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  • Question 1 - Regarding the phases of gastric secretion, which of the following statements is INCORRECT:...

    Incorrect

    • Regarding the phases of gastric secretion, which of the following statements is INCORRECT:

      Your Answer: In the gastric phase, stimulation of the vagus nerve stimulates the release of gastrin-releasing peptide (GRP), which mainly acts directly on G-cells to release gastrin.

      Correct Answer: A high pH in the stomach inhibits gastrin secretion.

      Explanation:

      A low pH in the stomach inhibits gastrin secretion, therefore when the stomach is empty or when acid has been secreted for some time after food has entered it, there is inhibition of acid secretion. However, when food first enters the stomach, the pH rises, and this leads to release of the inhibition and causes a maximum secretion of gastrin. Thus gastric acid secretion is self-regulating.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      17.3
      Seconds
  • Question 2 - A 29 year old man presents to ED followed an alleged assault whilst...

    Correct

    • A 29 year old man presents to ED followed an alleged assault whilst out drinking. He received blunt trauma to his right axilla. He is complaining of difficulty abducting his right arm above the level of his shoulder, and on inspection, the inferior angle of his right scapula protrudes more than that of his left scapula. Which of the following nerves has most likely been affected:

      Your Answer: Long thoracic nerve

      Explanation:

      Damage to the long thoracic nerve results in weakness/paralysis of the serratus anterior muscle causing difficulty abducting the upper limb above 90 degrees and giving a ‘winged ‘ scapula appearance where the medial border, particularly the inferior angle, of the scapula moves laterally and posteriorly away from the thoracic wall (this becomes more pronounced if the patient presses the upper limb against a wall).

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      13.8
      Seconds
  • Question 3 - A man presents to the emergency department with an injury that has damaged...

    Correct

    • A man presents to the emergency department with an injury that has damaged the opponens pollicis muscle.

      Which of the following statements regarding the opponens pollicis muscle is considered correct?

      Your Answer: It flexes the first metacarpal bone at the carpometacarpal joint

      Explanation:

      Opponens pollicis is a muscle of thenar eminence, it is triangular in shape and lies deep to flexor pollicis brevis and abductor pollicis brevis. It originates from the flexor retinaculum, tubercles of scaphoid and trapezium, abductor pollicis longus tendon.

      Its insertion is in the radial side of the base of proximal phalanx of thumb. It is supplied by the median nerve (C8, T1). It receives blood supply from superficial arch.

      It flexes the metacarpal bone medially across the palm, also rotating it medially, causing opposition, the palmar aspect of the terminal segment of thumb contacts the flexor aspects of any other digit.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      37.8
      Seconds
  • Question 4 - A 25 year old woman who is a known diabetic is brought to...

    Correct

    • A 25 year old woman who is a known diabetic is brought to the ED with diabetic ketoacidosis. She promptly received an insulin infusion. Which of the following are expected to increase upon infusion of insulin?

      Your Answer: Blood pH

      Explanation:

      Ketoacidosis is characterized by hyperglycaemia, glycosuria, hyperkalaemia, and metabolic acidosis with respiratory compensation. An insulin infusion would be able to address these by lowering blood glucose through increased insulin-mediated cellular uptake, lowering urine glucose concentration as cellular glucose uptake is increased, decreasing K+ in her blood by shifting it into cells, and increasing blood ph by addressing the metabolic acidosis. The metabolic acidosis is addressed by the reduction of ketoacids production thereby returning her blood ph to normal and reducing the need for compensatory hyperventilation.

    • This question is part of the following fields:

      • Endocrine
      • Physiology
      21.9
      Seconds
  • Question 5 - A 29 year old woman is unable to invert her foot after sustaining...

    Correct

    • A 29 year old woman is unable to invert her foot after sustaining an injury to her leg playing water-polo. Which of the following nerves are most likely damaged:

      Your Answer: Tibial and deep fibular nerve

      Explanation:

      Inversion of the foot is primarily produced by the tibialis anterior and the tibialis posterior muscles, innervated by the deep fibular nerve and the tibial nerve respectively.

    • This question is part of the following fields:

      • Anatomy
      • Lower Limb
      34.6
      Seconds
  • Question 6 - Which of the following is NOT a common clinical manifestation of sickle cell...

    Incorrect

    • Which of the following is NOT a common clinical manifestation of sickle cell disease?

      Your Answer: Hand-foot syndrome

      Correct Answer: Iron deficiency

      Explanation:

      Signs and symptoms of Sickle cell disease(SCD):
      Acute and chronic pain: The most common clinical manifestation of SCD is vaso-occlusive crisis; pain crises are the most distinguishing clinical feature of SCD
      Bone pain: Often seen in long bones of extremities, primarily due to bone marrow infarction
      Anaemia: Universally present, chronic, and haemolytic in nature
      Aplastic crisis: Serious complication due to infection with parvovirus B19 (B19V)
      Splenic sequestration: Characterized by the onset of life-threatening anaemia with rapid enlargement of the spleen and high reticulocyte count
      Infection: Organisms that pose the greatest danger include encapsulated respiratory bacteria, particularly Streptococcus pneumoniae; adult infections are predominantly with gram-negative organisms, especially Salmonella
      Growth retardation, delayed sexual maturation, being underweight
      Hand-foot syndrome: This is a dactylitis presenting as bilateral painful and swollen hands and/or feet in children
      Acute chest syndrome: Young children present with chest pain, fever, cough, tachypnoea, leucocytosis, and pulmonary infiltrates in the upper lobes; adults are usually afebrile, dyspnoeic with severe chest pain, with multilobar/lower lobe disease
      Pulmonary hypertension: Increasingly recognized as a serious complication of SCD
      Avascular necrosis of the femoral or humeral head: Due to vascular occlusion
      Central nervous system (CNS) involvement: Most severe manifestation is stroke
      Ophthalmologic involvement: Ptosis, retinal vascular changes, proliferative retinitis
      Cardiac involvement: Dilation of both ventricles and the left atrium
      Gastrointestinal involvement: Cholelithiasis is common in children; liver may become involved
      Genitourinary involvement: Kidneys lose concentrating capacity; priapism is a well-recognized complication of SCD
      Dermatologic involvement: Leg ulcers are a chronic painful problem

    • This question is part of the following fields:

      • Haematology
      • Pathology
      15.8
      Seconds
  • Question 7 - A 18-year-old man returns from a trip to Ibiza with a severely painful...

    Incorrect

    • A 18-year-old man returns from a trip to Ibiza with a severely painful left eye. He has copious mucopurulent discharge, is febrile and has left-sided tender preauricular lymphadenopathy. He attends the local eye casualty and is diagnosed with hyperacute conjunctivitis.
      What is the SINGLE most likely causatiave organism?

      Your Answer: Cytomegalovirus

      Correct Answer: Neisseria gonorrhoeae

      Explanation:

      Hyperacute bacterial conjunctivitis is a severe, sight-threatening ocular infection that warrants immediate ophthalmic work-up and management. The infection has an abrupt onset and is characterized by a copious yellow-green purulent discharge that reaccumulates after being wiped away. Typically caused by infection with Neisseria gonorrhoeae.

    • This question is part of the following fields:

      • Microbiology
      • Specific Pathogen Groups
      5.5
      Seconds
  • Question 8 - A blood culture was performed from a sample taken from a patient. It...

    Incorrect

    • A blood culture was performed from a sample taken from a patient. It was noted that a Gram-negative coccus organism was grown.

      Among the following microorganisms, which is considered an example of a Gram-negative coccus?

      Your Answer: Escherichia coli

      Correct Answer: Neisseria menigitidis

      Explanation:

      Staphylococcus aureus = Gram-positive coccus
      Bacillus cereus = Gram-positive bacillus
      Campylobacter jejuni = Gram-negative bacillus
      Escherichia coli = Gram-negative bacillus

      In Gram staining, crystal violet is a purple stain that is used to stain the bacteria first. The stained bacteria are decolorized and then stained with a red stain, which is safranin. Bacteria with thick cell walls keep the purple stain and are called Gram-positive. Thin-walled bacteria are easily decolorized so when safranin, the red stain, is placed on the organisms, they become red or Gram-negative.
      Neisseria species appear as Gram-negative diplococci because they form pairs and their adjacent ends are flattened that is why they are also described to have a coffee-bean or kidney-bean shape.

    • This question is part of the following fields:

      • Microbiology
      • Principles Of Microbiology
      20.5
      Seconds
  • Question 9 - Which of the following is NOT an adverse effect associated with statin therapy:...

    Incorrect

    • Which of the following is NOT an adverse effect associated with statin therapy:

      Your Answer: Interstitial lung disease

      Correct Answer: Aplastic anaemia

      Explanation:

      Adverse effects of statins include:, Headache, Epistaxis, Gastrointestinal disorders (such as constipation, flatulence, dyspepsia, nausea, and diarrhoea), Musculoskeletal and connective tissue disorders (such as myalgia, arthralgia, pain in the extremity, muscle spasms, joint swelling, and back pain), Hyperglycaemia and diabetes, Myopathy and rhabdomyolysis, Interstitial lung disease and Hepatotoxicity

    • This question is part of the following fields:

      • Cardiovascular
      • Pharmacology
      17.1
      Seconds
  • Question 10 - A 25-year-old athlete suffers an injury to the nerve that innervates the gluteus...

    Correct

    • A 25-year-old athlete suffers an injury to the nerve that innervates the gluteus minimus muscle.

      Which of the following nerves innervates the gluteus minimus muscle?

      Your Answer: Superior gluteal nerve

      Explanation:

      Gluteus minimus is the smallest muscle of the glutei. It is located just beneath the gluteus medius muscle. Gluteus minimus predominantly acts as a hip stabilizer and abductor of the hip.
      The superior gluteal nerve innervates the gluteus minimus.

    • This question is part of the following fields:

      • Anatomy
      • Lower Limb
      17.4
      Seconds
  • Question 11 - A 18 year old student presents to ED with a headache, fever and...

    Incorrect

    • A 18 year old student presents to ED with a headache, fever and photophobia. You suspect meningitis and agree to observe your junior performing a lumbar puncture. What is the highest safest vertebral level to perform lumbar puncture in adults:

      Your Answer: L2/L3

      Correct Answer: L3/L4

      Explanation:

      In adults, the spinal cord typically ends between L1/L2 whereas the subarachnoid space extends to approximately the lower border of vertebra S2. Lumbar puncture is performed in the intervertebral space L4/L5 or L3/L4.

    • This question is part of the following fields:

      • Anatomy
      • Head And Neck
      9.8
      Seconds
  • Question 12 - Infection with Campylobacter jejuni is one of the most common risk factors for...

    Correct

    • Infection with Campylobacter jejuni is one of the most common risk factors for which of the following conditions?

      Your Answer: Guillain-Barre syndrome

      Explanation:

      One of the most common risk factors for GBS is infection with Campylobacter jejuni, which causes diarrhoea.

      Guillain-Barré syndrome (GBS) is a rare autoimmune disorder in which the body’s immune system attacks the nerves, resulting in muscle weakness and paralysis.

      Infection with Streptococcus pyogenes can cause acute glomerulonephritis and rheumatic fever.

      Haemolytic uraemic syndrome is commonly linked to E. coli infection.

      Following measles infection, subacute sclerosing panencephalitis develops.

    • This question is part of the following fields:

      • Microbiology
      • Pathogens
      25.8
      Seconds
  • Question 13 - Which of these is an example of ordinal data? ...

    Incorrect

    • Which of these is an example of ordinal data?

      Your Answer: Marital status

      Correct Answer: Disease staging system

      Explanation:

      Categorical data or data that is ordered is Ordinal data e.g. disease staging system, pain scoring system.

      Disease staging system is the correct answer

    • This question is part of the following fields:

      • Evidence Based Medicine
      • Statistics
      7.6
      Seconds
  • Question 14 - Which of these increases osteoclast activity? ...

    Correct

    • Which of these increases osteoclast activity?

      Your Answer: Parathyroid hormone

      Explanation:

      Osteoclasts are bone cell that break down bone tissue.

      Parathyroid hormone increases osteoclastic activity.

      1,25-dihydroxycholecalciferol increases osteoclastic activity

      Calcitonin inhibits osteoclastic activity

      Bisphosphonates are osteoclast inhibitors.

    • This question is part of the following fields:

      • Endocrine Physiology
      • Physiology
      5
      Seconds
  • Question 15 - A 35-year-old man is feeling unwell following his return from a business trip....

    Correct

    • A 35-year-old man is feeling unwell following his return from a business trip. He is diagnosed with a vector transmitted disease.

      Which of these organisms is commonly spread by vector-borne transmission?

      Your Answer: Borrelia burgdorferi

      Explanation:

      Borrelia burgdorferiis, primarily spread by ticks and lice, is a zoonotic, vector-borne organism that causes Lyme disease.

      Neisseria meningitidis and Bordetella pertussis are droplet borne infections (airborne particle > 5 µm)

      Vibrio cholerae and Ascaris lumbricoides are spread by the faeco-oral route

    • This question is part of the following fields:

      • Microbiology
      • Principles Of Microbiology
      27.7
      Seconds
  • Question 16 - A 52-year-old female visits the Emergency Department complaining of an acute worsening of...

    Incorrect

    • A 52-year-old female visits the Emergency Department complaining of an acute worsening of her asthma symptoms. A detailed history reveals that she took one of her brother's heart pills without a prescription as she was experiencing palpitations and thought it would cure her. Her shortness of breath was suddenly exacerbated after ingesting this medicine.

      Which one of the following medications has this woman most likely consumed?

      Your Answer: Bisoprolol

      Correct Answer: Propranolol

      Explanation:

      Propranolol, like other non-selective beta-blockers, is contraindicated in patients with asthma. These drugs can cause acute bronchospasm, therefore worsening symptoms, especially in high doses. However, there has been some recent evidence that long-term use of selective beta-blockers in mild or moderate asthma patients can be safe.

    • This question is part of the following fields:

      • Cardiovascular Pharmacology
      • Pharmacology
      36.9
      Seconds
  • Question 17 - Cardiac myocytes are connected to each other by which of the following: ...

    Correct

    • Cardiac myocytes are connected to each other by which of the following:

      Your Answer: Intercalated discs

      Explanation:

      Adjacent cardiac myocytes are connected to each other by intercalated discs. The intercalated discs provide both a structural attachment by ‘glueing’ cells together at desmosomes and an electrical contact made up of proteins called connexons, called a gap junction, which essentially creates a low-resistance pathway between cells.

    • This question is part of the following fields:

      • Cardiovascular
      • Physiology
      9.4
      Seconds
  • Question 18 - You've been asked to visit a 20-year-old patient  who has been complaining of stomach pain,...

    Correct

    • You've been asked to visit a 20-year-old patient  who has been complaining of stomach pain, diarrhoea, and bloating. The  GP recently saw the patient and is now looking into numerous possible reasons for stomach hypermotility.

      Which of the following factors contributes to increased stomach motility?

      Your Answer: Gastrin

      Explanation:

      Gastrin is a peptide hormone that aids in gastric motility by stimulating the generation of gastric acid by the parietal cells of the stomach. G-cells in the stomach’s pyloric antrum, the duodenum, and the pancreas release it.

      The following stimuli cause the release of gastrin:

      Stimulation of the vagus nerve
      Hypercalcaemia
      stomach bloating
      Proteins that have been partially digested, particularly amino acids.
      The presence of acid and somatostatin inhibits the release of gastrin.
      Gastrin’s main actions are as follows:
      Gastric parietal cells are stimulated to release hydrochloric acid.
      ECL cells are stimulated to produce histamine.
      Gastric parietal cell maturation and fundal growth stimulation
      Causes the secretion of pepsinogen by the gastric chief cells.
      Improves antral muscle mobility
      stimulates gastric contractions
      Increases gastric emptying rate and stimulates pancreatic secretion
      Gallbladder emptying is induced.

    • This question is part of the following fields:

      • Gastrointestinal Physiology
      • Physiology
      24.9
      Seconds
  • Question 19 - Regarding haemophilia A, which of the following statements is INCORRECT: ...

    Incorrect

    • Regarding haemophilia A, which of the following statements is INCORRECT:

      Your Answer: Haemophilia A is caused by a deficiency of factor VIII.

      Correct Answer: In haemophilia both the APTT and PT are prolonged.

      Explanation:

      Haemophilia A is the most common of the hereditary clotting factor deficiencies. The inheritance is sex-linked but up to one-third of patients have no family history and these cases result from recent mutation. The vast majority of cases are inherited in an X-linked recessive fashion, affecting males born to carrier mothers. Females born to affected fathers can also, rarely, be affected due to homozygosity for the gene, where there is marriage to close relatives.

      The defect is an absence or low level of plasma factor VIII. The APTT is prolonged but the PT is normal. Recurrent painful haemarthroses and muscle haematomas dominate the clinical course of severely affected patients and if inadequately treated, lead to progressive joint deformity and disability. Local pressure can cause entrapment neuropathy or ischaemic necrosis. Prolonged bleeding occurs after dental extractions or post-trauma. Spontaneous haematuria and gastrointestinal haemorrhage may occur. The clinical severity of the disease correlates inversely with the factor VIII level. Operative and post-traumatic haemorrhage are life-threatening both in severely and mildly affected patients.

    • This question is part of the following fields:

      • Haematology
      • Pathology
      17.4
      Seconds
  • Question 20 - A patient with diplopia is found to have eye deviation downwards and outwards....

    Correct

    • A patient with diplopia is found to have eye deviation downwards and outwards. The likely nerves that are affected are:

      Your Answer: Oculomotor nerve

      Explanation:

      The results of an oculomotor (CN III) nerve palsy are a depressed and abducted (down and out) eye, ptosis, diplopia, and a fixed and dilated pupil.

    • This question is part of the following fields:

      • Anatomy
      • Cranial Nerve Lesions
      7.7
      Seconds
  • Question 21 - Regarding acute myeloid leukaemia (AML), which of the following statements is CORRECT: ...

    Incorrect

    • Regarding acute myeloid leukaemia (AML), which of the following statements is CORRECT:

      Your Answer: AML is classically associated with the Philadelphia chromosome.

      Correct Answer: AML becomes increasingly common with age.

      Explanation:

      Acute myeloid leukaemia (AML) is the most common form of acute leukaemia in adults and becomes increasingly common with age, with a median onset of 65 years. It forms only a minor fraction (10 – 15%) of childhood leukaemia. The clinical features of AML typically presents with clinical features secondary to leukaemic infiltration of bone marrow and extramedullary sites:
      Anaemia (lethargy, pallor and breathlessness)
      Thrombocytopaenia (petechiae, bruising, epistaxis, haemorrhage) – often profound
      Neutropenia (infections)
      Hepatosplenomegaly
      Gingival infiltration
      Central nervous system involvement in AML is uncommon.
      Leukaemia cutis is the infiltration of neoplastic leukocytes in the skin. It occurs in approximately 10% of patients with AML.Haematological investigations reveal a normochromic normocytic anaemia with thrombocytopenia in most cases. The total white cell count is usually increased and blood film examination typically shows a variable number of blast cells. The bone marrow is hypercellular and typically contains many blast cells.. The prognosis for patients with AML has been improving steadily, particularly for those under 60 years of age, and approximately one-third of patients of this group can expect to achieve long-term cure. For the elderly, the situation is poor and less than 10% of those over 70 years of age achieve long-term remission.
      CML is commonly associated with the Philadelphia chromosome. The Philadelphia chromosome is present in only 1% of adults AML cases.
      Lymphadenopathy is rare in AML.

    • This question is part of the following fields:

      • Haematology
      • Pathology
      27.3
      Seconds
  • Question 22 - Dysuria and urinary frequency are symptoms of a 29-year-old woman. A urine dipstick...

    Incorrect

    • Dysuria and urinary frequency are symptoms of a 29-year-old woman. A urine dipstick is used to detect the presence of blood, protein, leucocytes, and nitrites in the urine. You diagnose a urinary tract infection and give antibiotics to the patient.

      In the United Kingdom, which of the following antibiotics has the highest percentage of E.coli resistance?

      Your Answer: Ciprofloxacin

      Correct Answer: Trimethoprim

      Explanation:

      In the United Kingdom, antibiotic resistance is becoming a significant factor in the treatment of urinary tract infections and pyelonephritis. E. coli (the main causative organism of both urinary tract infections and acute pyelonephritis) resistance to the following antibiotics in laboratory-processed urine specimens is:
      30.3 percent trimethoprim (varies by area from 27.1 to 33.4 percent )
      19.8 percent co-amoxiclav (varies by area from 10.8 to 30.7 percent )
      Ciprofloxacin (Cipro): 10.6% (varies by area from 7.8 to 13.7 percent )
      Cefalexin has a concentration of 9.9%. (varies by area from 8.1 to 11.4 percent )

    • This question is part of the following fields:

      • Infections
      • Pharmacology
      19.6
      Seconds
  • Question 23 - A 30-year-old patient has a mild exacerbation of his asthma. His steroid inhaler...

    Correct

    • A 30-year-old patient has a mild exacerbation of his asthma. His steroid inhaler ran out a couple of weeks ago, and he has not replaced it.

      Which of these statements describes the mechanism of action of corticosteroids in asthma?

      Your Answer: Reduction of bronchial inflammation

      Explanation:

      Inhaled corticosteroids suppresses airway inflammation seen in asthma by downregulating pro-inflammatory proteins.
      They also appear to reverse components of asthma-induced structural changes (airway remodelling), including increased vascularity of the bronchial wall.
      Corticosteroids reduces the number of inflammatory cells (eosinophils, T lymphocytes, mast cells, and dendritic cells) in the airways.

    • This question is part of the following fields:

      • Pharmacology
      • Respiratory Pharmacology
      20.1
      Seconds
  • Question 24 - Which of the following is NOT a typical feature of a lesion to...

    Correct

    • Which of the following is NOT a typical feature of a lesion to the vestibulocochlear nerve:

      Your Answer: Hyperacusis

      Explanation:

      Hyperacusis is increased acuity of hearing with hypersensitivity to low tones resulting from paralysis of the stapedius muscle, innervated by the facial nerve. General sensation to the face and to the anterior two-thirds of the tongue is carried by the divisions of the trigeminal nerve (although taste to the anterior two-thirds of the tongue is supplied by the facial nerve). Eye movements are mediated by the oculomotor, trochlear and abducens nerve. Ptosis results from paralysis of the levator palpebrae superioris, innervated by the oculomotor nerve, or the superior tarsal muscle, innervated by the sympathetic chain.

    • This question is part of the following fields:

      • Anatomy
      • Cranial Nerve Lesions
      17.8
      Seconds
  • Question 25 - In inserting a nasogastric tube, which area is least likely to be a...

    Correct

    • In inserting a nasogastric tube, which area is least likely to be a site of resistance when the tube goes from the nose to the stomach?

      Your Answer: In the posterior mediastinum where the oesophagus is crossed by the pulmonary trunk

      Explanation:

      In the posterior mediastinum where the oesophagus is crossed by the pulmonary trunk offers the least resistance when nasogastric tube is inserted from the nose to the stomach.

    • This question is part of the following fields:

      • Anatomy
      • Thorax
      14.8
      Seconds
  • Question 26 - Noradrenaline exhibits its positive inotropic effect by which of the following mechanisms: ...

    Correct

    • Noradrenaline exhibits its positive inotropic effect by which of the following mechanisms:

      Your Answer: Binds to beta1-receptors and causes increased Ca2+ entry via L-type channels during the action potential

      Explanation:

      Noradrenaline (the sympathetic neurotransmitter) is a positive inotrope; it binds to β1-adrenoceptors on the membrane and causes increased Ca2+entry via L-type channels during the AP and thus increases Ca2+release from the SR. Noradrenaline also increases Ca2+sequestration into the SR and thus more Ca2+is available for the next contraction. Cardiac glycosides (e.g. digoxin) slow the removal of Ca2+from the cell by inhibiting the membrane Na+pump which generates the Na+gradient required for driving the export of Ca2+; consequently the removal of Ca2+from the myocyte is slowed and more Ca2+is available for the next contraction. Acidosis is negatively inotropic, largely because H+competes for Ca2+binding sites.

    • This question is part of the following fields:

      • Cardiovascular
      • Physiology
      38.9
      Seconds
  • Question 27 - Which of the following is an action of glucagon: ...

    Correct

    • Which of the following is an action of glucagon:

      Your Answer: Stimulates glycogenolysis

      Explanation:

      Glucagon is a peptide hormone that is produced and secreted by alpha cells of the islets of Langerhans, which are located in the endocrine portion of the pancreas. The main physiological role of glucagon is to stimulate hepatic glucose output, thereby leading to increases in glycaemia. It provides the major counter-regulatory mechanism to insulin in maintaining glucose homeostasis.
      Hypoglycaemia is the principal stimulus for the secretion of glucagon but may also be used as an antidote in beta-blocker overdose and in anaphylaxis in patients on beta-blockers that fail to respond to adrenaline.
      Glucagon then causes:
      Glycogenolysis
      Gluconeogenesis
      Lipolysis in adipose tissue
      The secretion of glucagon is also stimulated by:
      Adrenaline
      Cholecystokinin
      Arginine
      Alanine
      Acetylcholine
      The secretion of glucagon is inhibited by:
      Insulin
      Somatostatin
      Increased free fatty acids
      Increased urea production

      Glycolysis is the metabolic pathway that converts glucose into pyruvate. The free energy released by this process is used to form ATP and NADH. Glycolysis is inhibited by glucagon, and glycolysis and gluconeogenesis are reciprocally regulated so that when one cell pathway is activated, the other is inactive and vice versa.

      Glucagon has a minor effect of enhancing lipolysis in adipose tissue. Lipolysis is the breakdown of lipids and involves the hydrolysis of triglycerides into glycerol and free fatty acids. It makes fatty acids available for oxidation.

    • This question is part of the following fields:

      • Endocrine
      • Pharmacology
      16.9
      Seconds
  • Question 28 - Regarding cross-sectional studies, which of the following statements is CORRECT: ...

    Correct

    • Regarding cross-sectional studies, which of the following statements is CORRECT:

      Your Answer: They are particularly suitable for estimating point prevalence.

      Explanation:

      Cross-sectional studies aim to provide data about population health, normal ranges of biological parameters, and disease prevalence or severity by observing the entire population, or a representative subset, at a single point in time. Cross-sectional studies are relatively simple and quick to perform and can be used to study multiple outcomes, but are subject to confounding and recall bias and are not suitable for studying rare diseases. Cross-sectional studies cannot be used to assess causation or to consider trends over time.

    • This question is part of the following fields:

      • Evidence Based Medicine
      • Study Methodology
      2.9
      Seconds
  • Question 29 - Which of the following medications can block the effect of adrenaline? ...

    Correct

    • Which of the following medications can block the effect of adrenaline?

      Your Answer: Beta-blockers

      Explanation:

      Beta-blockers may reduce the response to adrenaline in the treatment of anaphylactic reactions.

      Noncardioselective beta-blockers in particular can antagonize the broncho dilating and cardio stimulatory effects of adrenaline by blocking beta-2 adrenergic receptors in the smooth muscles of the bronchial tree and in the heart muscles.

    • This question is part of the following fields:

      • Pharmacology
      • Respiratory
      26.7
      Seconds
  • Question 30 - A patient presents with a lump for a dermatological examination. There is a...

    Incorrect

    • A patient presents with a lump for a dermatological examination. There is a circumscribed skin elevation measuring 0.3 cm in diameter seen on examination.

      Which one of these best describes the lump you have found on examination?

      Your Answer: Nodule

      Correct Answer: Papule

      Explanation:

      A papule is a solid, well circumscribed, skin elevation measuring less than 0.5 cm in diameter.

      A nodule is a solid, well circumscribed, raised area that lies in or under the skin and measures greater than 0.5 cm in diameter. They are usually painless.

      A bulla is a visible collection of clear fluid measuring greater than 0.5 cm in diameter.

      A furuncle, or boil, is a pyogenic infection of the hair follicle commonly caused by infection with Staphylococcus aureus.

      A pustule is a small visible skin elevation containing an accumulation of pus.

    • This question is part of the following fields:

      • General Pathology
      • Pathology
      30.9
      Seconds

SESSION STATS - PERFORMANCE PER SPECIALTY

Gastrointestinal (0/1) 0%
Physiology (5/6) 83%
Anatomy (7/8) 88%
Upper Limb (2/2) 100%
Endocrine (2/2) 100%
Lower Limb (2/2) 100%
Haematology (0/3) 0%
Pathology (0/4) 0%
Microbiology (2/4) 50%
Specific Pathogen Groups (0/1) 0%
Principles Of Microbiology (1/2) 50%
Cardiovascular (2/3) 67%
Pharmacology (3/6) 50%
Head And Neck (0/1) 0%
Pathogens (1/1) 100%
Evidence Based Medicine (1/2) 50%
Statistics (0/1) 0%
Endocrine Physiology (1/1) 100%
Cardiovascular Pharmacology (0/1) 0%
Gastrointestinal Physiology (1/1) 100%
Cranial Nerve Lesions (2/2) 100%
Infections (0/1) 0%
Respiratory Pharmacology (1/1) 100%
Thorax (1/1) 100%
Study Methodology (1/1) 100%
Respiratory (1/1) 100%
General Pathology (0/1) 0%
Passmed