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  • Question 1 - Diabetic ketoacidosis is characterised by which of the following: ...

    Correct

    • Diabetic ketoacidosis is characterised by which of the following:

      Your Answer: Hyperglycaemia, ketonaemia and acidosis

      Explanation:

      DKA is characterised by the biochemical triad:
      1. Hyperglycaemia (> 11 mmol/L)
      2. Ketonaemia (> 3 mmol/L)
      3. Acidosis (pH < 7.3 +/- HCO3 < 15 mmol/L)

    • This question is part of the following fields:

      • Endocrine
      • Physiology
      19.7
      Seconds
  • Question 2 - Regarding the glomerular filtration barrier, which of the following statements is CORRECT: ...

    Correct

    • Regarding the glomerular filtration barrier, which of the following statements is CORRECT:

      Your Answer: The main factor determining whether a substance is filtered or not is molecular weight.

      Explanation:

      Molecular weight is the main factor in determining whether a substance is filtered or not – molecules < 7 kDa in molecular weight are filtered freely e.g. glucose, amino acids, urea, ions but larger molecules are increasingly restricted up to 70 kDa, above which filtration is insignificant. Negatively charged molecules are further restricted, as they are repelled by negative charges, particularly in the basement membrane. Albumin has a molecular weight of 69 kDa and is negatively charged, thus only very small amounts are filtered (and all of the filtered albumin is reabsorbed in the proximal tubule), whereas small molecules such as ions, glucose, amino acids and urea pass the filter without hindrance. This means that ultrafiltrate is virtually protein free, but otherwise has an identical composition of that of plasma. The epithelial lining of the Bowman's capsule consists of a single layer of cells called podocytes. The glomerular capillary endothelium is perforated by pores (fenestrations) which allow plasma components with a molecular weight of < 70 kDa to pass freely.

    • This question is part of the following fields:

      • Physiology
      • Renal
      121.3
      Seconds
  • Question 3 - Where does carbohydrate digestion begin: ...

    Correct

    • Where does carbohydrate digestion begin:

      Your Answer: Mouth

      Explanation:

      Carbohydrate digestion begins in the mouth, by alpha-amylase produced in saliva.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      6.1
      Seconds
  • Question 4 - A 22-year-old woman is brought in by ambulance from her GP surgery with...

    Incorrect

    • A 22-year-old woman is brought in by ambulance from her GP surgery with suspected meningitis. She has been given a dose of benzylpenicillin already.
      What is the mechanism of action of benzylpenicillin? Select ONE answer only.

      Your Answer: Disruption of cell membrane function

      Correct Answer: Inhibition of cell wall synthesis

      Explanation:

      Penicillins and the other ß-lactam antibiotics are bactericidal. They produce their antimicrobial action by preventing cross-linkage between the linear peptidoglycan polymer chains that make up the bacterial cell wall. They, therefore, inhibit cell wall synthesis.
      An overview of the different mechanisms of action of the various types of antimicrobial agents is shown below:
      Mechanism of action
      Examples
      Inhibition of cell wall synthesis
      Penicillins
      Cephalosporins
      Vancomycin
      Disruption of cell membrane function
      Polymyxins
      Nystatin
      Amphotericin B
      Inhibition of protein synthesis
      Macrolides
      Aminoglycosides
      Tetracyclines
      Chloramphenicol
      Inhibition of nucleic acid synthesis
      Quinolones
      Trimethoprim
      5-nitroimidazoles
      Rifampicin
      Anti-metabolic activity
      Sulfonamides
      Isoniazid

    • This question is part of the following fields:

      • Infections
      • Pharmacology
      80.6
      Seconds
  • Question 5 - A 67-year-old woman arrives at the Emergency Department with chest pain. Flecainide is...

    Correct

    • A 67-year-old woman arrives at the Emergency Department with chest pain. Flecainide is one of the medications she is taking.

      Which of the following statements about flecainide mechanism of action is correct?

      Your Answer: Blocks Na+ channels in the heart

      Explanation:

      Flecainide is an antiarrhythmic drug of class Ic that works by blocking the Nav1.5 sodium channel in the heart, prolonging the cardiac action potential and slowing cardiac impulse conduction. It has a significant impact on accessory pathway conduction, particularly retrograde conduction, and significantly reduces ventricular ectopic foci.

      Many different arrhythmias can be treated with flecainide, including:
      Pre-excitation syndromes (e.g. Wolff-Parkinson-White)
      Acute atrial arrhythmias
      Ventricular arrhythmias
      Chronic neuropathic pain

      The use of flecainide is contraindicated in the following situations:
      Abnormal left ventricular function
      Atrial conduction defects (unless pacing rescue available)
      Bundle branch block (unless pacing rescue available)
      Distal block (unless pacing rescue available)
      Haemodynamically significant valvular heart disease
      Heart failure
      History of myocardial infarction
      Long-standing atrial fibrillation where conversion to sinus rhythm not attempted
      Second-degree or greater AV block (unless pacing rescue available)
      Sinus node dysfunction (unless pacing rescue available)

      Flecainide should only be used in people who don’t have a structural heart problem. The CAST trial found a significant increase in sudden cardiac death and all-cause mortality in patients with an ejection fraction of less than 40% after a myocardial infarction, where it tended to be pro-arrhythmic.

      Anti-arrhythmic drugs have a limited and ineffective role in the treatment of atrial flutter. It’s important to keep in mind that flecainide shouldn’t be used by itself to treat atrial flutter. When used alone, there is a risk of inducing 1:1 atrioventricular conduction, which results in an increase in ventricular rate that is paradoxical. As a result, it should be used in conjunction with a beta-blocker or a calcium channel blocker with a rate-limiting effect.

    • This question is part of the following fields:

      • Cardiovascular Pharmacology
      • Pharmacology
      48.4
      Seconds
  • Question 6 - Which of the following is NOT a typical electrolyte disturbance caused by furosemide:...

    Correct

    • Which of the following is NOT a typical electrolyte disturbance caused by furosemide:

      Your Answer: Hypercalcaemia

      Explanation:

      Adverse effects of loop diuretics include:
      Mild gastrointestinal disturbances, pancreatitis and hepatic encephalopathy
      Hyperglycaemia
      Acute urinary retention
      Water and electrolyte imbalance
      Hyponatraemia, hypocalcaemia, hypokalaemia, hypomagnesaemia, hypochloraemiaHypotension, hypovolaemia, dehydration, and venous thromboembolism
      Metabolic alkalosis
      Hyperuricaemia
      Blood disorders (bone marrow suppression, thrombocytopenia, and leucopenia)
      Visual disturbance, tinnitus and deafness
      Hypersensitivity reactions

    • This question is part of the following fields:

      • Cardiovascular
      • Pharmacology
      26.4
      Seconds
  • Question 7 - Elevation of the mandible is produced primarily by which of the following muscles:...

    Correct

    • Elevation of the mandible is produced primarily by which of the following muscles:

      Your Answer: Temporalis, masseter and medial pterygoid

      Explanation:

      Elevation of the mandible is generated by the temporalis, masseter and medial pterygoid muscles.

    • This question is part of the following fields:

      • Anatomy
      • Head And Neck
      11.3
      Seconds
  • Question 8 - Urine flow rate = 2 ml/min
    Urine concentration of creatinine = 18 mg/ml
    Plasma...

    Incorrect

    • Urine flow rate = 2 ml/min
      Urine concentration of creatinine = 18 mg/ml
      Plasma concentration of creatinine = 0.25 mg/ml

      What is the estimated glomerular filtration rate (eGFR)?

      Your Answer: 40 ml/min

      Correct Answer: 144 ml/min

      Explanation:

      GFR can be estimated by:
      GFR = UCr x V / PCr
      Where:
      UCr = urine concentration of creatinine
      PCr = plasma concentration of creatinine
      V = rate of urine flow

      In this case GFR = (18 x 2) / 0.25 = 144 ml/min

      Note: Creatinine is used to estimate GFR because it is an organic base naturally produced by muscle breakdown, it is freely filtered at the glomerulus, it is not reabsorbed from the nephron, it is not produced by the kidney, it is not toxic, and it doesn’t alter GFR.

    • This question is part of the following fields:

      • Physiology
      • Renal Physiology
      81.3
      Seconds
  • Question 9 - Regarding haemoglobin, which of the following statements is CORRECT: ...

    Correct

    • Regarding haemoglobin, which of the following statements is CORRECT:

      Your Answer: In degradation of haemoglobin, the haem group is split from the haemoglobin and converted to biliverdin and ultimately to bilirubin.

      Explanation:

      Haemoglobin is composed of four polypeptide globin chains each with its own iron containing haem molecule. Haem synthesis occurs largely in the mitochondria by a series of biochemical reactions commencing with the condensation of glycine and succinyl coenzyme A under the action of the key rate-limiting enzyme delta-aminolevulinic acid (ALA) synthase. The globin chains are synthesised by ribosomes in the cytosol. Haemoglobin synthesis only occurs in immature red blood cells.
      There are three types of haemoglobin in normal adult blood: haemoglobin A, A2 and F:
      – Normal adult haemoglobin (HbA) makes up about 96 – 98 % of total adult haemoglobin, and consists of two alpha (α) and two beta (β) globin chains. 
      – Haemoglobin A2 (HbA2), a normal variant of adult haemoglobin, makes up about 1.5 – 3.5 % of total adult haemoglobin and consists of two α and two delta (δ) globin chains.
      – Foetal haemoglobin is the main Hb in the later two-thirds of foetal life and in the newborn until approximately 12 weeks of age. Foetal haemoglobin has a higher affinity for oxygen than adult haemoglobin. 
      Red cells are destroyed by macrophages in the liver and spleen after , 120 days. The haem group is split from the haemoglobin and converted to biliverdin and then bilirubin. The iron is conserved and recycled to plasma via transferrin or stored in macrophages as ferritin and haemosiderin. An increased rate of haemoglobin breakdown results in excess bilirubin and jaundice.

    • This question is part of the following fields:

      • Basic Cellular
      • Physiology
      89.2
      Seconds
  • Question 10 - A 26-year-old female cuts her hand on a knife while preparing dinner but...

    Correct

    • A 26-year-old female cuts her hand on a knife while preparing dinner but the bleeding stops within a few minutes.

      Which one of the following cells will be among the first to be present at the wound site to be involved in haemostasis?

      Your Answer: Platelets

      Explanation:

      Platelets are the first cells to be attracted to the wound site due to the release of the Von Willebrand factor from the damaged endothelium. Platelets, in turn, release cytokines such as platelet-derived growth factor, which will attract other inflammatory cells to the wound site.

    • This question is part of the following fields:

      • General Pathology
      • Pathology
      21.4
      Seconds
  • Question 11 - What is the interquartile range for these numbers: 11, 4, 6, 8, 3,...

    Incorrect

    • What is the interquartile range for these numbers: 11, 4, 6, 8, 3, 10, 8, 10, 4, 12, 31?

      Your Answer: 28

      Correct Answer: 7

      Explanation:

      We obtain 3, 4, 4, 6, 8, 8, 10, 11, 12, and 31, and sample size (n) = 11 when we order the data. [(n+1)/2] = median 6th value = (11+1)/2 = [(n+1)/4] represents the bottom (first) quartile. (3rd value = 4th value = (11 + 1)/4 3[(n+1)/4] for the top (third) quartile 3[(11 + 1)/4] = 9th value = 11th value = 11th value = 11th value = 11th value = 11th value = 11th value = 11th value = 11th The difference between the upper and lower quartiles is the interquartile range, which is equal to 11 minus 4 = 7.

    • This question is part of the following fields:

      • Evidence Based Medicine
      • Statistics
      71.8
      Seconds
  • Question 12 - A 30-year-old carpenter presented to the emergency room with a laceration of his...

    Incorrect

    • A 30-year-old carpenter presented to the emergency room with a laceration of his upper volar forearm. Upon further exploration and observation, it was revealed that the nerve that innervates the pronator teres muscle has been damaged.

      Which of the following nerves is most likely damaged in the case?

      Your Answer: The anterior interosseous nerve

      Correct Answer: The median nerve

      Explanation:

      Pronator teres syndrome (PTS) is caused by a compression of the median nerve (MN) by the pronator teres (PT) muscle in the forearm.

      The median nerve, C6 and C7, innervates the pronator teres.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      281
      Seconds
  • Question 13 - In adults, there are normally how many teeth: ...

    Correct

    • In adults, there are normally how many teeth:

      Your Answer: 32

      Explanation:

      In adults, there are 32 teeth, 16 in the upper jaw and 16 in the lower jaw. On each side in both upper and lower arches, there are two incisors, one canine, two premolars and three molar teeth.

    • This question is part of the following fields:

      • Anatomy
      • Head And Neck
      11
      Seconds
  • Question 14 - Which of the following muscles inserts into the patella? ...

    Correct

    • Which of the following muscles inserts into the patella?

      Your Answer: The quadriceps femoris complex

      Explanation:

      The quadriceps femoris muscle translates to “four-headed muscle” from Latin. It bears this name because it consists of four individual muscles; rectus femoris, vastus medialis, vastus lateralis, and vastus intermedius. Out of all four muscles, only the rectus femoris crosses both the hip and knee joints. The others cross only the knee joint. These muscles differ in their origin, but share a common quadriceps femoris tendon which inserts into the patella. The function of the quadriceps femoris muscle is to extend the leg at the knee joint and to flex the thigh at the hip joint.

    • This question is part of the following fields:

      • Anatomy
      • Lower Limb
      15.5
      Seconds
  • Question 15 - A diagnosis of acute osteomyelitis was made on a patient with a known...

    Incorrect

    • A diagnosis of acute osteomyelitis was made on a patient with a known history of sickle cell disease. He has no joint prosthesis on in-dwelling metal work and no known drug allergies.

      Which of the following is most likely the causative agent of the case presented above?

      Your Answer: Staphylococcus aureus

      Correct Answer: Salmonella spp .

      Explanation:

      Patients with sickle cell disease are prone to infection of the bone and bone marrow in areas of infarction and necrosis. Although Staphylococcus aureus is the most common cause of osteomyelitis in the general population, studies have shown that in patients with sickle cell disease, the relative incidence of Salmonella osteomyelitis is twice that of staphylococcal infection.

    • This question is part of the following fields:

      • Microbiology
      • Specific Pathogen Groups
      22.4
      Seconds
  • Question 16 - Through which of the following anatomical structures does an indirect inguinal hernia pass?...

    Incorrect

    • Through which of the following anatomical structures does an indirect inguinal hernia pass?

      Your Answer: Internal oblique

      Correct Answer: External oblique

      Explanation:

      Inguinal hernias are subdivided into direct and indirect.

      An indirect hernia occurs when abdominal contents protrude through the internal inguinal ring and into the inguinal canal. This occurs lateral to the inferior epigastric vessels. The hernia contents may extend into the scrotum.

      A direct inguinal hernia is protrusion of abdominal contents through the transversalis fascia within Hesselbach’s triangle. The borders of Hesselbach’s triangle are the inferior epigastric vessels superolaterally, the rectus sheath medially, and inguinal ligament inferiorly.

      The deep (internal) inguinal ring is located above and halfway between the pubic tubercle and the anterior superior iliac spine. This serves as the entrance to the inguinal canal. The superficial (external) inguinal ring lies immediately above and medial to the pubic tubercle. This triangular opening is a defect in the external oblique aponeurosis, and forms the exit of the inguinal canal.

    • This question is part of the following fields:

      • Abdomen And Pelvis
      • Anatomy
      66.4
      Seconds
  • Question 17 - A patient who shows symptoms of infection and is admitted under supervision of...

    Incorrect

    • A patient who shows symptoms of infection and is admitted under supervision of the medical team. The organism which caused this, is a Gram-negative bacterium, according to the culture. A penicillin therapy is suggested by the microbiologist.

      Which of the penicillins listed below is the most effective against Gram-negative bacteria?

      Your Answer: Benzylpenicillin

      Correct Answer: Amoxicillin

      Explanation:

      Amoxicillin and Ampicillin are more hydrophilic (broad-spectrum) penicillins than benzylpenicillin and phenoxymethylpenicillin. Because they may penetrate through gaps in the outer phospholipid membrane, they are effective against Gram-negative bacteria. Amoxicillin and Ampicillin are resistant to penicillinase-producing microbes.

      Community-acquired pneumonia, otitis media, sinusitis, oral infections, and urinary tract infections are among the most prevalent conditions for which they are prescribed. The normal adult oral dose of Amoxicillin is 500 mg three times/day, which can be increased to 1 g three times/day if necessary. Ampicillin is given to adults in doses of 0.5-1 g every 6 hours.

    • This question is part of the following fields:

      • Infections
      • Pharmacology
      42.2
      Seconds
  • Question 18 - About what percentage of patients with hepatitis A develop chronic infection: ...

    Correct

    • About what percentage of patients with hepatitis A develop chronic infection:

      Your Answer: None

      Explanation:

      Chronic hepatitis and carrier state does not occur in hepatitis A infection and complete immunity is attained after infection.

    • This question is part of the following fields:

      • Microbiology
      • Pathogens
      30.7
      Seconds
  • Question 19 - Which of the following pathogens is most likely to cause an infection in...

    Correct

    • Which of the following pathogens is most likely to cause an infection in a chemo patient with significant neutropenia?

      Your Answer: Candida

      Explanation:

      Chemotherapy that is too aggressive weakens your immune system, putting you at risk for a fungal and many other infection.

      Neutropenia is a condition in which a person’s neutrophil count is abnormally low. Neutrophils are an infection-fighting type of white blood cell. Neutrophils fight infection by killing bacteria and fungi (yeast) that infiltrate the body.

      Fungal organisms are significant pathogens in the setting of neutropenia.

    • This question is part of the following fields:

      • Immune Responses
      • Pathology
      26
      Seconds
  • Question 20 - Which of the following statements is INCORRECT. Fick's law tells us that the...

    Correct

    • Which of the following statements is INCORRECT. Fick's law tells us that the rate of diffusion of a gas across a membrane increases as:

      Your Answer: the partial pressure gradient decreases.

      Explanation:

      Fick’s law tells us that the rate of diffusion of a gas increases:
      the larger the surface area involved in gas exchange
      the greater the partial pressure gradient across the membrane
      the thinner the membrane
      the more soluble the gas in the membrane
      the lower the molecular weight of the gas

    • This question is part of the following fields:

      • Physiology
      • Respiratory
      111.9
      Seconds
  • Question 21 - Regarding defaecation, which of the following statements is CORRECT: ...

    Incorrect

    • Regarding defaecation, which of the following statements is CORRECT:

      Your Answer: The external sphincter is innervated by motor fibres from the genitofemoral nerve.

      Correct Answer: Colonic mass movement occurs shortly after a meal due to distension of the stomach and duodenum.

      Explanation:

      Colonic mass movement describes the intense contraction that begins halfway along the transverse colon and pushes the intestinal contents in the proximal colon towards the rectum. It occurs shortly after a meal due to distension of the stomach and duodenum as part of the gastrocolic reflex and if faeces is present in the rectum, stimulates the urge to defecate. Distention of the rectum causes firing of afferent cholinergic parasympathetic fibres. The internal sphincter is made up of circular smooth muscle innervated by the autonomic fibres, and the more distal external sphincter is composed of striated muscle innervated by motor fibres from the pudendal nerve. During defaecation, relaxation of pelvic muscles straightens the rectum.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      156.7
      Seconds
  • Question 22 - Which of the following globin chains makes up haemoglobin A2 (HbA2)? ...

    Correct

    • Which of the following globin chains makes up haemoglobin A2 (HbA2)?

      Your Answer: Two alpha chains and two delta chains

      Explanation:

      Haemoglobin is a 64.4 kd tetramer consisting of two pairs of globin polypeptide chains: one pair of alpha-like chains, and one pair of non-alpha chains. The chains are designated by Greek letters, which are used to describe the particular haemoglobin (e.g., Hb A is alpha2/beta2).

      Two copies of the alpha-globin gene (HBA2, HBA1) are located on chromosome 16 along with the embryonic zeta genes (HBZ). There is no substitute for alpha globin in the formation of any of the normal haemoglobins (Hb) following birth (e.g., Hb A, Hb A2, and Hb F). Thus, absence any alpha globin, as seen when all 4 alpha-globin genes are inactive or deleted is incompatible with extrauterine life, except when extraordinary measures are taken.

      A homotetramer of only alpha-globin chains is not thought to occur, but in the absence of alpha chains, beta and gamma homotetramers (HbH and Bart’s haemoglobin, respectively) can be found, although they lack cooperativity and function poorly in oxygen transport. The single beta-globin gene (HBB) resides on chromosome 11, within a gene cluster consisting of an embryonic beta-like gene, the epsilon gene (HBE1), the duplicated and nearly identical fetal, or gamma globin genes (HBG2, HBG1), and the poorly expressed delta-globin gene (HBD). A heme group, consisting of a single molecule of protoporphyrin IX co-ordinately bound to a single ferrous (Fe2+) ion, is linked covalently at a specific site to each globin chain. If the iron is oxidized to the ferric state (Fe3+), the protein is called methaemoglobin.

      Alpha globin chains contain 141 amino acids (residues) while the beta-like chains contain 146 amino acids. Approximately 75 percent of haemoglobin is in the form of an alpha helix. The non helical stretches permit folding of the polypeptide upon itself. Individual residues can be assigned to one of eight helices (A-H) or to adjacent non helical stretches.

      Heme iron is linked covalently to a histidine at the eighth residue of the F helix (His F8), at residue 87 of the alpha chain and residue 92 of the beta chain. Residues that have charged side groups, such as lysine, arginine, and glutamic acid, lie on the surface of the molecule in contact with the surrounding water solvent. Exposure of the hydrophilic (charged) amino acids to the aqueous milieu is an important determinant of the solubility of haemoglobin within the red blood cell and of the prevention of precipitation.

      The haemoglobin tetramer is a globular molecule (5.0 x 5.4 x 6.4 nm) with a single axis of symmetry. The polypeptide chains are folded such that the four heme groups lie in clefts on the surface of the molecule equidistant from one another.

    • This question is part of the following fields:

      • Basic Cellular
      • Physiology
      20.5
      Seconds
  • Question 23 - A 35-year-old woman has complaints of nausea, abdominal pain and dark urine. On...

    Correct

    • A 35-year-old woman has complaints of nausea, abdominal pain and dark urine. On examination, you notice she has jaundice. She tells you she recently started a new medication.

      Which drug is NOT likely to cause cholestatic jaundice out of the following?

      Your Answer: Isoniazid

      Explanation:

      Isoniazid is an antibiotic used in the treatment of tuberculosis. It can cause acute, dose-dependent, hepatitis but is not a recognised cause of cholestatic jaundice.

      The drugs that cause cholestatic jaundice are the following:
      1. Nitrofurantoin
      2. Erythromycin
      3. Cephalosporins
      4. Verapamil
      5. NSAIDs
      6. ACE inhibitors
      7. Tricyclic antidepressants
      8. Phenytoin
      9. Azathioprine
      10. Carbamazepine
      11. Oral contraceptive pills
      12. Diazepam
      13. Ketoconazole
      14. Tamoxifen

    • This question is part of the following fields:

      • Infections
      • Pharmacology
      61
      Seconds
  • Question 24 - Which of the following nerves is most likely associated with an anterior shoulder...

    Correct

    • Which of the following nerves is most likely associated with an anterior shoulder dislocation?

      Your Answer: Axillary nerve

      Explanation:

      In an anterior dislocation, the arm is an abducted and externally rotated position. In the externally rotated position, the posterosuperior aspect of the humeral head abuts and drives through the anteroinferior aspect of the glenoid rim. This can damage the humeral head, glenoid labrum, or both. An associated humeral head compression fracture is described as a Hill Sach’s lesion. If large enough, it can lead to locked dislocations that may require open reduction. The glenoid labrum is a fibrocartilaginous structure that rings the circumference of the glenoid fossa. Bankart lesions are injuries to the anteroinferior glenoid labrum complex and the most common capsulolabral injury. A bony Bankart lesion refers to an associated fracture of the glenoid rim. These capsulolabral lesions are risk factors for recurrent dislocation.

      Axillary nerve injury is identified in about 42% of acute anterior shoulder dislocations. Nerve transection is rare, and traction injuries are more common. Arterial injury has also been described. The subclavian artery becomes the axillary artery after passing the first rib. The distal portion of the axillary artery is anatomically fixed and, therefore, susceptible to injury in anterior dislocations. Ischemic injury, including pseudoaneurysm and arterial laceration, is rare but carries marked morbidity if not quickly identified.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      9.1
      Seconds
  • Question 25 - Regarding Campylobacter gastroenteritis, which of the following statements is INCORRECT: ...

    Correct

    • Regarding Campylobacter gastroenteritis, which of the following statements is INCORRECT:

      Your Answer: Infection usually requires antibiotic treatment.

      Explanation:

      Campylobacter jejuni is the primary human pathogen, typically causing dysentery (bloody diarrhoea illness) following ingestion of contaminated meat, especially poultry. Infection is typically self-limiting and does not require antibiotic therapy. Campylobacter gastroenteritis is associated with the immune-mediated complications of Guillain-Barre syndrome, reactive arthritis and Reiter’s syndrome.

    • This question is part of the following fields:

      • Microbiology
      • Pathogens
      16.2
      Seconds
  • Question 26 - Which of the following does NOT predispose to digoxin toxicity in a patient...

    Incorrect

    • Which of the following does NOT predispose to digoxin toxicity in a patient taking digoxin:

      Your Answer: Hypokalaemia

      Correct Answer: Hyponatraemia

      Explanation:

      Hypoxia, hypercalcaemia, hypokalaemia and hypomagnesaemia predispose to digoxin toxicity. Care should also be taken in the elderly who are particularly susceptible to digoxin toxicity. Hypokalaemia may be precipitated by use of diuretics. Although hyponatremia can result in the development of other pathological disturbances, it does not potentiate digoxin toxicity.

    • This question is part of the following fields:

      • Cardiovascular
      • Pharmacology
      54.3
      Seconds
  • Question 27 - The role of the juxtaglomerular (granular) cells of the juxtaglomerular apparatus is: ...

    Correct

    • The role of the juxtaglomerular (granular) cells of the juxtaglomerular apparatus is:

      Your Answer: Production of renin

      Explanation:

      Juxtaglomerular cells synthesise renin. These cells are specialised smooth muscle cells that are located in the walls of the afferent arterioles, and there are some in the efferent arterioles.

    • This question is part of the following fields:

      • Physiology
      • Renal
      37.4
      Seconds
  • Question 28 - On which of the following types of receptors does loperamide act? ...

    Incorrect

    • On which of the following types of receptors does loperamide act?

      Your Answer: Alpha receptors

      Correct Answer: Opioid receptors

      Explanation:

      Loperamide inhibits acetylcholine release from the myenteric plexus acts by action on opioid mu-receptors, and this then reduces bowel motility. The intestinal transit time is increased, thereby facilitating water reabsorption.

    • This question is part of the following fields:

      • Gastrointestinal
      • Pharmacology
      95.4
      Seconds
  • Question 29 - Which of the following bacteria is a rod-shaped, oxidase-positive, opportunistic gram-negative bacteria that...

    Correct

    • Which of the following bacteria is a rod-shaped, oxidase-positive, opportunistic gram-negative bacteria that can cause a catheter-related urinary tract infection (UTI)?

      Your Answer: Pseudomonas aeruginosa

      Explanation:

      Listeria monocytogenes is a gram-positive bacteria that does not produce spores.

      Staphylococcus aureus is a gram-positive bacteria, while Candida albicans is a gram-positive yeast with a single bud.

      Among the choices, gram-negative bacteria include only Klebsiella pneumoniae and Pseudomonas aeruginosa.

      Pseudomonas aeruginosa is an oxidase-positive bacterium, while Klebsiella pneumoniae is an oxidase-negative bacterium.

      P. aeruginosa can cause urinary tract infections (UTIs) and is spread through poor hygiene or contaminated medical equipment or devices, such as catheters that haven’t been fully sterilized.

    • This question is part of the following fields:

      • Infections
      • Microbiology
      67.3
      Seconds
  • Question 30 - The renal team is currently prescribing erythropoietin to a patient with chronic kidney...

    Incorrect

    • The renal team is currently prescribing erythropoietin to a patient with chronic kidney disease.

      Which of the following statements about erythropoietin is correct?

      Your Answer: It is only produced in the kidney

      Correct Answer: It protects red blood cell progenitors from apoptosis

      Explanation:

      Erythropoietin is a glycoprotein hormone that regulates the formation of red blood cells (red cell production). It is mostly produced by interstitial fibroblasts in the kidney, which are located near the PCT. It is also produced in the liver’s perisinusoidal cells, however this is more common during the foetal and perinatal periods.

      The kidneys produce and secrete erythropoietin in response to hypoxia. On red blood cells, erythropoietin has two main effects:
      – It encourages stem cells in the bone marrow to produce more red blood cells.
      – It protects red blood cell progenitors and precursors from apoptosis by targeting them in the bone marrow.
      As a result of the increased red cell mass, the oxygen-carrying capacity and oxygen delivery increase.

    • This question is part of the following fields:

      • Physiology
      • Renal Physiology
      30.5
      Seconds

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