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Question 1
Incorrect
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With regards to the cardiac cycle which of the following is true
Your Answer: Left ventricular ejection begins before right ventricular ejection
Correct Answer: Right atrial systole occurs before left atrial systole: as below
Explanation:Cardiac cycle: The first event in the cycle is atrial depolarization (a P wave on the surface ECG) follows by RIGHT ATRIAL and then LEFT ATRIAL contraction. Ventricular activation (QRS) follows after a short interval (the PR interval). LEFT VENTRICULAR contraction starts shortly thereafter RIGHT VENTRICULAR contraction begins. At the end, the aortic valve closure is followed by pulmonary valve closure.
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This question is part of the following fields:
- Cardiovascular
- Medicine
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Question 2
Incorrect
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The positive inotropic effect of digoxin is due to?
Your Answer: Inhibition of breakdown of cAMP
Correct Answer: Inhibition of the sodium potassium ATPase in the myocardium
Explanation:Digitalis compounds are potent inhibitors of cellular Na+/K+-ATPase. This ion transport system moves sodium ions out of the cell and brings potassium ions into the cell. By inhibiting the Na+/K+-ATPase, cardiac glycosides cause the intracellular sodium concentration to increase. This then leads to an accumulation of intracellular calcium via the Na+/Ca++ exchange system. In the heart, increased intracellular calcium causes more calcium to be released by the sarcoplasmic reticulum, thereby making more calcium available to bind to troponin-C, which increases contractility (inotropy).
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This question is part of the following fields:
- Cardiovascular
- Medicine
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Question 3
Correct
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Which is the most common site for primary cardiac tumours to occur in adults?
Your Answer: Left atrium
Explanation:Myxomas are the most common type of primary heart tumour. The tumour is derived from multipotential mesenchymal cells and may cause a ball valve-type obstruction. About 75% of myxomas occur in the left atrium of the heart, usually beginning in the wall that divides the two upper chambers of the heart.
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This question is part of the following fields:
- Cardiovascular
- Medicine
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Question 4
Correct
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Which of the following corresponds to an oblique line drawn from the sternal end of the left 3rd costal cartilage to the sternal end of the right 6th costal cartilage?
Your Answer: Atrio-ventricular (coronary) groove
Explanation:The AV groove corresponds to the right border of the heart. The right border corresponds to a line drawn from the 3rd right costal cartilage to the 6th right costal cartilage; this border is slightly convex to the right.
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This question is part of the following fields:
- Cardiovascular
- Medicine
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Question 5
Incorrect
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The function of Troponin T in cardiac muscle is?
Your Answer:
Correct Answer: Allows attachment of troponin components to tropomyosin
Explanation:Troponin T binds the troponin components to tropomyosin. Troponin I inhibits the interaction of myosin with actin, and troponin C contains the binding sites for the Ca2+ that helps initiate contraction.
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This question is part of the following fields:
- Cardiovascular
- Medicine
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Question 6
Incorrect
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Question 7
Incorrect
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Question 8
Incorrect
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Which is the commonest cardiovascular abnormality seen in an adult patient with Marfan’s syndrome?
Your Answer:
Correct Answer: Aortic aneurysm
Explanation:Marfan syndrome (MFS) is a genetic disorder of connective tissue. The degree to which people are affected varies. People with Marfan’s tend to be tall, and thin, with long arms, legs, fingers and toes. They also typically have flexible joints and scoliosis. The most serious complications involve the heart and aorta with an increased risk of mitral valve prolapse and aortic aneurysm.
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This question is part of the following fields:
- Cardiovascular
- Medicine
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Question 9
Incorrect
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Which one of the following have not been shown to improve mortality in patients with chronic heart failure?
Your Answer:
Correct Answer: Furosemide
Explanation:A number of drugs have been shown to improve mortality in patients with chronic heart failure:
- ACE inhibitors (SAVE, SOLVD, CONSENSUS)
- spironolactone (RALES)
- beta-blockers (CIBIS)
- hydralazine with nitrates (VHEFT-1)
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This question is part of the following fields:
- Cardiovascular
- Medicine
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Question 10
Incorrect
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Which of the following is NOT true of the parasympathetic control of the heart?
Your Answer:
Correct Answer: It can be blocked by beta blockers
Explanation:Parasympathetic fibers do not innervate the Beta receptors on the heart. They are innervated by the sympathetic nerve fibers. Then a beta blocker such as propranolol will block the sympathetic outflow and increase the parasympathetic tone of the heart.
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This question is part of the following fields:
- Cardiovascular
- Medicine
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