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  • Question 1 - Which of the following is an example of continuous data: ...

    Incorrect

    • Which of the following is an example of continuous data:

      Your Answer: Number of nurses working on a night shift

      Correct Answer: Height

      Explanation:

      Continuous data is data where there is no limitation on the numerical value that the variable can take e.g. weight, height.

    • This question is part of the following fields:

      • Evidence Based Medicine
      • Statistics
      34.9
      Seconds
  • Question 2 - A suspicious growth on the posterior tongue of a 40-year-old man was discovered...

    Correct

    • A suspicious growth on the posterior tongue of a 40-year-old man was discovered by his dentist and was immediately referred for possible oral cancer.

      The lymph from the posterior tongue will drain to which of the following nodes?

      Your Answer: Deep cervical nodes

      Explanation:

      Lymph from the medial anterior two thirds of the tongue travels to the deep cervical lymph nodes.
      Lymph from the lateral anterior tongue goes to the submandibular nodes.

    • This question is part of the following fields:

      • Anatomy
      • Head And Neck
      45.1
      Seconds
  • Question 3 - Your consultant decides to use ketamine for a patient requiring procedural sedation in...

    Correct

    • Your consultant decides to use ketamine for a patient requiring procedural sedation in the Emergency Department. At what receptor does ketamine primarily act:

      Your Answer: NMDA receptor

      Explanation:

      In contrast to most other anaesthetic agents, ketamine is a NMDA (N-methyl-D-aspartate) receptor antagonist. It is a non-competitive antagonist of the calcium-ion channel in the NMDA receptor. It further inhibits the NMDA-receptor by binding to its phencyclidine binding site. Ketamine also acts at other receptors as an opioid receptor agonist (analgesic effects), as an muscarinic anticholinergic receptor antagonist (antimuscarinic effects) and by blocking fast sodium channels (local anaesthetic effect).

    • This question is part of the following fields:

      • Anaesthesia
      • Pharmacology
      19.2
      Seconds
  • Question 4 - An 8-year-old boy was brought to the emergency room with complaints of a...

    Correct

    • An 8-year-old boy was brought to the emergency room with complaints of a rash and fever that have been present for the past 3 days. Upon history taking and observation, it was noted that the rash started behind the ears and then spread to the face and body. The presence of coryzal symptoms, dry cough, and conjunctivitis was also observed.

      What is most likely the diagnosis of the case presented above?

      Your Answer: Measles

      Explanation:

      The measles virus is an enveloped virus classified in the genus
      Morbillivirus.
      Measles is highly contagious and spreads by aerosol. Initial replication takes place in the mucosal cells of the respiratory tract; measles virus then replicates in the local lymph nodes and spreads systemically. The virus circulates in the T and B cells and monocytes, until eventually the lungs, gut, bile duct, bladder, skin, and lymphatic organs are involved. After an incubation period of 7 to 10 days, there is an abrupt onset, with symptoms of sneezing, runny nose and cough, red eyes, and rapidly rising fever. About 2 to 3 days later, a maculopapular rash appears on the head and trunk. Koplik spots, lesions on the oral mucosa consisting of irregular red spots, with a bluish white speck in the centre, generally appear 2 to 3 days before the rash and are diagnostic.

      Measles is easily diagnosed clinically, so few requests for laboratory identification are made. The virus is fragile and must be handled carefully. The specimens of choice are from the nasopharynx and urine, but the virus can only be recovered from these sources in the early stages of infection. The virus grows on PMK cells, causing the formation of distinctive spindle-shaped or multinucleated cells.

    • This question is part of the following fields:

      • Microbiology
      • Specific Pathogen Groups
      84.5
      Seconds
  • Question 5 - The neurotransmitter in the synaptic cleft is either eliminated or deactivated after the...

    Correct

    • The neurotransmitter in the synaptic cleft is either eliminated or deactivated after the postsynaptic cell responds to the neurotransmitter.

      Which of the following enzymes catalyses the breakdown of noradrenaline?

      Your Answer: Catechol-O-methyltransferase (COMT)

      Explanation:

      The neurotransmitter in the synaptic cleft is either eliminated or deactivated after the post-synaptic cell responds to the neurotransmitter.

      This can be accomplished in a variety of ways:
      Re-uptake
      Breakdown
      Diffusion

      Serotonin is an example of a neurotransmitter that is uptake. Serotonin is absorbed back into the presynaptic neuron via the serotonin transporter (SERT), which is found in the presynaptic membrane. Re-uptake neurotransmitters are either recycled by repackaging into vesicles or broken down by enzymes.
      Specific enzymes found in the synaptic cleft can also break down neurotransmitters. The following enzymes are examples of these enzymes:
      Acetylcholinesterase (AChE) catalyses the acetylcholine breakdown (ACh)
      The enzyme catechol-O-methyltransferase (COMT) catalyses the breakdown of catecholamines like adrenaline , dopamine and noradrenaline.

      The breakdown of catecholamines, as well as other monoamines like serotonin, tyramine, and tryptamine, is catalysed by monoamine oxidases (MOA).
      Diffusion of neurotransmitters into nearby locations can also be used to eliminate them.

    • This question is part of the following fields:

      • Basic Cellular Physiology
      • Physiology
      17.2
      Seconds
  • Question 6 - In the Paediatric Emergency Department, you saw a 6-year-old girl with severe bilateral conjunctivitis....

    Incorrect

    • In the Paediatric Emergency Department, you saw a 6-year-old girl with severe bilateral conjunctivitis. You give her mother some general eye hygiene advice and prescribe chloramphenicol eye drops.

      What is the chloramphenicol's mechanism of action?

      Your Answer: Inhibition of cell wall synthesis

      Correct Answer: Inhibition of protein synthesis

      Explanation:

      Chloramphenicol is a broad-spectrum antibiotic that inhibits bacterial protein synthesis by blocking the 50S subunit of the bacterial ribosome’s peptidyl transferase activity. When administered systemically, it has limited usage due to the potential of significant side effects such as aplastic anaemia, peripheral neuropathy, and optic neuritis. It’s only used to treat typhoid fever and Haemophilus influenzae meningitis, but it’s usually better to use a broad-spectrum cephalosporin.

    • This question is part of the following fields:

      • Infections
      • Pharmacology
      58.1
      Seconds
  • Question 7 - Which of the following pathogens is the common cause of diarrhoea in a...

    Correct

    • Which of the following pathogens is the common cause of diarrhoea in a patient who has had a prolonged course of a broad spectrum of antibiotics?

      Your Answer: Clostridium difficile

      Explanation:

      Clostridium difficile is the most likely cause of diarrhoea after a long course of broad-spectrum antibiotic treatment.

      Clostridium difficile-associated diarrhoea appeared to be linked to an increase in the usage of third-generation cephalosporins.

    • This question is part of the following fields:

      • Microbiology
      • Pathogens
      42.8
      Seconds
  • Question 8 - What is the primary mode of action of Enoxaparin? ...

    Incorrect

    • What is the primary mode of action of Enoxaparin?

      Your Answer: Directly inhibits thrombin

      Correct Answer: Inhibits factor Xa

      Explanation:

      Heparin acts as an anticoagulant by enhancing the inhibition rate of clotting proteases by antithrombin III impairing normal haemostasis and inhibition of factor Xa. Low molecular weight heparins have a small effect on the activated partial thromboplastin time and strongly inhibit factor Xa. Enoxaparin is derived from porcine heparin that undergoes benzylation followed by alkaline depolymerization.

    • This question is part of the following fields:

      • Cardiovascular
      • Pharmacology
      53.1
      Seconds
  • Question 9 - Regarding acute lymphoblastic leukaemia (ALL), which of the following statements is CORRECT: ...

    Incorrect

    • Regarding acute lymphoblastic leukaemia (ALL), which of the following statements is CORRECT:

      Your Answer: The bone marrow is hypocellular with an deficiency of blast cells.

      Correct Answer: ALL is the most common malignancy of childhood.

      Explanation:

      Acute lymphoblastic leukaemia (ALL) is caused by an accumulation of lymphoblasts in the bone marrow and is the most common malignancy of childhood. The incidence of ALL is highest at 3 – 7 years, with 75% of cases occurring before the age of 6. 85% of cases are of B-cell lineage. Haematological investigations reveal a normochromic normocytic anaemia with thrombocytopenia in most cases. The total white cell count may be decreased, normal or increased. The blood film typically shows a variable number of blast cells. The bone marrow is hypercellular with >20% blast cells.

    • This question is part of the following fields:

      • Haematology
      • Pathology
      50
      Seconds
  • Question 10 - The parasympathetic supply to the rectum is from which of the following: ...

    Correct

    • The parasympathetic supply to the rectum is from which of the following:

      Your Answer: Pelvic splanchnic nerves

      Explanation:

      Parasympathetic supply is from the pelvic splanchnic nerves (S2 – S4) and inferior hypogastric plexus.

    • This question is part of the following fields:

      • Abdomen
      • Anatomy
      26.6
      Seconds
  • Question 11 - You proceed to administer lorazepam intravenously to a 21-year-old patient with status epilepticus....

    Correct

    • You proceed to administer lorazepam intravenously to a 21-year-old patient with status epilepticus. Which of the following best describes lorazepam's action?

      Your Answer: Potentiates effect of GABA

      Explanation:

      Lorazepam is a type of benzodiazepine.

      Benzodiazepines are gamma-aminobutyric acid (GABA) receptor agonists with sedative, hypnotic, anxiolytic, anticonvulsant, and muscle relaxant characteristics that promote inhibitory synaptic transmission across the central nervous system.

    • This question is part of the following fields:

      • Central Nervous System
      • Pharmacology
      58.1
      Seconds
  • Question 12 - In the United Kingdom, which of the following is the most often used...

    Correct

    • In the United Kingdom, which of the following is the most often used intravenous aesthetic:

      Your Answer: Propofol

      Explanation:

      In the United Kingdom, propofol is the most widely used intravenous anaesthetic. In adults and children, it can be used to induce or maintain anaesthesia, although it is not commonly used in newborns. It can also be used to sedate individuals in intensive care and for sedation during operations.

    • This question is part of the following fields:

      • Anaesthesia
      • Pharmacology
      42.5
      Seconds
  • Question 13 - The ECG of a patient presenting with a history of intermittent palpitations has...

    Correct

    • The ECG of a patient presenting with a history of intermittent palpitations has a prolonged QT interval.

      Which of these can cause prolongation of the QT interval on the ECG?

      Your Answer: Hypomagnesaemia

      Explanation:

      The causes of a prolonged QT interval include:

      Hypomagnesaemia
      Hypothermia
      Hypokalaemia
      Hypocalcaemia
      Hypothyroidism
      Jervell-Lange-Nielsen syndrome (autosomal dominant)
      Romano Ward syndrome (autosomal recessive)
      Ischaemic heart disease
      Mitral valve prolapse
      Rheumatic carditis
      Erythromycin
      Amiodarone
      Quinidine
      Tricyclic antidepressants
      Terfenadine
      Methadone
      Procainamide
      Sotalol

    • This question is part of the following fields:

      • Cardiovascular Physiology
      • Physiology
      23.9
      Seconds
  • Question 14 - One of your patients has been infected by an obligate pathogen and presents...

    Incorrect

    • One of your patients has been infected by an obligate pathogen and presents with features of this condition.

      Which of these is an example of an obligate pathogen?

      Your Answer: Bacteroides fragilis

      Correct Answer: Trepenoma pallidum

      Explanation:

      Treponema pallidum is an obligate pathogen. Obligate pathogens are almost always associated with disease and usually cannot survive outside of the body for long periods of time. Examples include and HIV.

      Staphylococcus aureus and Bacteroides fragilis are conditional pathogens. These are pathogens that usually cause disease only if certain conditions are met.

      Pneumocystis jiroveci and Pseudomonas aeruginosa, are opportunistic pathogens. These are pathogens that can only cause disease in an immunocompromised host or under unusual circumstances.

    • This question is part of the following fields:

      • Microbiology
      • Principles Of Microbiology
      75.7
      Seconds
  • Question 15 - A 53-year-old male has presented to your clinic with the complaint of a...

    Correct

    • A 53-year-old male has presented to your clinic with the complaint of a rash on his right forearm. On examination, you discover small reddish-purple spots on the skin measuring less than 2-3 mm. They do not blanch on applying pressure.

      Which one of the following best fits the description given above?

      Your Answer: Petechiae

      Explanation:

      Petechiae are small red or purple spots on the skin measuring less than 3 mm, caused by minor haemorrhages which do not blanch on applying pressure.
      Purpura measures between 3mm and 1 cm in diameter, while ecchymoses are greater than 1 cm in diameter. Both are caused due to haemorrhage.

      Erythema is the generalised redness of the skin.

      A macule is a flat, discoloured area of the skin measuring less than 1 cm in diameter.

    • This question is part of the following fields:

      • General Pathology
      • Pathology
      110.4
      Seconds
  • Question 16 - During bedside rounds, an 82-year old female in the Medicine Ward complains of...

    Correct

    • During bedside rounds, an 82-year old female in the Medicine Ward complains of pain and tingling of all fingers of the right hand. The attending physician is considering carpal tunnel syndrome.

      Which of the following is expected to undergo atrophy in carpal tunnel syndrome?

      Your Answer: The thenar eminence

      Explanation:

      Carpal tunnel syndrome (CTS) is an entrapment neuropathy caused by compression of the median nerve as it travels through the wrist’s carpal tunnel. It is the most common nerve entrapment neuropathy, accounting for 90% of all neuropathies. Early symptoms of carpal tunnel syndrome include pain, numbness, and paraesthesia’s. These symptoms typically present, with some variability, in the thumb, index finger, middle finger, and the radial half (thumb side) of the ring finger. Pain also can radiate up the affected arm. With further progression, hand weakness, decreased fine motor coordination, clumsiness, and thenar atrophy can occur.

      The muscles innervated by the median nerve can be remembered using the mnemonic ‘LOAF’:
      L– lateral two lumbricals
      O– Opponens pollicis
      A– Abductor pollicis
      F– Flexor pollicis brevis

      In the early presentation of the disease, symptoms most often present at night when lying down and are relieved during the day. With further progression of the disease, symptoms will also be present during the day, especially with certain repetitive activities, such as when drawing, typing, or playing video games. In more advanced disease, symptoms can be constant.

      Typical occupations of patients with carpal tunnel syndrome include those who use computers for extended periods of time, those who use equipment that has vibration such as construction workers, and any other occupation requiring frequent, repetitive movement.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      16.4
      Seconds
  • Question 17 - An very unwell patient is receiving treatment in your hospital's HDU and is...

    Incorrect

    • An very unwell patient is receiving treatment in your hospital's HDU and is found to have an Escherichia coli O157 infection.

      Which one of these statements about Escherichia coli O157 is true?

      Your Answer: It is enteroaggregative

      Correct Answer: Haemolytic uraemic syndrome develops in approximately 6% of patients

      Explanation:

      Escherichia coli O157 is a serotype of Escherichia coli.
      The Escherichia coliO157 strain is ‘enterohaemorrhagic’ and causes severe forms of acute haemorrhagic diarrhoea. It can also cause non-haemorrhagic diarrhoea.

      Incubation period of Escherichia coli O157 is usually 3-4 days and bloody diarrhoea usually begins on the 3rd or 4th day of the infection.

      Infections with Escherichia coliO157 are more common during the warmer months than in winter.

      Haemolytic uraemic syndrome develops in approximately 6% of patients. It is commonly seen in children and in the elderly.

      Escherichia coli O157 can also cause:
      Haemorrhagic colitis
      Haemolytic uraemic syndrome
      Thrombotic thrombocytopenic purpura but not immune thrombocytopenic purpura.

    • This question is part of the following fields:

      • Microbiology
      • Specific Pathogen Groups
      86.6
      Seconds
  • Question 18 - Which of the following nerves has been damaged when a patient presents with...

    Correct

    • Which of the following nerves has been damaged when a patient presents with a foot drop?

      Your Answer: Common peroneal nerve

      Explanation:

      The common peroneal nerve often referred to as the common fibular nerve, is a major nerve that innervates the lower extremity. It is one of the two major branches off the sciatic nerve and receives fibres from the posterior divisions of L4 through S2 nerve roots. The common peroneal nerve separates from the sciatic nerve in the distal posterior thigh proximal to the popliteal fossa. After branching off of the sciatic nerve, it continues down the thigh, running posteroinferior to the biceps femoris muscle, and crosses laterally to the head of the lateral gastrocnemius muscle through the posterior intermuscular septum. The nerve then curves around the fibular neck before dividing into two branches, the superficial peroneal nerve (SPN) and the deep peroneal nerve (DPN). The common peroneal nerve does not have any motor innervation before dividing; however, it provides sensory innervation to the lateral leg via the lateral sural nerve.

      The superficial peroneal nerve innervates the lateral compartment of the leg, and the deep peroneal nerve innervates the anterior compartment of the leg and the dorsum of the foot. These two nerves are essential in the eversion of the foot and dorsiflexion of the foot, respectively. The superficial and deep peroneal nerves provide both motor and sensory innervation.

      The most common presentation with common peroneal nerve injury or palsy is acute foot drop, although symptoms may be progressive and can include sensory loss or pain. Weakness in foot eversion may occur if the superficial peroneal nerve component is involved.

    • This question is part of the following fields:

      • Anatomy
      • Lower Limb
      26
      Seconds
  • Question 19 - You investigated a patient with a chest infection and want to start antibiotics right...

    Incorrect

    • You investigated a patient with a chest infection and want to start antibiotics right away. The patient says they she can't take cephalosporins when you ask about allergies.

      Choose the 'second-generation' cephalosporin from the following choices?

      Your Answer: Ceftazidime

      Correct Answer: Cefuroxime

      Explanation:

      Cephalosporins of the first generation  include cephalexin, cefradine, and cefadroxil. Urinary tract infections, respiratory tract infections, otitis media, and skin and soft-tissue infections are all treated with them.

      Second-generation cephalosporins include cefuroxime, cefaclor, and cefoxitin. These cephalosporins are less vulnerable to beta-lactamase inactivation than the ‘first-generation’ cephalosporins. As a result, they’re effective against germs that are resistant to other antibiotics, and they’re especially effective against Haemophilus influenzae.

      Cephalosporins of the third generation include cefotaxime, ceftazidime, and ceftriaxone. They are more effective against Gram-negative bacteria than second generation’ cephalosporins. They are, however, less effective against Gram-positive bacteria such Staphylococcus aureus than second-generation cephalosporins.

    • This question is part of the following fields:

      • Infections
      • Pharmacology
      61.3
      Seconds
  • Question 20 - Regarding calcium channel blockers, which of the following statements is CORRECT: ...

    Incorrect

    • Regarding calcium channel blockers, which of the following statements is CORRECT:

      Your Answer: Verapamil is the calcium channel blocker of choice post-myocardial infarction in patients with heart failure.

      Correct Answer: Calcium channel blockers inhibit L-type voltage-sensitive calcium channels in arterial smooth muscle causing vasodilation.

      Explanation:

      Calcium channel blockers inhibit L-type voltage-sensitive calcium channels in arterial smooth muscle, causing relaxation and vasodilation (reduction in peripheral vascular resistance). They also block calcium channels within the myocardium and conducting tissues of the heart which produces a negative inotropic effect by reducing calcium influx during the plateau phase of the action potential.
      They have a variety of uses, including:
      Hypertension
      Angina
      Atrial fibrillation
      Migraine
      Calcium channel blockers have been found to be moderately useful in the prevention of migraines. The best evidence is for this is with verapamil. This may be due to the prevention of the arteriolar constriction that is associated with migraine. They are commonly used for this elsewhere in the world but are not currently licensed for this use in the UK.
      The following are common side effects of all calcium-channel blockers:
      Abdominal pain
      Dizziness
      Drowsiness
      Flushing
      Headache
      Nausea and vomiting
      Palpitations
      Peripheral oedema
      Skin reactions
      Tachycardia
      Verapamil is highly negatively inotropic and reduces cardiac output, slows the heart rate and may impair atrioventricular conduction. It may precipitate heart failure, exacerbate conduction disorders, and cause hypotension at high doses and should not be used with beta-blockers. Nifedipine has less myocardial effects than verapamil and has no antiarrhythmic properties but has more influence on the vessels. Nimodipine is used solely for the prevention and treatment of vascular spasm following aneurysmal subarachnoid haemorrhage.

    • This question is part of the following fields:

      • Cardiovascular
      • Pharmacology
      210.4
      Seconds
  • Question 21 - Which of the following clinical features is NOT typical of a facial nerve...

    Correct

    • Which of the following clinical features is NOT typical of a facial nerve palsy:

      Your Answer: Inability to raise the eyelid

      Explanation:

      Facial nerve palsy can result in inability to close the eye due to paralysis of the orbicularis oculi muscle. Elevation of the eyelid in eye opening is a function of the levator palpebrae superioris muscle and the superior tarsal muscle, innervated by the oculomotor nerve and the sympathetic chain respectively.

    • This question is part of the following fields:

      • Anatomy
      • Cranial Nerve Lesions
      24.6
      Seconds
  • Question 22 - Which of the following does NOT predispose to digoxin toxicity in a patient...

    Incorrect

    • Which of the following does NOT predispose to digoxin toxicity in a patient taking digoxin:

      Your Answer: Hypercalcaemia

      Correct Answer: Hyponatraemia

      Explanation:

      Hypoxia, hypercalcaemia, hypokalaemia and hypomagnesaemia predispose to digoxin toxicity. Care should also be taken in the elderly who are particularly susceptible to digoxin toxicity. Hypokalaemia may be precipitated by use of diuretics. Although hyponatremia can result in the development of other pathological disturbances, it does not potentiate digoxin toxicity.

    • This question is part of the following fields:

      • Cardiovascular
      • Pharmacology
      150.6
      Seconds
  • Question 23 - A 67-year-old female presents with a history of morning stiffness and arthritis of...

    Correct

    • A 67-year-old female presents with a history of morning stiffness and arthritis of her hand joints. She is being investigated for rheumatoid arthritis.

      Which test is most sensitive and specific for this diagnosis?

      Your Answer: Anti-CCP

      Explanation:

      Anti-cyclic citrullinated peptide (anti-CCP) is an antibody present in 60-80% of rheumatoid arthritis patients. It is measured by enzyme-linked immunosorbent assay (ELISA). It may be present years before the onset of the disease and is associated with a more severe disease course.

      While most patients with anti-CCP antibodies are also positive for rheumatoid factor (RF), RF antibody is not specific for rheumatoid arthritis as it can occur in patients with other conditions such as infections and other autoimmune conditions.

      ESR, antinuclear antibodies(ANA) and Synovial fluid examination are not specific for rheumatoid arthritis.

    • This question is part of the following fields:

      • General Pathology
      • Pathology
      73.9
      Seconds
  • Question 24 - Insulin binds to the insulin receptor (IR) on cell surfaces to exert its...

    Incorrect

    • Insulin binds to the insulin receptor (IR) on cell surfaces to exert its action. The IR is a very specific transmembrane receptor belonging to the tyrosine kinase receptor class.

      One of these also activates the IR:

      Your Answer: Somatostatin

      Correct Answer: IGF-I

      Explanation:

      Insulin receptor (IR), in addition to being activated by insulin, is also activated by IGF-I and IGF-II.

      The IR is a dimer with two identical subunits spanning the cell membrane and are connected by a single disulphide bond. The two sub-units include: The alpha chain situated on the exterior of the cell membrane and the beta chain spanning the cell membrane in a single segment.

      When insulin is detected, the alpha chains move together folding around the insulin making the beta chains move together, converting them into an active tyrosine kinase. This initiates a phosphorylation cascade increasing the expression of GLUT4 and allowing uptake of glucose by cells.

    • This question is part of the following fields:

      • Endocrine Physiology
      • Physiology
      75.3
      Seconds
  • Question 25 - A 55-year-old woman with mild dyspepsia seeks advice from her pharmacist on how...

    Correct

    • A 55-year-old woman with mild dyspepsia seeks advice from her pharmacist on how to deal with her symptoms. In the first instance, the pharmacist advises her to take an over-the-counter antacid. She buys an antacid that contains aluminium hydroxide, which relieves her symptoms but has a negative side effect.

      She's most likely to have developed which of the following side effects?

      Your Answer: Constipation

      Explanation:

      Aluminium hydroxide is a common antacid that is used to treat ulcer dyspepsia and non-erosive gastro-oesophageal reflux disease.

      When antacids containing aluminium salts are given to patients with renal impairment, there is a risk of accumulation and aluminium toxicity. If renal function is normal, aluminium accumulation does not appear to be a risk.

      Because it reduces gastrointestinal phosphate absorption, aluminium hydroxide can also be used to treat hyperphosphatemia in patients with renal failure.

      Magnesium-based antacids are generally laxative, whereas aluminium-based antacids can be constipating. Renal impairment, angioedema, and anaphylaxis are not significantly increased.

    • This question is part of the following fields:

      • Gastrointestinal Pharmacology
      • Pharmacology
      78.4
      Seconds
  • Question 26 - Which of the following does NOT increase free ionised calcium levels: ...

    Correct

    • Which of the following does NOT increase free ionised calcium levels:

      Your Answer: Calcitonin

      Explanation:

      Calcium homeostasis is primarily controlled by three hormones: parathyroid hormone, activated vitamin D and calcitonin.

      Parathyroid hormone acts on the kidneys to increase calcium reabsorption in the distal tubule by activating Ca2+entry channels in the apical membrane and the Ca2+ATPase pump in the basolateral membrane (and to decrease phosphate reabsorption in the proximal tubule).

      Activated vitamin D acts to increase calcium reabsorption in the distal tubule via activation of a basolateral Ca2+ATPase pump (and to increase phosphate reabsorption).

      Calcitonin acts to inhibit renal reabsorption of calcium (and phosphate).

    • This question is part of the following fields:

      • Physiology
      • Renal
      110.8
      Seconds
  • Question 27 - Which of the following statements is false regarding the biceps brachii muscle? ...

    Incorrect

    • Which of the following statements is false regarding the biceps brachii muscle?

      Your Answer: It weakly assists with flexion of the arm at the shoulder

      Correct Answer: It pronates the radioulnar joint in the forearm

      Explanation:

      The biceps brachii muscle is one of the chief muscles of the arm. The origin at the scapula and the insertion into the radius of the biceps brachii means it can act on both the shoulder joint and the elbow joint, which is why this muscle participates in a few movements of the arm. It derives its name from its two heads which merge in one unique distal body, defining the unusual structure of the muscle.

      The biceps brachii muscle is supplied by the musculocutaneous nerve (C5-C6), a branch of the brachial plexus.

      Arterial supply to the biceps brachii muscle varies considerably, coming from up to eight vessels originating from the brachial artery in the middle third of the arm.

      In the shoulder joint both muscle heads partially enforce opposite movements. The long head pulls the arm away from the trunk (abduction) and turns it inwards (inward rotation) whereas the short head pulls the arm back towards the trunk (adduction). When both heads contract simultaneously it leads to an arm bend (flexion). In the elbow joint the muscle bends the forearm (flexion) and rotates it outwards (supination). The supination is most powerful in a flexed elbow. In addition to the movement functions, the biceps has the important task to support the humeral head within the shoulder joint. Its antagonist is the triceps brachii in the posterior compartment of the arm.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      94.9
      Seconds
  • Question 28 - Which of the following immunoglobulins is most important for mast cell degranulation: ...

    Correct

    • Which of the following immunoglobulins is most important for mast cell degranulation:

      Your Answer: IgE

      Explanation:

      IgA is the major Ig in secretions, particularly from the gastrointestinal tract (but also in saliva, tears, sweat and breast milk).
      IgE is important for mast cell degranulation in allergic and antiparasitic response. In the allergic response, the plasma cell produces IgE-antibodies, which, like antibodies of other immunoglobulin isotypes, are capable of binding a specific allergen via its Fab portion.
      IgG is the most abundant in plasma (comprising 80% of normal serum immunoglobulin) and the main circulatory Ig for the secondary immune response.

    • This question is part of the following fields:

      • Immune Responses
      • Pathology
      93
      Seconds
  • Question 29 - Which anatomical structure is divided following an emergency department anterolateral thoracotomy? ...

    Correct

    • Which anatomical structure is divided following an emergency department anterolateral thoracotomy?

      Your Answer: Latissimus dorsi

      Explanation:

      Thoracotomy describes an incision made in the chest wall to access the contents of the thoracic cavity. Thoracotomies typically can be divided into two categories; anterolateral thoracotomies and posterolateral thoracotomies. These can be further subdivided into supra-mammary and infra-mammary and, of course, further divided into the right or left chest. Each type of incision has its utility given certain circumstances.

      A scalpel is used to sharply divide the skin along the inframammary crease overlying the fifth rib. Electrocautery is then used to divide the pectoralis major muscle and serratus anterior muscle. Visualization of the proper operative field can be achieved with the division and retraction of the latissimus dorsi. Either the fourth or fifth intercostal space is then entered after the division of intercostal muscles above the rib to ensure the preservation of the neurovascular bundle. Once the patient is properly secured to the operating table, the ipsilateral arm is raised and positioned anteriorly and cephalad to rest above the head. The incision is started along the inframammary crease and extended posterolaterally below the tip of the scapula. It is then extended superiorly between the spine and the edge of the scapula, a short distance. The trapezius muscle and the subcutaneous tissues are divided with electrocautery. The serratus anterior and latissimus dorsi muscles are identified and can be retracted. The intercostal muscles are then divided along the superior border of the ribs, and the thoracic cavity is accessed.

    • This question is part of the following fields:

      • Anatomy
      • Thorax
      85.8
      Seconds
  • Question 30 - You're taking a history of a 59-year-old banker who has had heartburn in...

    Correct

    • You're taking a history of a 59-year-old banker who has had heartburn in the past.

      Which of the following information about antacids is correct?

      Your Answer: Magnesium carbonate can reduce the absorption of drugs taken at the same time

      Explanation:

      Antacids such as aluminium hydroxide and magnesium carbonate are commonly used. They’re both water-insoluble and can reduce the absorption of drugs taken together. Allow at least 1-2 hours between taking these antacids and any other medications.

      Because it reduces gastrointestinal phosphate absorption, aluminium hydroxide can also be used to treat hyperphosphatemia in patients with renal failure.

      Magnesium carbonate has a laxative effect, whereas aluminium hydroxide has a constipating effect.

    • This question is part of the following fields:

      • Gastrointestinal Pharmacology
      • Pharmacology
      162.8
      Seconds

SESSION STATS - PERFORMANCE PER SPECIALTY

Evidence Based Medicine (0/1) 0%
Statistics (0/1) 0%
Anatomy (6/7) 86%
Head And Neck (1/1) 100%
Anaesthesia (2/2) 100%
Pharmacology (5/10) 50%
Microbiology (2/4) 50%
Specific Pathogen Groups (1/2) 50%
Basic Cellular Physiology (1/1) 100%
Physiology (3/4) 75%
Infections (0/2) 0%
Pathogens (1/1) 100%
Cardiovascular (0/3) 0%
Haematology (0/1) 0%
Pathology (3/4) 75%
Abdomen (1/1) 100%
Central Nervous System (1/1) 100%
Cardiovascular Physiology (1/1) 100%
Principles Of Microbiology (0/1) 0%
General Pathology (2/2) 100%
Upper Limb (1/2) 50%
Lower Limb (1/1) 100%
Cranial Nerve Lesions (1/1) 100%
Endocrine Physiology (0/1) 0%
Gastrointestinal Pharmacology (2/2) 100%
Renal (1/1) 100%
Immune Responses (1/1) 100%
Thorax (1/1) 100%
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