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  • Question 1 - A 35 year old patient presents to ED having sustained an injury to...

    Incorrect

    • A 35 year old patient presents to ED having sustained an injury to his right hand whilst playing cricket. He is unable to fully straighten his right middle finger as the distal phalanx remains flexed. Which of the following structures within the digit was most likely injured:

      Your Answer: Insertion of central slip of extensor digitorum tendon

      Correct Answer: Insertion of terminal extensor digitorum tendon

      Explanation:

      Damage to the insertion of the terminal extensor digitorum tendon would result in loss of extension at the distal interphalangeal joint causing a fixed flexion deformity, called the Mallet deformity.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      33.7
      Seconds
  • Question 2 - Regarding cytotoxic T cells, which of the following statements is CORRECT: ...

    Incorrect

    • Regarding cytotoxic T cells, which of the following statements is CORRECT:

      Your Answer: They secrete cytokines which are required for activation of other immune cells.

      Correct Answer: They kill target cells by inducing cell apoptosis.

      Explanation:

      CD8+ T-cells (Cytotoxic T cells)
      Recognise antigen only in association with HLA Class I molecules (found on all nucleated cells; present endogenous antigens such as those found in cells infected by viruses or intracellular bacteria.)
      Comprise about 25% of peripheral T-cells
      Responsible for cytotoxic killing of target cells

    • This question is part of the following fields:

      • Immune Responses
      • Pathology
      59.8
      Seconds
  • Question 3 - A 70-year-old patient is diagnosed with Cushing's disease. She has a history of...

    Correct

    • A 70-year-old patient is diagnosed with Cushing's disease. She has a history of weight gain, hypertension, and easy bruising.

      In this patient, which of the following is the MOST LIKELY UNDERLYING CAUSE?

      Your Answer: Pituitary adenoma

      Explanation:

      Cushing’s syndrome is a collection of symptoms and signs caused by prolonged exposure to elevated levels of either endogenous or exogenous glucocorticoids.

      The most common cause of Cushing’s syndrome is the iatrogenic administration of corticosteroids. The second most common cause of Cushing’s syndrome is Cushing’s disease.

      Cushing’s disease should be distinguished from Cushing’s syndrome and refers to one specific cause of the syndrome, an adenoma of the pituitary gland that secretes large amounts of ACTH and, in turn, elevates cortisol levels. This patient has a diagnosis of Cushing’s disease, and this is, therefore, the underlying cause in this case.

      The endogenous causes of Cushing’s syndrome include:
      Pituitary adenoma (Cushing’s disease)
      Ectopic corticotropin syndrome, e.g. small cell carcinoma of the lung
      Adrenal hyperplasia
      Adrenal adenoma
      Adrenal carcinoma

    • This question is part of the following fields:

      • Endocrine Physiology
      • Physiology
      17
      Seconds
  • Question 4 - Which of the following is NOT an effect of gastrin: ...

    Correct

    • Which of the following is NOT an effect of gastrin:

      Your Answer: Stimulation of insulin release

      Explanation:

      Gastrin acts to:
      Stimulate acid secretion from parietal cells (both directly and indirectly by stimulating release of histamine from ECL cells)
      Stimulate pepsinogen secretion from chief cells
      Increase gastric motility
      Stimulate growth of gastric mucosa

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      23.6
      Seconds
  • Question 5 - Which of the following statements regarding the infectivity periods of these corresponding diseases...

    Incorrect

    • Which of the following statements regarding the infectivity periods of these corresponding diseases is correct?

      Your Answer: Hepatitis A is infectious from the onset of jaundice for 1 month

      Correct Answer: Rubella is infectious until 5 days after the rash appears

      Explanation:

      Rubella can be contagious from 7 days before to 7 days after the rash appears.

      Patients with measles are contagious from 1-2 days before the onset of symptoms.

      A person with chickenpox is considered contagious beginning 1 to 2 days before rash onset until all the chickenpox lesions have crusted (scabbed).

      The infectious period of mumps is considered from 2 days before to 5 days after parotitis onset.

      Hepatitis A is highly transmissible and has an average incubation period of 28 to 30 days (range 15–50 days). The maximum infectivity is during the second half of the incubation period (i.e. while asymptomatic) and most cases are considered non-infectious after the first week of jaundice.

    • This question is part of the following fields:

      • Microbiology
      • Specific Pathogen Groups
      5.5
      Seconds
  • Question 6 - A 30-year-old woman presents with a history of fever and sore throat. On...

    Correct

    • A 30-year-old woman presents with a history of fever and sore throat. On examination, there is tonsillar exudate and cervical lymphadenopathy and a diagnosis of tonsillitis is made. A course of penicillin is prescribed.

      What is the mechanism of action of penicillin?

      Your Answer: Inhibition of cell wall synthesis

      Explanation:

      Penicillin is bactericidal and produces its antimicrobial action by preventing cross-linkage between the linear peptidoglycan polymer chains that make up the bacterial cell wall. This action inhibits cell wall synthesis.

    • This question is part of the following fields:

      • Infections
      • Pharmacology
      21.2
      Seconds
  • Question 7 - Adenosine has a half-life of approximately: ...

    Correct

    • Adenosine has a half-life of approximately:

      Your Answer: 8 - 10 seconds

      Explanation:

      Adenosine stimulates A1-adenosine receptors and opens acetylcholine sensitive K+ channels, increasing K+ efflux. This hyperpolarises the cell membrane in the atrioventricular node and, by inhibiting the calcium channels, slows conduction in the AVN. As it has a very short duration of action (half-life only about 8 – 10 seconds), most side effects are short lived.

    • This question is part of the following fields:

      • Cardiovascular
      • Pharmacology
      9.8
      Seconds
  • Question 8 - Regarding bicarbonate handling by the proximal tubule, which of the following statements is...

    Correct

    • Regarding bicarbonate handling by the proximal tubule, which of the following statements is CORRECT:

      Your Answer: For each H + secreted into the lumen, one Na + and one HCO 3 - is reabsorbed into the plasma.

      Explanation:

      About 80% of bicarbonate is reabsorbed in the proximal tubule. HCO3-is not transported directly, tubular HCO3-associates with H+secreted by epithelial Na+/H+antiporters to form carbonic acid (H2CO3) which readily dissociates to form carbon dioxide and water in the presence of carbonic anhydrase. CO2and water diffuse into the tubular cells, where they recombine to form carbonic acid which dissociates to H+and HCO3-. This HCO3-is transported into the interstitium largely by Na+/HCO3-symporters on the basolateral membrane (and H+is secreted back into the lumen). For each H+secreted into the lumen, one Na+and one HCO3-are reabsorbed into the plasma. H+is recycled so there is little net secretion of H+at this stage.

    • This question is part of the following fields:

      • Physiology
      • Renal
      654.8
      Seconds
  • Question 9 - A 67-year-old woman arrives at the Emergency Department with chest pain. Flecainide is...

    Correct

    • A 67-year-old woman arrives at the Emergency Department with chest pain. Flecainide is one of the medications she is taking.

      Which of the following statements about flecainide mechanism of action is correct?

      Your Answer: Blocks Na+ channels in the heart

      Explanation:

      Flecainide is an antiarrhythmic drug of class Ic that works by blocking the Nav1.5 sodium channel in the heart, prolonging the cardiac action potential and slowing cardiac impulse conduction. It has a significant impact on accessory pathway conduction, particularly retrograde conduction, and significantly reduces ventricular ectopic foci.

      Many different arrhythmias can be treated with flecainide, including:
      Pre-excitation syndromes (e.g. Wolff-Parkinson-White)
      Acute atrial arrhythmias
      Ventricular arrhythmias
      Chronic neuropathic pain

      The use of flecainide is contraindicated in the following situations:
      Abnormal left ventricular function
      Atrial conduction defects (unless pacing rescue available)
      Bundle branch block (unless pacing rescue available)
      Distal block (unless pacing rescue available)
      Haemodynamically significant valvular heart disease
      Heart failure
      History of myocardial infarction
      Long-standing atrial fibrillation where conversion to sinus rhythm not attempted
      Second-degree or greater AV block (unless pacing rescue available)
      Sinus node dysfunction (unless pacing rescue available)

      Flecainide should only be used in people who don’t have a structural heart problem. The CAST trial found a significant increase in sudden cardiac death and all-cause mortality in patients with an ejection fraction of less than 40% after a myocardial infarction, where it tended to be pro-arrhythmic.

      Anti-arrhythmic drugs have a limited and ineffective role in the treatment of atrial flutter. It’s important to keep in mind that flecainide shouldn’t be used by itself to treat atrial flutter. When used alone, there is a risk of inducing 1:1 atrioventricular conduction, which results in an increase in ventricular rate that is paradoxical. As a result, it should be used in conjunction with a beta-blocker or a calcium channel blocker with a rate-limiting effect.

    • This question is part of the following fields:

      • Cardiovascular Pharmacology
      • Pharmacology
      18.3
      Seconds
  • Question 10 - Giemsa-stained blood film microscopy is typically used for the diagnosis of which of...

    Incorrect

    • Giemsa-stained blood film microscopy is typically used for the diagnosis of which of the following:

      Your Answer: Tuberculosis

      Correct Answer: Malaria

      Explanation:

      Giemsa-stained blood film microscopy can be used to identify malarial parasites.

    • This question is part of the following fields:

      • Microbiology
      • Principles
      25.5
      Seconds
  • Question 11 - The juxtacapillary receptors, or J receptors, are sensory cells that play an important...

    Correct

    • The juxtacapillary receptors, or J receptors, are sensory cells that play an important role in the control of respiration.
      At which of the following anatomical sites are the J receptors located? Select ONE answer only.

      Your Answer: The alveolar walls

      Explanation:

      Juxtacapillary receptors (J receptors) are sensory cells that are located within the alveolar walls in juxtaposition to the pulmonary capillaries of the lung.
      The J receptors are innervated by the vagus nerve and are activated by physical engorgement of the pulmonary capillaries or increased pulmonary interstitial volume, for example, in the presence of pulmonary oedema, pulmonary embolus, pneumonia and barotraumas. They may also be stimulated by hyperinflation of the lung.
      Stimulation of the J receptors causes a reflex increase in breathing rate and is also thought to be involved in the sensation of dyspnoea. The reflex response that is produced is apnoea, followed by rapid breathing, bradycardia, and hypotension.

    • This question is part of the following fields:

      • Physiology
      • Respiratory Physiology
      262.3
      Seconds
  • Question 12 - A 32 year old woman presents with episodes of flushing, headaches and palpitations....

    Correct

    • A 32 year old woman presents with episodes of flushing, headaches and palpitations. On examination her blood pressure is significantly elevated. Which of the following is the most likely diagnosis:

      Your Answer: Pheochromocytoma

      Explanation:

      Phaeochromocytomas are catecholamine-secreting tumours which occur in about 0.1% of patients with hypertension. In about 90% of cases they arise from the adrenal medulla. The remaining 10%, which arise from extra-adrenal chromaffin tissue, are termed paragangliomas. Common presenting symptoms include one or more of headache, sweating, pallor and palpitations. Less commonly, patients describe anxiety, panic attacks and pyrexia. Hypertension, whether sustained or episodic, is present in at least 90% of patients. Left untreated phaeochromocytoma can occasionally lead to hypertensive crisis, encephalopathy, hyperglycaemia, pulmonary oedema, cardiac arrhythmias, or even death.

    • This question is part of the following fields:

      • Endocrine
      • Physiology
      16.8
      Seconds
  • Question 13 - A patient with history of weight loss and diarrhoea was found out to...

    Correct

    • A patient with history of weight loss and diarrhoea was found out to have Giardia lamblia in her stool since returning from a holiday to Nepal.

      Which of the following statements is considered true regarding the life cycle of Giardia lamblia?

      Your Answer: Trophozoites attach to the intestinal wall via a specialised sucking disc

      Explanation:

      Cysts are resistant forms and are responsible for transmission of giardiasis. Both cysts and trophozoites can be found in the faeces (diagnostic stages). The cysts are hardy and can survive several months in cold water. Infection occurs by the ingestion of cysts in contaminated water, food, or by the faecal-oral route (hands or fomites).
      In the small intestine, excystation releases trophozoites (each cyst produces two trophozoites).
      Trophozoites multiply by longitudinal binary fission, remaining in the lumen of the proximal small bowel where they can be free or attached to the mucosa by a ventral sucking disk.
      Encystation occurs as the parasites transit toward the colon. The cyst is the stage found most commonly in non diarrheal faeces.
      Because the cysts are infectious when passed in the stool or shortly afterward, person-to-person transmission is possible. While animals are infected with Giardia, their importance as a reservoir is unclear.

    • This question is part of the following fields:

      • Microbiology
      • Principles Of Microbiology
      54.6
      Seconds
  • Question 14 - A 30 year old man presents to ED after a road traffic accident....

    Correct

    • A 30 year old man presents to ED after a road traffic accident. Free intraperitoneal fluid is found on FAST (Focussed assessment for sonography in trauma) done in the supine position.

      Which of these is most likely to be affected?

      Your Answer: Hepatorenal recess

      Explanation:

      Fluid accumulates most often in the hepatorenal pouch (of Morrison) in a supine patient. The hepatorenal pouch is located behind the liver and anterior to the right kidney and is the lowest space in the peritoneal cavity in the supine position.

      Although the vesicouterine and rectouterine spaces are also potential spaces for fluid accumulation, fluid accumulation in them occur in the erect position.

    • This question is part of the following fields:

      • Abdomen
      • Anatomy
      17.2
      Seconds
  • Question 15 - Which of the following is a common adverse effect of glucagon: ...

    Correct

    • Which of the following is a common adverse effect of glucagon:

      Your Answer: Nausea

      Explanation:

      Adverse effects include:
      Common: Nausea
      Uncommon: Vomiting
      Rare: Abdominal pain, hypertension, hypotension, tachycardia

    • This question is part of the following fields:

      • Endocrine
      • Pharmacology
      13.3
      Seconds
  • Question 16 - Which of the following cytokines is important for the maintenance of granulomatous inflammation:...

    Correct

    • Which of the following cytokines is important for the maintenance of granulomatous inflammation:

      Your Answer: TNF-alpha

      Explanation:

      Granulomatous inflammation is a distinctive pattern of chronic inflammation that is encountered in a limited number of infectious and some non-infectious conditions. Briefly, a granuloma is a cellular attempt to contain an offending agent that is difficult to eradicate. In this attempt, there is often strong activation of T lymphocytes leading to macrophage activation, which can cause injury to normal tissues. IL-1 is important in initiating granuloma formation, IL-2 can cause them to enlarge and TNF-α maintains them.

    • This question is part of the following fields:

      • Inflammatory Responses
      • Pathology
      6.3
      Seconds
  • Question 17 - Which of the following is a clinical effect of hyperkalaemia: ...

    Correct

    • Which of the following is a clinical effect of hyperkalaemia:

      Your Answer: Muscle weakness

      Explanation:

      Clinical features of hyperkalaemia may include:
      paraesthesia, muscle weakness or paralysis, cardiac conduction abnormalities and dysrhythmias.

      Clinical features of hypokalaemia may include:
      muscle weakness, muscle cramps, rhabdomyolysis and myoglobinuria, ascending paralysis resulting in respiratory failure, constipation, gut ileus with distension, anorexia, nausea and vomiting, impaired ADH action with polyuria and polydipsia, ECG changes and cardiac arrhythmias.

    • This question is part of the following fields:

      • Physiology
      • Renal
      5.6
      Seconds
  • Question 18 - Which of the following statements is correct regarding the lymphatic system? ...

    Correct

    • Which of the following statements is correct regarding the lymphatic system?

      Your Answer: Lymphatic vessels contain both smooth muscle and unidirectional valves.

      Explanation:

      Fluid filtration out of the capillaries is usually slightly greater than fluid absorption into the capillaries. About 8 L of fluid per day is filtered by the microcirculation and returns to the circulation by the lymphatic system. Lymphatic capillaries drain into collecting lymphatics, then into larger lymphatic vessels. Both of these containing smooth muscle and unidirectional valves. From this point, lymph is propelled by smooth muscle constriction and vessel compression by body movements into afferent lymphatics. It then goes to the lymph nodes where phagocytes remove bacteria and foreign materials. It is here that most fluid is reabsorbed by capillaries, and the remainder returns to the subclavian veins via efferent lymphatics and the thoracic duct. The lymphatic system has a major role to play in the body’s immune defence and also has a very important role in the absorption and transportation of fats.

    • This question is part of the following fields:

      • Cardiovascular
      • Physiology
      14.2
      Seconds
  • Question 19 - Among the following infectious diseases, which is typically considered to have an incubation...

    Incorrect

    • Among the following infectious diseases, which is typically considered to have an incubation period of less than 3 weeks?

      Your Answer: Hepatitis A

      Correct Answer: Diphtheria

      Explanation:

      C. diphtheriae, which is the causative agent of diphtheria, is carried in the upper respiratory tract and spread by droplet infection or hand-to-mouth contact. The incubation period averages 2 to 5 days.

      Infectious mononucleosis is caused by Epstein-Barr virus (EBV). The incubation period for EBV varies from 2 weeks to 2 months.

      The incubation for Hepatitis A virus is approximately 1 month.

      The incubation period for Hepatitis C ranges from 2 weeks to 6 months.

      The period from infection to development of anti-HIV antibodies is usually less than 1 month but may be up to 3 months.

    • This question is part of the following fields:

      • Microbiology
      • Specific Pathogen Groups
      19.3
      Seconds
  • Question 20 - Regarding fat digestion, which of the following statements is CORRECT: ...

    Correct

    • Regarding fat digestion, which of the following statements is CORRECT:

      Your Answer: Chylomicrons consist of a cholesterol and triglyceride core with a phospholipid coat studded with apolipoproteins.

      Explanation:

      Dietary fat is chiefly composed of triglycerides. In the duodenum fat is emulsified by bile acids, a process where larger lipid droplets are broken down into much smaller droplets providing a greater surface area for enzymatic digestion. Once inside the epithelial cell, lipid is taken into the smooth endoplasmic reticulum where much of it is re esterified. Dietary and synthesised lipids are then incorporated into chylomicrons in the Golgi body, which are exocytosed from the basolateral membrane to enter lacteals. Chylomicrons consist mainly of triglyceride with small amounts of cholesterol and cholesteryl esters in the centre with a phospholipid coat studded with apolipoproteins. Fat-soluble are absorbed into enterocytes from micelles by simple diffusion together with the products of fat digestion.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      31.1
      Seconds
  • Question 21 - Which of the following data types does a pain-scoring system represent? ...

    Incorrect

    • Which of the following data types does a pain-scoring system represent?

      Your Answer: Nominal

      Correct Answer: Ordinal

      Explanation:

      Pain scoring systems are processes for assessing pain and the severity of illnesses that have been scientifically designed and tested. An example of ordinal categorical data is a pain scoring system.

    • This question is part of the following fields:

      • Evidence Based Medicine
      • Statistics
      10.9
      Seconds
  • Question 22 - A 71-year-old patient has been diagnosed with a dopamine-secreting neuroendocrine tumour.

    Which of the...

    Correct

    • A 71-year-old patient has been diagnosed with a dopamine-secreting neuroendocrine tumour.

      Which of the following statements about dopamine is correct?

      Your Answer: It inhibits prolactin release from the anterior pituitary

      Explanation:

      Dopamine is a neurotransmitter and amine hormone that is derived from the amino acid tyrosine. It is made in a number of places throughout the human body, both inside and outside the central nervous system. The adrenal medulla, dopamine neurons in the arcuate nucleus of the hypothalamus, the substantia nigra, and other areas of the brain produce dopamine.

      The tuberoinfundibular pathway refers to the dopamine neurons in the arcuate nucleus of the hypothalamus’ tubeal region. Dopamine is discharged into the hypothalamo-hypophyseal portal system from these neurons’ neurosecretory terminals at the median eminence.

      The major function of dopamine produced from the hypothalamus is to suppress prolactin production from the anterior pituitary, and it is released in reaction to excessive levels of prolactin secretion. Modulation of motor-control centres and activation of reward centres are two more crucial activities of the brain.
      Dopamine-secreting cells can also be found in other areas of the body, where they perform mostly paracrine functions (acting on nearby cells).

    • This question is part of the following fields:

      • Endocrine Physiology
      • Physiology
      27.4
      Seconds
  • Question 23 - A 56-year-old female presents at the hospital with a diabetic foot ulcer that...

    Incorrect

    • A 56-year-old female presents at the hospital with a diabetic foot ulcer that has become infected. She has a longstanding history of type 2 diabetes mellitus and diabetic polyneuropathy. She has trouble controlling her blood sugar levels, and recently, she was converted to a new insulin regimen that includes intermediate-acting insulin.

      Out of the following, which one is the intermediate-acting insulin?

      Your Answer: Insulin aspart

      Correct Answer: Isophane insulin

      Explanation:

      Insulin is used mainly in type 1 diabetes, where the pancreas makes no insulin and can sometimes be prescribed in type 1 diabetes. There are different types of insulin categorized by their onset of action:

      1. Intermediate-acting insulins (isophane insulin NPH):
      – intermediate duration of action, designed to mimic the effect of endogenous basal insulin
      – starts their action in 1 to 4 hours
      – peaks in 4 to 8 hours
      – dosing is usually twice a day and helps maintain blood sugar throughout the day
      – Isophane insulin is a suspension of insulin with protamine

      2. Short-acting insulins (regular insulin)
      – starts the action in 30 to 40 minutes
      – peaks in 90 to 120 minutes
      – duration of action is 6 to 8 hours
      – taken before meals, and food is necessary within 30 minutes after its administration to avoid hypoglycaemia

      3. Long-acting insulins (glargine, detemir, degludec)
      – start action in 1 to 2 hours
      – plateau effect over 12 to 24 hours
      – Dosing is usually during the night-time after meals. Their long duration of action helps in reducing the frequency of dosing throughout the day.

      4. Rapid-acting insulins (lispro, aspart, glulisine)
      – start their action in 5 to 15 minutes
      – peak in 30 minutes
      – The duration of action is 3 to 5 hours
      – generally used before meals and always used along with short-acting or long-acting insulins to control sugar levels throughout the day.

    • This question is part of the following fields:

      • Endocrine Pharmacology
      • Pharmacology
      33.2
      Seconds
  • Question 24 - The transport of oxygen from maternal to fetal circulation is made possible by...

    Correct

    • The transport of oxygen from maternal to fetal circulation is made possible by fetal haemoglobin. Which of the statements about fetal haemoglobin (HbF) is also correct?

      Your Answer: The oxygen dissociation curve for foetal haemoglobin is shifted to the left of that of adult haemoglobin

      Explanation:

      Fetal haemoglobin is the most common type of haemoglobin found in the foetus during pregnancy. It transports oxygen from the maternal circulation to the fetal circulation. It can easily bind to oxygen from the maternal circulation because it has a high affinity for oxygen. From 10 to 12 weeks of pregnancy to the first six months after birth, the erythroid precursor cells produce fetal haemoglobin. In comparison to adult haemoglobin, fetal haemoglobin has two alpha and two gamma subunits, whereas adult haemoglobin has two alpha and two beta subunits in its major form.

      And, unlike adult haemoglobin, the oxygen dissociation curve of fetal haemoglobin is left-shifted. Myoglobin is an oxygen storage molecule with a very high affinity for oxygen. Only when the partial pressure of oxygen is exceeded does it release oxygen.

    • This question is part of the following fields:

      • Physiology
      • Respiratory Physiology
      25.1
      Seconds
  • Question 25 - In a 7-year-old child with chickenpox, which of the following would you advise...

    Incorrect

    • In a 7-year-old child with chickenpox, which of the following would you advise the mother NOT to do?

      Your Answer: Use topical emollients to help ease the itching

      Correct Answer: Give ibuprofen for the fever

      Explanation:

      Chickenpox (varicella zoster) is a highly contagious airborne disease and has an incubation period of between 7-21 days. It often has a prodromal phase when there is a fever, aches and headaches, dry cough, and sore throat before onset of rash.

      Some recognized complications of chickenpox are:
      Orchitis
      Hepatitis
      Pneumonia
      Encephalitis
      Infected spots
      Otitis media
      Myocarditis
      Glomerulonephritis
      Appendicitis
      Pancreatitis

      Treatment is symptomatic and includes using paracetamol to manage fever. There is a link between use of ibuprofen in patients with chicken-pox and necrotizing fasciitis so Ibuprofen should NOT be used.

      An emollient and antihistamine can be used to ease the itchy rash and oral hydration is encouraged.

    • This question is part of the following fields:

      • Microbiology
      • Specific Pathogen Groups
      24.9
      Seconds
  • Question 26 - Regarding gas exchange at the alveolar-capillary membrane, which of the following statements is...

    Incorrect

    • Regarding gas exchange at the alveolar-capillary membrane, which of the following statements is CORRECT:

      Your Answer: Rate of diffusion is primarily dependent on the alveolar-capillary concentration gradient of O 2 and CO 2 .

      Correct Answer: The rate of diffusion in lungs can be estimated by measuring the diffusing capacity of the lungs for carbon monoxide.

      Explanation:

      Gas exchange between alveolar air and blood in the pulmonary capillaries takes place by diffusion across the alveolar-capillary membrane. Diffusion occurs from an area of high partial pressure to an area of low partial pressure, thus the driving force for diffusion is the alveolar-capillary partial pressure gradient. Diffusion occurs across a membrane and is therefore governed by Fick’s law. Although CO2is larger than O2, it is is much more soluble and diffuses 20 times more rapidly. The diffusing capacity for oxygen (DLO2) cannot be measured directly but the rate of diffusion in the lungs can be estimated by measuring the diffusing capacity of the lungs for carbon monoxide (DLCO).

    • This question is part of the following fields:

      • Physiology
      • Respiratory
      34.4
      Seconds
  • Question 27 - Regarding the varicella zoster virus, which of the following statements is CORRECT: ...

    Incorrect

    • Regarding the varicella zoster virus, which of the following statements is CORRECT:

      Your Answer: Childhood chickenpox should be treated with oral antiviral medication.

      Correct Answer: Contracting chickenpox infection while pregnant is associated with a higher risk of developing varicella pneumonitis.

      Explanation:

      Chickenpox infection in neonates, adults/adolescents and pregnant women is associated with more severe disease. Varicella zoster pneumonitis typically occurs in pregnant women or immunocompromised individuals and is associated with a high mortality. A live attenuated-virus vaccine is available and recommended for non-immune healthcare workers but is not part of the routine childhood immunisation schedule. Antiviral treatment is not typically recommended in childhood chickenpox but is indicated for shingles.

    • This question is part of the following fields:

      • Microbiology
      • Pathogens
      28.4
      Seconds
  • Question 28 - Regarding the human cell, which of the following cell organelles is responsible for...

    Correct

    • Regarding the human cell, which of the following cell organelles is responsible for the production of ATP:

      Your Answer: Mitochondria

      Explanation:

      Mitochondria are membrane-bound organelles that are responsible for the production of the cell’s supply of chemical energy. This is achieved by using molecular oxygen to utilise sugar and small fatty acid molecules to generate adenosine triphosphate (ATP). This process is known as oxidative phosphorylation and requires an enzyme called ATP synthase. ATP acts as an energy-carrying molecule and releases the energy in situations when it is required to fuel cellular processes. Mitochondria are also involved in other cellular processes, including Ca2+homeostasis and signalling. Mitochondria contain a small amount of maternal DNA.
      Mitochondria have two phospholipid bilayers, an outer membrane and an inner membrane. The inner membrane is intricately folded inwards to form numerous layers called cristae. The cristae contain specialised membrane proteins that enable the mitochondria to synthesise ATP. Between the two membranes lies the intermembrane space, which stores large proteins that are required for cellular respiration. Within the inner membrane is the perimitochondrial space, which contains a jelly-like matrix. This matrix contains a large quantity of ATP synthase.
      Mitochondrial disease, or mitochondrial disorder, refers to a group of disorders that affect the mitochondria. When the number or function of mitochondria in the cell are disrupted, less energy is produced and organ dysfunction results.

    • This question is part of the following fields:

      • Basic Cellular
      • Physiology
      8.6
      Seconds
  • Question 29 - Lidocaine's antiarrhythmic mode of action is as follows: ...

    Correct

    • Lidocaine's antiarrhythmic mode of action is as follows:

      Your Answer: Blocks inactivated Na+ channels

      Explanation:

      Lidocaine is a class 1B antidysrhythmic; combines with fast Na channels and thereby inhibits recovery after repolarization, resulting in decreasing myocardial excitability and conduction velocity. However, in ischaemic areas, where anoxia causes depolarisation and arrhythmogenic activity, many Na+ channels are inactivated and therefore susceptible to lidocaine.

    • This question is part of the following fields:

      • Cardiovascular
      • Pharmacology
      11.2
      Seconds
  • Question 30 - A 24-year-old waiter cuts his hand on a dropped plate that smashed and...

    Incorrect

    • A 24-year-old waiter cuts his hand on a dropped plate that smashed and damages the nerve that innervates opponens digiti minimi.
      The opponens digiti minimi muscle is innervated by which of the following nerves? Select ONE answer only.

      Your Answer: The recurrent branch of the median nerve

      Correct Answer: The deep branch of the ulnar nerve

      Explanation:

      Opponens digiti minimi is a triangular-shaped muscle in the hand that forms part of the hypothenar eminence. It originates from the hook of the hamate bone and the flexor retinaculum and inserts into the medial border of the 5thmetacarpal.
      Opponens digiti minimi is innervated by the deep branch of the ulnar nerve and receives its blood supply from the ulnar artery.
      Opponens digiti minimi draws the fifth metacarpal bone anteriorly and rotates it, bringing the fifth digiti into opposition with the thumb.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      20.7
      Seconds

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