00
Correct
00
Incorrect
00 : 00 : 0 00
Session Time
00 : 00
Average Question Time ( Secs)
  • Question 1 - Peristalsis is an example of: ...

    Incorrect

    • Peristalsis is an example of:

      Your Answer: Both central and enteric nervous system

      Correct Answer: Enteric nervous system

      Explanation:

      Peristalsis is a type of contraction where radial symmetrical contraction and relaxation of muscles propagates food in a downward wave through the gut. The enteric nervous system is one of the main divisions of the nervous system and consists of a mesh-like system of neurons that controls the function of the gastrointestinal tract. It has an independent reflex activity. The neurons of this system re collected into two types of ganglia: myenteric (or Auerbach’s) and submucosal (or Meissner’s plexuses). Myenteric plexuses are located between the inner and outer layers of the muscularis externa, while submucosal plexuses are located in the submucosa.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      27.6
      Seconds
  • Question 2 - There is normally an inverse relationship between the hepatic artery and portal venous...

    Correct

    • There is normally an inverse relationship between the hepatic artery and portal venous blood flow. This is maintained by:

      Your Answer: All of the options are correct

      Explanation:

      There is an inverse relationship between the blood flow of the hepatic artery and portal vein. It is maintained by several factors such as chemicals like adenosine, neurohumoral substances, the morphology of the hepatic portal system (especially the ability of hepatic sinusoids to collapse) and myogenic control which causes vasoconstriction or vasodilation.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      26.6
      Seconds
  • Question 3 - What is the primary problem of achalasia ...

    Incorrect

    • What is the primary problem of achalasia

      Your Answer: Defective interstitial cells of cajal

      Correct Answer: Deficiency of myenteric plexus at the lower oesophageal sphincter

      Explanation:

      Oesophageal achalasia is an oesophageal motility disorder involving the smooth muscle layer of the oesophagus is characterized by the failure of the lower oesophageal sphincter (LES) relaxation and aperistalsis, caused primarily by the loss of the inhibitory innervation of the oesophageal myenteric plexus.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      12.1
      Seconds
  • Question 4 - During the gastric phase, the acid secretion process is stimulated in the G...

    Correct

    • During the gastric phase, the acid secretion process is stimulated in the G cells by?

      Your Answer: Vagal stimulation, distention of the stomach wall, oligopeptides in the stomach

      Explanation:

      Before the meal enters into the stomach, the amount of secretion is limited. Swallowing of a food bolus triggers the release of gastrin. Once in the stomach, the meal physically distends the stomach activating the stretch receptors and initiating the vago vagal reflex amplifying the secretion during the gastric phase.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      35.6
      Seconds
  • Question 5 - Where does most fat digestion begin? ...

    Incorrect

    • Where does most fat digestion begin?

      Your Answer: Stomach

      Correct Answer: Duodenum

      Explanation:

      Digestion of some fats can begin in the mouth where lingual lipase breaks down some short chain lipids into diglycerides. However fats are mainly digested in the small intestine (in the duodenum). The presence of fat in the small intestine produces hormones that stimulate the release of pancreatic lipase from the pancreas and bile from the liver which helps in the emulsification of fats for absorption of fatty acids.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      8.8
      Seconds
  • Question 6 - The central veins in the liver: ...

    Incorrect

    • The central veins in the liver:

      Your Answer: Drain into the hepatic duct

      Correct Answer: Coalesce to form the hepatic vein

      Explanation:

      The central veins coalesce to form the hepatic vein which in turn drains into the inferior vena cava. The portal vein mainly carries blood from different parts of the GIT and is not drained to the inferior vena cava.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      18.2
      Seconds
  • Question 7 - The end product of trehalase action on oligosaccharides is ...

    Incorrect

    • The end product of trehalase action on oligosaccharides is

      Your Answer: Maltotriose and maltose

      Correct Answer: Two glucose molecules

      Explanation:

      Disaccharides are glycoside hydrolases, enzymes that break down certain types of sugars called disaccharides into simpler sugars called monosaccharides.Examples of disaccharides:Lactase (breaks down lactose into glucose and galactose)Maltase (breaks down maltose into 2 glucoses)Sucrase (breaks down sucrose into glucose and fructose)Trehalase (breaks down trehalose into 2 glucoses)

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      32.9
      Seconds
  • Question 8 - Which enzyme facilitates the function of pancreatic lipase by increasing exposure of its...

    Incorrect

    • Which enzyme facilitates the function of pancreatic lipase by increasing exposure of its active site?

      Your Answer: Pancreatic amylase

      Correct Answer: Colipase

      Explanation:

      Colipase is a co enzyme that optimize the activity of lipase by facilitating the exposure of its active sites.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      27
      Seconds
  • Question 9 - Which of the following happens when anterograde neurons are stimulated? ...

    Correct

    • Which of the following happens when anterograde neurons are stimulated?

      Your Answer: Smooth muscle relaxation ahead of the stimulus

      Explanation:

      Nitric oxide is thought to act as an anterograde neurotransmitter. Nitric oxide causes relaxation of smooth muscles ahead of the stimulus. Clinically used as a potent vasodilator.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      15.6
      Seconds
  • Question 10 - One function of the liver is synthesis and storage of protein. Which of...

    Correct

    • One function of the liver is synthesis and storage of protein. Which of the following will result in hypoalbuminemia?

      Your Answer: All of the above

      Explanation:

      Both trauma and sepsis cause an acute inflammatory response causing plasma leakage of albumin. Nephropathy causes leakage of albumin from glomeruli and excretion of albumin in urine known as albuminuria. A hypercatabolic state is characterized by increased circulating catabolic hormones and increase break down of proteins.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      18.2
      Seconds
  • Question 11 - The pyloric sphincter is largely made up of thickening of ...

    Correct

    • The pyloric sphincter is largely made up of thickening of

      Your Answer: The circular muscle layer

      Explanation:

      The pyloric sphincter, or valve, is a strong ring of smooth muscle (circular muscle layer) at the end of the pyloric canal which lets food pass from the stomach to the duodenum. It controls the outflow of gastric contents into the duodenum. It receives sympathetic innervation from the celiac ganglion.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      19.1
      Seconds
  • Question 12 - G cells release which of the following substances ...

    Correct

    • G cells release which of the following substances

      Your Answer: Gastrin

      Explanation:

      The G cell is a type of cell in the stomach and duodenum that secretes gastrin. It works in conjunction with gastric chief cells and parietal cells. G cells are found deep within the pyloric glands of the stomach antrum, and occasionally in the pancreas and duodenum. Gastrin-releasing peptide, as well as the presence of amino acids in the stomach, stimulates the release of gastrin from the G cells. Gastrin stimulates enterochromaffin-like cells to secrete histamine. Gastrin also targets parietal cells by increasing the amount of histamine and the direct stimulation by gastrin, causing the parietal cells to increase HCl secretion in the stomach.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      3.9
      Seconds
  • Question 13 - The oesophagus is lined by ...

    Incorrect

    • The oesophagus is lined by

      Your Answer: Simple columnar epithelium

      Correct Answer: Stratified squamous epithelium

      Explanation:

      The wall of the oesophagus from the lumen outwards consists of mucosa, submucosa (connective tissue), layers of muscle fibers between layers of fibrous tissue, and an outer layer of connective tissue. The mucosa is a stratified squamous epithelium of around three layers of squamous cells, which contrasts to the single layer of columnar cells of the stomach. The transition between these two types of epithelium is visible as a zig-zag line. Most of the muscle is smooth muscle although striated muscle predominates in its upper two thirds.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      12.8
      Seconds
  • Question 14 - Which two ducts form the ampulla of Vater? ...

    Incorrect

    • Which two ducts form the ampulla of Vater?

      Your Answer: Pancreatic duct of Vater and the pancreatic duct of Wirsung

      Correct Answer: The common bile duct and the pancreatic duct of Wirsung

      Explanation:

      The ampulla of Vater, also known as the hepatopancreatic ampulla or the hepatopancreatic duct, is formed by the union of the pancreatic duct and the common bile duct. The ampulla is specifically located at the major duodenal papilla.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      21.1
      Seconds
  • Question 15 - After eating a meal containing a moderate amount of fat, which percentage of...

    Incorrect

    • After eating a meal containing a moderate amount of fat, which percentage of fat is likely to be absorbed from the GIT in an adult?

      Your Answer: 25%

      Correct Answer: 95%

      Explanation:

      About 95% of dietary fat is absorbed.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      14.1
      Seconds
  • Question 16 - Where does protein digestion begin? ...

    Correct

    • Where does protein digestion begin?

      Your Answer: Stomach

      Explanation:

      Digestion typically begins in the stomach when pepsinogen is converted to pepsin by the action of hydrochloric acid, and continued by trypsin and chymotrypsin in the small intestine.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      9.3
      Seconds
  • Question 17 - Regarding carbohydrates absorption; ...

    Incorrect

    • Regarding carbohydrates absorption;

      Your Answer: Intestinal glucose absorption requires phosphorylation

      Correct Answer: Intestinal absorption of sugars is inhibited by the drug phlorizin

      Explanation:

      The main role of insulin is in the uptake of glucose from blood to tissues where it is metabolised. Glycose transporters in the intestines do not depend on the action of insulin. Phlorizin is a competitive inhibitor of SGLT1 and SGLT2 because it competes with glucose for the binding site, reducing intestinal and renal glucose transport.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      1003.3
      Seconds
  • Question 18 - Portal vein receives its blood from all the following except: ...

    Incorrect

    • Portal vein receives its blood from all the following except:

      Your Answer: Stomach

      Correct Answer: Kidney

      Explanation:

      The portal vein receives blood from the intestines via the superior and inferior mesenteric veins, from stomach via the gastric veins and from the spleen and pancreas via splenic vein. The kidney is supplied by the renal artery and drains into the renal vein into the inferior venacava.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      27.6
      Seconds
  • Question 19 - Which area in the GIT lacks Basic Electrical Rhythm ...

    Correct

    • Which area in the GIT lacks Basic Electrical Rhythm

      Your Answer: Oesophagus

      Explanation:

      The basal or basic electrical rhythm acts to coordinate peristalsis and are initiated in the interstitial cells of Cajal, specialized pacemaker cells located in the wall of the stomach. Thus below the oesophagus.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      16.2
      Seconds
  • Question 20 - Sympathetic supply to the stomach is derived from ...

    Incorrect

    • Sympathetic supply to the stomach is derived from

      Your Answer: T5-T9 spinal segments via the superior mesenteric ganglion

      Correct Answer: T5-T9 spinal segments via the coeliac ganglion

      Explanation:

      Parasympathetic innervation to the stomach is from the vagus nerve and the sympathetic innervation is from the T5-T9 spinal segments via the coeliac ganglion through the greater splanchnic nerve.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      24.9
      Seconds
  • Question 21 - Which of the following initiates migrating motor complex ...

    Incorrect

    • Which of the following initiates migrating motor complex

      Your Answer: Acetylcholine

      Correct Answer: Motilin

      Explanation:

      Migrating motor complexes (MMC) are thought to be partially regulated by motilin, which is initiated in the stomach as a response to vagal stimulation, and does not directly depend on extrinsic nerves.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      27.7
      Seconds
  • Question 22 - Which of the following forms an important constituent of the brush border on...

    Correct

    • Which of the following forms an important constituent of the brush border on the microvilli of the intestinal epithelium?

      Your Answer: Hydrolases

      Explanation:

      There are certain enzymes which are part of the brush border cells including hydrolases also known as the brush border hydrolases. They perform the final step in digestion of certain nutrients.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      23.7
      Seconds
  • Question 23 - The parietal cells of the stomach secrete which of the following? ...

    Correct

    • The parietal cells of the stomach secrete which of the following?

      Your Answer: Hydrochloric acid

      Explanation:

      Parietal cells are the epithelial cells that secrete hydrochloric acid (HCl) and intrinsic factor. These cells are located in the gastric glands found in the lining of the fundus and in the body of the stomach.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      7.6
      Seconds
  • Question 24 - Role of bile salts in digestion of fats include ...

    Incorrect

    • Role of bile salts in digestion of fats include

      Your Answer: Increasing lipase concentration

      Correct Answer: Reduce surface tension, emulsification and transportation

      Explanation:

      Bile acts to some extent as a surfactant reducing surface tension, helping to emulsify the lipids in food. Bile salt anions are hydrophilic on one side and hydrophobic on the other side; consequently, they tend to aggregate around droplets of lipids (triglycerides and phospholipids) to form micelles, with the hydrophobic sides towards the fat and hydrophilic sides facing outwards. The hydrophilic sides are negatively charged, and this charge prevents fat droplets coated with bile from re-aggregating into larger fat particles.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      20.5
      Seconds
  • Question 25 - In addition to its role in digestion and absorption of fats, bile: ...

    Incorrect

    • In addition to its role in digestion and absorption of fats, bile:

      Your Answer: Takes part in bilirubin metabolism

      Correct Answer: Is the major excretory route for lipid-soluble waste products

      Explanation:

      The end product of haem metabolism is bilirubin and jaundice is caused by increased bilirubin levels in the blood. Gallstones are mainly caused by cholesterol and bile pigments. Bile is the main route of excretion for lipid soluble waste products whereas urine is the main route of excretion of water soluble waste products.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      27.5
      Seconds
  • Question 26 - The principal enzyme of lipid digestion is: ...

    Correct

    • The principal enzyme of lipid digestion is:

      Your Answer: Lipase

      Explanation:

      Lipase is the principle enzyme that digest lipids. Amylase digest carbohydrates. Colipase is a co-enzyme that optimize the activity of lipase. Trypsin digest proteins and cholesterol esterase digest cholesterol.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      14.4
      Seconds
  • Question 27 - Cholesterol is synthesized in all of these organs EXCEPT? ...

    Incorrect

    • Cholesterol is synthesized in all of these organs EXCEPT?

      Your Answer: Skin

      Correct Answer: Stomach

      Explanation:

      The liver primarily synthesizes about 20-25% of the total daily cholesterol. Cholesterol is also synthesized to smaller extents in the adrenal glands, reproductive organs (as cholesterol is the precursor of sex hormones), skin and is also produced in the intestines.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      7.6
      Seconds
  • Question 28 - Select the correct statement regarding cholecystokinin: ...

    Correct

    • Select the correct statement regarding cholecystokinin:

      Your Answer: It causes gallbladder contraction and pancreatic enzyme secretion.

      Explanation:

      CCK has a primary action of increasing the motility of the gallbladder by contracting the muscles in the mucosa of the gall bladder. Apart from this, it augments the action of secretin, resulting in the production of an alkaline pancreatic juice. It increases the synthesis of enterokinase, inhibits gastric emptying and may also enhance the motility of the small intestine and colon.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      20.1
      Seconds
  • Question 29 - In the gastric mucosa, which of the following cells is known to secrete...

    Correct

    • In the gastric mucosa, which of the following cells is known to secrete gastric lipase?

      Your Answer: Chief cell

      Explanation:

      Chief cells produce pepsinogen and gastric lipase. Parietal cells produce stomach acid and intrinsic factor.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      20.2
      Seconds
  • Question 30 - The rate limiting pump in the HCL secretion is the? ...

    Incorrect

    • The rate limiting pump in the HCL secretion is the?

      Your Answer: Chloride/bicarbonate exchanger

      Correct Answer: Hydrogen potassium ATPase

      Explanation:

      The rate limiting pump in HCl secretion is the H+/K+ ATPase pump.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      34.5
      Seconds
  • Question 31 - What is the result of maltase deficiency in the brush border of the...

    Incorrect

    • What is the result of maltase deficiency in the brush border of the small intestine?

      Your Answer: Results in lack of absorption of lactose

      Correct Answer: Results in increased passage of maltose in stool

      Explanation:

      Maltase is an enzyme produced from the surface cells of the villi, lining the small intestine and aids in hydrolysing the disaccharide maltose, which splits into two molecules of α-glucose. It is done by breaking the glycosidic bond between the ‘first’ carbon of one glucose and the ‘fourth’ carbon of the other (a 1–4 bond). Hence, a deficiency of enzyme maltase will result in the increased passage of maltose in the stool.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      41.4
      Seconds
  • Question 32 - Chief cells secrete: ...

    Correct

    • Chief cells secrete:

      Your Answer: Pepsinogen and gastric lipase

      Explanation:

      A gastric chief cell (or peptic cell, or gastric zymogenic cell) is a type of cell in the stomach that releases pepsinogen and gastric lipase.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      13.6
      Seconds
  • Question 33 - The pressure in the portal circulation is normally adjusted in the: ...

    Incorrect

    • The pressure in the portal circulation is normally adjusted in the:

      Your Answer: Hepatic arterioles

      Correct Answer: Sinusoids

      Explanation:

      The pressure in the portal circulation depends on the pressure of the hepatic sinusoids mainly because the direction of transport of nutrients in the portal vein occurs from the portal vein to the hepatic sinusoids.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      48.2
      Seconds
  • Question 34 - The hepatic portal vein: ...

    Incorrect

    • The hepatic portal vein:

      Your Answer: Responsible for venous drainage of the liver

      Correct Answer: Carries mainly nutrients from the GIT.

      Explanation:

      The portal vein contains oxygen as any other vein in the body does. The hepatic veins are responsible for venous drainage of the liver. The main function of the portal vein is to carry absorbed nutrients in the gut for metabolism and detoxification.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      23
      Seconds
  • Question 35 - VIP, GIP and somatostatin play an inhibitory role in gastric acid secretion by...

    Incorrect

    • VIP, GIP and somatostatin play an inhibitory role in gastric acid secretion by inactivating?

      Your Answer: Chief cells

      Correct Answer: G cells

      Explanation:

      Gastrin is secreted from the G cells. VIP, GIP and somatostatin all inhibit acid production by inhibiting the G cells.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      25.4
      Seconds
  • Question 36 - Where in the gastrointestinal tract are Brunner glands? ...

    Incorrect

    • Where in the gastrointestinal tract are Brunner glands?

      Your Answer: Jejunum

      Correct Answer: Duodenum

      Explanation:

      Brunner’s glands (or duodenal glands) are compound tubular submucosal glands found in that portion of the duodenum which is above the hepatopancreatic sphincter (aka sphincter of Oddi). The main function of these glands is to produce a mucus-rich alkaline secretion (containing bicarbonate) in order to:- protect the duodenum from the acidic content of chyme (which is introduced into the duodenum from the stomach);- provide an alkaline condition for the intestinal enzymes to be active, thus enabling absorption to take place; lubricate the intestinal walls.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      20.8
      Seconds
  • Question 37 - Pepsinogens are inactive pepsin precursors which are activated by ...

    Correct

    • Pepsinogens are inactive pepsin precursors which are activated by

      Your Answer: Gastric acid

      Explanation:

      Pepsinogen is converted to pepsin by the action of hydrochloric acid i.e. gastric acid

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      20.2
      Seconds
  • Question 38 - The cells that secrete HCL are found in which part of the stomach?...

    Incorrect

    • The cells that secrete HCL are found in which part of the stomach?

      Your Answer: Duodenum

      Correct Answer: Body

      Explanation:

      The stomach can be divided in to different regions. Cardia, fundus, body, antrum and pylorus from proximal end to distal end respectively. Different cell types are distributed accordingly among the regions of the stomach. Cells that secret HCl in the gastric mucosa are known as parietal cells and are abundant in the gastric body region. They have receptors for acetylcholine stimulated via the vagus nerve, histamine receptors and gastrin receptors which stimulate gastric acid secretion. G cells that secret gastrin are abundant in the antrum.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      71.4
      Seconds
  • Question 39 - Di and tri peptides are absorbed via a different mechanism as amino acids,...

    Incorrect

    • Di and tri peptides are absorbed via a different mechanism as amino acids, this is due to the working of which transporter?

      Your Answer: GLUT 1

      Correct Answer: PEPT 1

      Explanation:

      GLUT and SGLT are glucose transporters. Peptides which are longer that four amino acids are not absorbed. There is abundant absorption of di and tri peptidases in the small intestine. They are absorbed into the epithelial cells of the small intestine via a transporter called PepT1 by co-transport with H+ ions.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      16.6
      Seconds
  • Question 40 - Colipase is secreted in an inactive form. Its activation in the intestinal lumen...

    Correct

    • Colipase is secreted in an inactive form. Its activation in the intestinal lumen is by

      Your Answer: Trypsin

      Explanation:

      The enzyme trypsin exists in pancreatic juice in the inactive form trypsinogen, it is activated by the intestinal enterokinase in intestinal juice. Trypsin can then activate other protease enzymes and catalyse the reaction pro-colipase → colipase. Colipase is necessary, along with bile salts, to enable lipase function.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      86.8
      Seconds
  • Question 41 - Which of the following prevents auto-digestion of the stomach by gastric secretions: ...

    Correct

    • Which of the following prevents auto-digestion of the stomach by gastric secretions:

      Your Answer: Trefoil peptides and mucus- bicarbonate layer.

      Explanation:

      Pepsinogen is the inactive form of pepsin, a protein digesting enzyme. Bombesin is a peptide which stimulates gastrin secreting cells in the stomach increasing production of gastric acid. Ecl or enterochromaffin cells are neuroendocrine cells that aid in the production of gastric acid via the release of histamine. Oxyntic cells are also known as parietal cells and are the main cells secreting gastric hydrochloric acid (HCl). Gastric acid and pepsin are harmful agents for the gastric mucosa and can result in autodigestion. It is therefore protected by several agents including bicarbonate which neutralizes the acidity of gastric acid while Trefoil peptides are a component of gastric mucosa that form a gel like layer in the gastric epithelium protecting it from harmful agents.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      53.5
      Seconds
  • Question 42 - What is the function of basic electrical rhythm ...

    Correct

    • What is the function of basic electrical rhythm

      Your Answer: To coordinate peristalsis and other motor activity

      Explanation:

      The basal or basic electrical rhythm (BER) or electrical control activity (ECA) determines the frequency of the contractions in the gastrointestinal (GI) tract, thus acting to coordinate peristalsis.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      16.5
      Seconds
  • Question 43 - The following are synthesized in the liver EXCEPT? ...

    Correct

    • The following are synthesized in the liver EXCEPT?

      Your Answer: Cholecystokinin

      Explanation:

      The liver is responsible for the mainstay of protein metabolism, synthesis as well as degradation. It is also responsible for a large part of amino acid synthesis. The liver plays a role in the production of clotting factors as well as red blood cell production. Some of the proteins synthesized by the liver include coagulation factors I (fibrinogen), II (prothrombin), V, VII, VIII, IX, X, XI, XIII, as well as protein C, protein S and antithrombin. The liver is a major site of production for thrombopoietin, a glycoprotein hormone that regulates the production of platelets by the bone marrow. The liver also produces albumin, the most abundant protein in blood serum and angiotensinogen. Cholecystokinin, previously called pancreozymin, is synthesized and secreted by enteroendocrine cells in the duodenum

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      12.9
      Seconds
  • Question 44 - Concerning protein digestion: ...

    Incorrect

    • Concerning protein digestion:

      Your Answer: Pepsinogen 1 is found in acid secreting regions as well as the pyloric region

      Correct Answer: Most protein digestion occurs in the duodenum

      Explanation:

      Human pepsinogens can be divided into two immunochemically distinct groups: Pepsinogen I (PG I) and Pepsinogen II (PGII). PG I is secreted mainly by chief cells in the fundic mucosa whereas PGII is secreted by the pyloric glands and the proximal duodenal mucosa. Maximal acid secretion correlates with PG I. Most protein digestion occurs in the duodenum/jejunum. Pepsin functions best in an acidic environment and specifically at a pH of 1.5 to 3.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      51.8
      Seconds
  • Question 45 - Protein digestion starts in the stomach by which enzyme? ...

    Correct

    • Protein digestion starts in the stomach by which enzyme?

      Your Answer: Pepsin

      Explanation:

      Pepsinogen is the inactive form of pepsin which is secreted by gastric chief cells and is converted to pepsin, in the presence of gastric HCL. Pepsin is a peptidase that breaks down proteins into smaller peptides.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      24.3
      Seconds
  • Question 46 - Intrinsic Factor is released by, ...

    Correct

    • Intrinsic Factor is released by,

      Your Answer: Parietal cell

      Explanation:

      Intrinsic factor (IF), also known as gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells of the stomach. It is necessary for the absorption of vitamin B12 (cobalamin) later on in the small intestine.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      16.6
      Seconds
  • Question 47 - Which glucose transporter is responsible for the uptake of dietary glucose from the...

    Incorrect

    • Which glucose transporter is responsible for the uptake of dietary glucose from the gut?

      Your Answer: GLUT3

      Correct Answer: SGLT1

      Explanation:

      SGLT 1 is responsible for the uptake of glucose via secondary active transport from the small intestine and the renal tubules.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      13.5
      Seconds
  • Question 48 - Vagotomy leads to the following: ...

    Incorrect

    • Vagotomy leads to the following:

      Your Answer: No peristalsis

      Correct Answer: Irregular and chaotic peristalsis

      Explanation:

      The Vagus nerve is primarily responsible for autonomic regulation involved in heart, lung and gastrointestinal function. The gastric branches supply the stomach. The right branch joins the celiac plexus and supplies the intestines. Vagotomy involves cutting of the vagus nerve or its branches which is a now-obsolete therapy that was performed for peptic ulcer disease. Vagotomy causes a decrease in peristalsis and a change in the emptying patterns of the stomach.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      34.1
      Seconds
  • Question 49 - Carbohydrates digestion starts in the ...

    Correct

    • Carbohydrates digestion starts in the

      Your Answer: Mouth

      Explanation:

      Digestion begins in the mouth with the secretion of saliva and its digestive enzymes. Food is formed into a bolus by the mechanical mastication and swallowed into the oesophagus from where it enters the stomach through the action of peristalsis.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      18.4
      Seconds
  • Question 50 - The lamina propria contains all of the following except: ...

    Incorrect

    • The lamina propria contains all of the following except:

      Your Answer: Eosinophils

      Correct Answer: Plasma cells

      Explanation:

      The connective tissue of the lamina propria is very loose, allowing it to be very cell rich. The cell population of the lamina propria is variable and can include, for example, fibroblasts, lymphocytes, plasma cells, macrophages, eosinophilic leukocytes, and mast cells. It provides support and nutrition to the epithelium, as well as the means to bind to the underlying tissue.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      18.6
      Seconds
  • Question 51 - The infoldings or spaces between the bases of the villi are known as...

    Correct

    • The infoldings or spaces between the bases of the villi are known as

      Your Answer: Crypts of Lieberkühn

      Explanation:

      An intestinal gland (also crypt of Lieberkühn and intestinal crypt) is a gland found in the intestinal epithelium lining of the small intestine and large intestine (colon) between the villi.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      570.1
      Seconds
  • Question 52 - Which of the following is NOT a pancreatic enzyme? ...

    Correct

    • Which of the following is NOT a pancreatic enzyme?

      Your Answer: Pepsinogen 1

      Explanation:

      Pancreatic juice, composed of the secretions of both ductal and acinar cells, is made up of the following digestive enzymes:Trypsinogen, which is an inactive(zymogenic) protease that, once activated in the duodenum into trypsin, breaks down proteins at the basic amino acids. Trypsinogen is activated via the duodenal enzyme enterokinase into its active form trypsin.Colipase is a protein co-enzyme required for optimal enzyme activity of pancreatic lipase. It is secreted by the pancreas in an inactive form, procolipase, which is activated in the intestinal lumen by trypsin.Chymotrypsinogen, which is an inactive (zymogenic) protease that, once activated by duodenal enterokinase, breaks down proteins at their aromatic amino acids. Chymotrypsinogen can also be activated by trypsin.Carboxypeptidase, which is a protease that takes off the terminal amino acid group from a proteinSeveral elastases that degrade the protein elastin and some other proteins.Pancreatic lipase that degrades triglycerides into fatty acids and glycerol.Sterol esterasePhospholipaseSeveral nucleases that degrade nucleic acids, like DNase and RNase.Pancreatic amylase that breaks down starch and glycogen which are alpha-linked glucose polymers.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      9.7
      Seconds
  • Question 53 - Acetylcholine from enteric nerve endings stimulates this pair: ...

    Correct

    • Acetylcholine from enteric nerve endings stimulates this pair:

      Your Answer: Parietal cells and chief cells

      Explanation:

      In the body of the stomach, the vagal postganglionic muscarinic nerves release acetylcholine(ACh) which stimulates parietal cell H+ secretion. Gastric chief cells are primarily activated by ACh. However the decrease in pH caused by activation of parietal cells further activates gastric chief cells.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      29.9
      Seconds
  • Question 54 - Which of the following is responsible for transporting both glucose and fructose into...

    Incorrect

    • Which of the following is responsible for transporting both glucose and fructose into the interstitium?

      Your Answer: SGLT 2

      Correct Answer: GLUT 2

      Explanation:

      Absorption of glucose involves transport from the intestinal lumen, across the epithelium and into blood. The transporter that carries glucose and galactose into the enterocyte is the sodium-dependent hexose transporter, known as SGLT1. As the name indicates, this molecule transports both glucose and sodium ions into the cell. Once absorbed into the enterocyte, glucose must be exported from the cell into blood. Sodium is rapidly shuttled out in exchange for potassium by Na+/K+ ATPase pumps on the basolateral membrane, and that process maintains the electrochemical gradient across the epithelium. Glucose, galactose and fructose are transported out of the enterocyte into the interstitium and in turn into the blood through another hexose transporter (called GLUT-2) in the basolateral membrane. These monosaccharides then diffuse down a concentration gradient into capillary blood.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      14.3
      Seconds
  • Question 55 - Which of the following is a product of D cells ...

    Correct

    • Which of the following is a product of D cells

      Your Answer: Somatostatin

      Explanation:

      Somatostatin is secreted by D cells, HCL and intrinsic factor secreted by parietal cells. Trefoil peptides are secreted by mucus secreting goblet cells and gastrin releasing peptide (grp) by post-ganglionic fibers of the vagus nerve (which innervate the G cells of the stomach).

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      16
      Seconds
  • Question 56 - Which of the following acts on the pancreas to secrete pancreatic juice that...

    Correct

    • Which of the following acts on the pancreas to secrete pancreatic juice that is rich in enzymes?

      Your Answer: CCK

      Explanation:

      CCK has a primary action of increasing the motility of the gallbladder by contracting the muscles in the mucosa of the gall bladder. Apart from this, it augments the action of secretin resulting in the production of an alkaline pancreatic juice. It increases the synthesis of enterokinase, inhibits gastric emptying and may also enhance the motility of the small intestine and colon.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      9.6
      Seconds
  • Question 57 - Cholinergic neurons that pass into a retrograde direction activate neurons that release: ...

    Incorrect

    • Cholinergic neurons that pass into a retrograde direction activate neurons that release:

      Your Answer: Vasoactive intestinal polypeptide (VIP)

      Correct Answer: Substance P and acetyl choline

      Explanation:

      Serotonin activates sensory neurons that activate the myenteric plexus. Cholinergic neurons passing in a retrograde direction in the myenteric plexus activate neurons that release substance P and acetylcholine, causing smooth muscle contraction.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      31.6
      Seconds
  • Question 58 - The oligosaccharidases responsible for further digestion of starch after breakdown by the above...

    Correct

    • The oligosaccharidases responsible for further digestion of starch after breakdown by the above mentioned enzymes is located where?

      Your Answer: Brush border of small intestine

      Explanation:

      The final step in digestion of carbohydrates, which is conversion of disaccharides to absorbable monosaccharides occurs on the small intestinal epithelial cells. The enzymes responsible for this final stage of digestion are not freely found in the intestinal lumen, but they are found as integral membrane proteins in the plasma membrane of the epithelial cell. The apical plasma membrane of the intestinal epithelial cell has numerous microvilli known as the brush border. Thus, the enzymes embedded in those microvilli are referred to as brush border enzymes.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      55.2
      Seconds
  • Question 59 - H+ ions used in the production of acid by parietal cells is produced...

    Incorrect

    • H+ ions used in the production of acid by parietal cells is produced with the help of which enzyme?

      Your Answer: Histamine

      Correct Answer: Carbonic anhydrase ii

      Explanation:

      Carbonic anhydrase enzyme catalyses the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa). This is a reversible reaction that takes place in the gastric parietal cells.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      55.5
      Seconds
  • Question 60 - Glucose absorption in the small intestine is coupled with which of the following...

    Incorrect

    • Glucose absorption in the small intestine is coupled with which of the following electrolytes?

      Your Answer: Cl

      Correct Answer: Na

      Explanation:

      Sodium-glucose linked transporter are family of proteins of different types. SGLT1 transporter is found in the intestinal mucosa of the small intestine and absorbs glucose via cotransport of Na+ ions.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      33.3
      Seconds
  • Question 61 - The chief cells of the stomach secrete which of the following? ...

    Incorrect

    • The chief cells of the stomach secrete which of the following?

      Your Answer: Hydrochloric acid

      Correct Answer: Pepsinogens

      Explanation:

      A gastric chief cell (or peptic cell, or gastric zymogenic cell) is a type of cell in the stomach that releases pepsinogen and gastric lipase.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      8.3
      Seconds
  • Question 62 - The cells that secrete pepsinogen and gastric lipase are found in which part...

    Incorrect

    • The cells that secrete pepsinogen and gastric lipase are found in which part of the stomach?

      Your Answer: Antrum

      Correct Answer: Body and antrum

      Explanation:

      Stomach can be divided in to different regions. Cardia, fundus, body, antrum and pylorus from proximal end to distal end respectively. Cells that secret the inactive form of pepsin or pepsinogen are chief cells and are abundant in the body and the antral region of the stomach.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      29.2
      Seconds
  • Question 63 - Which pair is correct concerning enteroendocrine cells in the GIT mucosa and their...

    Correct

    • Which pair is correct concerning enteroendocrine cells in the GIT mucosa and their products?

      Your Answer: D cells and somatostatin

      Explanation:

      Somatostatin, an inhibitory hormone is secreted form the D cells of the Pancreatic Islets.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      48.2
      Seconds
  • Question 64 - The parasympathetic innervation of the parotid salivary gland arrives from the salivary nuclei:...

    Correct

    • The parasympathetic innervation of the parotid salivary gland arrives from the salivary nuclei:

      Your Answer: CN IX

      Explanation:

      Parasympathetic presynaptic nerve fibers from the glossopharyngeal nerve (CN IX) synapse in the otic ganglion and the postsynaptic parasympathetic nerve fibers pass to the parotid gland via the auriculotemporal nerve.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      18.2
      Seconds
  • Question 65 - What is the function of migrating motor complex ...

    Incorrect

    • What is the function of migrating motor complex

      Your Answer: Stimulate peristalsis following ingestion of food

      Correct Answer: Clears the gut of luminal contents in preparation of the next meal

      Explanation:

      Migrating motor complexes (MMC) are waves of electrical activity that sweep through the intestines in a regular cycle during fasting. These motor complexes trigger peristaltic waves, which facilitate transportation of indigestible substances such as bone, fiber, and foreign bodies from the stomach, through the small intestine, past the ileocecal sphincter, and into the colon. The MMC occurs every 90–120 minutes during the interdigestive phase (between meals), and is responsible for the rumbling experienced when hungry. It also serves to transport bacteria from the small intestine to the large intestine, and to inhibit the migration of colonic bacteria into the terminal ileum.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      17.6
      Seconds
  • Question 66 - With regard to carbohydrate absorption, which sodium-dependent glucose transporter (SGLT) is responsible for...

    Correct

    • With regard to carbohydrate absorption, which sodium-dependent glucose transporter (SGLT) is responsible for the uptake of dietary glucose from the gut?

      Your Answer: SGLT 1

      Explanation:

      SGLT- Sodium-dependent glucose cotransporter or sodium-glucose linked transporter are family of proteins of different types. SGLT1 transporter is found in the intestinal mucosa of the small intestine.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      10.6
      Seconds
  • Question 67 - Two types of gallstones are: ...

    Incorrect

    • Two types of gallstones are:

      Your Answer: Bilirubinate and carbonate

      Correct Answer: Calcium and cholesterol

      Explanation:

      Cholesterol stones are the most common gallstones followed by calcium carbonate and bilirubinate.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      21.2
      Seconds
  • Question 68 - Which of the following statements correctly describes a function of the parasympathetic innervation...

    Incorrect

    • Which of the following statements correctly describes a function of the parasympathetic innervation of the GI tract.

      Your Answer: Glucose, ph, osmolality, movement of material, stretch and level of contractile strength are monitored by efferent parasympathetic fibers.

      Correct Answer: Parasympathetic cholinergic activity increases the activity of intestinal smooth muscle

      Explanation:

      The parasympathetic nerves stimulate peristalsis and relax the sphincters; they also stimulate secretion. Acetylcholine is the neurotransmitter of the parasympathetic system.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      41.8
      Seconds
  • Question 69 - The blood supply to the liver is by ...

    Correct

    • The blood supply to the liver is by

      Your Answer: Hepatic artery and hepatic portal vein

      Explanation:

      The liver receives a dual blood supply from the hepatic portal vein and hepatic arteries. The hepatic portal vein delivers approximately 75% of the liver’s blood supply, and carries venous blood drained from the spleen, gastrointestinal tract, and its associated organs. The hepatic arteries supply arterial blood to the liver, accounting for the remaining quarter of its blood flow.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      21.9
      Seconds
  • Question 70 - At rest, proton pumps are sequestered within the parietal cell in a series...

    Incorrect

    • At rest, proton pumps are sequestered within the parietal cell in a series of membrane compartments known as:

      Your Answer: Golgi apparatus

      Correct Answer: Tubulovesicles

      Explanation:

      The gastric H, K-ATPase pump, which pumps gastric acid (HCl), in the resting state is found in cytoplasmic tubular membranes. In the stimulated state this pump moves from the tubulovesicles to the apical membrane.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      22.6
      Seconds
  • Question 71 - HCL is secreted by which cells in the stomach ...

    Correct

    • HCL is secreted by which cells in the stomach

      Your Answer: Parietal cells

      Explanation:

      Parietal cells are the epithelial cells that secrete hydrochloric acid (HCl) and intrinsic factor. These cells are located in the gastric glands found in the lining of the fundus and in the body of the stomach.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      5.5
      Seconds
  • Question 72 - Cells responsible for completely renewing the epithelium of the intestine are located: ...

    Incorrect

    • Cells responsible for completely renewing the epithelium of the intestine are located:

      Your Answer: At the base of the microvilli

      Correct Answer: At the base of the crypts

      Explanation:

      Epithelial cells are renewed every 4-5 days through a process of renewal and migration. Renewal relies on proliferative cells or stem cells that reside at the crypt base of the intestinal glands. Crypts are epithelial invasions into the underlying connective tissue.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      16.7
      Seconds
  • Question 73 - Emulsification of dietary lipids is brought about by ...

    Correct

    • Emulsification of dietary lipids is brought about by

      Your Answer: Bile salts

      Explanation:

      Digestion of fats can begin in the mouth where lingual lipase breaks down some short chain lipids into diglycerides. However fats are mainly digested in the small intestine. The presence of fat in the small intestine produces hormones that stimulate the release of pancreatic lipase from the pancreas and bile from the liver which helps in the emulsification of fats for absorption of fatty acids.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      8.9
      Seconds
  • Question 74 - The intestine is lined by: ...

    Incorrect

    • The intestine is lined by:

      Your Answer: Simple squamous epithelium

      Correct Answer: Simple columnar epithelium

      Explanation:

      In the small intestine, epithelium is simple columnar and specialised for absorption. The epithelium is arranged into villi, creating a brush border and increasing the area for absorption. The epithelium is simple columnar with microvilli.In the colon, epithelium is simple columnar and without villi. Goblet cells, which secrete mucous, are also present.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      12.4
      Seconds
  • Question 75 - Regarding the anatomy of the intestine, the muscularis propria contains all of which...

    Incorrect

    • Regarding the anatomy of the intestine, the muscularis propria contains all of which of the following constituents?

      Your Answer: Submucosa, muscularis mucosa, mesothelium

      Correct Answer: Circular muscle, myenteric plexus, longitudinal muscle

      Explanation:

      The muscularis mucosa/propria consists of the inner circular muscles and the outer longitudinal muscles. Between these muscles is the myenteric plexus.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      45.7
      Seconds
  • Question 76 - Where in the course of the gastrointestinal tract does the first significant digestion...

    Incorrect

    • Where in the course of the gastrointestinal tract does the first significant digestion of fat begin in a normal human being?

      Your Answer: Stomach

      Correct Answer: Duodenum

      Explanation:

      The enzyme lipase which is responsible for digestion of fat is secreted by the exocrine pancreas in the 2nd part of the duodenum at the point where the pancreatic duct opens. It opens together with the common bile duct which contains bile that emulsify fat aiding in digestion. The oesophagus, stomach and mouth do not contain enzymes related to fat digestion.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      48.5
      Seconds
  • Question 77 - Which enzyme is responsible for the formation of the active endopeptidases from their...

    Correct

    • Which enzyme is responsible for the formation of the active endopeptidases from their inactive precursors?

      Your Answer: Enterokinase

      Explanation:

      Enterokinase is a brush border enzyme of the duodenum that activates proteolytic enzymes for further digestion of proteins. Trypsinogen is converted to trypsin by the action of enterokinase. Trypsin and chymotrypsin are secreted by the pancreatic acinar cells and are enzymes that aid in protein digestion. Pepsin is secreted by chief cells of gastric mucosa. Procarboxydase is the inactive form of carboxypeptidase which is converted to its active form by trypsin and is secreted by pancreatic acinar cells.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      26.8
      Seconds
  • Question 78 - Bile contains: ...

    Incorrect

    • Bile contains:

      Your Answer: Steroids, pigments, salts

      Correct Answer: Bile acids, phosphatidylcholine, cholesterol

      Explanation:

      The main components of bile include bile acids or bile salts, phospholipids; mainly phosphatidylcholine, cholesterol, bilirubin, inorganic salts; potassium, sodium and bicarbonate.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      19.6
      Seconds
  • Question 79 - All of the following constitute small intestinal brush border enzymes except: ...

    Incorrect

    • All of the following constitute small intestinal brush border enzymes except:

      Your Answer: Maltase

      Correct Answer: Alpha-amylase

      Explanation:

      The final step in digestion of carbohydrates, which is conversion of disaccharides to absorbable monosaccharides occurs on the small intestinal epithelial cells. The enzymes responsible for this final stage of digestion are not freely found in the intestinal lumen, but they are found as integral membrane proteins in the plasma membrane of the epithelial cell. The apical plasma membrane of the intestinal epithelial cell has numerous microvilli which extend from the cell known as the brush border. Thus, the enzymes embedded in those microvilli are referred to as brush border enzymes. All these enzymes except alfa amylase are brush border enzymes. Alfa amylase is secreted by pancreatic acinar cells.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      65.7
      Seconds
  • Question 80 - The ATPase of parietal cells moves: ...

    Incorrect

    • The ATPase of parietal cells moves:

      Your Answer: H+ from the gastric lumen in exchange for a K+

      Correct Answer: H+ into the gastric lumen in exchange for a k+

      Explanation:

      ATPase of the parietal cell is also known as the proton pump, which moves H+ ions into the gastric lumen in exchange for K+ ions into the cell.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      11.4
      Seconds
  • Question 81 - Which intestinal cells play a major role in secretory immunity? ...

    Incorrect

    • Which intestinal cells play a major role in secretory immunity?

      Your Answer: Mucous cells

      Correct Answer: M cells

      Explanation:

      M cells are specialized epithelial cells of the MALT or mucosa-associated lymphoid tissues. They transport antigens from the intestinal lumen to cells of the immune system, thereby initiating an immune response. T and B cells are lymphocytes found in blood. Mucous cells secrete mucous and can be considered as a part of innate immunity. Chief cells in the gastric mucosa secret pepsin.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      21.5
      Seconds
  • Question 82 - Majority of gastrinomas are found in the: ...

    Incorrect

    • Majority of gastrinomas are found in the:

      Your Answer: Stomach

      Correct Answer: Duodenum

      Explanation:

      A gastrinoma is a tumour in the pancreas or duodenum that secretes excess of gastrin leading to ulceration in the duodenum, stomach and the small intestine. It is usually found in the duodenum, although it may arise in the stomach or pancreas. Those occurring in the pancreas have a greater potential for malignancy. Most gastrinomas are found in the gastrinoma triangle; this is bound by the junction of cystic and common bile ducts, junction of the second and third parts of the duodenum, and the junction of the neck and body of the pancreas.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      12
      Seconds
  • Question 83 - The lower oesophageal sphincter is under neural control. Which of the following causes...

    Incorrect

    • The lower oesophageal sphincter is under neural control. Which of the following causes contraction of the intrinsic sphincter?

      Your Answer: Vasoactive intestinal polypeptide (VIP)

      Correct Answer: Acetylcholine

      Explanation:

      The lower oesophageal sphincter (LOS) is a specific region of the oesophageal circular smooth muscle. It allows the passage of a food bolus to the stomach and prevents the reflux of gastric contents into the oesophagus. The tone of the LOS is myogenic in origin and depends on smooth muscle properties that lead to the opening of Ca2+ channels but can also be modulated by enteric motor neurons, the parasympathetic and sympathetic extrinsic nervous system and several neurohumoral substances. Nitric oxide causes LOS relaxation. Acetylcholine and tachykinins are involved in the LOS contraction.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      23.2
      Seconds
  • Question 84 - Which of the following is not secreted by cells in the antrum of...

    Incorrect

    • Which of the following is not secreted by cells in the antrum of the stomach?

      Your Answer: Pepsinogen

      Correct Answer: Hydrochloric acid

      Explanation:

      Cells in the body of the stomach secrete mucus, HCl and pepsinogen. Cells in the antrum secrete pepsinogen, gastrin and mucus.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      11.3
      Seconds
  • Question 85 - Gastrin activates all of the following cells except: ...

    Incorrect

    • Gastrin activates all of the following cells except:

      Your Answer: Stomach smooth muscle

      Correct Answer: Mucus neck cells

      Explanation:

      The G cell is a type of cell in the stomach and duodenum that secretes gastrin. It works in conjunction with gastric chief cells and parietal cells. G cells are found deep within the pyloric glands of the stomach antrum, and occasionally in the pancreas and duodenum. Gastrin-releasing peptide, as well as the presence of amino acids in the stomach, stimulates the release of gastrin from the G cells. Gastrin stimulates enterochromaffin-like cells to secrete histamine. Gastrin also targets parietal cells by increasing the amount of histamine and the direct stimulation by gastrin, causing the parietal cells to increase HCl secretion in the stomach.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      18.8
      Seconds
  • Question 86 - Cholecystokinin causes the pancreas to ...

    Correct

    • Cholecystokinin causes the pancreas to

      Your Answer: Produce pancreatic juice rich in enzymes

      Explanation:

      Cholecystokinin (CCK) mediates digestion in the small intestine by inhibiting gastric emptying and decreasing gastric acid secretion. It stimulates the acinar cells of the pancreas to release a juice rich in pancreatic digestive enzymes, hence the old name pancreozymin. Together these enzymes catalyse the digestion of fat, protein, and carbohydrates.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      9.1
      Seconds
  • Question 87 - Which of the following substances inhibits pancreatic secretion? ...

    Incorrect

    • Which of the following substances inhibits pancreatic secretion?

      Your Answer: Cholecystokinin

      Correct Answer: Pancreatic polypeptide

      Explanation:

      Number of hormones and neurotransmitters can stimulate and inhibit pancreatic exocrine secretion. Cholecystokinin, secretin, vasoactive intestinal peptide and substance P stimulate pancreatic secretion. Pancreatic polypeptide, somatostatin inhibit pancreatic secretion.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      27.5
      Seconds
  • Question 88 - Which of the following proteins are NOT synthesized in the liver? ...

    Correct

    • Which of the following proteins are NOT synthesized in the liver?

      Your Answer: Steroid

      Explanation:

      Human steroidogenesis occurs in a number of locations:- Corticosteroids are produced in the adrenal cortex.- Oestrogen and progesterone are made primarily in the ovary and the placenta during pregnancy, and testosterone in the testes.- Testosterone is also converted to oestrogen to regulate the supply of each in females and males.- Some neurons and glia in the central nervous system (CNS) express the enzymes required for the local synthesis of pregnant neurosteroids, de novo or from peripheral sources.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      14.7
      Seconds
  • Question 89 - Which three parietal cell agonists bind at the basolateral membrane at specific receptors...

    Correct

    • Which three parietal cell agonists bind at the basolateral membrane at specific receptors respectively: M3 , H2 , CCK-B, to stimulate acid secretion?

      Your Answer: Acetylcholine, histamine , gastrin

      Explanation:

      The three agonists of parietal cell secretion are gastrin, acetylcholine and histamine. Parietal cells are responsible for the secretion of HCl and intrinsic factor.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      45.3
      Seconds
  • Question 90 - Dietary starch is mainly: ...

    Incorrect

    • Dietary starch is mainly:

      Your Answer: Fructose

      Correct Answer: Amylopectin

      Explanation:

      Dietary starch consists of two types of molecules: the linear and helical amylose and the branched amylopectin. Starch generally contains 20 to 25% amylose and 75 to 80% amylopectin by weight but depends in the plant. Glycogen, the glucose store of animals, is a more branched version of amylopectin.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      11.5
      Seconds
  • Question 91 - Somatostatin is responsible for? ...

    Correct

    • Somatostatin is responsible for?

      Your Answer: Decreased gastrin release

      Explanation:

      Somatostatin is an inhibitory hormone secreted from the D cells of the Pancreatic Islets. It causes the inhibition of gastrin (decreasing stomach acid production), CCK (decreasing gallbladder motility), gastrin inhibitory peptide and secretin. Gastrin production is also inhibited by secretin, GIP, VIP, glucagon and calcitonin.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      9.6
      Seconds
  • Question 92 - Which of the following is true with regard to the acini? ...

    Correct

    • Which of the following is true with regard to the acini?

      Your Answer: The central zone (Zone III) is the least oxygenated

      Explanation:

      The acini are divided into zone I (periportal), zone II (transition zone), and zone III (pericentral). Cells located close to the portal triad or peripheral zone which consist of an arteriole from the hepatic artery are the most oxygenated cells. Cells in the central zone (III) are least oxygenated and mainly receive blood supply from the central vein which is a branch of hepatic vein.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      18.2
      Seconds
  • Question 93 - The first enzyme carbohydrates encounter in the digestive tract is? ...

    Correct

    • The first enzyme carbohydrates encounter in the digestive tract is?

      Your Answer: Amylase

      Explanation:

      Carbohydrate digesting enzymes are known as amylase. Salivary amylase or ptyalin is the first enzyme to begin carbohydrate digestion in he oral cavity. Amylose is a component of carbohydrates and is not an enzyme. Isomaltase, maltase and sucrase are enzymes found in the small intestines that digest disaccharides like maltose and sucrose to monosaccharides.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      18.1
      Seconds
  • Question 94 - The pressure in the sinusoids is normally: ...

    Incorrect

    • The pressure in the sinusoids is normally:

      Your Answer: The same as portal venous pressure

      Correct Answer: Lower than portal venous pressure

      Explanation:

      The direction of transport of nutrients in the portal vein occurs from the portal vein to the hepatic sinusoids. Thus, he pressure of sinusoids should be lower than the pressure of he portal vein.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      19.8
      Seconds
  • Question 95 - Absorption of protein antigens i.e. bacterial and viral proteins takes place in the:...

    Incorrect

    • Absorption of protein antigens i.e. bacterial and viral proteins takes place in the:

      Your Answer: Mucosa-associated lymphoid tissue

      Correct Answer: Microfold cells (m cells) of the intestine

      Explanation:

      M cells are specialized epithelial cells. They have a high capacity of transcytosis of microorganisms and macromolecules. They rapidly uptake antigens and present them to immune cells associated with the gut. In contrast to absorptive enterocytes, M cells do not exert direct defence mechanisms to antigens and pathogens in the intestinal cavity. Crypts of Lieberkühn are located mainly in the small intestine and large intestine and the main function is to replenish epithelial cells and to secrete intestinal enzymatic juice as well as mucous. Brunner’s glands empty into intestinal glands and their main function is to secrete mucin and to form a protective mucus layer on the duodenal epithelial cells to protect it from acidic chyme coming from the stomach. Islets of Langerhans are located in the pancreas and secrets insulin mainly. Mucosa associated lymphoid tissue plays a role in inducing immune response after presentation of antigens.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      17.8
      Seconds
  • Question 96 - Almost all of the protein that appears in the stool is: ...

    Correct

    • Almost all of the protein that appears in the stool is:

      Your Answer: Comes from bacteria and cellular debris

      Explanation:

      75% of faecal weight is water. By dry weight 30% of faeces is bacteria,10-20% is fat and 2-3% proteins. Almost all proteins ingested are absorbed in the gut.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      20.1
      Seconds
  • Question 97 - Which of the following provides the sympathetic nervous supply to the stomach? ...

    Correct

    • Which of the following provides the sympathetic nervous supply to the stomach?

      Your Answer: Coeliac plexus

      Explanation:

      Parasympathetic innervation to the stomach is from the vagus nerve and the sympathetic innervation is from the coeliac plexus.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      18.9
      Seconds
  • Question 98 - Absorption of fructose is via: ...

    Correct

    • Absorption of fructose is via:

      Your Answer: Facilitated diffusion

      Explanation:

      Dietary fructose may be ingested as a monosaccharide or as a disaccharide. Sucrose is hydrolysed by sucrase to produce equal amounts of glucose and fructose and in this form, is usually completely absorbed. Fructose is mostly absorbed in the small intestine through GLUT-5 transporter mediated facilitative diffusion. This is an energy independent process.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      9.6
      Seconds
  • Question 99 - The sympathetic supply to the stomach comes from the: ...

    Correct

    • The sympathetic supply to the stomach comes from the:

      Your Answer: Celiac plexus

      Explanation:

      The vagus nerve supplies the stomach and up to proximal two-thirds of the large intestine and has parasympathetic stimulation. The sympathetic chain which begins at the level of he 1st thoracic vertebra and extends up to 3rd lumbar vertebra gives off the celiac plexus which mainly supplies the stomach. The mesenteric plexus mainly supplies the small intestine and is located below the celiac plexus in the sympathetic chain.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      20.2
      Seconds
  • Question 100 - Which hormone results in the production of pancreatic juice rich in enzymes but...

    Correct

    • Which hormone results in the production of pancreatic juice rich in enzymes but low in volume?

      Your Answer: Cholecystokinin

      Explanation:

      Cholecystokinin (CCK) mediates digestion in the small intestine by inhibiting gastric emptying and decreasing gastric acid secretion. It stimulates the acinar cells of the pancreas to release a juice rich in pancreatic digestive enzymes, hence the old name pancreozymin.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      14.9
      Seconds

SESSION STATS - PERFORMANCE PER SPECIALTY

Gastrointestinal (45/99) 45%
Physiology (45/99) 45%
Passmed