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  • Question 1 - Which type of collagen is initially laid down in early wound healing: ...

    Incorrect

    • Which type of collagen is initially laid down in early wound healing:

      Your Answer: IV

      Correct Answer: III

      Explanation:

      Fibroblasts migrate to the wound (about 2 – 5 days after wounding), proliferate and secrete extracellular matrix comprising mainly collagen (type III) and fibronectin to plug the gap.

    • This question is part of the following fields:

      • Pathology
      • Wound Healing
      7.5
      Seconds
  • Question 2 - A tumour is discovered behind the pectinate line during an examination of a...

    Incorrect

    • A tumour is discovered behind the pectinate line during an examination of a 72-year-old patient with rectal bleeding. Which of the following is the lymphatic drainage of the pectinate line?

      Your Answer: Preaortic nodes

      Correct Answer: Superficial inguinal nodes

      Explanation:

      The pectinate line is known as the watershed line because it divides the anal canal into two sections. Below the pectinate line, lymphatic drainage drains to the superficial inguinal lymph nodes.

    • This question is part of the following fields:

      • Abdomen
      • Anatomy
      14.2
      Seconds
  • Question 3 - Regarding forest plots, which of the following is the purpose of this graph?...

    Incorrect

    • Regarding forest plots, which of the following is the purpose of this graph?

      Your Answer: To check for publication bias in meta-analyses and systematic reviews

      Correct Answer: To graphically display the relative strength of multiple studies attempting to answer the same question

      Explanation:

      The results of meta-analysis are often displayed graphically in a forest plot. A properly constructed forest plot is the most effective way to graphically display the relative strength of multiple studies attempting to answer the same question. A typical meta-analysis consists of three main objectives that include estimation of effect sizes from individual studies and a pooled summary estimate with their confidence intervals (CIs), heterogeneity among the studies, and any publication bias. The forest plot illustrates the first two of these objectives. Forest plots visualize the effect measure and CI of individual studies, which provide the raw data for the meta-analysis, as well the pooled-effect measure and CI. The individual studies also can be grouped in the forest plot by some of their characteristics for ease of interpretation such as by study size or year of publication. When comparing the outcomes between an intervention and a control group, dichotomous outcome variables are expressed as ratios (i.e. odds ratios, ORs or risk ratios, RRs), while for continuous outcomes, a weighted mean difference is reported.

    • This question is part of the following fields:

      • Evidence Based Medicine
      17.9
      Seconds
  • Question 4 - You proceed to administer lorazepam intravenously to a 21-year-old patient with status epilepticus....

    Correct

    • You proceed to administer lorazepam intravenously to a 21-year-old patient with status epilepticus. Which of the following best describes lorazepam's action?

      Your Answer: Potentiates effect of GABA

      Explanation:

      Lorazepam is a type of benzodiazepine.

      Benzodiazepines are gamma-aminobutyric acid (GABA) receptor agonists with sedative, hypnotic, anxiolytic, anticonvulsant, and muscle relaxant characteristics that promote inhibitory synaptic transmission across the central nervous system.

    • This question is part of the following fields:

      • Central Nervous System
      • Pharmacology
      39.4
      Seconds
  • Question 5 - Regarding likelihood ratios, which of the following statements is INCORRECT: ...

    Correct

    • Regarding likelihood ratios, which of the following statements is INCORRECT:

      Your Answer: Likelihood ratios, like predictive values, are affected by the prevalence of the disease in the population.

      Explanation:

      A likelihood ratio is a measure of the diagnostic value of a test. Likelihood ratios show how many times more likely patients with a disease are to have a particular test result than patients without the disease. Likelihood ratios are more useful than predictive values because they are calculated from sensitivity and specificity and therefore remain constant even when the prevalence of the disorder changes.

    • This question is part of the following fields:

      • Evidence Based Medicine
      • Statistics
      42.8
      Seconds
  • Question 6 - A 23-year-old man is discovered to have an infection from Helicobacter pylori.

    Which...

    Correct

    • A 23-year-old man is discovered to have an infection from Helicobacter pylori.

      Which of the following types of cancer is mostly associated with Helicobacter pylori infection?

      Your Answer: Gastric cancer

      Explanation:

      H. pylori is recognized as a major cause of type B gastritis, a chronic condition formerly associated primarily with stress and chemical irritants. In addition, the strong association between long-term H. pylori infection and gastric cancer has raised more questions regarding the clinical significance of this organism. There is speculation that long-term H. pylori infection resulting in chronic gastritis is an important risk factor for gastric carcinoma resulting in H. pylori being classified as a carcinogen.

    • This question is part of the following fields:

      • Microbiology
      • Specific Pathogen Groups
      25.4
      Seconds
  • Question 7 - An 85-year-old woman is brought in from her nursing home. She arrives in...

    Incorrect

    • An 85-year-old woman is brought in from her nursing home. She arrives in the Emergency Department and appears confused. The staff member from the nursing home accompanying her informs you that she takes a water tablet.

      From her past medical history and records, you deduce that the water tablet is a loop diuretic.

      Which of the following parts of a nephron does a loop diuretic act on?

      Your Answer: Glomerulus

      Correct Answer: Ascending loop of Henlé

      Explanation:

      Loop diuretics are drugs used to manage and treat fluid overload associated with CHF, liver cirrhosis, and renal disease. The drugs commonly used are:
      Furosemide
      Bumetanide
      Torsemide
      Ethacrynic Acid

      Loop diuretics act on the apical membrane of the thick ascending loop of Henle and inhibit the Na-K-Cl cotransporter. This blocks the reabsorption of sodium and chloride and results in salt-water excretion. This relieves congestion and reduces oedema.

      Other diuretics act on the following part of the nephron:
      1. Thiazide diuretics – Na/Cl co-transporter in the distal convoluted tubule
      2. Osmotic diuretics – PCT and the loop of Henle
      3. Aldosterone antagonists – distal convoluted tubule
      4. Carbonic anhydrase inhibitors – inhibit the carbonic anhydrase and act on proximal tubular cells

    • This question is part of the following fields:

      • Cardiovascular Pharmacology
      • Pharmacology
      46.8
      Seconds
  • Question 8 - Regarding the phases of gastric secretion, which of the following statements is INCORRECT:...

    Incorrect

    • Regarding the phases of gastric secretion, which of the following statements is INCORRECT:

      Your Answer: The cephalic phase is initiated by the sight, smell and taste of food.

      Correct Answer: A high pH in the stomach inhibits gastrin secretion.

      Explanation:

      A low pH in the stomach inhibits gastrin secretion, therefore when the stomach is empty or when acid has been secreted for some time after food has entered it, there is inhibition of acid secretion. However, when food first enters the stomach, the pH rises, and this leads to release of the inhibition and causes a maximum secretion of gastrin. Thus gastric acid secretion is self-regulating.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      53.2
      Seconds
  • Question 9 - A 62 year old man has sustained a penetrating injury to the submandibular...

    Incorrect

    • A 62 year old man has sustained a penetrating injury to the submandibular triangle. On examination, his tongue is weak and when protruded deviates to the left. Which of the following nerves has most likely been injured:

      Your Answer: Right glossopharyngeal nerve

      Correct Answer: Left hypoglossal nerve

      Explanation:

      Damage to the hypoglossal nerve results in weakness of the tongue, with deviation of the tongue towards the weak side on protrusion.

    • This question is part of the following fields:

      • Anatomy
      • Cranial Nerve Lesions
      44
      Seconds
  • Question 10 - Before a patient is discharged, you are asked to review them. He is...

    Incorrect

    • Before a patient is discharged, you are asked to review them. He is a 59-year-old man who was seen with epigastric pain that has since subsided, and he will be seen by his GP in the coming days. He's been hearing a lot about aspirin lately and wants to learn more about it.

      Which of the following statements about aspirin's mechanism of action is correct?

      Your Answer: Antagonism of glycoprotein IIb/IIIa receptors

      Correct Answer: Inhibition of cyclo-oxygenase

      Explanation:

      Aspirin works by inhibiting cyclo-oxygenase in an irreversible manner, resulting in a decrease in prostaglandin and thromboxane production. As a result, platelet activation and aggregation are reduced.

    • This question is part of the following fields:

      • Cardiovascular Pharmacology
      • Pharmacology
      14.1
      Seconds
  • Question 11 - A 29-year-old woman presents with night sweats, fever, and haemoptysis. A diagnosis of...

    Correct

    • A 29-year-old woman presents with night sweats, fever, and haemoptysis. A diagnosis of tuberculosis was suspected.

      Which of the following statements regarding the diagnosis of tuberculosis is considered correct?

      Your Answer: Mycobacteria tuberculosis can be typed using a RFLP method

      Explanation:

      Although a variety of clinical specimens may be submitted to the
      laboratory to recover MTB and NTM, respiratory secretions such
      as sputum and bronchial aspirates are the most common. An
      early-morning specimen should be collected on three consecutive
      days, although recent studies have suggested that the addition of
      a third specimen does not significantly increase the sensitivity
      of detecting Mycobacteria.

      Mycobacterium tuberculosis appear red on acid-fast staining because they take up the primary stain, which is carbolfuchsin, and is not decolorized by the acid alcohol anymore.

      Culture on Lowenstein-Jensen medium should be read within 5 to 7 days after inoculation and once a week thereafter for up to 8 weeks.

      Nucleic acid amplification assays designed to detect M. tuberculosis complex
      bacilli directly from patient specimens can be performed in as little as 6 to 8 hours on processed specimens.

    • This question is part of the following fields:

      • Microbiology
      • Specific Pathogen Groups
      40.3
      Seconds
  • Question 12 - A 67-year-old female is admitted under your care with the complaint of shortness...

    Incorrect

    • A 67-year-old female is admitted under your care with the complaint of shortness of breath and massive pedal oedema. There are fine crepitations up to the mid zones on both lung fields on chest auscultation. When questioned about her medication, she doesn't remember everything she takes but knows that there is a tablet to get rid of excess water.

      Out of the following medications, which one increases the osmolality of the filtrate in the glomerulus and the tubule, creating an osmotic effect?

      Your Answer: Furosemide

      Correct Answer: Mannitol

      Explanation:

      Mannitol is an osmotic diuretic that stops the absorption of water throughout the tubule, thus increasing the osmolality of both glomerular and tubular fluid. It is used to:
      1. decrease intraocular pressure in glaucoma
      2. decrease intracerebral pressure
      3. oliguria.

      Furosemide is a loop diuretic that inhibits the Na/K/2Cl transported in the ascending limb of the Loop of Henle.

      Bendroflumethiazide is a thiazide diuretic which inhibits the Na/Cl transporter.

      Spironolactone is a potassium-sparing diuretic that acts as an aldosterone receptor antagonist.

      Acetazolamide is a carbonic anhydrase inhibitor.

    • This question is part of the following fields:

      • Cardiovascular Pharmacology
      • Pharmacology
      34.3
      Seconds
  • Question 13 - Regarding Clostridium perfringens, which of the following statements is CORRECT: ...

    Incorrect

    • Regarding Clostridium perfringens, which of the following statements is CORRECT:

      Your Answer: It is a facultative anaerobe.

      Correct Answer: It can cause exotoxin-mediated food poisoning.

      Explanation:

      Clostridium perfringens is an obligate anaerobe and has exotoxin mediated effects. It is the most common cause of gas gangrene. C. perfringens is also implicated in food poisoning, cellulitis, enteritis necrotican (life-threatening infection involving ischaemic necrosis of the jejunum), and rarely, CNS infections such as meningitis and encephalitis.

    • This question is part of the following fields:

      • Microbiology
      • Pathogens
      20.7
      Seconds
  • Question 14 - While on morning rounds in the medical ward, the attending physician asks a...

    Incorrect

    • While on morning rounds in the medical ward, the attending physician asks a medical student about the differences between transudates and exudates and their causes. The student explains that a transudate is an excess fluid that leaks out of an intravascular compartment due to an imbalance between oncotic and hydrostatic pressures.

      Which ONE of the following conditions will he mention as the cause of a transudate?

      Your Answer: Empyema

      Correct Answer: Meig’s syndrome

      Explanation:

      Transudative effusions are caused due to systemic causes leading to increased hydrostatic pressure or decreased oncotic pressure. These include:
      1) Meig’s Syndrome (Ovarian tumour causing ascites and pleural effusion)
      2) Congestive heart failure
      3) Nephrotic Syndrome
      4) Myxoedema
      5) Cirrhosis
      6) Sarcoidosis

      An exudate is caused by local inflammation and results from increased vascular permeability. Causes include:
      1) Rheumatoid arthritis
      2) Pneumonia leading to empyema
      3) Malignancies
      4) Pericarditis

    • This question is part of the following fields:

      • General Pathology
      • Pathology
      34.9
      Seconds
  • Question 15 - By what mechanism does Vibrio cholerae causes diarrhoea? ...

    Correct

    • By what mechanism does Vibrio cholerae causes diarrhoea?

      Your Answer: Increases Cl- secretory channels in crypt cells

      Explanation:

      Cholera is a severe diarrheal illness caused by the Vibrio cholerae bacteria infecting the bowel. Ingesting cholera-infected food or drink is the a way to contract the disease. In the intestinal crypt cells, the toxigenic bacterium Vibrio cholera activates adenylate cyclase and raises cyclic adenosine monophosphate (cAMP).

      cAMP stimulates the Cl-secretory channels in crypt cells, resulting in the secretion of chloride with sodium ions and water. The toxin it produces causes the body to secrete massive amounts of water, resulting in diarrhoea and significant fluid and electrolyte loss.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      243.8
      Seconds
  • Question 16 - A 20-year-old male patient lives in a travelling community and has never...

    Correct

    • A 20-year-old male patient lives in a travelling community and has never received any vaccinations. He presents to you with fever.

      Which of these statements concerning indications and contraindications for vaccination is TRUE?

      Your Answer: Inactivated vaccines are safe in pregnancy

      Explanation:

      All vaccines are contraindicated in individuals with: A confirmed anaphylactic reaction to a previous dose of the vaccine or a vaccine containing the same antigens.
      A confirmed anaphylactic reaction to a component in the vaccine e.g. neomycin

      There is no evidence that vaccinating pregnant women with inactivated vaccine or toxoids harms the woman or foetus.

      The current protocol is that a child with history of egg allergy can be safely vaccinated with Fluenz tetra. However, if they had a previous severe anaphylaxis to egg requiring intensive care, then Flenz tetra is contraindicated.

      BCG, yellow fever or oral typhoid vaccinations are not safe in HIV positive patients.

      The normal times recommended for immunization of full-term babies should also be applied to premature infants and correction for gestational age should not be implemented.

      Concurrent antibiotic therapy is not a contraindication to vaccination.

    • This question is part of the following fields:

      • Microbiology
      • Principles Of Microbiology
      9.7
      Seconds
  • Question 17 - When treating diabetic ketoacidosis (DKA), glucose should be given together with insulin as...

    Incorrect

    • When treating diabetic ketoacidosis (DKA), glucose should be given together with insulin as soon as the blood glucose concentration falls below 14 mmol/L in the form of:

      Your Answer: 20% glucose intravenous infusion at a rate of 125 mL/hour

      Correct Answer: 10% glucose intravenous infusion at a rate of 125 mL/hour

      Explanation:

      In addition to the sodium chloride 0.9 percent infusion, glucose 10% should be given intravenously (into a large vein with a large-gauge needle) at a rate of 125 mL/hour once blood glucose concentration falls below 14 mmol/litre.

    • This question is part of the following fields:

      • Endocrine
      • Pharmacology
      55.5
      Seconds
  • Question 18 - If the ejection fraction increases, there will be a decrease in: ...

    Incorrect

    • If the ejection fraction increases, there will be a decrease in:

      Your Answer: Mean arterial pressure

      Correct Answer: End-systolic volume

      Explanation:

      An increase in ejection fraction means that a higher fraction of the end-diastolic volume is ejected in the stroke volume (e.g. because of the administration of a positive inotropic agent). When this situation occurs, the volume remaining in the ventricle after systole, the end-systolic volume, will be reduced. Cardiac output, stroke volume, and mean arterial pressure will be increased.

    • This question is part of the following fields:

      • Cardiovascular
      • Physiology
      20.7
      Seconds
  • Question 19 - The following statements about leukotrienes as chemical mediators of the acute inflammatory response...

    Incorrect

    • The following statements about leukotrienes as chemical mediators of the acute inflammatory response are all true EXCEPT?

      Your Answer: They have a chemotactic effect on migrating neutrophils

      Correct Answer: They decrease vascular permeability

      Explanation:

      Leukotrienes increases (not decrease) vascular permeability during acute inflammation.

      All the other statements are correct

    • This question is part of the following fields:

      • General Pathology
      • Pathology
      9.9
      Seconds
  • Question 20 - Regarding the penis, which of the following statements is CORRECT: ...

    Correct

    • Regarding the penis, which of the following statements is CORRECT:

      Your Answer: The corpus spongiosum is ventral in the erect penis.

      Explanation:

      Because the anatomical position of the penis is erect, the paired corpora cavernosa are defined as dorsal in the body of the penis and the single corpus spongiosum as ventral. The nerves and vessels lie superficial to the corpus cavernosum. The urethra lies within the corpus spongiosum.

    • This question is part of the following fields:

      • Abdomen
      • Anatomy
      15
      Seconds
  • Question 21 - Which of the following drugs decreases plasma-theophylline levels: ...

    Incorrect

    • Which of the following drugs decreases plasma-theophylline levels:

      Your Answer: Fluconazole

      Correct Answer: Carbamazepine

      Explanation:

      Examples of enzyme-inhibiting drugs (raise plasma theophylline level):
      Erythromycin
      Clarithromycin
      Ciprofloxacin
      Fluconazole
      Verapamil
      Allopurinol
      Cimetidine
      Examples of enzyme-inducing drugs (lower plasma theophylline level):
      Primidone
      Phenobarbital
      Carbamazepine
      Phenytoin
      Ritonavir
      Rifampicin
      St John’s Wort

    • This question is part of the following fields:

      • Pharmacology
      • Respiratory
      14.3
      Seconds
  • Question 22 - A patient suffers a stab wound to the neck. The entry point of...

    Incorrect

    • A patient suffers a stab wound to the neck. The entry point of the blade is situated within the anterior triangle of the neck.
      Which of the following muscles is most likely to be involved? Select ONE answer only.

      Your Answer: Platysma

      Correct Answer: Sternohyoid

      Explanation:

      The anterior triangle is the triangular area of the neck found anteriorly to the sternocleidomastoid muscle. It is formed by the anterior border of sternocleidomastoid laterally, the median line of the neck medially and by the inferior border of the mandible superiorly. The apex of the anterior triangle extends towards the manubrium sterni. The anterior triangle contains:
      Muscles: thyrohyoid, sternothyroid, sternohyoid muscles
      Organs: thyroid gland, parathyroid glands, larynx, trachea, esophagus, submandibular gland, caudal part of the parotid gland
      Arteries: superior and inferior thyroid, common carotid, external carotid, internal carotid artery (and sinus), facial, submental, lingual arteries
      Veins: anterior jugular veins, internal jugular, common facial, lingual, superior thyroid, middle thyroid veins, facial vein, submental vein, lingual veins
      Nerves: vagus nerve (CN X), hypoglossal nerve (CN XII), part of sympathetic trunk, mylohyoid nerve

      The posterior triangle is a triangular area found posteriorly to the sternocleidomastoid muscle. It has three borders; anterior, posterior and inferior borders. The anterior border is the posterior margin of the sternocleidomastoid muscle. The posterior border is the anterior margin of the trapezius muscle, while the inferior border is the middle one-third of the clavicle. The investing layer of deep cervical fascia and integument forms the roof of the space, while the floor is covered with the prevertebral fascia along with levator scapulae, splenius capitis and the scalene muscles. The inferior belly of omohyoid subdivides the posterior triangle into a small supraclavicular, and a large occipital, triangle.
      Contents:
      Vessels: the third part of the subclavian artery, suprascapular and transverse cervical branches of the thyrocervical trunk, external jugular vein, lymph nodes
      Nerves: accessory nerve (CN XI), the trunks of the brachial plexus, fibers of the cervical plexus

    • This question is part of the following fields:

      • Anatomy
      • Head And Neck
      9.3
      Seconds
  • Question 23 - A 20-year-old with type I diabetes mellitus has an episode of hypoglycaemia following...

    Incorrect

    • A 20-year-old with type I diabetes mellitus has an episode of hypoglycaemia following inadvertent administration of too much insulin.

      The mechanism by which insulin causes glucose to be transported into cells is?

      Your Answer: Co-transport

      Correct Answer: Facilitated diffusion

      Explanation:

      The only mechanism by which insulin facilitates uptake of glucose into cells is by facilitated diffusion through a family of hexose transporters.

      The major transporter used for glucose uptake is GLUT4. GLUT4 is made available in the plasma membrane by the action of insulin.
      When insulin concentrations are low, GLUT4 transporters are present in cytoplasmic vesicles, where they are cannot be used for transporting glucose.

    • This question is part of the following fields:

      • Endocrine Physiology
      • Physiology
      175.3
      Seconds
  • Question 24 - Which of the following is NOT an adverse effect of amitriptyline: ...

    Incorrect

    • Which of the following is NOT an adverse effect of amitriptyline:

      Your Answer: Narrow-angle glaucoma

      Correct Answer: Hypokalaemia

      Explanation:

      Adverse effects include:
      Antimuscarinic effects: Dry mouth, Blurred vision, Constipation, Urinary retention, Sedation, Confusion
      Cardiovascular effects: Heart block, Arrhythmias, Tachycardia, Postural hypotension, QT-interval prolongation, Hepatic impairment, Narrow-angle glaucoma

    • This question is part of the following fields:

      • Central Nervous System
      • Pharmacology
      5.4
      Seconds
  • Question 25 - A patient complains of stomach ache. You see a midline scar in the...

    Incorrect

    • A patient complains of stomach ache. You see a midline scar in the epigastric area when you examine the abdomen. Upon further interrogation, the patient reveals that she had a subtotal gastrectomy for recurring stomach ulcers several years ago. The stomach mucosa secretes a variety of vital compounds, and her ability to secrete some of these molecules has been harmed as a result of his surgery.

      The stomach mucous neck cells secrete which of the following substances?

      Your Answer: Secretin

      Correct Answer: Bicarbonate

      Explanation:

      Foveolar cells, also known as gastric mucous-neck cells, are cells that line the stomach mucosa and are found in the necks of the gastric pits. Mucus and bicarbonate are produced by these cells, which prevent the stomach from digesting itself. At pH 4, the mucous allows the acid to penetrate the lining, while below pH 4, the acid is unable to do so. Viscous fingering is the term for this procedure.

      The table below summarizes the many cell types found in the stomach, as well as the substances secreted by each cell type and the function of the secretion:

      Cell type/ Substance secreted/ Function of secretion
      Parietal cells/ Hydrochloric acid/ Kills microbes and activates pepsinogen
      Parietal cells/ Intrinsic factor/Binds to vitamin B12 and facilitates its absorption
      Chief cells/ Pepsinogen/ Protein digestion
      Chief cells/ Gastric lipase/ Fat digestion
      G-cells/ Gastrin/ Stimulates gastric acid secretion
      Enterochromaffin-like cells (ECL cells) /Histamine/ Stimulates gastric acid secretion
      Mucous-neck cells/ Mucous and bicarbonate/ Protects stomach epithelium from acid
      D-cells/ Somatostatin/ Inhibits gastric acid secretion

    • This question is part of the following fields:

      • Gastrointestinal Physiology
      • Physiology
      15.6
      Seconds
  • Question 26 - A 16-year-old male with a known case of Haemophilia A is referred to...

    Incorrect

    • A 16-year-old male with a known case of Haemophilia A is referred to your orthopaedic clinic for evaluation and aspiration of a hemarthrosis of the left knee joint.

      Out of the modes of inheritance listed below, which one is present in this disease?

      Your Answer: Mitochondrial

      Correct Answer: X-linked recessive

      Explanation:

      All the Haemophilia’s have an X-linked recessive inheritance pattern, so they only manifest in male patients. Diseases with a mitochondrial inheritance pattern include MELAS syndrome, Leigh syndrome, LHON and MERRF syndrome. Autosomal dominant disorders include Huntingdon disease and Marfan syndrome. X-linked dominant diseases include Fragile X syndrome. Autosomal recessive diseases include cystic fibrosis and sickle cell disease.

    • This question is part of the following fields:

      • Haematology
      • Pathology
      5
      Seconds
  • Question 27 - The primary mechanism of action of ketamine is: ...

    Incorrect

    • The primary mechanism of action of ketamine is:

      Your Answer: Dopamine antagonist

      Correct Answer: N-methyl-D-aspartate (NMDA)-receptor antagonist

      Explanation:

      Ketamine is a non-competitive antagonist of the calcium-ion channel in the NMDA (N-methyl-D-aspartate) receptor. It further inhibits the NMDA-receptor by binding to its phencyclidine binding site. Ketamine also acts at other receptors as an opioid receptor agonist (analgesic effects), as an muscarinic anticholinergic receptor antagonist (antimuscarinic effects) and by blocking fast sodium channels (local anaesthetic effect).

      Overdose may lead to panic attacks and aggressive behaviour; rarely seizures, increased ICP, and cardiac arrest

      Very similar in chemical makeup to PCP (phencyclidine), but it is shorter acting and less toxic

    • This question is part of the following fields:

      • Anaesthesia
      • Pharmacology
      43.2
      Seconds
  • Question 28 - Which of the following is NOT a function of the commensal intestinal bacterial...

    Incorrect

    • Which of the following is NOT a function of the commensal intestinal bacterial flora:

      Your Answer:

      Correct Answer: Breakdown of haem into bilirubin

      Explanation:

      Commensal intestinal bacterial flora have a role in:Keeping pathogenic bacteria at bay by competing for space and nutrientConverting conjugated bilirubin to urobilinogen (some of which is reabsorbed and excreted in urine) and stercobilinogen which is excreted in the faecesThe synthesis of vitamins K, B12, thiamine and riboflavinThe breakdown of primary bile acids to secondary bile acidsThe breakdown of cholesterol, some food additives and drugs

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      0
      Seconds
  • Question 29 - Which of the following could denote a diagnosis of acquired immunodeficiency syndrome (AIDS)...

    Incorrect

    • Which of the following could denote a diagnosis of acquired immunodeficiency syndrome (AIDS) in a patient infected with HIV:

      Your Answer:

      Correct Answer: CD4 count < 200 cells/uL

      Explanation:

      A diagnosis of AIDS can be made in a patient infected with HIV if the patient has a CD4 count < 200 cells/uL, or an AIDS-defining illness. Antiretroviral treatment should be considered in patients with CD4 counts < 350 cells/uL.

      Oral candidiasis is not an AIDS defining illness – candidiasis of the bronchi, trachea, lungs or of the oesophagus is an AIDS defining illness.

      A positive p24 antigen test seen in early HIV infection and does not indicate the development of AIDS.

    • This question is part of the following fields:

      • Microbiology
      • Pathogens
      0
      Seconds
  • Question 30 - Which of the following is true about the extensor carpi radialis longus? ...

    Incorrect

    • Which of the following is true about the extensor carpi radialis longus?

      Your Answer:

      Correct Answer: It assists with abduction of the hand at the wrist

      Explanation:

      The majority of extensor carpi radialis longus originates from the lateral supracondylar ridge of humerus (distal third) and anterior aspect of the lateral intermuscular septum of the arm. A small portion of its fibres originate from the common extensor tendon attached to the lateral epicondyle of humerus. The fibres unite into a muscle belly which extends approximately to the middle of the forearm. The muscle belly is then replaced by a flat tendon that travels distally along the lateral surface of the radius, together with the tendon of extensor carpi radialis brevis. Both tendons course towards the radial styloid process, deep to the tendons of abductor pollicis longus and extensor pollicis brevis muscles. Proximal to the wrist, the tendons of extensor carpi radialis longus and brevis pass behind the radial styloid process within a common synovial sheath and continue along the radial groove deep to the extensor retinaculum of the wrist. At this level, the tendon of extensor carpi radialis longus is crossed by the tendon of extensor pollicis longus, after which it inserts on the posterior aspect of the base of the second metacarpal bone. Some tendon slips can insert into the first and third metacarpal bones.

      Extensor carpi radialis longus receives innervation from the radial nerve, with contributions mainly from spinal nerves C5-C8. The radial nerve is a branch of the brachial plexus.

      Extensor carpi radialis longus receives blood supply mainly from the radial artery. It directly supplies the distal part of the muscle, while the rest of the muscle receives blood from one of its radial recurrent branches. The brachial artery also supplies a small portion of the muscle via the radial collateral artery.

      Extensor carpi radialis longus primarily acts on the wrist joint to produce two major actions: (1) wrist extension by working synergistically with extensor carpi radialis brevis and extensor carpi ulnaris, and (2) hand abduction (radial deviation), with the help of flexor carpi radialis.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      0
      Seconds

SESSION STATS - PERFORMANCE PER SPECIALTY

Pathology (1/3) 33%
Wound Healing (0/1) 0%
Abdomen (1/2) 50%
Anatomy (2/5) 40%
Central Nervous System (2/2) 100%
Pharmacology (5/8) 63%
Microbiology (4/5) 80%
Specific Pathogen Groups (1/2) 50%
Cardiovascular Pharmacology (2/3) 67%
Gastrointestinal (1/3) 33%
Physiology (2/6) 33%
Cranial Nerve Lesions (0/1) 0%
Pathogens (2/2) 100%
General Pathology (1/2) 50%
Principles Of Microbiology (1/1) 100%
Endocrine (0/1) 0%
Cardiovascular (1/1) 100%
Respiratory (0/1) 0%
Head And Neck (0/1) 0%
Endocrine Physiology (0/1) 0%
Gastrointestinal Physiology (0/1) 0%
Anaesthesia (1/1) 100%
Upper Limb (1/1) 100%
Passmed