-
Question 1
Correct
-
Which Immunoglobulin (or antibody) is secreted in large amounts in breast milk?
Your Answer: IgA
Explanation:When considering immunoglobulins in neonates. There are only a few key points you are likely to be tested on. 1. IgA is resistant to stomach acid and found in large amounts in breast milk. 2. IgG is the only Ig that can cross the placenta so is key for passive neonatal immunity 3. When the neonate starts synthesising its own Ig it is IgM that is produced first.
-
This question is part of the following fields:
- Immunology
-
-
Question 2
Correct
-
Question 3
Correct
-
Fetal immunoglobulin production begins at what gestation?
Your Answer: Week 10
Explanation:Fetal production of immunoglobulin begins early on, at about 10 weeks gestation with the production of IgM antibodies. Maternal IgG, which is a key component of fetal immunity, is passed on to the foetus through the placenta from 12 weeks of gestation. Secretory IgA is not produced until after birth.
-
This question is part of the following fields:
- Immunology
-
-
Question 4
Correct
-
Macrophages are derived from what type of white blood cell?
Your Answer: Monocytes
Explanation:Macrophages are derived from monocytes. When monocytes come across a pathogen they differentiate into macrophages for phagocytosis to occur.
-
This question is part of the following fields:
- Immunology
-
-
Question 5
Correct
-
Which of the following cell types act as professional antigen presenter cells (APCs)
Your Answer: Macrophages
Explanation:Macrophages are the antigen presenting cells, they phagocytose the pathogen and after breaking them down present their protein structure to the B and T cells for a specific immune reaction to take place.
-
This question is part of the following fields:
- Immunology
-
-
Question 6
Correct
-
Which of the following will require Anti-D administration post partum?
Your Answer: Rhesus negative mother, non-sensitised, fetal cord blood Rh positive
Explanation:Rhesus positive mothers should not get anti-D. They have Rhesus antigens and the anti-D would result in maternal blood being bound and removed from her circulation. The danger is to children born to mothers who are rhesus negative. As the mother may develop antibodies against Rhesus positive fetal blood. Therefore if the baby is Rhesus negative then there is no risk of alloimmunisation (sensitisation)
-
This question is part of the following fields:
- Immunology
-
-
Question 7
Correct
-
To avoid potential haemolysis, Anti D immunoglobulin should be administered to which of the following?
Your Answer: Rhesus negative mother, non-sensitised, fetal cord blood Rh positive
Explanation:The Rhesus status of a mother is important in pregnancy and even abortion. The exposure of an Rh-negative mother exposed to Rh antigens from a positive foetus, will influence the development of anti-Rh antibodies. This may cause problems in subsequent pregnancies leading to haemolysis in the newborn. Rh Anti RhD- globulin is therefore given to non-sensitised Rh-negative mothers who give birth to Rh-positive children to prevent the formation of anti-Rh antibodies. Anti RhD globulin is not useful for already sensitized, or RhD positive mothers; its administration could result in maternal blood being bound and taken out of circulation.
-
This question is part of the following fields:
- Immunology
-
-
Question 8
Correct
-
Question 9
Correct
-
Question 10
Correct
-
Which immunoglobulin is the first to be synthesised by the neonate?
Your Answer: IgM
Explanation:Fetal production of immunoglobulin begins early on at about 10 weeks gestation with the production of IgM antibodies. Maternal IgG, which is a key component of fetal immunity is passed on to the foetus through the placenta from 12 weeks of gestation. Secretory IgA is not produced until after birth, through breast milk.
-
This question is part of the following fields:
- Immunology
-
SESSION STATS - PERFORMANCE PER SPECIALTY
