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Question 1
Incorrect
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Which of the following hormones inhibits lactogenesis during pregnancy?
Your Answer: Prolactin and hPL (human Placental Lactogen)
Correct Answer: Oestrogen and Progesterone
Explanation:Under the influence of prolactin, oestrogen and progesterone and human placental lactogen (hPL), the mammary epithelium proliferates but remains presecretory during mammogenesis. Lactogenesis is inhibited by high circulating levels of progesterone and oestrogen which block cortisol binding sites. Cortisol would have otherwise have worked synergistically with prolactin in milk production. A sharp decrease in progesterone levels after delivery allows prolactin and oxytocin to stimulate milk production and the milk ejection reflex in response to suckling. Prolactin continues to maintain milk production in galactopoiesis.
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This question is part of the following fields:
- Clinical Management
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Question 2
Correct
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Which one of the following features indicates fetal asphyxia?
Your Answer: Type II (late) decelerations with tachycardia
Explanation:A type II deceleration is due to placental insufficiency which can result in fetal distress and asphyxia. The fetal heart rate is lowest at the start of the contraction and returns to normal after the contraction is complete.
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This question is part of the following fields:
- Physiology
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Question 3
Incorrect
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How many days after fertilisation does the blastocyst form?
Your Answer: 3 days
Correct Answer: 5 days
Explanation:Shortly after the Morula enters into the uterus, approximately on the 4th day after fertilization a fluid filled cystic cavity appears in the morula and transforms the morula into a blastocyst.
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This question is part of the following fields:
- Embryology
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Question 4
Incorrect
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During pregnancy, which among these is NOT counted as physiological change?
Your Answer: ESR up by 4 folds
Correct Answer: Tidal volume 500ml.
Explanation:There is a significant increase in oxygen demand during pregnancy due to a 15% increase in the metabolic rate and a 20% increased consumption of oxygen. There is a 40–50% increase in minute ventilation, mostly due to an increase in tidal volume, rather than in the respiratory rate. In a healthy, young human adult, tidal volume is approximately 500 mL per inspiration
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This question is part of the following fields:
- Obstetrics
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Question 5
Incorrect
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What percentage of haemoglobin is HbF by 6 months of age?
Your Answer: 20-25%
Correct Answer:
Explanation:HB gower 1 is the predominant embryonic haemoglobin when the foetus is 6 week old and is replaced by adult haemoglobin by the age of 5 months post natally. Only 2% of the haemoglobin is HbF.
Embryonic Haemoglobin:
Haemoglobin Gower 1 (HbE Gower-1)
Haemoglobin Gower 2 (HbE Gower-2)
Haemoglobin Portland I (HbE Portland-1)
Haemoglobin Portland II (HbE Portland-2)Fetal Haemoglobin (haemoglobin F, HbF)
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This question is part of the following fields:
- Physiology
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Question 6
Correct
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All of the following statements are true about Androgen insensitivity syndrome except:
Your Answer: The chromosomal sex is 46XX
Explanation:Patients suffering from androgen insensitivity syndrome have 46XY chromosomes. Due to insensitivity to androgens, they have female characteristics e.g. scant pubic or body hairs, enlarged mammary glands, and a small penis.
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This question is part of the following fields:
- Embryology
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Question 7
Correct
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A 26-year-old G2P0+1 comes to the emergency department with vaginal spotting. She experienced periodic stomach pain related with the bleeding, but no fetal product passing, about 6 hours before presentation. She is now in the first trimester of her pregnancy and claims that her previous pregnancy was uneventful. She takes her prenatal vitamins regularly and does not use any other prescriptions or drugs.
Her vital signs are normal, and her physical examination reveals that she has a closed cervical os. Which of the following diagnoses is the most likely?Your Answer: Threatened abortion
Explanation:Threatened abortion consists of any vaginal bleeding during early pregnancy without cervical dilatation or change in cervical consistency. Usually, no significant pain exists, although mild cramps may occur. More severe cramps may lead to an inevitable abortion.
Threatened abortion is very common in the first trimester; about 25-30% of all pregnancies have some bleeding during the pregnancy. Less than one half proceed to a complete abortion. On examination, blood or brownish discharge may be present in the vagina. The cervix is not tender, and the cervical os is closed. No fetal tissue or membranes have passed. The ultrasound shows a continuing intrauterine pregnancy. If an ultrasound was not performed previously, it is required at this time to rule out an ectopic pregnancy, which could present similarly. If the uterine cavity is empty on ultrasound, obtaining a human chorionic gonadotropin (hCG) level is necessary to determine if the discriminatory zone has been passed.
Placenta previa is an antenatal complication occurring around the third trimester of pregnancy. The cervix is closed in this condition which rules out inevitable abortion and the patient has no history of passage of tissue, this rules out complete abortion. The patient has no history of fever or offensive vaginal discharge which makes septic abortion unlikely.
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This question is part of the following fields:
- Gynaecology
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Question 8
Correct
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Maternal blood flow through the uterine artery at term is approximately
Your Answer: 750ml/min
Explanation:Uterine blood flow increases 40-fold to approximately 700 mL/min at term, with 80 per cent of the blood distributed to the intervillous spaces of the placentae, and 20 per cent to the uterine myometrium.
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This question is part of the following fields:
- Endocrinology
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Question 9
Correct
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The maternal blood volume in normal pregnancy:
Your Answer: Increases up to 40%
Explanation:Changes in the cardiovascular system in pregnancy are profound and begin early in pregnancy, such that by eight weeks’ gestation, the cardiac output has already increased by 20%. The primary event is probably peripheral vasodilatation. This is mediated by endothelium-dependent factors, including nitric oxide synthesis, upregulated by oestradiol and possibly vasodilatory prostaglandins (PGI2). Peripheral vasodilation leads to a 25–30% fall in systemic vascular resistance, and to compensate for this, cardiac output increases by around 40% during pregnancy.
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This question is part of the following fields:
- Physiology
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Question 10
Incorrect
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What is the definition of puberty in girls?
Your Answer:
Correct Answer: Becoming capable of sexual reproduction
Explanation:Puberty is the process of reproductive and sexual development and the maturation which changes a child into an adult.
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This question is part of the following fields:
- Endocrinology
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Question 11
Incorrect
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A 39-week pregnant patient presents with acute epigastric pain and general signs of malaise. She has a normal body temperature but clinical examination shows RUQ tenderness. Blood tests revealed a mild anaemia, high liver enzyme values, low platelets and haemolysis. What is the most possible diagnosis?
Your Answer:
Correct Answer: HELLP syndrome
Explanation:HELLP syndrome stands for haemolysis, elevated liver enzyme levels, and low platelet levels and is a very severe condition that can happen during pregnancy. Management of this condition requires immediate delivery of the baby.
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This question is part of the following fields:
- Obstetrics
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Question 12
Incorrect
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A 34-year-old woman presents to your clinic with a chief complaint of vague stomach pain. A unilocular cyst (3.8 x 4.3 x 3.0 cm) was discovered in the left ovary during a trans-abdominal ultrasound.
What is the best management strategy?Your Answer:
Correct Answer: Reassurance, no further action required
Explanation:In premenopausal women, watchful waiting usually involves monitoring for symptoms (pelvic pain or pressure) and repeating the pelvic ultrasound after six to eight weeks. If the ovarian cyst does not enlarge or if it resolves during the period of watchful waiting, it does not usually require surgical removal. Some premenopausal women will be advised to take a birth control pill during this time to help prevent new ovarian cysts from developing.
If a cyst decreases in size or does not change, the ultrasound is often repeated at regular intervals until your healthcare provider is certain that the cyst is not growing. If the cyst resolves, no further testing or follow-up is required.
Surgery may be recommended in the following situations:
– A cyst is causing persistent pain or pressure, or may rupture or twist.
– A cyst appears on ultrasound to be caused by endometriosis and is removed for fertility reasons.
– Large cysts (>5 to 10 cm) are more likely to require surgical removal compared to smaller cysts. However, a large size does not predict whether a cyst is cancerous.
– If the cyst appears suspicious for cancer. If you have risk factors for ovarian cancer or the cyst looks potentially cancerous on imaging studies, your healthcare provider may recommend surgery.
– If the suspicion for ovarian cancer is low but the cyst does not resolve after several ultrasounds, you may choose to have it removed after a discussion with your healthcare provider. However, surgical removal is not usually necessary in this case. -
This question is part of the following fields:
- Gynaecology
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Question 13
Incorrect
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A 38 year old women attends clinic follow up. You note pelvic ultrasound shows a 36mm simple cyst. What is the most appropriate course of action regarding this cyst according to the RCOG green top guidelines?
Your Answer:
Correct Answer: Discharge with no follow up
Explanation:As this is a simple cyst less than 50mm in diameter the patient does not require further investigation or routine follow up
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This question is part of the following fields:
- Clinical Management
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Question 14
Incorrect
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Question 15
Incorrect
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A 19-year-old girl, with menarche at age 12, presents with a 2-year duration of severe dysmenorrhea. Analgesia with paracetamol, panadeine as well as indomethacin did not provide much relief. The girl is very concerned that the underlying cause could be something sinister.
What is the most likely cause of her dysmenorrhea?
Your Answer:
Correct Answer: Endometrial prostaglandin release.
Explanation:It is less common for a girl of this age to develop fibroids, endometriosis and endometrial polyps, although these are all causes of severe dysmenorrhea. Chronic pelvic infection can be due to sexually transmitted disease but the history does not mention any previous episodes of pelvic pain or symptoms of infection such as fever. In this case, it is most likely that she has primary dysmenorrhea. Primary dysmenorrhea, in which no pathological cause can be identified, is believed to be due to the prostaglandins released by the secretory endometrium. If secondary dysmenorrhea is suspected, then endometriosis would be the most prominent cause.
While hysteroscopic and laparoscopic examinations are commonly done in adult women to rule out organic causes such as those mentioned earlier, in younger girls, they are usually only carried out if pain management with, for example, NSAIDs and the use of COCPs, have failed to either provide symptom relief or reduction.
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This question is part of the following fields:
- Gynaecology
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Question 16
Incorrect
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What is the RCOG advice regarding timing of Rhesus Anti-D Immunoglobulin following abortion?
Your Answer:
Correct Answer: Anti-D IgG within 72 hours following abortion
Explanation:All non-sensitised RhD negative women should receive Anti-D IgG within 72 hours following abortion
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This question is part of the following fields:
- Clinical Management
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Question 17
Incorrect
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The juxtaglomerular apparatus (JGA) lies within which part of the kidney?
Your Answer:
Correct Answer: Renal Cortex
Explanation:The substructures of the nephrons are mainly located within the cortex. The JGA sits next to the glomerulus in the cortex (click on the magnifying glass of the image to see the arrangement). They play an important role in blood pressure homeostasis as the juxtaglomerular cells produce renin. The descending and ascending limbs of the loop of Henle and collecting ducts have sections within both the cortex and medulla
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This question is part of the following fields:
- Anatomy
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Question 18
Incorrect
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Sensory supply to the clitoris is via branches of which nerve?
Your Answer:
Correct Answer: Pudendal nerve
Explanation:The pudenal nerves has three branches, namely the inferior rectal, perineal and the dorsal nerve of the clitoris. The perineal nerve has two branches: The superficial perineal nerve gives rise to posterior scrotal or labial (cutaneous) branches, and the deep perineal nerve supplies the muscles of the deep and superficial perineal pouches, the skin of the vestibule, and the mucosa of the inferior most part of the vagina. The inferior rectal nerve communicates with the posterior scrotal or labial and perineal nerves. The dorsal nerve of the penis or clitoris is the primary sensory nerve serving the male or female organ, especially the sensitive glans at the distal end.
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This question is part of the following fields:
- Anatomy
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Question 19
Incorrect
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What is the anterior boundary of the pelvic outlet?
Your Answer:
Correct Answer: pubic arch
Explanation:The pelvic outlet is bounded anteriorly by the inferior border of the pubic arch, posteriorly by the sacrotuberous ligament and the tip of the coccyx and laterally by the ischial tuberosities.
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This question is part of the following fields:
- Anatomy
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Question 20
Incorrect
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In a pregnant lady with polyhydramnios, the cause could be:
Your Answer:
Correct Answer: Foetus with oesophageal-atresia
Explanation:An underlying disease is only found in 17 % of cases in mild polyhydramnios. In contrast, an underlying disease is detected in 91 % of cases in moderate to severe polyhydramnios. The literature lists the following potential aetiologies: fetal malformations and genetic anomalies (8–45 %), maternal diabetes mellitus (5–26 %), multiple pregnancies (8–10 %), fetal anaemia (1–11 %), other causes, e.g. viral infections, Bartter syndrome, neuromuscular disorders, maternal hypercalcemia. Viral infections which can lead to polyhydramnios include parvovirus B19, rubella, and cytomegalovirus. Other infections, e.g. toxoplasmosis and syphilis, can also cause polyhydramnios.
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This question is part of the following fields:
- Physiology
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Question 21
Incorrect
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Which of the following drugs is most associated with coronary artery spasm?
Your Answer:
Correct Answer: Ergometrine
Explanation:Ergot alkaloids e.g. Ergometrine, produce marked and prolonged alpha receptor mediated vasoconstriction. Its overdose can cause ischemia and gangrene of the limbs and bowel. It also causes coronary artery spasm and has been used by cardiologist as a provocation test.
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This question is part of the following fields:
- Clinical Management
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Question 22
Incorrect
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Which of the following factors as shown to decrease ovarian cancer risk?
Your Answer:
Correct Answer: Taking statins
Explanation:Factors shown to decrease risk of ovarian cancer are:
– Oral contraceptive use
– Higher Parity
– Breast feeding
– Hysterectomy
– Tubal Ligation
– Statins
– SLE -
This question is part of the following fields:
- Epidemiology
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Question 23
Incorrect
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Question 24
Incorrect
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What is the prevalence of antiphospholipid syndrome in patients with recurrent miscarriage?
Your Answer:
Correct Answer: 15%
Explanation:Anti phospholipid syndrome is an autoimmune disorder in which abnormal antibodies are formed which increases the risk of blood clots to develop in vessels and leads to recurrent miscarriages to occurs. The changes of recurrent miscarriage in a previously known case of APL is 15%.
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This question is part of the following fields:
- Clinical Management
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Question 25
Incorrect
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A 29 year old obese woman presents complaining of difficult or painful sexual intercourse and dysmenorrhea. She is requesting a reversible contraceptive method. Which of the following would be most suitable?
Your Answer:
Correct Answer: Mirena
Explanation:Mirena is a form of contraception also indicated for the treatment of heavy menstrual bleeding and the management of dysmenorrhea, being able to reduce the latter considerably.
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This question is part of the following fields:
- Gynaecology
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Question 26
Incorrect
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What is the average lifespan of a basophil (white blood cell)?
Your Answer:
Correct Answer: 3-4 days
Explanation:Basophils are granulocytic white blood cells. They express IgE antibody on their surface and react to release prostaglandins and leukotrienes to mediate an inflammatory, allergic reaction.
Blood Cell Lifespans:
Red Blood Cells 120 days
Platelets 5-9 days
White blood cells 2-5 daysNeutrophils (up to 5 days)
Basophils (2 to 3 days)
Eosinophils (2 to 5 days)
Monocytes (1 to 5 days)
Lymphocytes (variable) -
This question is part of the following fields:
- Physiology
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Question 27
Incorrect
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A patient comes to your office with her last menstrual period 4 weeks ago. She thinks that she may be pregnant because she has not had her period yet, but denies any symptoms such as nausea, fatigue, urinary frequency, or breast tenderness.
As she has a history of previous ectopic pregnancy, she is very anxious to find out and wants to be sure to get early prenatal care.
Among the following actions which is most appropriate at this time?Your Answer:
Correct Answer: Order a serum quantitative pregnancy test.
Explanation:Nausea, fatigue, breast tenderness, and increased frequency of urination are the most common symptoms of pregnancy, but their presence is not considered definitive as they are nonspecific symptoms which are not consistently found in early pregnancy, also these symptoms can occur even prior to menstruation.
In pregnancy a physical examination will reveal an enlarged uterus which is more boggy and soft, but these findings are not apparent until after 6th week of gestation. In addition, other conditions like adenomyosis, fibroids, or previous pregnancies can also result in an enlarged uterus which is palpable on physical examination.
An abdominal ultrasound will not demonstrate a gestational sac until a gestational age of 5 to 6 weeks, nor will it detect an ectopic pregnancy soon after a missed menstrual period, therefore it is not indicated in this patient.
A Doppler instrument will detect fetal cardiac action usually after 10 weeks of gestation.
A sensitive serum quantitative pregnancy test can detect placental HCG levels by 8 to 9 days post-ovulation and is considered as the most appropriate next step in evaluation of this patient.
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This question is part of the following fields:
- Obstetrics
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Question 28
Incorrect
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Raised FSH levels are found in all of the following conditions, EXCEPT:
Your Answer:
Correct Answer: Women on combined oral contraceptive pills
Explanation:Oestrogen- and progesterone-containing oral contraceptives inhibit LH, which suppresses the FSH and LH levels, preventing follicular development and ovulation. Combined pills suppress FSH and LH throughout the cycle, inhibit endometrial proliferation, and produce a scanty cervical mucus.
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This question is part of the following fields:
- Endocrinology
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Question 29
Incorrect
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A 32-year-old woman at 33 weeks of gestation presents with vaginal bleeding.
A pelvic ultrasound was done, which confirms the diagnosis of placenta praevia and you are planning a cesarean section as it is the most appropriate mode of delivery.
Which among the following is considered a possible outcome of cesarean section delivery?Your Answer:
Correct Answer: Increase risk of adhesions
Explanation:Obstetric complications during or following a cesarean section delivery include:
-Increased risk of maternal mortality.
-Increased need for cesarean sections in the subsequent pregnancies.
-Increased risk for damage to adjacent visceral organs especially bowels and bladder.
-Increased risk of infections.Increased risk for formation of adhesions is a complication after cesarean section and this is the correct response for the given question.
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This question is part of the following fields:
- Obstetrics
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Question 30
Incorrect
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Adult Polycystic Kidney Disease (PKD) typically follows which pattern of inheritance
Your Answer:
Correct Answer: Autosomal Dominant
Explanation:Polycystic kidney disease (PKD) can either be autosomal dominant or recessive. The autosomal dominant variant is more common in adult PKD however, the recessive pattern is more common in infantile PKD.
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This question is part of the following fields:
- Endocrinology
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SESSION STATS - PERFORMANCE PER SPECIALTY
