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  • Question 1 - What occurs during cellular atrophy? ...

    Correct

    • What occurs during cellular atrophy?

      Your Answer: Cell size decreases

      Explanation:

      Atrophy is the decrease in the size of cells, tissues, or organs. There are several causes including inadequate nutrition, poor circulation, loss of hormonal support or nerve supply, disuse, lack of exercise, or disease. An increase in cell size is termed hypertrophy which is distinguished from hyperplasia, in which the cells remain approximately the same size but increase in number.

    • This question is part of the following fields:

      • Cell Injury & Wound Healing; Urology
      • Pathology
      24.2
      Seconds
  • Question 2 - The stomach is an organ that is divided into several important anatomical parts....

    Correct

    • The stomach is an organ that is divided into several important anatomical parts. These parts of the stomach have varied arterial blood supply that ensure that the whole organ receive oxygenated blood. Which of the following arteries if ligated, will not render any portion of the stomach ischaemic?

      Your Answer: Superior mesenteric

      Explanation:

      The blood supply to the stomach is through the following arteries:

      – The superior mesenteric artery supplies blood to the lower part of the duodenum, pancreas and two-thirds of the transverse colon. Thus ligation of the superior mesenteric artery would not affect the stomach.

      – The right and the left gastroepiploic arteries supply the greater curvature of the stomach – along its edges.

      – The short gastric artery supplies blood to the upper portion of the of the greater curvature and the fundus of the stomach.

      – The gastroduodenal artery supplies blood to the distal part of the stomach (the pyloric sphincter) and the proximal end of the duodenum.

      – The left gastroepiploic and the short gastric are branches of the splenic artery and therefore ligation of the splenic artery would directly affect the stomach.

    • This question is part of the following fields:

      • Abdomen
      • Anatomy
      23.1
      Seconds
  • Question 3 - Two boys were playing when one of them brought the forearm of the...

    Incorrect

    • Two boys were playing when one of them brought the forearm of the other behind his back. This resulted in a stretching of the lateral rotator of the arm. Which of the following muscles was most likely to have been involved?

      Your Answer: Latissimus dorsi

      Correct Answer: Infraspinatus

      Explanation:

      There are two lateral rotators of the arm, the infraspinatus and the teres minor muscles. The infraspinatus muscle receives nerve supply from C5 and C6 via the suprascapular nerve, whilst the teres minor is supplied by C5 via the axillary nerve.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      34.5
      Seconds
  • Question 4 - You are asked to help a junior medical student studying anatomy to identify...

    Correct

    • You are asked to help a junior medical student studying anatomy to identify the left lung. Which of the following features found only in the left lung will you use the identify it?

      Your Answer: Cardiac notch

      Explanation:

      Oblique fissure: is found on both the left and the right lungs. It separates the upper from the lower lobes in both lungs and the middle lobe from the lower lobe in the right lung(which has three lobes.)

      The superior lobar bronchus is found in both lungs.

      Cardiac notch: found only on the left lung.

      Horizontal fissure: a deep groove separating the middle lobe from the upper lobe of the right lung is absent on the left lung.

      Diaphragmatic surface: refers to the part of the lung, both the left and the right, that is in contact with the diaphragm.

    • This question is part of the following fields:

      • Anatomy
      • Thorax
      9.5
      Seconds
  • Question 5 - A 13 year old girl presented with signs of shortness of breath, chest...

    Correct

    • A 13 year old girl presented with signs of shortness of breath, chest pain, non-productive cough, oedema of the lower extremities and cyanosis of the fingertips. She has a history of a ventricular septal defect not surgically corrected. The most probable cause of these symptoms is:

      Your Answer: Shunt reversal

      Explanation:

      A ventricular septal defect (VSD) is a common form of congenital heart defects and is characterised by the presence of a hole in the wall that separates the right from the left ventricle. Medium or large defects can cause many complications. One of these complication is Eisenmenger syndrome, characterised by reversal of the shunt (from left-to-right shunt into a right-to-left) ,cyanosis and pulmonary hypertension.

    • This question is part of the following fields:

      • Cardiovascular
      • Pathology
      19.3
      Seconds
  • Question 6 - Which one of the following groups of lymph nodes is most likely to...

    Correct

    • Which one of the following groups of lymph nodes is most likely to be inflamed due to paronychia involving the big toe?

      Your Answer: Vertical group of superficial inguinal lymph nodes

      Explanation:

      Paronychia affecting the big toe will result in inflammation of the superficial inguinal lymph nodes as it drains lymph from the big toe.

    • This question is part of the following fields:

      • Anatomy
      • Lower Limb
      5.9
      Seconds
  • Question 7 - Which structure holds the duodenojejunal flexure in place? ...

    Correct

    • Which structure holds the duodenojejunal flexure in place?

      Your Answer: Suspensory ligament (of Treitz)

      Explanation:

      The duodenum is connected to the diaphragm by the suspensory ligament called the ligament of Treitz. It is a slip of skeletal muscle from the right crus of the diaphragm and a fibromuscular band of smooth muscle from the 3rd and 4th parts of the duodenum. It is an important landmark, used to divide the gastrointestinal tract into the upper and lower parts. Contraction of this ‘ligament’ leads to opening of the duodenojejunal flexure allowing the flow of chyme.

    • This question is part of the following fields:

      • Abdomen
      • Anatomy
      4.6
      Seconds
  • Question 8 - Which of the following muscles attach to the hyoid bone? ...

    Incorrect

    • Which of the following muscles attach to the hyoid bone?

      Your Answer: Inferior pharyngeal constrictor

      Correct Answer: Middle pharyngeal constrictor

      Explanation:

      The hyoid bone is a horseshoe-shaped bone situated in the anterior midline of the neck between the chin and the thyroid cartilage. A large number of muscles attach to the hyoid: Superiorly – the middle pharyngeal constrictor muscle, hyoglossus muscle, genioglossus, intrinsic muscles of the tongue and suprahyoid muscles. Inferiorly – the thyrohyoid muscle, omohyoid muscle and sternohyoid muscle.

    • This question is part of the following fields:

      • Anatomy
      • Head & Neck
      13.1
      Seconds
  • Question 9 - Which of the cranial nerves is responsible for touch sensation on the skin...

    Correct

    • Which of the cranial nerves is responsible for touch sensation on the skin over the maxilla region and the mandible?

      Your Answer: Trigeminal

      Explanation:

      The sensation of the face is provided by the trigeminal nerve which is cranial nerve V. It is also responsible for other motor functions such as biting and chewing. The trigeminal nerve has three branches; the ophthalmic nerve (V1), the maxillary nerve((V2) and the mandibular nerve (V3). These three branches exit the skull through separate foramina, namely; the superior orbital fissure, the foramen rotundum and the foramen ovale respectively. The mnemonic for this is ‘Standing room only’. The sensory fibres of the maxillary nerve are distributed to the lower eyelid and cheek, the nares and upper lip, the upper teeth and gums, the nasal mucosa, the palate and roof of the pharynx, the maxillary, ethmoid and sphenoid sinuses, and parts of the meninges. The sensory fibres of the mandibular nerve are distributed to the lower lip, the lower teeth and gums, the floor of the mouth, the anterior two-thirds of the tongue, the chin and jaw (except the angle of the jaw, which is supplied by C2–C3), parts of the external ear, and parts of the meninges. The mandibular nerve carries touch/ position and pain/temperature sensation from the mouth. The sensory fibres of the ophthalmic nerve are distributed to the scalp and forehead, the upper eyelid, the conjunctiva and cornea of the eye, the nose (including the tip of the nose), the nasal mucosa, the frontal sinuses and parts of the meninges (the dura and blood vessels). The sensory fibres of the maxillary nerve are distributed to the lower eyelid and cheek, the nares and upper lip, the upper teeth and gums, the nasal mucosa, the palate and roof of the pharynx, the maxillary, ethmoid and sphenoid sinuses, and parts of the meninges.

    • This question is part of the following fields:

      • Anatomy
      • Head & Neck
      14.6
      Seconds
  • Question 10 - Which tumour marker is associated with medullary carcinoma of thyroid? ...

    Correct

    • Which tumour marker is associated with medullary carcinoma of thyroid?

      Your Answer: Calcitonin

      Explanation:

      Medullary carcinoma of thyroid accounts for 3% of thyroid cancers. It arises from the parafollicular cells (C cells) of the thyroid gland that produce calcitonin. It is often familial and caused by mutation of ret proto-oncogene, but can occasionally be sporadic. The familial cases can also occur as part of MEN syndromes IIA and IIB. The high calcitonin leads to down-regulation of the receptors, which does not affect the calcium levels significantly. Medullary carcinoma of thyroid shows characteristic amyloid deposits that stain positively with Congo red. The initial presentation consists of an asymptomatic thyroid nodule. Many cases are diagnosed due to routine screening of relatives of patients with MEN IIA and IIB. Medullary carcinoma can also cause ectopic production of other hormones/peptides such as adrenocorticotrophic hormone, vasoactive intestinal polypeptide, kallikreins and serotonin.

      Metastasis from medullary carcinoma spread via the lymphatics to cervical and mediastinal nodes, and can also affect the liver, lungs and bone. Diagnosis is by raised serum calcitonin levels. A provocative test with calcium (15 mg/kg intravenously over 4 hours) also aids in diagnosis by leading to excessive secretion of calcitonin. X-ray might also show dense, conglomerate calcification.

      CA-125 is frequently elevated in ovarian carcinomas. CA 15-3 is often associated with breast carcinomas. Alpha-fetoprotein is seen raised in hepatomas and gonadal tumours. Elevated HCG is associated with normal pregnancies, gonadal tumours, and choriocarcinomas. Thyroglobulin is used for surveillance in papillary carcinoma of thyroid. CA 19-9 is used in the management of pancreatic cancer.

    • This question is part of the following fields:

      • Endocrine
      • Pathology
      4
      Seconds
  • Question 11 - During a laparoscopic surgery, the surgeon visualizes the medical umbilical folds on the...

    Correct

    • During a laparoscopic surgery, the surgeon visualizes the medical umbilical folds on the deep surface of the anterior abdominal wall. What causes the medial umbilical folds?

      Your Answer: Obliterated umbilical arteries

      Explanation:

      The medial umbilical ligament is a structure found on the deep surface of the anterior abdominal wall and is covered by the medial umbilical folds. It is a paired structure that represents the remnants of the fetal umbilical artery. They have no role in humans after birth other than to be used as a landmark for exploring the medial inguinal fossa during laparoscopic inguinal hernia repair.

    • This question is part of the following fields:

      • Abdomen
      • Anatomy
      13.8
      Seconds
  • Question 12 - A 14-year old girl presented with a 2cm, mobile, cystic mass in the...

    Correct

    • A 14-year old girl presented with a 2cm, mobile, cystic mass in the midline of her neck. Fine needle aspiration of the mass revealed clear fluid. This is most likely a case of:

      Your Answer: Thyroglossal duct cyst

      Explanation:

      Thyroglossal cyst is the most common congenital thyroid anomaly which is clinically significant and affects women more than men. It is a vestigial remnant of developing thyroid. Although the thyroglossal cyst can develop anywhere along the thyroglossal duct, the most common site is in the midline between the isthmus of thyroid and hyoid bone, or just above the hyoid. Thyroglossal cysts are also associated with ectopic thyroid tissue. Clinically, the cyst moves upward with protrusion of the tongue. Rarely, the persistent duct can become malignant (thyroglossal duct carcinoma) where the cancerous cells arise in the ectopic thyroid tissue that are deposited along the duct. Exposure to radiation is a predisposing factor.

    • This question is part of the following fields:

      • Endocrine
      • Pathology
      5.5
      Seconds
  • Question 13 - A 30-year-old female was alarmed when she started to experience hair loss and...

    Incorrect

    • A 30-year-old female was alarmed when she started to experience hair loss and balding, however, she also noted increased hair on her face and body and developed an acne breakout. Deepening of her voice also became prominent. She was referred to an oncologist and was diagnosed with a hormone-producing tumour. What is the most likely diagnosis ?

      Your Answer: Nephroblastoma

      Correct Answer: Arrhenoblastoma

      Explanation:

      Arrhenoblastoma, known as ‘Sertoli–Leydig tumour’ is a rare ovarian stromal neoplasm that secretes testosterone. It is mostly seen in women in the reproductive years. The key clinical features of this tumour is due to excessive production of testosterone which leads to progressive masculinisation in a woman who was typical normal beforehand. The lesion tends to grow slowly and rarely metastasises. Treatment is surgical removal of the tumour and the prognosis is generally good.

    • This question is part of the following fields:

      • Neoplasia
      • Pathology
      151.2
      Seconds
  • Question 14 - A 29-year-old woman presents to the doctor complaining of cough, shortness of breath,...

    Correct

    • A 29-year-old woman presents to the doctor complaining of cough, shortness of breath, fever and weight loss. Chest X-ray revealed bilateral hilar and mediastinal lymph node enlargement and bilateral pulmonary opacities. Non-caseating granulomas were found on histological examination. The most likely diagnosis is:

      Your Answer: Sarcoidosis

      Explanation:

      Sarcoidosis is an inflammatory disease of unknown aetiology that affects multiple organs but predominantly the lungs and intrathoracic lymph nodes. Systemic and pulmonary symptoms may both be present. Pulmonary involvement is confirmed by a chest X-ray and other imaging studies. The main histological finding is the presence of non-caseating granulomas.

    • This question is part of the following fields:

      • Pathology
      • Respiratory
      3334.5
      Seconds
  • Question 15 - With respect to far accommodation, which of the following is a TRUE statement?...

    Incorrect

    • With respect to far accommodation, which of the following is a TRUE statement?

      Your Answer: The zonular fibres are relaxed

      Correct Answer: The ciliary muscles are relaxed

      Explanation:

      Myopia or near-sightedness is a disease due to elongated eyeballs or too strong a lens. For far accommodation (focus of a distant object onto the retina), the lens needs to decrease its refractive power, or in other words, increase its focal length. This is done by relaxation of ciliary muscles which tightens the zonular fibres and flattening of the lens. Relaxation of the zonular fibres, rounding of the lens, shortening of the focal length and constriction of the pupil occurs during near accommodation.

    • This question is part of the following fields:

      • Neurology
      • Physiology
      12.2
      Seconds
  • Question 16 - A 53 year old women with a history of atrial fibrillation developed an...

    Correct

    • A 53 year old women with a history of atrial fibrillation developed an acute abdomen. On laparoscopic examination her bowels appeared to be dusky to red-purple in colour and her mesenteric veins appeared to be patent. Which of the following is most likely to occur in this situation?

      Your Answer: Wet gangrene

      Explanation:

      Infarction of the small bowel following a sudden and complete occlusion of the mesenteric artery can involve any portion of the bowel, whether small or a large. The splenic flexure is at most risk for infarction as it is the watershed area between the superior and inferior mesenteric vessels. Regardless of whether the arterial or the venous blood vessels are occluded, because of the blood reflow into the damaged portion, it will appear haemorrhagic. The bowel appearing congested at first and then becoming oedematous. If the artery is occluded then there will be a clear cut demarcation and in venous occlusion the dusky colour fades with the rest of the normal bowel. Wet gangrene is characteristic of ischaemic injury to the gut.

    • This question is part of the following fields:

      • Cell Injury & Wound Healing; Gastrointestinal
      • Pathology
      17.6
      Seconds
  • Question 17 - After a cerebral infarction, which of these histopathogical findings is most likely to...

    Correct

    • After a cerebral infarction, which of these histopathogical findings is most likely to be found?

      Your Answer: Liquefactive necrosis

      Explanation:

      The brain has a high lipid content and typically undergoes liquefaction with ischaemic injury, because it contains little connective tissue but high amounts of digestive enzymes.

    • This question is part of the following fields:

      • Neurology
      • Pathology
      12.1
      Seconds
  • Question 18 - When inserting a chest drain anteriorly into the second intercostal space, one must...

    Correct

    • When inserting a chest drain anteriorly into the second intercostal space, one must identify the second costal cartilage by palpating which landmark?

      Your Answer: Sternal angle

      Explanation:

      The sternal angle is the site for identification of the second rib as the second rib is attached to the sternum at this point.

    • This question is part of the following fields:

      • Anatomy
      • Thorax
      12.6
      Seconds
  • Question 19 - A 55-year-old woman complains of pain in the proximal and distal interphalangeal joins,...

    Correct

    • A 55-year-old woman complains of pain in the proximal and distal interphalangeal joins, and back pain which has increased over the last 4 years and worsens after activity. X-rays reveal Heberden’s and Bouchard’s nodes in her interphalangeal joints and the presence of osteophytes in her spine. What is the most likely diagnosis?

      Your Answer: Osteoarthritis

      Explanation:

      Osteoarthritis is most common in older adults, predominating in women between the ages of 40 and 70; after this age, men and women are affected equally. It affects an entire joint, with disruption and potential loss of joint cartilage, along with other joint changes, including bone hypertrophy (osteophyte formation). The pain is usually gradual and is worse after activity, with occasional joint swelling. X-ray findings include marginal osteophytes, narrowing of the joint space, increased density of the subchondral bone, subchondral cyst formation, bony remodelling and joint effusions.

    • This question is part of the following fields:

      • Orthopaedics
      • Pathology
      40.2
      Seconds
  • Question 20 - The mandibular nerve, which is the largest of the 3 divisions of the...

    Incorrect

    • The mandibular nerve, which is the largest of the 3 divisions of the trigeminal nerve, exits the cranial cavity through which foramen?

      Your Answer: Foramen rotundum

      Correct Answer: Foramen ovale

      Explanation:

      At the base of the skull the foramen ovale is one of the larger of the several holes that transmit nerves through the skull. The following structures pass through foramen ovale: mandibular nerve, motor root of the trigeminal nerve, accessory meningeal artery, lesser petrosal nerve, a branch of the glossopharyngeal nerve, emissary vein connecting the cavernous sinus with the pterygoid plexus of veins and occasionally the anterior trunk of the middle meningeal vein.

    • This question is part of the following fields:

      • Anatomy
      • Head & Neck
      40.9
      Seconds
  • Question 21 - The Brunner glands secrete an alkaline product that helps maintain an optimal pH...

    Correct

    • The Brunner glands secrete an alkaline product that helps maintain an optimal pH for pancreatic enzyme activity. Where are these glands located?

      Your Answer: Submucosa of the duodeneum

      Explanation:

      The Brunner glands are located in the submucosa of the duodenum. These glands are connected to the interstitial lumen by ducts that open into certain crypts. They secrete an alkaline product that protects the duodenal mucosa from the acidic chyme and helps achieve an optimal pH for the enzymes.

    • This question is part of the following fields:

      • Abdomen
      • Anatomy
      3.7
      Seconds
  • Question 22 - After having donated a unit of blood. The blood bank will prefer to...

    Correct

    • After having donated a unit of blood. The blood bank will prefer to use which of the following anticoagulants to store the blood?

      Your Answer: Citrate

      Explanation:

      Calcium is necessary for coagulation to occur. Citrate being a chelator and combining with calcium ions to form un-ionised compound will prevent coagulation. Following transfusion the citrate is removed by the liver with in a few minutes. Oxalate also works on the same principle but it is toxic to the body.

    • This question is part of the following fields:

      • General
      • Physiology
      13
      Seconds
  • Question 23 - The specialist registrar, while performing the repair of an infrarenal abdominal aortic aneurysm,...

    Correct

    • The specialist registrar, while performing the repair of an infrarenal abdominal aortic aneurysm, decides not to re-implant the inferior mesenteric artery into the repaired abdominal aorta. She says that an anastomotic artery running along the border of the large intestine is good enough to supply blood to the territory of the inferior mesenteric artery. Which vessel is she referring to?

      Your Answer: Marginal

      Explanation:

      The marginal artery is a key anastomosis for the large intestine that runs around the border of the large intestine and is formed by the anastomosis of the branches of the ileocolic artery, right colic artery, middle colic artery, left colic artery and sigmoid artery. If a small artery is occluded, these branches allow blood to reach all segments of the colon.

      The arcades are anastomotic loops between the arteries that provide alternative pathways for blood flow. They are more prominent in the small intestine than the large intestine.

      Arteriae rectae are small branches that run from the marginal artery to reach the colon.

      The ileocolic artery is the branch of the superior mesenteric artery that supplies the caecum, appendix and terminal part of the ileum.

      The coronary arteries supply blood to the heart.

    • This question is part of the following fields:

      • Abdomen
      • Anatomy
      99.2
      Seconds
  • Question 24 - A 45 year old lady has been diagnosed with Friedreich's ataxia that has...

    Correct

    • A 45 year old lady has been diagnosed with Friedreich's ataxia that has affected her medial group of nuclei in the anterior horn of the spinal cord. Which of the following structures will have their muscles affected?

      Your Answer: Axial muscles

      Explanation:

      The cells in the anterior horn can be arranged in the following three main groups: medial, lateral and central. The medial group of nuclei in the anterior horn of the spinal cord are located along the entire length of the spinal cord and are responsible for the innervation of the axial muscles of the body ( muscles of the head and neck region). Thus this disease will most likely affect the functioning of the muscles of the head and neck.

    • This question is part of the following fields:

      • Anatomy
      • Neurology
      8.8
      Seconds
  • Question 25 - A 28 years old women presents with a history of chronic cough with...

    Incorrect

    • A 28 years old women presents with a history of chronic cough with fever for the past 2 months. A chest x ray revealed a diffuse bilateral reticulonodular pattern. A transbronchial biopsy was performed and histological examination showed focal areas of inflammation with epithelioid macrophages, Langhans cells and lymphocytes. Which of the immune reaction is responsible for this?

      Your Answer: Type II hypersensitivity

      Correct Answer: Type IV hypersensitivity

      Explanation:

      A reactivated tuberculosis with granuloma formation is characteristic of type IV reaction. It is also called a delayed type of hypersensitivity reaction and takes around 2-8 days to deliver. It is a cell mediated response with the involvement of CD8 and CD4 cells and the release of IL-1 from macrophages that further activate these CD cells.

      Granulomatous reactions are mostly cell-mediated.

      Type I reactions are allergic and anaphylactic reactions and type II are complement-mediated immune reactions.

    • This question is part of the following fields:

      • Inflammation & Immunology; Respiratory
      • Pathology
      20.9
      Seconds
  • Question 26 - The primary motor cortex is located in the: ...

    Incorrect

    • The primary motor cortex is located in the:

      Your Answer: Postcentral gyrus

      Correct Answer: Precentral gyrus

      Explanation:

      The primary motor cortex is located in the dorsal part of the precentral gyrus and the anterior bank of the central sulcus. The precentral gyrus lies anterior to the postcentral gyrus and is separated from it by a central sulcus. Its anterior border is the precentral sulcus, while inferiorly it borders to the lateral fissure (Sylvian fissure).

    • This question is part of the following fields:

      • Neurology
      • Physiology
      14.9
      Seconds
  • Question 27 - A 79-year-old has been bedridden for 2 months after suffering from a stroke....

    Correct

    • A 79-year-old has been bedridden for 2 months after suffering from a stroke. She suddenly developed shortness of breath and chest pain, and was diagnosed with a pulmonary embolism. Which of the following is most likely to increase in this case?

      Your Answer: Ventilation/perfusion ratio

      Explanation:

      Pulmonary embolism (PE) is a blockage of an artery in the lungs by an embolus that has travelled from elsewhere in the body through the bloodstream. The change in cardiopulmonary function is proportional to the extent of the obstruction, which varies with the size and number of emboli obstructing the pulmonary arteries. The resulting physiological changes may include pulmonary hypertension with right ventricular failure and shock, dyspnoea with tachypnoea and hyperventilation, arterial hypoxaemia and pulmonary infarction. Consequent alveolar hyperventilation is manifested by a lowered pa(CO2). After occlusion of the pulmonary artery, areas of the lung are ventilated but not perfused, resulting in wasted ventilation with an increased ventilation/perfusion ratio – the physiological hallmark of PE – contributing to a further hyperventilatory state. The risk of blood clots is increased by cancer, prolonged bed rest, smoking, stroke, certain genetic conditions, oestrogen-based medication, pregnancy, obesity, and post surgery.

    • This question is part of the following fields:

      • Physiology
      • Respiratory
      17.9
      Seconds
  • Question 28 - A 60-year-old male who was admitted due to cerebrovascular disease on his 5th...

    Correct

    • A 60-year-old male who was admitted due to cerebrovascular disease on his 5th hospital stay developed pneumonia. The most likely organism that causes hospital acquired pneumonia is pseudomonas aeruginosa. What is the most likely mechanism for the pathogenesis on pseudomonas infection?

      Your Answer: Exotoxin

      Explanation:

      Pseudomonas aeruginosa is a common Gram-negative, rod-shaped bacterium that can cause disease in plants and animals, including humans. It is citrate, catalase, and oxidase positive. P. aeruginosa uses the virulence factor exotoxin A to inactivate eukaryotic elongation factor 2 via ADP-ribosylation in the host cell, much the same as the diphtheria toxin does. Without elongation factor 2, eukaryotic cells cannot synthesize proteins and necrotise. The release of intracellular contents induces an immunologic response in immunocompetent patients.

    • This question is part of the following fields:

      • Microbiology
      • Pathology
      14.2
      Seconds
  • Question 29 - What principal artery that supplies the meninges is susceptible to rupture following trauma...

    Correct

    • What principal artery that supplies the meninges is susceptible to rupture following trauma to the side of the head over the temporal region:

      Your Answer: Middle meningeal artery

      Explanation:

      The middle meningeal artery normally arises from the first or mandibular segment of the maxillary artery. The artery runs in a groove on the inside of the cranium, this can clearly be seen on a lateral skull X-ray. An injured middle meningeal artery is the most common cause of an epidural hematoma.

    • This question is part of the following fields:

      • Anatomy
      • Head & Neck
      6.8
      Seconds
  • Question 30 - Which of the following is the most likely cause of prolonged thrombin clotting...

    Incorrect

    • Which of the following is the most likely cause of prolonged thrombin clotting time?

      Your Answer: Warfarin therapy

      Correct Answer: Hypofibrinogenemia

      Explanation:

      Thrombin clotting time, also called thrombin time (TT), is test used for the investigation of possible bleeding or clotting disorders. TT reflects the conversion of fibrinogen to fibrin and it’s also very sensitive to the presence of the anticoagulant heparin. A prolonged thrombin time may indicate the presence of hypofibrinogenemia (decreased fibrinogen level ), dysfibrinogenaemia, disseminated intravascular coagulation (DIC), end stage liver disease or malnutrition.

    • This question is part of the following fields:

      • Haematology
      • Pathology
      58.8
      Seconds
  • Question 31 - What is the percentage of bone calcium that is freely exchangeable with the...

    Correct

    • What is the percentage of bone calcium that is freely exchangeable with the extracellular fluid that is available for buffering changes in the calcium ion balance?

      Your Answer: 1%

      Explanation:

      Around 1% of calcium in the body is available for buffering changes in calcium ion balance. These are mainly derived from the bone that are freely exchangeable with extracellular fluid.

    • This question is part of the following fields:

      • Fluids & Electrolytes
      • Pathology
      5
      Seconds
  • Question 32 - A 72-year-old male presents with dysuria and chronic haematuria. He was diagnosed with...

    Incorrect

    • A 72-year-old male presents with dysuria and chronic haematuria. He was diagnosed with bladder cancer and tumour invasion of the perivesical fat. What is the stage of the patient's bladder cancer?

      Your Answer: T2

      Correct Answer: T3

      Explanation:

      Bladder cancer is the growth of abnormal or cancerous cells on the inner lining of the bladder wall. The staging is as follows; stage 0is (Tis, N0, M0): Cancerous cells in the inner lining tissue of the bladder only, stage I (T1, N0, M0): tumour has spread onto the bladder wall, stage II (T2, N0, M0): tumour has penetrated the inner wall and is present in muscle of the bladder wall, stage III (T3, N0, M0): tumour has spread through the bladder to fat around the bladder and stage IV: (T4, N0, M0): tumour has grown through the bladder wall and into the pelvic or abdominal wall. The stage of cancer in the case presented is T3 because of the invasion of perivesical fat.

    • This question is part of the following fields:

      • Neoplasia
      • Pathology
      50.1
      Seconds
  • Question 33 - To reach the oral vestibule, the parotid duct must pierce this muscle: ...

    Incorrect

    • To reach the oral vestibule, the parotid duct must pierce this muscle:

      Your Answer: Masseter muscle

      Correct Answer: Buccinator muscle

      Explanation:

      The parotid duct or Stensen duct is a duct and the route that saliva takes from the major salivary gland, the parotid gland into the mouth. The parotid duct is formed when several interlobular ducts—the largest ducts inside the parotid gland join. It emerges from the gland and runs forward along the lateral side of the masseter muscle. In this course, the duct is surrounded by the buccal fat pad. It takes a steep turn at the border of the masseter and passes through the buccinator muscle, opening into the vestibule of the mouth, between the cheek and the gums, at the parotid papilla, which lies across the second superior molar tooth.

    • This question is part of the following fields:

      • Anatomy
      • Head & Neck
      13.4
      Seconds
  • Question 34 - During a street fight a boy sustained a laceration below the elbow. It...

    Incorrect

    • During a street fight a boy sustained a laceration below the elbow. It was a deep cut that led to profuse bleeding from an artery situated on the supinator muscle immediately below the elbow. The vessel most likely to have been injured is?

      Your Answer: Common interosseous artery

      Correct Answer: Radial recurrent artery

      Explanation:

      The radial recurrent artery is situated on the supinator muscle then passing between the brachialis and the brachioradialis muscles. It originates from the radial artery and ends by anastomosing with the terminal part of the Profunda brachii.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      54.4
      Seconds
  • Question 35 - A 50-year-old woman goes to the doctor complaining of myalgia, muscle cramps, and...

    Correct

    • A 50-year-old woman goes to the doctor complaining of myalgia, muscle cramps, and weakness; she is diagnosed with severe hypokalaemia. Which of the following is the most common cause of hypokalaemia?

      Your Answer: Prolonged vomiting

      Explanation:

      Potassium is one of the body’s major ions. Nearly 98% of the body’s potassium is intracellular. The ratio of intracellular to extracellular potassium is important in determining the cellular membrane potential. Small changes in the extracellular potassium level can have profound effects on the function of the cardiovascular and neuromuscular systems. Hypokalaemia may result from conditions as varied as renal or gastrointestinal (GI) losses, inadequate diet, transcellular shift (movement of potassium from serum into cells) and medications. The important causes of hypokalaemia are:

      Renal losses: renal tubular acidosis, hyperaldosteronism, magnesium depletion, leukaemia (mechanism uncertain).

      GI losses: vomiting or nasogastric suctioning, diarrhoea, enemas or laxative use, ileal loop.

      Medication effects: diuretics (most common cause), β-adrenergic agonists, steroids, theophylline, aminoglycosides.

      Transcellular shift: insulin, alkalosis.

      Severe hypokalaemia, with serum potassium concentrations of 2.5–3 meq/l, may cause muscle weakness, myalgia, tremor, muscle cramps and constipation.

    • This question is part of the following fields:

      • Fluids & Electrolytes
      • Physiology
      41.1
      Seconds
  • Question 36 - A 73-year-old woman goes to the doctor complaining of pain and stiffness in...

    Correct

    • A 73-year-old woman goes to the doctor complaining of pain and stiffness in her shoulders and hips for 4 months, which is worst in the mornings. She has also been suffering from fatigue, weight loss and depression. There were no abnormal findings on physical examination. The erythrocyte sedimentation rate was 110 mm/hour, and serum rheumatoid factor and antinuclear antibody assays were negative. Mild normochromic normocytic anaemia was also found. What is the most likely diagnosis in this case?

      Your Answer: Polymyalgia rheumatica

      Explanation:

      Polymyalgia rheumatica (PMR) affects older adults, with an acute or subacute onset. Symptoms include severe pain and stiffness of the neck and pectoral or pelvic girdles, which is worse in the morning or after a period of inactivity and is usually bilateral. Other symptoms can include fatigue, weight loss, depression and fever. The erythrocyte sedimentation rate is usually elevated, and normochromic normocytic anaemia can occur. Other tests are usually normal in this disease.

    • This question is part of the following fields:

      • Orthopaedics
      • Pathology
      66.6
      Seconds
  • Question 37 - A significantly elevated white cell count of 50 x 109/l with 5% blasts...

    Correct

    • A significantly elevated white cell count of 50 x 109/l with 5% blasts and raised leucocyte alkaline phosphatase is seen in which of the following conditions?

      Your Answer: Leukaemoid reaction

      Explanation:

      Non-neoplastic proliferation of leucocytes causes an increase in leukocyte alkaline phosphatase (LAP). This is referred to as ‘leukemoid reaction’ because of the similarity to leukaemia with an increased white cell count (>50 × 109/l) with immature forms. Causes of leukemoid reaction includes haemorrhage, drugs (glucocorticoids, all-trans retinoic acid etc), infections such as tuberculosis and pertussis, and as a paraneoplastic phenomenon. Leukemoid reaction can also be seen in infancy as a feature of trisomy 21. This is usually a benign condition, but can be a response to a disease state. Differential diagnosis include chronic myelogenous leukaemia (CML).

    • This question is part of the following fields:

      • Haematology
      • Pathology
      14.8
      Seconds
  • Question 38 - The Carpal tunnel does NOT contain: ...

    Correct

    • The Carpal tunnel does NOT contain:

      Your Answer: Flexor carpi ulnaris

      Explanation:

      The contents of the carpal tunnel include:

      – Median nerve

      – Flexor digitorum supervicialis

      – Flexor digitorum profundus

      – Flexor policis longus

      – Flexor carpi radialis

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      14.4
      Seconds
  • Question 39 - Which of the following is the most common germ cell tumour of the...

    Incorrect

    • Which of the following is the most common germ cell tumour of the testis affecting an adult male?

      Your Answer: Teratoma

      Correct Answer: Seminoma

      Explanation:

      Germ cell tumours represent 90% of primary tumours arising in the testis. They are broadly divided into seminomas and non-seminomas. Seminomas are the most common testicular germ cell tumour seen in 40% cases. The other non-seminomatous histological subtypes include embryonal (25%), teratocarcinoma (25%), teratoma (5%) and pure choriocarcinoma (1%).

    • This question is part of the following fields:

      • Pathology
      • Urology
      22.6
      Seconds
  • Question 40 - An organ transplant patient may be at risk of developing which type of...

    Correct

    • An organ transplant patient may be at risk of developing which type of cancer?

      Your Answer: Skin cancer

      Explanation:

      The most common malignancies encountered in the post–solid organ transplant setting are non-melanoma skin cancers, post-transplant lymphoproliferative disorders and Kaposi’s sarcoma (KS). The pathogenesis of these tumours is likely related to the immunosuppressive drugs used post-transplantation and subsequent viral infection.

    • This question is part of the following fields:

      • Neoplasia
      • Pathology
      8.3
      Seconds
  • Question 41 - Which of the following foramina will the ophthalmic artery pass through in order...

    Correct

    • Which of the following foramina will the ophthalmic artery pass through in order to reach the eye?

      Your Answer: Optic canal

      Explanation:

      The optic foramen is the opening to the optic canal. The canal is located in the sphenoid bone; it is bounded medially by the body of the sphenoid and laterally by the lesser wing of the sphenoid. The superior surface of the sphenoid bone is bounded behind by a ridge, which forms the anterior border of a narrow, transverse groove, the chiasmatic groove (optic groove). The groove ends on either side in the optic foramen, which transmits the optic nerve and ophthalmic artery into the orbital cavity. Compared to the optic nerve, the ophthalmic artery is located inferolaterally within the canal.

    • This question is part of the following fields:

      • Anatomy
      • Head & Neck
      17.7
      Seconds
  • Question 42 - A 35 year-old man presents with high grade fever for 7 days after...

    Correct

    • A 35 year-old man presents with high grade fever for 7 days after returning from a trip to India. He tested positive for widal test. What is the most likely organism that caused his fever?

      Your Answer: Salmonella typhi

      Explanation:

      Typhoid fever is caused by virulent bacteria called Salmonella typhi. Salmonella typhi spread through contaminated food or water and occasionally through direct contact with someone who is infected.

    • This question is part of the following fields:

      • Microbiology
      • Pathology
      12.8
      Seconds
  • Question 43 - At which cervical level does the common carotid artery bifurcate into the internal...

    Correct

    • At which cervical level does the common carotid artery bifurcate into the internal and external carotid arteries?

      Your Answer: C4

      Explanation:

      The common carotid arteries are present on the left and right sides of the body. These arteries originate from different sources, but follow symmetrical courses. The right common carotid originates in the neck from the brachiocephalic trunk; the left from the aortic arch in the thorax. These split into the external and internal carotid arteries at the upper border of the thyroid cartilage, at around the level of the fourth cervical vertebra.

    • This question is part of the following fields:

      • Anatomy
      • Head & Neck
      9
      Seconds
  • Question 44 - A 40-year old Caucasian male came to the hospital with complaints of fatigue...

    Correct

    • A 40-year old Caucasian male came to the hospital with complaints of fatigue and lethargy. On examination, he was found to have raised blood pressure. Urine examination showed >300 mg/dl proteinuria (4+) and 24-hour urine protein 3.5g. No glucose, blood, nitrites, urobilinogen or casts were present in urine. What is the most likely diagnosis?

      Your Answer: Membranous glomerulonephritis

      Explanation:

      Membranous glomerulonephritis or nephropathy, is a renal disorder with insidious course and usually affects people aged 30-50 years. 85% cases are primary (or idiopathic). The other 15% are secondary to autoimmune conditions like SLE, infections like malaria or hepatitis B, drugs like captopril and NSAIDs, or malignancies (particularly lung or colonic carcinoma). This disease is caused due to circulating immune complexes which are said to form by binding of antibodies to antigens in glomerular basement membrane. This antigens could be endogenous or derived from systemic circulation. This immune complex triggers the complement system, resulting in formation of membrane attack complex (MAC) on glomerular epithelial cells. This further results in release of proteases and oxidants which damage the capillaries making them ‘leaky’. Moreover, the epithelial cells also secrete a mediator to reduce nephron synthesis and distribution.

    • This question is part of the following fields:

      • Pathology
      • Renal
      28.6
      Seconds
  • Question 45 - The muscle that forms the posterior wall of the axilla along with the...

    Correct

    • The muscle that forms the posterior wall of the axilla along with the scapula, subscapularis muscle and teres major muscle is the?

      Your Answer: Latissimus dorsi

      Explanation:

      The latissimus dorsi forms the posterior wall of the axilla along with the scapula. It is responsible for extension, adduction, transverse extension also known as horizontal abduction, flexion from an extended position, and (medial) internal rotation of the shoulder joint. It also has a synergistic role in extension and lateral flexion of the lumbar spine.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      6
      Seconds
  • Question 46 - A patient who complained of pain on the lower left side of the...

    Correct

    • A patient who complained of pain on the lower left side of the back had an x-ray done which confirmed a hernia passing posterolaterally, just superior to the iliac crest. Where is this hernia passing through?

      Your Answer: Lumbar triangle

      Explanation:

      The lumber triangle is bound medially by the border of the latissimus dorsi, laterally by the external abdominal oblique and by the iliac crest inferiorly. This is exactly where the hernia that is described is located.

    • This question is part of the following fields:

      • Anatomy
      • Lower Limb
      20.3
      Seconds
  • Question 47 - A patient under went repair of a lingual artery aneurysm in the floor...

    Correct

    • A patient under went repair of a lingual artery aneurysm in the floor of the mouth. During surgical dissection from the inside of the mouth which muscle would you have to pass through to reach the main portion of the lingual artery?

      Your Answer: Hyoglossus

      Explanation:

      The lingual artery first runs obliquely upward and medialward to the greater horns of the hyoid bone. It then curves downward and forward, forming a loop which is crossed by the hypoglossal nerve, and passing beneath the digastric muscle and stylohyoid muscle it runs horizontally forward, beneath the hyoglossus, and finally, ascending almost perpendicularly to the tongue, turns forward on its lower surface as far as the tip, to become the deep lingual artery.

    • This question is part of the following fields:

      • Anatomy
      • Head & Neck
      25.7
      Seconds
  • Question 48 - All the following arteries contribute to the blood supply of the hip joint...

    Correct

    • All the following arteries contribute to the blood supply of the hip joint except:

      Your Answer: Pudendal

      Explanation:

      The blood supply to the hip joint is from two main arteries, the medial circumflex femoral and lateral circumflex femoral arteries. These are branches of the deep artery of the thigh, which itself is a branch of the femoral artery. There is contribution of blood supply from the inferior gluteals, foveal and obturator arteries.

    • This question is part of the following fields:

      • Anatomy
      • Lower Limb
      22.5
      Seconds
  • Question 49 - During an exploratory laparotomy in a 22 year-old man shot in the abdomen,...

    Correct

    • During an exploratory laparotomy in a 22 year-old man shot in the abdomen, the operating doctor discovers the large bowel is perforated. Which of the following characteristics of the bowel enabled the surgeon to identify it as the large bowel?

      Your Answer: Epiploic appendages

      Explanation:

      The large intestine doesn’t have a continuous layer of longitudinal muscle. Instead, it has three strips of longitudinal muscle called taenia coli. The large intestine is covered with omental appendages that are fat filled. It is also folded into sacculations called haustrations. Serosa is a general term for the outermost coat or serous layer of a visceral structure that lies in the body cavities of the abdomen or thorax.

      Complete circular folds are only found in the small intestine.

      Valvulae conniventes or valves of Kerckring are the circular folds which are large valvular flaps projecting into the lumen of the small bowel.

    • This question is part of the following fields:

      • Abdomen
      • Anatomy
      41.8
      Seconds
  • Question 50 - Which of the following accumulates within a cell due to the aging process?...

    Correct

    • Which of the following accumulates within a cell due to the aging process?

      Your Answer: Lipofuscin

      Explanation:

      Lipofuscin , also known as lipochrome, is a wear and tear pigment or an aging pigment. It represents free radical injury or lipid peroxidation. On microscopic examination is appears as a yellowish brown pigment around the nucleus (perinuclear pigment). It is often seen in cells which are undergoing regressive changes, commonly in the liver and heart of old patients or patients with cancer, cachexia or severe malnutrition.

    • This question is part of the following fields:

      • Cell Injury & Wound Healing
      • Pathology
      7
      Seconds
  • Question 51 - A 40 year old man from Japan was diagnosed with cancer of the...

    Correct

    • A 40 year old man from Japan was diagnosed with cancer of the oesophagus. He is to undergo esophagectomy. While mobilizing the oesophagus in the neck, for resection and anastomosis with the stomach tube on the left side, the surgeon must be cautious not to injure a vital structure. Which of the following is it?

      Your Answer: Thoracic duct

      Explanation:

      The oesophagus is divided into 3 portions: cervical (part that is in the neck), thoracic portion and the abdominal portion. The cervical part is bordered by the trachea anteriorly and the prevertebral fascia covering the bodies of the 6,7 and 8th vertebra posteriorly. The thoracic duct lies on the left side at the level of the sixth cervical vertebra. The carotid sheath with its contents and lower poles of the lateral lobes of thyroid gland are lateral. The thoracic duct is the structure most likely to be injured.

    • This question is part of the following fields:

      • Anatomy
      • Thorax
      13.9
      Seconds
  • Question 52 - Which tumour site is more commonly involved in adults than in children? ...

    Correct

    • Which tumour site is more commonly involved in adults than in children?

      Your Answer: Lung

      Explanation:

      In adults, the most common primary site of tumour is in the lungs, compared to children wherein the most common primary site is the blood.

    • This question is part of the following fields:

      • Neoplasia
      • Pathology
      28.7
      Seconds
  • Question 53 - Which of the following structures is derived from the dorsal mesogastrium of the...

    Incorrect

    • Which of the following structures is derived from the dorsal mesogastrium of the stomach during the development of the gut?

      Your Answer: Hepatogastric ligament

      Correct Answer: Greater omentum

      Explanation:

      In a developing foetus, the stomach has two mesogastria from which most of the abdominal ligaments develop. These two mesogastria are the; ventral mesogastrium and the dorsal mesogastrium. During the embryological development of the gut, different organs develop in each mesogastrium; the spleen and pancreas in the dorsal mesogastrium while the liver in the ventral mesogastrium (with their associated ligaments). In the dorsal mesogastrium the following structures develop; the greater omentum (containing the gastrophrenic ligament and the gastrocolic ligament), gastrosplenic ligament, mesentery, splenorenal ligament and phrenicocolic ligament. The structures that develop from the ventral mesogastrium include the; lesser omentum (containing the hepatoduodenal ligament and the hepatogastric ligament) in association with the liver; the coronary ligament (left triangular ligament, right triangular ligament and hepatorenal ligament) and the falciform ligament (round ligament of liver and ligamentum venosum within).

      There are also folds that develop from the dorsal mesogastrium which include; umbilical folds, supravesical fossa, medial inguinal fossa, lateral umbilical fold, lateral inguinal fossa and Ileocecal fold.

    • This question is part of the following fields:

      • Abdomen
      • Anatomy
      23.4
      Seconds
  • Question 54 - A lesion involving the lateral portion of the dorsal columns at the level...

    Correct

    • A lesion involving the lateral portion of the dorsal columns at the level of the nape of the neck will most likely affect:

      Your Answer: Vibratory sensations from the ipsilateral arm

      Explanation:

      At the level mentioned in the question, the lateral portion of dorsal columns comprises of the fasciculus cuneatus. Axons carrying the sensations of touch, vibration and proprioception from the ipsilateral arm enter the spinal cord and ascend in the fasciculus cuneatus, synapsing in the nucleus cuneatus of the caudal medulla. Secondary neurons from this nucleus give rise to internal arcuate fibres, which decussate and ascend to the thalamus as the medial lemniscus. Tertiary neurons from there project to the ipsilateral somatosensory cortex. Thus, any damage to the fasciculus cuneatus will result in a deficit in tactile, proprioceptive and vibratory sensations in the ipsilateral arm, and not the contralateral arm.

      Fine motor control of the fingers is mainly carried by the ipsilateral lateral corticospinal tract in the lateral funiculus of the cord. Motor control of the contralateral foot is carried by the ipsilateral corticospinal tract in the lateral funiculus of the cord. Lack of sweating of the face could be produced by interruption of sympathetic innervation. Proprioception from the ipsilateral leg is carried by the fasciculus gracilis in the medial part of the dorsal columns.

    • This question is part of the following fields:

      • Neurology
      • Physiology
      129.1
      Seconds
  • Question 55 - Intravenous diazepam was administered to a man who was brought to the emergency...

    Incorrect

    • Intravenous diazepam was administered to a man who was brought to the emergency department with status epilepticus. He was administered 15 l/min oxygen via a reservoir bag mask. Blood investigations showed sodium = 140 mmol/l, potassium = 4 mmol/l and chloride = 98 mmol/l. His arterial blood gas analysis revealed pH 7.08, p(CO2)= 61.5 mmHg, p(O2) = 111 mmHg and standard bicarbonate = 17 mmol/l. This patient had:

      Your Answer: Metabolic alkalosis

      Correct Answer: Mixed acidosis

      Explanation:

      Acidosis with high p(CO2) and low standard bicarbonate indicates mixed acidosis. Lower p(O2) is due to breathing of 70% oxygen. The prolonged seizures lead to lactic acidosis and the intravenous diazepam is responsible for the respiratory acidosis. Treatment includes airway manoeuvres and oxygen, assisted ventilation if needed, and treatment with fluids.

    • This question is part of the following fields:

      • Physiology
      • Respiratory
      30.4
      Seconds
  • Question 56 - The presence of oval fat bodies in the urine is most likely to...

    Correct

    • The presence of oval fat bodies in the urine is most likely to be seen in which of the following conditions?

      Your Answer: Nephrotic syndrome

      Explanation:

      Nephrotic syndrome is associated with the presence of oval fat bodies on urinalysis due to increased proteinuria and lipiduria.

    • This question is part of the following fields:

      • Pathology
      • Renal
      8.4
      Seconds
  • Question 57 - A 40-year old gentleman, who is a known with ulcerative colitis, complains of...

    Correct

    • A 40-year old gentleman, who is a known with ulcerative colitis, complains of recent-onset of itching and fatigue. On examination, his serum alkaline phosphatase level was found to be high. Barium radiography of the biliary tract showed a 'beaded' appearance. What is the likely diagnosis?

      Your Answer: Sclerosing cholangitis

      Explanation:

      Primary sclerosing cholangitis is characterised by patchy inflammation, fibrosis and strictures in intra- and extra-hepatic bile ducts. It is a chronic cholestatic condition with 80% patients having associated inflammatory bowel disease (likely to be ulcerative colitis). Symptoms include pruritus and fatigue. ERCP (endoscopic retrograde cholangiopancreatography) or MRCP (magnetic resonance cholangiopancreatography) are diagnostic. Disease can lead to complete obliteration of ducts, which can result in liver failure. Cholangiocarcinoma is also a recognised complication..

    • This question is part of the following fields:

      • Gastrointestinal; Hepatobiliary
      • Pathology
      33.4
      Seconds
  • Question 58 - A medical intern wanting to perform her first thoracentesis (remove fluid from the...

    Correct

    • A medical intern wanting to perform her first thoracentesis (remove fluid from the pleural cavity) wishes to be reminded where to insert the needle to aspirate in order to avoid injuring the lung or neurovascular elements. Where is this place?

      Your Answer: The bottom of interspace 9 in the midaxillary line

      Explanation:

      Thoracentesis is performed in the costodiaphragmatic recess. The needle needs to be inserted below the level of the lungs to avoid injury to the lungs. At the paravertebral line, is between ribs 10 and 12, at the midaxillary line between ribs 8 and 10 and at the midclavicular line between interspaces 6 and 8. The needle should be inserted at the top of the rib (or the bottom of the interspace) to avoid damage to the neurovascular structures found below the rib running in the costal groove.

      The recommended location for the needle insertion varies depending upon the source. It is critical that the patient hold his or her breath to avoid piercing of the lung.

    • This question is part of the following fields:

      • Anatomy
      • Thorax
      12
      Seconds
  • Question 59 - A 50-year old lady presented to the clinic with chronic pain in the...

    Correct

    • A 50-year old lady presented to the clinic with chronic pain in the abdomen. On physical examination, she was found to be pale. Further investigations revealed a decrease in both serum iron and total iron-binding capacity, along with an increase in serum ferritin. These findings are seen in:

      Your Answer: Anaemia of chronic disease

      Explanation:

      Anaemia of chronic disease is characterized by low serum iron, iron-binding capacity and saturation with increased ferritin (storage iron). Haemolytic anaemia is characterized by normal iron levels as the haemoglobin released from the haemolysed red blood cells is recycled. Anaemia due to chronic blood loss leads to low serum iron, low ferritin and high total iron-binding capacity (TIBC). Malabsorption, especially with duodenal involvement can also lead to iron deficiency anaemia with low ferritin and high TIBC. Megaloblastic anaemia due to vitamin B12 and folate deficiency is not associated with abnormalities in metabolism of iron.

    • This question is part of the following fields:

      • Haematology
      • Pathology
      80.6
      Seconds
  • Question 60 - A 70-year old man had had a large indirect inguinal hernia for 3...

    Correct

    • A 70-year old man had had a large indirect inguinal hernia for 3 years. He presents at the out patient clinic complaining of pain in the scrotum. There is, however, no evidence of obstruction or inflammation. You conclude that the hernial sac is most probably compressing the:

      Your Answer: Ilioinguinal nerve

      Explanation:

      The ilioinguinal nerve arises together with the iliohypogastric nerve from the first lumbar nerve to emerge from the lateral border of the psoas major muscle just below the iliohypogastric and passing obliquely across the quadratus lumborum and iliacus muscles. It perforates the transversus abdominis, near the anterior part of the iliac crest and communicates with the iliohypogastric nerve between the internal oblique and the transversus. It then pierces the internal oblique to distribute filaments to it and accompanying the spermatic cord through the subcutaneous inguinal ring, is distributed to the skin of the upper and medial parts of the thigh, the skin over the root of the penis and the upper part of the scrotum in man and to the skin covering the mons pubis and labium majus in the woman. As the ilioinguinal nerve runs through the inguinal canal, it could easily be compressed by a hernial sac.

      The femoral branch of genitofemoral nerve provides sensory innervation of the upper medial thigh.

      The femoral nerve innervates the compartment of the thigh and also has some cutaneous sensory branches to the thigh.

      The iliohypogastric nerve innervates the skin of the lower abdominal wall, upper hip and upper thigh. The subcostal nerve innervates the skin of the anterolateral abdominal wall and the anterior scrotal nerve is a terminal branch of the ilioinguinal nerve.

    • This question is part of the following fields:

      • Abdomen
      • Anatomy
      13.4
      Seconds
  • Question 61 - The vagus nerve passes through which of the following foramen? ...

    Incorrect

    • The vagus nerve passes through which of the following foramen?

      Your Answer: Foramen magnum

      Correct Answer: Jugular foramen

      Explanation:

      The jugular foramen is a large foramen in the base of the skull. It is located behind the carotid canal and is formed in front by the petrous portion of the temporal bone, and behind by the occipital bone. Cranial nerves IX, X, and XI and the internal jugular vein pass through the jugular foramen.

    • This question is part of the following fields:

      • Anatomy
      • Head & Neck
      15.1
      Seconds
  • Question 62 - A 30-year old lady was admitted to the general surgical ward after a...

    Correct

    • A 30-year old lady was admitted to the general surgical ward after a diagnosis of perforation of the first part of the duodenum that resulted from a long standing ulcer. If this perforation led to the expulsion of the gastric content that resulted to the erosion of an artery found in this part of the duodenum (the posterior of the first part of the duodenum). Which of the following arteries is this most likely to be?

      Your Answer: Gastroduodenal

      Explanation:

      The proximal part of the duodenum is supplied by the gastroduodenal artery. This artery is found descending behind the first part of the duodenum after branching from the hepatic artery. If gastric content was to be expelled in the posterior portion of the first part of the duodenum, then this artery would be most likely to be damaged. The common hepatic artery and the left gastric artery are branches of the coeliac trunk that are found superior to the duodenum. The proper hepatic artery is a branch of the common hepatic artery also found superior to the duodenum. The superior mesenteric artery is found behind the pancreas as a branch of the aorta that is at the bottom of the L1 level. The right gastric artery arises above the pylorus from the proper hepatic artery and supplies the lesser curvature of the stomach. The intestinal arteries supply the ileum and the jejunum.

    • This question is part of the following fields:

      • Abdomen
      • Anatomy
      24.9
      Seconds
  • Question 63 - A middle aged man presented in OPD with a low grade fever and...

    Correct

    • A middle aged man presented in OPD with a low grade fever and a persistent cough. His blood smear showed an increase in cells with large bi-lobed nuclei. Which of these cells represent the one seen on the smear?

      Your Answer: Monocytes

      Explanation:

      Monocytes are white cells that protect the body against harmful pathogens. They are mobile and are produced in the bone marrow, mature there and circulate in the blood for about 1-3 days, where they enter the tissues and transform into macrophages. They are characteristically identified by their large bi-lobed nuclei.

    • This question is part of the following fields:

      • Inflammation & Immunology
      • Pathology
      18.2
      Seconds
  • Question 64 - What is a major source of fuel being oxidised by the skeletal muscles...

    Correct

    • What is a major source of fuel being oxidised by the skeletal muscles of a man who has undergone starvation for 7 days?

      Your Answer: Serum fatty acids

      Explanation:

      Starvation is the most extreme form of malnutrition. Prolonged starvation can lead to permanent organ damage and can be fatal. Starved individuals eventually lose significant fat and muscle mass as the body uses these for energy.

    • This question is part of the following fields:

      • Gastroenterology
      • Physiology
      14.9
      Seconds
  • Question 65 - A surgeon performing a laparoscopic repair of an inguinal hernia visualizes a loop...

    Incorrect

    • A surgeon performing a laparoscopic repair of an inguinal hernia visualizes a loop of bowel protruding through the abdominal wall to form a direct inguinal hernia. When this is viewed from the side of the abdomen with a laparoscope, in which region would the hernial sac be?

      Your Answer: Superficial inguinal ring

      Correct Answer: Medial inguinal fossa

      Explanation:

      In a direct inguinal hernia, visceral contents exit the abdomen through a weak point in the fascia in the medial inguinal fossa i.e. the area between the medial and lateral umbilical folds. Such a hernia doesn’t pass through the deep inguinal ring or the lateral inguinal fossa. Note that direct hernias can go through the superficial inguinal ring, although rarely. The supravesical fossa, between the median and medial umbilical folds, is formed by a peritoneal reflection from the anterior abdominal wall onto the bladder and the retrovesical fossa is the region behind the urinary bladder.

    • This question is part of the following fields:

      • Abdomen
      • Anatomy
      145.2
      Seconds
  • Question 66 - What percentage of the cardiac output is delivered to the brain? ...

    Correct

    • What percentage of the cardiac output is delivered to the brain?

      Your Answer: 15%

      Explanation:

      Among all body organs, the brain is most susceptible to ischaemia. Comprising of only 2.5% of total body weight, the brain receives 15% of the cardiac output. Oxygen extraction is also higher with venous oxygen levels approximating 13 vol%, and arteriovenous oxygen difference of 7 vol%.

    • This question is part of the following fields:

      • Cardiovascular
      • Physiology
      5.9
      Seconds
  • Question 67 - A 19 year old male patient exhibiting signs of shock was brought to...

    Correct

    • A 19 year old male patient exhibiting signs of shock was brought to the casualty after he had fallen from the 3rd floor of a building. An examination carried out revealed tenderness on the left mid-posterior axillary line and low blood pressure. Further palpation revealed a large swelling that protruded downward and medially below the left costal margin. X-rays showed that the 9th and the 10th ribs were fractured near their angles. Considering these results, which abdominal organ was likely injured by the fractured ribs.

      Your Answer: Spleen

      Explanation:

      The spleen, left kidney, stomach, the splenic flexure of the colon and the suprarenal glands are all in the same quadrant- the left upper quadrant. However, the spleen is the most readily injured organ when there is fracture to the 10th, 11th and the 12th ribs because of its close association with these ribs. This patient exhibits a great indication of a ruptured spleen (tenderness on the left mid and posterior axillary line). The spleen is a thin capsulated organ with a spongy parenchyma, allowing it to bleed profusely in the event of injury. The liver, head of the pancreas and the duodenum are all in the right upper quadrant.

    • This question is part of the following fields:

      • Abdomen
      • Anatomy
      109.6
      Seconds
  • Question 68 - Which of the following terms best describes the movement of leukocytes towards a...

    Correct

    • Which of the following terms best describes the movement of leukocytes towards a specific target?

      Your Answer: Chemotaxis

      Explanation:

      The movement of leukocytes towards a chemical mediator is termed chemotaxis and the mediators likewise called chemoattractants.

      Diapedesis is the squeezing of the leukocytes from the capillary wall into the intercellular space.

      Endocytosis is engulfing of a small substance by the cells e.g. glucose, protein, fats.

      Margination is lining of the WBC along the periphery of the blood vessel.

      Adhesion is attachment with the vessel wall.

      Phagocytosis is described as engulfing the bacteria or the offending substance.

    • This question is part of the following fields:

      • Inflammation & Immunology
      • Pathology
      40.9
      Seconds
  • Question 69 - A patient who has used NSAIDS for many years presents to the A&E...

    Correct

    • A patient who has used NSAIDS for many years presents to the A&E with symptoms of acute haemorrhagic shock. An emergency endoscopy is done that shows that a duodenal ulcer has perforated the posterior wall of the first part of the duodenum. Which artery is most likely to be the cause of the haemorrhage?

      Your Answer: Gastroduodenal

      Explanation:

      The gastroduodenal artery is a branch of the hepatic artery and descends near the pylorus between the first part of the duodenum and the neck of the pancreas to divide at the lower border of the duodenum into the right gastroepiploic and pancreaticoduodenal arteries. Before it divides, it gives off a few branches to the pyloric end of the stomach and to the pancreas. The artery that is most likely involved in this situation is the gastroduodenal artery since it is posterior to the first part of the duodenum.

    • This question is part of the following fields:

      • Abdomen
      • Anatomy
      104
      Seconds
  • Question 70 - An enlarged lymph node which shows well-defined, prominent paracortical follicles with germinal centres...

    Correct

    • An enlarged lymph node which shows well-defined, prominent paracortical follicles with germinal centres is most likely from which of the following patients?

      Your Answer: A 5-year-old boy with a sore throat and runny nose

      Explanation:

      Lymphadenopathy is common in children and is usually reactive in nature. The description fits that of a benign, reactive lymph node.

    • This question is part of the following fields:

      • Haematology
      • Pathology
      19.2
      Seconds
  • Question 71 - A 24 year old mother is breastfeeding her first child. Which of the...

    Correct

    • A 24 year old mother is breastfeeding her first child. Which of the following cellular adaptations occurred in her breast tissue to allow her to do this?

      Your Answer: Lobular hyperplasia

      Explanation:

      Under the influence of oestrogen in pregnancy, there is an increase in the number of lobules which will facilitate lactation.

      Steatocytes occur due to loss of weight and nutritional deficit.

      Metaplasia is a normal physiological process which is due to a change in normal epithelium with another type.

      Lobular atrophy will result in a decreased capacity to provide milk.

    • This question is part of the following fields:

      • Cell Injury & Wound Healing; Female Health
      • Pathology
      34.5
      Seconds
  • Question 72 - The tympanic membrane is a thin semi-transparent membrane that separates the tympanic cavity...

    Correct

    • The tympanic membrane is a thin semi-transparent membrane that separates the tympanic cavity from the bottom of the external acoustic meatus. The interior of the tympanic membrane is innervated by which of the following cranial nerves?

      Your Answer: Glossopharyngeal

      Explanation:

      The glossopharyngeal nerve, known as the ninth cranial nerve (CN IX), is a mixed nerve that carries afferent sensory and efferent motor information. The glossopharyngeal nerve has five distinct general functions:

      – The branchial motor (special visceral efferent), supplies the stylopharyngeus muscle.

      – The visceral motor (general visceral efferent), provides parasympathetic innervation of the parotid gland via the otic ganglion.

      – The visceral sensory (general visceral afferent), carries visceral sensory information from the carotid sinus and carotid body.

      – The general sensory (general somatic afferent), provides general sensory information from the inner surface of the tympanic membrane, upper pharynx (GVA), and the posterior one-third of the tongue.

      – The visceral afferent (special visceral afferent), provides taste sensation from the posterior one-third of the tongue, including the circumvallate papillae.

    • This question is part of the following fields:

      • Anatomy
      • Head & Neck
      13.5
      Seconds
  • Question 73 - A 50 year old female patient with an history of chronic headache was...

    Correct

    • A 50 year old female patient with an history of chronic headache was scheduled for CT scan. If the CT scan revealed a tumour at the horn of the lateral ventricle, which of the following structures is most likely to be compressed by this tumour?

      Your Answer: Fibres of the corpus callosum

      Explanation:

      The ventricular system of the brain is made up of four ventricles namely; two lateral and a third and forth ventricle. The ventricles are the site of the development of the cerebrospinal fluid. The left and right lateral ventricles are located in each of the brain’s hemispheres. The roof of the lateral ventricles are made up of the fibres of the corpus callosum. This is the structure that would be compressed by the a tumour on the roof of the lateral ventricles.

    • This question is part of the following fields:

      • Anatomy
      • Head & Neck
      214.6
      Seconds
  • Question 74 - Which condition presents with a positive urine dipstick test for blood, but no...

    Incorrect

    • Which condition presents with a positive urine dipstick test for blood, but no blood cells on urine microscopy?

      Your Answer: Post-streptococcal glomerulonephritis

      Correct Answer: Myoglobinuria

      Explanation:

      Myoglobinuria, or presence of myoglobulin in the urine is seen due to rhabdomyolysis (muscle destruction). Common causes of rhabdomyolysis include trauma, electrical injuries, burns, venom and drugs. Damaged muscle leads to release of myoglobin in the blood. Ideally, the released myoglobin gets filtered and excreted by the kidneys. However, excess myoglobin can occlude the renal filtration system leading to acute tubular necrosis and acute renal dysfunction.

    • This question is part of the following fields:

      • Pathology
      • Renal
      24.5
      Seconds
  • Question 75 - A 4-year-old child was brought to a paediatrician for consult due to a...

    Correct

    • A 4-year-old child was brought to a paediatrician for consult due to a palpable mass in his abdomen. The child has poor appetite and regularly complains of abdominal pain. The child was worked up and diagnosed with a tumour. What is the most likely diagnosis ?

      Your Answer: Nephroblastoma

      Explanation:

      Nephroblastoma is also known as Wilms’ tumour. It is a cancer of the kidneys that typically occurs in children. The median age of diagnose is approximately 3.5 years. With the current treatment, approximately 80-90% of children with Wilms’ tumour survive.

    • This question is part of the following fields:

      • Neoplasia
      • Pathology
      9.9
      Seconds
  • Question 76 - From which of the following cells is heparin produced? ...

    Correct

    • From which of the following cells is heparin produced?

      Your Answer: Mast cells

      Explanation:

      Heparin is a natural highly-sulphated glycosaminoglycan that has anticoagulant functions. It is produced by the body basophils and mast cells.

    • This question is part of the following fields:

      • Haematology
      • Pathology
      46
      Seconds
  • Question 77 - Which name is given to the inferior fascia of the urogenital diaphragm? ...

    Correct

    • Which name is given to the inferior fascia of the urogenital diaphragm?

      Your Answer: Perineal membrane

      Explanation:

      The urogenital fascia is mostly commonly referred to as the perineal membrane. This term refers to an anatomical fibrous membrane in the perineum. It is triangular in shape, and thus at times referred to as the triangular ligament. It is about 4 cm in depth. Its The perineal membrane’s apex is anterior and is separated from the arcuate pubic ligament by an oval opening for the passage of the deep dorsal vein of the penis. The lateral marginas of this triangular ligament are attached on either side to the inferior rami of the pubis and ischium, above the crus penis. Its base faces the rectum, and connects to the central tendinous point of the perineum. The pelvic fascia and Colle’s fascia is fused to the base of this triangle.

    • This question is part of the following fields:

      • Anatomy
      • Pelvis
      5.5
      Seconds
  • Question 78 - The muscle that depresses the glenoid fossa directly is the: ...

    Incorrect

    • The muscle that depresses the glenoid fossa directly is the:

      Your Answer: Serratus anterior

      Correct Answer: Pectoralis minor

      Explanation:

      Situated at the upper part of the thorax beneath the pectoralis major, is a thin pectoralis minor, triangular muscle. It originates from the third, fourth and fifth ribs, near the cartilage and from the aponeurosis which covers the intercostals. These fibres move upwards and laterally to join and form a flat tendon. This is inserted into the medial border and upper surface of the coracoid process of the scapula. Through this medial anterior thoracic nerve, fibres from the pectoralis minor are received from the eighth cervical and first thoracic nerves. This pectoralis minor pushes down on the point of the shoulder (glenoid fossa), drawing the scapula downward and medially towards the thorax which throws the inferior angle backwards.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      89.7
      Seconds
  • Question 79 - If a catheter is placed in the main pulmonary artery of a healthy...

    Correct

    • If a catheter is placed in the main pulmonary artery of a healthy 30-year-old woman, which of the following will be its mean pulmonary arterial pressure?

      Your Answer: 15 mmHg

      Explanation:

      The pulmonary artery pressure (PA pressure) is a measure of the blood pressure found in the main pulmonary artery. The hydrostatic pressure of the pulmonary circulation refers to the actual pressure inside pulmonary vessels relative to atmospheric pressure. Hydrostatic (blood pressure) in the pulmonary vascular bed is low compared with that of similar systemic vessels. The mean pulmonary arterial pressure is about 15 mmHg (ranging from about 13 to 19 mmHg) and is much lower than the average systemic arterial pressure of 90 mmHg.

    • This question is part of the following fields:

      • Physiology
      • Respiratory
      8.8
      Seconds
  • Question 80 - A 44-year old gentleman presented to the hospital in congestive cardiac failure. On...

    Correct

    • A 44-year old gentleman presented to the hospital in congestive cardiac failure. On further investigation, he was found to have a right-sided retroperitoneal mass. On enquiry, he gave a history of intermittent hypertensive attacks. 24-hour urine specimen revealed raised metanephrine and vanillylmandelic acid levels. What is the likely diagnosis?

      Your Answer: Pheochromocytoma

      Explanation:

      A neuroendocrine tumour of the chromaffin cells in adrenal medulla, pheochromocytoma secretes excessive catecholamines – adrenaline (epinephrine) and noradrenaline (norepinephrine). Pheochromocytomas are also known as the ‘10% tumour’. This is because 10% of them are bilateral, 10% are malignant, and 10% are extra-adrenal. Extra-adrenal paragangliomas (also known as extra-adrenal pheochromocytomas) are less common than pheochromocytomas and arise in the ganglia of sympathetic nervous system. Around 25% of pheochromocytomas are familial. Symptoms are described as feeling of ‘impending doom’, and include tachycardia, hypertension, palpitations, anxiety, headaches and pallor. Orthostatic hypertension is typically seen where there is a more than 100 mmHg fall in systolic pressure when the patient stands up. Pheochromocytomas can also lead to malignant hypertension. Diagnosis is by measurement of catecholamines and metanephrines in blood or in 24-hour urine, after exclusion of other possible causes such as stress, hypoglycaemia and drugs (methyldopa, dopamine agonists, ganglion-blocking antihypertensive). Imaging is also needed to localize the tumour. Localization of the tumour can also be done by Iodine-131 meta-iodobenzylguanidine (I131-MIBG) imaging.

    • This question is part of the following fields:

      • Endocrine
      • Pathology
      17.5
      Seconds
  • Question 81 - Pseudomonas aeruginosa is a multidrug resistant pathogen that causes hospital-acquired infections. It is...

    Correct

    • Pseudomonas aeruginosa is a multidrug resistant pathogen that causes hospital-acquired infections. It is usually treated with piperacillin or another antibiotic. Which of the following is the other antibiotic?

      Your Answer: Azlocillin

      Explanation:

      Azlocillin, like piperacillin, is an acylampicillin antibiotic with an extended spectrum of activity and greater in vitro potency than the carboxypenicillins. Azlocillin is similar to mezlocillin and piperacillin. It demonstrates antibacterial activity against a broad spectrum of bacteria, including Pseudomonas aeruginosa.

    • This question is part of the following fields:

      • Pathology
      • Pharmacology
      33.1
      Seconds
  • Question 82 - Which of the following statements regarding the arteries in the neck are TRUE?...

    Correct

    • Which of the following statements regarding the arteries in the neck are TRUE?

      Your Answer: The thyrocervical trunk typically gives rise to the inferior thyroid artery, transverse cervical artery and suprascapular artery

      Explanation:

      The thyrocervical trunk is one of the three branches of the first part of the subclavian artery and gives numerous branches which supply viscera of the neck, the brachial plexus, neck muscles and scapular anastomoses. The vertebral arteries are major arteries of the neck. They arise as branches from the subclavian arteries and merge to form the single midline basilar artery. The carotid sinus is a dilated area at the base of the internal carotid artery just superior to the bifurcation of the internal carotid and external carotid at the level of the superior border of thyroid cartilage.

    • This question is part of the following fields:

      • Anatomy
      • Head & Neck
      7.3
      Seconds
  • Question 83 - Cranial nerve XII, the hypoglossal nerve, innervates which one of the following muscles...

    Correct

    • Cranial nerve XII, the hypoglossal nerve, innervates which one of the following muscles in the list?

      Your Answer: Hyoglossus

      Explanation:

      The cranial nerve XII, hypoglossal nerve, innervates all the intrinsic and extrinsic muscles of the tongue except the palatoglossus. The muscles of the tongue innervated by this nerve include the extrinsic muscles; hyoglossus, styloglossus, genioglossus and the intrinsic muscles; superior longitudinal, inferior longitudinal, vertical and transverse muscles. The salpingopharyngeus, palatoglossus and the palatopharyngeus muscles are innervated by the vagus nerve. The stylopharyngeus muscle is innervated by the glossopharyngeal nerve (CN IX). The mylohyoid muscle is innervated by the inferior alveolar nerve, a branch of the mandibular nerve. Finally, the geniohyoid muscle is innervated by the olfactory nerve (CN I) via the hypoglossal nerve.

    • This question is part of the following fields:

      • Anatomy
      • Head & Neck
      10
      Seconds
  • Question 84 - A 45-year old gentleman presents with diarrhoea for two weeks. He has no...

    Correct

    • A 45-year old gentleman presents with diarrhoea for two weeks. He has no history of fever and the diarrhoea stops on fasting. Which is the most likely type of diarrhoea that he is suffering from?

      Your Answer: Osmotic

      Explanation:

      The different types of diarrhoea are:

      1. Secretory diarrhoea – Due to increased secretion or decreased absorption. There is minimal to no structural damage in this type. The most common cause is cholera toxin which stimulates secretion of anions (especially chloride), with sodium and water.

      2. Osmotic diarrhoea – Due to increased osmotic load, there is water loss. This occurs in cases of maldigestion syndromes, such as coeliac or pancreatic disease.

      3. Motility-related diarrhoea – Occurs in cases of abnormal gastrointestinal motility. Due to increased motility, there is poor absorption and this leads to diarrhoea. This is seen post-vagotomy or in diabetic neuropathy.

      4. Inflammatory diarrhoea – Due to damage to the mucosa or brush border, there is a loss of protein-rich fluids and poor absorption. Features of all the above three types can be seen in this type. Aetiology includes bacterial, viral, parasitic infections or autoimmune problems including inflammatory bowel disease.

    • This question is part of the following fields:

      • Gastroenterology
      • Physiology
      33.4
      Seconds
  • Question 85 - Signals pass through neuromuscular junctions via the neurotransmitter acetylcholine. After release from the...

    Incorrect

    • Signals pass through neuromuscular junctions via the neurotransmitter acetylcholine. After release from the skeletal neuromuscular junction, acetylcholine:

      Your Answer: Is triggered by acetylcholinesterase

      Correct Answer: Causes postsynaptic depolarisation

      Explanation:

      Acetylcholine is released from the presynaptic membrane into the cleft where it binds to the ion gated channels on the post synaptic membrane, causing them to open. This results in sodium entering into the fibre and further depolarizing it, creating an action potential.

    • This question is part of the following fields:

      • General
      • Physiology
      70.4
      Seconds
  • Question 86 - After being admitted to the hospital, a 60-year-old man is administered sodium nitroprusside....

    Correct

    • After being admitted to the hospital, a 60-year-old man is administered sodium nitroprusside. Which class of drugs does nitroprusside belong to?

      Your Answer: Vasodilators

      Explanation:

      Sodium nitroprusside is a potent peripheral vasodilator that affects both arterioles and venules. It is often administered intravenously to patients who are experiencing a hypertensive emergency. It reduces both total peripheral resistance as well as venous return, so decreasing both preload and afterload. For this reason it can be used in severe cardiogenic heart failure where this combination of effects can act to increase cardiac output. It is administered by intravenous infusion. Onset is typically immediate and effects last for up to ten minutes. The duration of treatment should not exceed 72 hours.

    • This question is part of the following fields:

      • Pathology
      • Pharmacology
      6.5
      Seconds
  • Question 87 - Which of the following chemotherapy regimens is most likely to be used in...

    Correct

    • Which of the following chemotherapy regimens is most likely to be used in colorectal cancer?

      Your Answer: FOLFOX

      Explanation:

      Chemotherapy regimens are often identified by acronyms, identifying the agents used in the drug combination. However, the letters used are not consistent across regimens. FOLFOX is a chemotherapy regimen used for the treatment of colorectal cancer, made up of the following drugs: • FOL: fluorouracil (5-fluorouracil or 5-FU) • F: folinic acid (leucovorin) • OX: oxaliplatin (Eloxatin®).

    • This question is part of the following fields:

      • Pathology
      • Pharmacology
      4.5
      Seconds
  • Question 88 - A 66 year old male, was involved in a MVA. He sustained third...

    Correct

    • A 66 year old male, was involved in a MVA. He sustained third degree burns to his abdomen and open bleeding wound to his left leg. The patient complains of dizziness. He is a known hypertensive but during examination was found to be hypotensive. His heart rate is 120/min, with regular rhythm. What is the possible cause of his hypotension?

      Your Answer: Hypovolaemia

      Explanation:

      Hypovolemia can be recognized by tachycardia, diminished blood pressure, and the absence of perfusion as assessed by skin signs (skin turning pale) and/or capillary refill time. The patient may feel dizzy, faint, nauseated, or very thirsty. Common causes of hypovolemia are loss of blood, loss of plasma which occurs in severe burns and lesions discharging fluid, loss of body sodium and consequent intravascular water which may occur in cases of diarrhoea and vomiting. In this case the cause of patients hypotension is due to hypovolemia from both loss of plasma and blood.

    • This question is part of the following fields:

      • Fluids & Electrolytes
      • Pathology
      10.3
      Seconds
  • Question 89 - For calculation of cardiac output by Fick's principle, which of the following vessels...

    Correct

    • For calculation of cardiac output by Fick's principle, which of the following vessels is the best source of venous blood to determine the arterial-to-venous oxygen tension difference?

      Your Answer: Pulmonary artery

      Explanation:

      Fick’s principle states that the total uptake (or release) of a substance by peripheral tissues is equal to the product of the blood flow to the peripheral tissues and the arterial– venous concentration difference (gradient) of the substance. It is used to measure the cardiac output, and the formula is Cardiac output = oxygen consumption divided by arteriovenous oxygen difference. Assuming there are no shunts across the pulmonary system, the pulmonary blood flow equals the systemic blood flow. The arterial and venous blood oxygen content is measured by sampling from the pulmonary artery (low oxygen content) and pulmonary vein (high oxygen content). Peripheral arterial blood is used as a surrogate for the pulmonary vein.

    • This question is part of the following fields:

      • Cardiovascular
      • Physiology
      13.7
      Seconds
  • Question 90 - A patient is diagnosed with Conn’s syndrome. Aldosterone is secreted from where? ...

    Correct

    • A patient is diagnosed with Conn’s syndrome. Aldosterone is secreted from where?

      Your Answer: Zona glomerulosa of the adrenal cortex

      Explanation:

      The adrenal gland comprises an outer cortex and an inner medulla, which represent two developmentally and functionally independent endocrine glands.

      The adrenal medulla secretes adrenaline (70%) and noradrenaline (30%)

      The adrenal cortex consists of three layers (remembered by the mnemonic GFR):

      G = zona glomerulosa – secretes aldosterone

      F = zona fasciculata – secretes cortisol and sex steroids

      R = zona reticularis – secretes cortisol and sex steroids.

      Aldosterone facilitates the reabsorption of sodium and water and the excretion of potassium and hydrogen ions from the distal convoluted tubule and collecting ducts. Conn’s syndrome is characterized by increased aldosterone secretion from the adrenal glands.

    • This question is part of the following fields:

      • Endocrine
      • Physiology
      7.1
      Seconds
  • Question 91 - Skin infiltration by neoplastic T lymphocytes is seen in: ...

    Correct

    • Skin infiltration by neoplastic T lymphocytes is seen in:

      Your Answer: Mycosis fungoides

      Explanation:

      Mycosis fungoides is a chronic T-cell lymphoma that involves the skin and less commonly, the internal organs such as nodes, liver, spleen and lungs. It is usually diagnosed in patients above 50 years and the average life expectancy is 7-10 years. It is insidious in onset and presents as a chronic, itchy rash, eventually spreading to involve most of the skin. Lesions are commonly plaque-like, but can be nodular or ulcerated. Symptoms include fever, night sweats and weight loss. Skin biopsy is diagnostic. However, early cases may pose a challenge due to fewer lymphoma cells. The malignant cells are mature T cells (T4+, T11+, T12+). The epidermis shows presence of characteristic Pautrier’s micro abscesses are present in the epidermis.

    • This question is part of the following fields:

      • Haematology
      • Pathology
      9.3
      Seconds
  • Question 92 - A 60 year old patient with a history of carcinoma of the head...

    Correct

    • A 60 year old patient with a history of carcinoma of the head of the pancreas, and obstructive jaundice presents with a spontaneous nose bleed and easy bruising. What is the most likely reason for this?

      Your Answer: Vitamin-K-dependent clotting factors deficiency

      Explanation:

      Vitamin K is a fat soluble vitamin requiring fat metabolism to function properly to allow for its absorption. People with obstructive jaundice develop vitamin k deficiency as fat digestion is impaired. Vit K causes carboxylation of glutamate residue and hence regulates blood coagulation including: prothrombin (factor II), factors VII, IX, X, protein C, protein S and protein Z.

    • This question is part of the following fields:

      • General
      • Physiology
      35.4
      Seconds
  • Question 93 - Which organ is responsible for the secretion of enzymes that aid in digestion...

    Incorrect

    • Which organ is responsible for the secretion of enzymes that aid in digestion of complex starches?

      Your Answer: Small intestine

      Correct Answer: Pancreas

      Explanation:

      α-amylase is secreted by the pancreas, which is responsible for hydrolysis of starch, glycogen and other carbohydrates into simpler compounds.

    • This question is part of the following fields:

      • Gastroenterology
      • Physiology
      38.1
      Seconds
  • Question 94 - What is the nerve supply of the muscle that is inserted onto the...

    Correct

    • What is the nerve supply of the muscle that is inserted onto the crest of the lesser tubercle of the humerus?

      Your Answer: Lower subscapular

      Explanation:

      The muscle is the subscapularis muscle which is supplied by the lower subscapular nerve.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      12.3
      Seconds
  • Question 95 - Which cells are most commonly seen in a granulomatous lesion that suggests an...

    Incorrect

    • Which cells are most commonly seen in a granulomatous lesion that suggests an underlying chronic inflammation?

      Your Answer: Mast cells

      Correct Answer: Lymphocytes

      Explanation:

      Lymphocytes and monocytes are commonly and characteristically recognised in a case of chronic inflammation.

      Eosinophils and neutrophils are seen with acute inflammation.

      Mast cells release histamine in early inflammation.

      Basophils are seen with allergies.

      Plasma cells are seen with viral infection.

      Platelets are not characteristic of any type of inflammation.

    • This question is part of the following fields:

      • Inflammation & Immunology
      • Pathology
      10.8
      Seconds
  • Question 96 - Which of the following is responsible for the activation of pepsinogen released in...

    Incorrect

    • Which of the following is responsible for the activation of pepsinogen released in the stomach?

      Your Answer: Gastrin and pepsin

      Correct Answer: Acid pH and pepsin

      Explanation:

      Pepsinogen is the inactive precursor of pepsin. Once secreted, it comes in contact with hydrochloric acid and pepsin, previously formed, and undergoes cleavage to form active pepsin.

    • This question is part of the following fields:

      • Gastroenterology
      • Physiology
      13.7
      Seconds
  • Question 97 - A 62-year-old woman presented to the doctor complaining of spine pain, fatigue and...

    Correct

    • A 62-year-old woman presented to the doctor complaining of spine pain, fatigue and oliguria. She is diagnosed with chronic renal failure. Dipstick testing shows no protein, glucose, nitrite or ketones but a semi-quantitative sulphosalicylic acid test for urine protein is positive. Which of the following is the most probable cause of chronic renal failure in this patient.

      Your Answer: Multiple myeloma

      Explanation:

      Dipstick results are negative because the proteins found in the urine of this patient are not albumin but Bence Jones proteins. A Bence Jones protein is a monoclonal globulin protein commonly detected in patients affected by multiple myeloma. Multiple myeloma is a malignancy of plasma cells characterised by the production of monoclonal immunoglobulin. Symptoms include bone pain, bone fractures, bleeding, neurologic symptoms, fatigue, frequent infections and weight loss.

    • This question is part of the following fields:

      • Pathology
      • Renal
      186.4
      Seconds
  • Question 98 - Regarding the extensor retinaculum of the wrist, which of these is CORRECT? ...

    Correct

    • Regarding the extensor retinaculum of the wrist, which of these is CORRECT?

      Your Answer: It prevents the tendons of the posterior compartment of the forearm from ‘bowstringing’ when the hand is extended at the wrist

      Explanation:

      This extensor retinaculum, as the name indicates, holds the tendons of the extensors against the dorsal surface of the distal radius and ulna. Therefore, the correct answer is that it prevents bowstringing of the extensor tendons with wrist extension. It forms compartments between it and its bony attachment, and these compartments guide and hold the tendons.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      7.6
      Seconds
  • Question 99 - An 8 year old boy presents with a history of repeated bacterial/pyogenic infections....

    Incorrect

    • An 8 year old boy presents with a history of repeated bacterial/pyogenic infections. He had a normal recovery from chickenpox and measles and shows normal antibody response. A decrease in which of the cell types can best explain this history of repeated pyogenic infections?

      Your Answer: B lymphocytes

      Correct Answer: Neutrophils

      Explanation:

      A decrease in the number of granulocytes, particularly neutrophils is known as agranulocytosis and it increases the susceptibility of an individual towards recurrent infections. Neutropenia can be either due to decreased production or increased elimination of neutrophils.

      Ineffective agranulopoiesis is seen in: 1. myeloid stem cell suppression, 2. disease conditions associated with granulopoiesis such as megaloblastic anaemia and myelodysplastic syndromes, 3. rare genetic diseases, 4. splenic sequestration and 5. increased peripheral utilization.

    • This question is part of the following fields:

      • Inflammation & Immunology
      • Pathology
      24.4
      Seconds
  • Question 100 - An 80 year-old lady presents to the out patient clinic complaining of chest...

    Correct

    • An 80 year-old lady presents to the out patient clinic complaining of chest pain of 2 months' duration with a normal electrocardiogram and cardiac enzymes. A computed tomographic scan is done which reveals a mass lesion involving a structure in the middle mediastinum. Which among the following structures could be involved?

      Your Answer: Ascending aorta

      Explanation:

      The middle mediastinum is the broadest part of the mediastinal cavity containing the heart enclosed in the pericardium, ascending aorta, lower half of the superior vena cava with the azygos vein opening into it, the bifurcation of the trachea and the two bronchi, the pulmonary artery with its branches, pulmonary veins, phrenic nerves and bronchial lymph nodes. The most likely structure involved is the ascending aorta, perhaps with an aneurysm.

    • This question is part of the following fields:

      • Anatomy
      • Thorax
      23.9
      Seconds

SESSION STATS - PERFORMANCE PER SPECIALTY

Cell Injury & Wound Healing; Urology (1/1) 100%
Pathology (33/41) 80%
Abdomen (10/12) 83%
Anatomy (32/41) 78%
Upper Limb (4/7) 57%
Thorax (4/4) 100%
Cardiovascular (3/3) 100%
Lower Limb (3/3) 100%
Head & Neck (9/13) 69%
Endocrine (4/4) 100%
Neoplasia (3/5) 60%
Respiratory (3/4) 75%
Neurology (3/5) 60%
Physiology (11/17) 65%
Cell Injury & Wound Healing; Gastrointestinal (1/1) 100%
Orthopaedics (2/2) 100%
General (2/3) 67%
Inflammation & Immunology; Respiratory (0/1) 0%
Microbiology (2/2) 100%
Haematology (5/6) 83%
Fluids & Electrolytes (3/3) 100%
Urology (0/1) 0%
Renal (3/4) 75%
Cell Injury & Wound Healing (1/1) 100%
Gastrointestinal; Hepatobiliary (1/1) 100%
Inflammation & Immunology (2/4) 50%
Gastroenterology (2/4) 50%
Cell Injury & Wound Healing; Female Health (1/1) 100%
Pelvis (1/1) 100%
Pharmacology (3/3) 100%
Passmed