seconds

  • Question 21 - Which of the following conditions has no effect on cardiac output? ...

    Correct

    • Which of the following conditions has no effect on cardiac output?

      Your Answer: Sleep

      Explanation:

      Sleep has no effect on the cardiac output. Anxiety, excitement and pregnancy will increase the cardiac output. Standing from a lying position will decrease the cardiac output transiently.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      12.2
      Seconds

  • Question 22 - Troponin I is inhibited by calcium binding to: ...

    Correct

    • Troponin I is inhibited by calcium binding to:

      Your Answer: Troponin c

      Explanation:

      At rest troponin I is bound to actin and tropomyosin and covers the site where the myosin head interacts with actin. When calcium enters into the muscle, it binds with troponin C and cause a structural change in troponin I which moves out of the myosin binding site and causes the cross bridges between the actin and myosin filaments to occur.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      6.5
      Seconds

  • Question 23 - Which coronary artery supplies the right atria? ...

    Correct

    • Which coronary artery supplies the right atria?

      Your Answer: Right coronary

      Explanation:

      The left coronary artery distributes blood to the left side of the heart, the left atrium and ventricle, and the interventricular septum. The circumflex artery arises from the left coronary artery and follows the coronary sulcus to the left. Eventually, it will fuse with the small branches of the right coronary artery. The right coronary artery proceeds along the coronary sulcus and distributes blood to the right atrium, portions of both ventricles, and the heart conduction system.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      5.6
      Seconds

  • Question 24 - Which of the following factors serve to decrease cardiac output? ...

    Correct

    • Which of the following factors serve to decrease cardiac output?

      Your Answer: Standing from a lying position

      Explanation:

      Sleep has no effect on the cardiac output. Anxiety, excitement, increased body temperature and pregnancy will increase the cardiac output. Standing from a lying position will decrease the cardiac output transiently.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      15.3
      Seconds

  • Question 25 - Myocardial contractility is improved by: ...

    Correct

    • Myocardial contractility is improved by:

      Your Answer: Caffeine

      Explanation:

      Caffeine and other theophyllines breakdown cAMP and have a positive ionotropic effect on the heart. Drugs like quinidine, procainamide and conditions like hypoxia and hypercapnia decreases the contractility of the heart.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      15
      Seconds

  • Question 26 - Which of the following pairs are correct concerning arteriolar tone? ...

    Incorrect

    • Which of the following pairs are correct concerning arteriolar tone?

      Your Answer: Metabolic control: vascular accumulation of waste products stimulates vasoconstriction

      Correct Answer: Hormonal control: catecholamines affect the adrenergic receptors of the vascular smooth muscle

      Explanation:

      Catecholamines released from the adrenal medulla act on the noradrenergic receptors of the vascular smooth muscles. In the skeletal muscles and liver it causes vasodilation whilst it causes vasoconstriction in the rest of the blood vessels of the body.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      43
      Seconds

  • Question 27 - Which vagus nerve mainly supplies the AV node? ...

    Correct

    • Which vagus nerve mainly supplies the AV node?

      Your Answer: Left vagus

      Explanation:

      As the AV node develops from the left side of the embryo It is supplied by the left vagus nerve.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      4.9
      Seconds

  • Question 28 - When observing a JVP, which of the following would lead to prominent v...

    Incorrect

    • When observing a JVP, which of the following would lead to prominent v waves?

      Your Answer: Pulmonary Regurgitation

      Correct Answer: Tricuspid regurgitation

      Explanation:

      The v wave corresponds to Venous filling when the tricuspid valve is closed and venous pressure increases from venous return. In Tricuspid regurgitation there is additional blood from the regurgitant flow and thus this leads to a more prominent V wave.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      139.4
      Seconds

  • Question 29 - Following an action potential, cytosolic Ca2+ is increased. The binding of free Ca2+...

    Incorrect

    • Following an action potential, cytosolic Ca2+ is increased. The binding of free Ca2+ to troponin C results in all of the following except:

      Your Answer: Formation of myosin/troponin i cross-bridges

      Correct Answer: Weakening of the troponin i interaction with actin

      Explanation:

      At rest, troponin i is bound to actin and tropomyosin and covers the site where the myosin head interacts with actin. When Calcium enters into the muscle, it binds with troponin C and cause a structural change in troponin i which moves out of the myosin binding site and causes the cross bridges between the actin and myosin filaments to occur.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      20.6
      Seconds

  • Question 30 - What is pulse pressure? ...

    Correct

    • What is pulse pressure?

      Your Answer: Difference between systolic and diastolic pressure

      Explanation:

      The pulse pressure is the difference between the measured systolic and diastolic pressures.

    • This question is part of the following fields:

      • Cardiovascular
      • Medicine
      10.8
      Seconds

SESSION STATS - PERFORMANCE PER SPECIALTY

Cardiovascular (25/30) 83%
Medicine (25/30) 83%
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