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  • Question 1 - Aside from the inability to extend the leg above the knee, which of...

    Correct

    • Aside from the inability to extend the leg above the knee, which of the following clinical symptoms should you anticipate seeing in a patient who had a pelvic and right leg injury as well as femoral nerve damage?

      Your Answer: Loss of sensation over the anterior thigh

      Explanation:

      The femoral nerve runs down the front of the leg from the pelvis. It gives the front of the thigh and a portion of the lower leg sensation.

      Extension of the leg at the knee joint, flexion of the thigh at the hip are produced by muscles that is primarily innervated by the femoral nerve.

    • This question is part of the following fields:

      • Anatomy
      • Lower Limb
      144.2
      Seconds
  • Question 2 - About case-control studies, one of the following is true. ...

    Correct

    • About case-control studies, one of the following is true.

      Your Answer: They are suitable to be used in the study of rare diseases

      Explanation:

      Case-control studies are suitable when investigating a rare disease or in cases where little is known about the disease and the proposed aetiological factor, as a preliminary study. They have the ability to look at multiple risk-factors (exposures) but can only look at a single outcome.

      In a case-control study, two groups of patients, one with the disease and one without, are compared on the basis of a proposed causative factor that occurred in the past. They are therefore a retrospective study and useful in hypothesis generation.

      Cohort studies are better at identifying rare exposures. One group with an exposure is compared to a control group without that exposure.

      Case-control studies are usually less expensive to run and also shorter in duration compared with prospective cohort studies.

    • This question is part of the following fields:

      • Evidence Based Medicine
      8.7
      Seconds
  • Question 3 - Which of the following immunoglobulins is predominant in saliva: ...

    Incorrect

    • Which of the following immunoglobulins is predominant in saliva:

      Your Answer: IgE

      Correct Answer: IgA

      Explanation:

      Immunoglobulin A is predominant in saliva.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      22.6
      Seconds
  • Question 4 - Digoxin is predominantly used for which of the following: ...

    Incorrect

    • Digoxin is predominantly used for which of the following:

      Your Answer: Acute treatment of new-onset fast atrial fibrillation

      Correct Answer: Rate control in persistent and permanent atrial fibrillation

      Explanation:

      Digoxin is most useful for controlling the ventricular response in persistent and permanent atrial fibrillation and atrial flutter. Digoxin is usually only effective for controlling the ventricular rate at rest, and should therefore only be used as monotherapy in predominantly sedentary patients with non-paroxysmal atrial fibrillation. It is now rarely used for rapid control of heart rate, as even with intravenous administration, response may take many hours. Digoxin is reserved for patients with worsening or severe heart failure due to left ventricular systolic dysfunction refractory to combination therapy with first-line agents. Digoxin is contraindicated in supraventricular arrhythmias associated with accessory conduction pathways e.g. Wolff-Parkinson-White syndrome.

    • This question is part of the following fields:

      • Cardiovascular
      • Pharmacology
      413.5
      Seconds
  • Question 5 - You are reviewing a patient complaining of loss of vision. Previous images shows...

    Incorrect

    • You are reviewing a patient complaining of loss of vision. Previous images shows a lesion at the optic chiasm. What type of visual field defect are you most likely to see in a lesion at the optic chiasm:

      Your Answer: Homonymous hemianopia with macular sparing

      Correct Answer: Bitemporal hemianopia

      Explanation:

      A lesion at the optic chiasm will result in a bitemporal hemianopia.
      A lesion of the optic nerve will result in ipsilateral monocular visual loss.
      A lesion of the optic tract will result in a contralateral homonymous hemianopia.

    • This question is part of the following fields:

      • Anatomy
      • Central Nervous System
      161.2
      Seconds
  • Question 6 - You examine a 79-year-old woman who has had hypertension and atrial fibrillation in...

    Incorrect

    • You examine a 79-year-old woman who has had hypertension and atrial fibrillation in the past. Her most recent blood tests show that she has severe renal impairment.

      Which medication adjustments should you make in this patient's case?

      Your Answer: Stop aspirin

      Correct Answer: Reduce dose of digoxin

      Explanation:

      Digoxin is excreted through the kidneys, and impaired renal function can lead to elevated digoxin levels and toxicity.
      The patient’s digoxin dose should be reduced in this case, and their digoxin level and electrolytes should be closely monitored.

    • This question is part of the following fields:

      • Cardiovascular Pharmacology
      • Pharmacology
      9
      Seconds
  • Question 7 - Which of the following is a common adverse effect of glucagon: ...

    Incorrect

    • Which of the following is a common adverse effect of glucagon:

      Your Answer: Hyponatraemia

      Correct Answer: Nausea

      Explanation:

      Adverse effects include:
      Common: Nausea
      Uncommon: Vomiting
      Rare: Abdominal pain, hypertension, hypotension, tachycardia

    • This question is part of the following fields:

      • Endocrine
      • Pharmacology
      35.3
      Seconds
  • Question 8 - A migrant from Eastern Europe needs to have screening performed for tuberculosis (TB)...

    Incorrect

    • A migrant from Eastern Europe needs to have screening performed for tuberculosis (TB) because he is a high-risk patient.

      Which statement concerning TB screening in the UK is true?

      Your Answer: The interferon gamma release assay (IGRA) should be used for neonates

      Correct Answer: Vaccination with the BCG can result in a false positive test

      Explanation:

      Vaccination with the BCG can result in a false positive test.

      The Mantoux test replaced the Heaf test as the TB screening test in the UK in 2005.
      The ‘Sterneedle’ gun is used to inject 100,000 units/ml of tuberculin purified protein derivative into the skin for the Heaf test

      The Mantoux test involves the injection of 5 Tuberculin units (0.1mL) intradermally and the result read 2-3 days later.

      The interferon gamma release assay (IGRA) should NOT be used for neonates

    • This question is part of the following fields:

      • Microbiology
      • Specific Pathogen Groups
      23.6
      Seconds
  • Question 9 - An 80-year-old female complains of chest pain characteristic of angina. A dose of...

    Incorrect

    • An 80-year-old female complains of chest pain characteristic of angina. A dose of glyceryl trinitrate (GTN) is administered that resolves the chest pain rapidly.

      Which ONE of the following is released on the initial metabolism of GTN?

      Your Answer: Cyclic AMP

      Correct Answer: Nitrite ions

      Explanation:

      Angina pectoris is the most common symptom of ischemic heart disease and presents with chest pain relieved by rest and nitro-glycerine.

      Nitrates are the first-line treatment to relieve chest pain caused by angina. The commonly used nitrates are:
      1. Glyceryl trinitrate
      2. Isosorbide dinitrate

      The nitrate drugs are metabolized in the following steps:
      1. Release Nitrite ions (NO2-), which are then converted to nitric oxide (NO) within cells.
      2. NO activates guanylyl cyclase, which causes an increase in the intracellular concentration of cyclic guanosine-monophosphate (cGMP) in vascular smooth muscle cells.
      3. Relaxation of vascular smooth muscle.

      Although nitrates are potent coronary vasodilators, their principal benefit in the management of angina results from a predominant mechanism of venous dilation:
      – Bigger veins hold more blood
      – Takes blood away from the left ventricle
      – Lowers LVEDV (preload), LA pressure
      – Less pulmonary oedema → improved dyspnoea

    • This question is part of the following fields:

      • Cardiovascular Pharmacology
      • Pharmacology
      38.2
      Seconds
  • Question 10 - What is the appropriate dose of 1:1000 adrenaline solution for a 15-year-old patient...

    Incorrect

    • What is the appropriate dose of 1:1000 adrenaline solution for a 15-year-old patient with suspected anaphylactic shock?

      Your Answer: 300 micrograms intramuscularly

      Correct Answer: 500 micrograms intramuscularly

      Explanation:

      1: 1000 Adrenaline solution dosage for children above the age of 12 and adults, including pregnant women (over 50 kg) is 0.50 mL, which is equivalent to 500 mcg of adrenaline.

    • This question is part of the following fields:

      • Pharmacology
      • Respiratory
      19.2
      Seconds
  • Question 11 - Which of the following does NOT increase free ionised calcium levels: ...

    Incorrect

    • Which of the following does NOT increase free ionised calcium levels:

      Your Answer: Myeloma

      Correct Answer: Calcitonin

      Explanation:

      Calcium homeostasis is primarily controlled by three hormones: parathyroid hormone, activated vitamin D and calcitonin.

      Parathyroid hormone acts on the kidneys to increase calcium reabsorption in the distal tubule by activating Ca2+entry channels in the apical membrane and the Ca2+ATPase pump in the basolateral membrane (and to decrease phosphate reabsorption in the proximal tubule).

      Activated vitamin D acts to increase calcium reabsorption in the distal tubule via activation of a basolateral Ca2+ATPase pump (and to increase phosphate reabsorption).

      Calcitonin acts to inhibit renal reabsorption of calcium (and phosphate).

    • This question is part of the following fields:

      • Physiology
      • Renal
      301
      Seconds
  • Question 12 - Digoxin exhibits its positive inotropic effect by which of the following mechanisms: ...

    Incorrect

    • Digoxin exhibits its positive inotropic effect by which of the following mechanisms:

      Your Answer: Activates Ca2+ release channels on the sarcoplasmic reticulum

      Correct Answer: Inhibits the Na+/K+ pump on the myocyte membrane

      Explanation:

      Cardiac glycosides (e.g. digoxin) slow the removal of Ca2+from the cell by inhibiting the membrane Na+pump (Na+/K+ATPase) which generates the Na+gradient required for driving the export of Ca2+by Na+/Ca2+exchange; consequently the removal of Ca2+from the myocyte is slowed and more Ca2+is available for the next contraction.

    • This question is part of the following fields:

      • Cardiovascular
      • Physiology
      19.3
      Seconds
  • Question 13 - A newborn baby is rushed to the neonatal ICU 4 hours after birth...

    Correct

    • A newborn baby is rushed to the neonatal ICU 4 hours after birth due to sudden onset severe jaundice and generalised oedema. Family history reveals that this is the second baby, while blood testing shows that the mother has an Rh-negative blood group while the baby is Rh-positive. A diagnosis of haemolytic disease of the newborn is established.

      Which one of the following hypersensitivity reactions have occurred in this case?

      Your Answer: Type II hypersensitivity reaction

      Explanation:

      Hepatitis A usually doesn’t pose a special risk to a pregnant woman or her baby. Maternal infection doesn’t result in birth defects, and a mother typically doesn’t transmit the infection to her baby. HAV is almost always transmitted by the faecal-oral route and is usually acquired through close personal contact or via contaminated food.

      When a woman has chickenpox in the first 20 weeks of pregnancy, there is a 1 in 50 chance for the baby to develop a set of birth defects. This is called the congenital varicella syndrome. It includes scars, defects of muscle and bone, malformed and paralyzed limbs, small head size, blindness, seizures, and intellectual disability.

      TORCH Syndrome refers to infection of a developing foetus or newborn by any of a group of infectious agents. “TORCH” is an acronym meaning (T)oxoplasmosis, (O)ther Agents, (R)ubella (also known as German Measles), (C)ytomegalovirus, and (H)erpes Simplex.
      Infection with any of these agents may cause a constellation of similar symptoms in affected newborns. These may include fever; difficulties feeding; small areas of bleeding under the skin, causing the appearance of small reddish or purplish spots; enlargement of the liver and spleen (hepatosplenomegaly); yellowish discoloration of the skin, whites of the eyes, and mucous membranes (jaundice); hearing impairment; abnormalities of the eyes; and other symptoms and findings.

    • This question is part of the following fields:

      • General Pathology
      • Pathology
      28.4
      Seconds
  • Question 14 - A patient who has a nerve injury has sparing of the upper half...

    Incorrect

    • A patient who has a nerve injury has sparing of the upper half of the orbicularis oculi muscle but not the lower half. Which branch of the facial nerve supplies the lower half of the orbicularis oculi?

      Your Answer: Cervical branch

      Correct Answer: Zygomatic branch

      Explanation:

      The facial nerve divides into five terminal branches once in the parotid gland.
      1. The temporal branch innervates muscles in the temple, forehead and supraorbital areas.
      2. The zygomatic branch innervates muscles in the infraorbital area, the lateral nasal area and the upper lip.
      3. The buccal branch innervates muscles in the cheek, the upper lip and the corner of the mouth.
      4. The marginal mandibular branch innervates muscles of the lower lip and chin.
      5. The cervical branch innervates the platysma muscle.

    • This question is part of the following fields:

      • Anatomy
      • Cranial Nerve Lesions
      42.4
      Seconds
  • Question 15 - You need to give your patient antibiotics, so you call microbiology for some advice.

    Of...

    Incorrect

    • You need to give your patient antibiotics, so you call microbiology for some advice.

      Of the following antibacterial drugs, which of them is a protein synthesis inhibitor?

      Your Answer: Rifampicin

      Correct Answer: Erythromycin

      Explanation:

      Bacteriostatic antibiotics include erythromycin and other macrolides. They work by attaching to the bacterial ribosome’s 50S subunit, preventing translocation and, as a result, inhibit protein synthesis. Macrolide antibiotics are actively concentrated inside leukocytes and delivered into the infection site as a result.

      Action Mechanisms- Examples:

      Cell wall production is inhibited
      Vancomycin
      Vancomycin
      Cephalosporins

      The function of the cell membrane is disrupted
      Nystatin
      Polymyxins
      Amphotericin B

      Inhibition of protein synthesis
      Chloramphenicol
      Macrolides
      Aminoglycosides
      Tetracyclines

      Nucleic acid synthesis inhibition
      Quinolones
      Trimethoprim
      Rifampicin
      5-nitroimidazoles
      Sulphonamides
      Anti-metabolic activity
      Isoniazid

    • This question is part of the following fields:

      • Infections
      • Pharmacology
      20.3
      Seconds
  • Question 16 - What is the most common application of Nitrates? ...

    Correct

    • What is the most common application of Nitrates?

      Your Answer: Angina

      Explanation:

      In patients with exertional stable angina, nitrates improve exercise tolerance, time to onset of angina, and ST-segment depression during exercise testing. In combination with beta-blockers or calcium channel blockers, nitrates produce greater anti-anginal and anti-ischemic effects.
      While they act as vasodilators, coronary vasodilators, and modest arteriolar dilators, the primary anti ischemic effect of nitrates is to decrease myocardial oxygen demand by producing systemic vasodilation more than coronary vasodilation. This systemic vasodilation reduces left ventricular systolic wall stress.

    • This question is part of the following fields:

      • Cardiovascular
      • Pharmacology
      16.3
      Seconds
  • Question 17 - You review a sick patient in resus who has been prescribed mannitol as...

    Incorrect

    • You review a sick patient in resus who has been prescribed mannitol as part of his treatment protocol.
      Which SINGLE statement regarding mannitol is true?

      Your Answer: It can be used in the ICU treatment of pulmonary oedema

      Correct Answer: It is irritant to veins and causes phlebitis

      Explanation:

      Mannitol is a low molecular weight compound and is therefore freely filtered at the glomerulus and is not reabsorbed. It, therefore, increases the osmolality of the glomerular filtrate and tubular fluid, increasing urinary volume by an osmotic effect. It also does not cross the blood-brain barrier (BBB).
      Mannitol is primarily used to reduce the pressure and volume of cerebrospinal fluid (CSF). It decreases the volume of CSF by:
      Decreasing the rate of CSF formation,and;
      Withdrawing extracellular fluid from the brain across the BBB
      Other uses of mannitol include:
      Short-term management of glaucoma
      Treatment of rhabdomyolysis
      Preserve renal function in peri-operative jaundiced patients
      To initiate diuresis in transplanted kidneys
      Bowel preparation prior to colorectal procedures
      The recommended dose of mannitol for the reduction of CSF pressure/cerebral oedema is 0.25-2g/kg as an intravenous infusion over 30-60 minutes. This can be repeated 1-2 times after 4-8 hours if needed.
      Circulatory overload and rebound increases in intracranial pressure may occur following the use of mannitol. It is irritant to tissues and veins and can cause inflammation and phlebitis.
      Mannitol causes an expansion of the extracellular fluid space, which may worsen congestive cardiac failure. Contraindications to the use of mannitol include:
      Anuria
      Intracranial bleeding (except during craniotomy)
      Severe cardiac failure
      Severe dehydration
      Severe pulmonary oedema

    • This question is part of the following fields:

      • Cardiovascular Pharmacology
      • Pharmacology
      48.2
      Seconds
  • Question 18 - Regarding flucloxacillin, which of the following statements is CORRECT: ...

    Incorrect

    • Regarding flucloxacillin, which of the following statements is CORRECT:

      Your Answer: It is used first line for infected animal bites.

      Correct Answer: It is resistant to bacterial beta-lactamases.

      Explanation:

      Flucloxacillin is unique in that it is beta-lactamase stable and it can be used in infections caused by beta-lactamase producing staphylococci e.g. S. aureus. It is acid-stable and can therefore be given by mouth as well as by injection. It is used first line for treatment of widespread impetigo infection, cellulitis, mastitis, osteomyelitis, septic arthritis, severe erysipelas, severe/spreading otitis externa and infective endocarditis caused by staphylococci. The most common adverse effects of flucloxacillin include nausea, vomiting, skin rash, and diarrhoea. Cholestatic jaundice and hepatitis may occur very rarely, up to two months after treatment with flucloxacillin has been stopped. Administration for more than 2 weeks and increasing age are risk factors. First line treatment of animal and human bites is co-amoxiclav.

    • This question is part of the following fields:

      • Infections
      • Pharmacology
      9.5
      Seconds
  • Question 19 - A 42-year-old woman with a history of hyposplenism arrives at the Emergency Department...

    Incorrect

    • A 42-year-old woman with a history of hyposplenism arrives at the Emergency Department sick and feverish. A complete set of bloods, including a peripheral blood film, is organised.

      On a hyposplenic blood film, which of the following features is LEAST likely to be seen?

      Your Answer: Heinz bodies

      Correct Answer: Teardrop cells

      Explanation:

      The collection of abnormalities found in these patients is referred to as a hyposplenic film.
      The following features can be seen on hyposplenic blood films:
      Howell-Jolly bodies
      Heinz’s bodies
      Target cells
      RBCs with nuclei on occasion
      Lymphocytosis
      Macrocytosis
      Acanthocytes
      Teardrop cells, also known as dacrocytes, are named for their teardrop-shaped shape.

      Dacrocytosis is a condition in which a large number of these cells are present. Myelofibrosis and beta thalassemia major both have dacrocytes, but hyposplenism does not.

    • This question is part of the following fields:

      • Haematology
      • Pathology
      13.6
      Seconds
  • Question 20 - Which of the following data types does a pain-scoring system represent? ...

    Correct

    • Which of the following data types does a pain-scoring system represent?

      Your Answer: Ordinal

      Explanation:

      Pain scoring systems are processes for assessing pain and the severity of illnesses that have been scientifically designed and tested. An example of ordinal categorical data is a pain scoring system.

    • This question is part of the following fields:

      • Evidence Based Medicine
      • Statistics
      26.7
      Seconds
  • Question 21 - Cardiac myocytes are connected to each other by which of the following: ...

    Incorrect

    • Cardiac myocytes are connected to each other by which of the following:

      Your Answer: Sarcolemma

      Correct Answer: Intercalated discs

      Explanation:

      Adjacent cardiac myocytes are connected to each other by intercalated discs. The intercalated discs provide both a structural attachment by ‘glueing’ cells together at desmosomes and an electrical contact made up of proteins called connexons, called a gap junction, which essentially creates a low-resistance pathway between cells.

    • This question is part of the following fields:

      • Cardiovascular
      • Physiology
      16.6
      Seconds
  • Question 22 - Which lobe of the prostate gland is most commonly affected in benign prostatic...

    Incorrect

    • Which lobe of the prostate gland is most commonly affected in benign prostatic hypertrophy?

      Your Answer: Anterior

      Correct Answer: Median

      Explanation:

      Benign enlargement of the prostate is common in men older than 50 years. The cause is possibly an imbalance in the hormonal control of the gland. The median lobe of the gland enlarges upward and encroaches within the sphincter vesicae, located at the neck of the bladder. The leakage of urine into the prostatic urethra causes an intense reflex desire to micturate. The enlargement of the median and lateral lobes of the gland produces elongation and lateral compression and distortion of the urethra so that the patient experiences difficulty in passing urine and the stream is weak. Back-pressure effects on the ureters and both kidneys are a common complication. The enlargement of the uvula vesicae (owing to the enlarged median lobe) results in the formation of a pouch of stagnant urine behind the urethral orifice within the bladder. The stagnant urine frequently becomes infected, and the inflamed bladder (cystitis) adds to the patient’s symptoms.

      In all operations on the prostate, the surgeon regards the prostatic venous plexus with respect. The veins have thin walls, are valveless, and are drained by several large trunks directly into the internal iliac veins. Damage to these veins can result in a severe haemorrhage.

    • This question is part of the following fields:

      • Abdomen And Pelvis
      • Anatomy
      0.8
      Seconds
  • Question 23 - Regarding benzylpenicillin, which of the following statements is CORRECT: ...

    Correct

    • Regarding benzylpenicillin, which of the following statements is CORRECT:

      Your Answer: If meningococcal disease is suspected, benzylpenicillin should be given before transfer to hospital.

      Explanation:

      Benzylpenicillin (although inactivated by bacterial beta-lactamases) is effective for many streptococcal (including pneumococcal), gonococcal, and meningococcal infections and also for anthrax, diphtheria, gas gangrene, leptospirosis, and treatment of Lyme disease. If meningococcal disease (meningitis with non-blanching rash or meningococcal septicaemia) is suspected, benzylpenicillin should be given before transfer to hospital, so long as this does not delay the transfer; benzylpenicillin is no longer the drug of first choice for pneumococcal meningitis. Although benzylpenicillin is effective in the treatment of tetanus, metronidazole is preferred. Benzylpenicillin is inactivated by gastric acid and absorption from the gastrointestinal tract is poor and therefore it must be given by injection.

    • This question is part of the following fields:

      • Infections
      • Pharmacology
      29.9
      Seconds
  • Question 24 - The sensory innervation of the oropharynx is provided by which of the following...

    Incorrect

    • The sensory innervation of the oropharynx is provided by which of the following nerves:

      Your Answer: Vagus nerve

      Correct Answer: Glossopharyngeal nerve

      Explanation:

      Each subdivision of the pharynx has a different sensory innervation:the nasopharynx is innervated by the maxillary nervethe oropharynx is innervated by the glossopharyngeal nervethe laryngopharynx is innervated by the vagus nerve.

    • This question is part of the following fields:

      • Anatomy
      • Head And Neck
      23.1
      Seconds
  • Question 25 - Regarding the factor V Leiden gene mutation, which of the following best describes...

    Incorrect

    • Regarding the factor V Leiden gene mutation, which of the following best describes the clinical effect:

      Your Answer: It results in deficiency of protein C.

      Correct Answer: It results in increased levels of activated factor V.

      Explanation:

      Factor V Leiden gene mutation is the most common inherited cause of an increased risk of venous thrombosis. Activated protein C normally breaks down activated factor V and so should slow the clotting reaction and prolong the APTT, but a mutation in the factor V gene makes factor V less susceptible to cleavage by activated protein C, resulting in increased levels of activated factor V.Heterozygotes for factor V Leiden are at an approximately five- to eight- fold increased risk of venous thrombosis compared to the general population (but only 10% of carriers will develop thrombosis in their lifetime). Homozygotes have a 30 – 140-fold increased risk. The incidence of factor V Leiden in patients with venous thrombosis is approximately 20 – 40%. It does not increase the risk of arterial thrombosis.

    • This question is part of the following fields:

      • Haematology
      • Pathology
      51.8
      Seconds
  • Question 26 - Identify the type of graph described below:

    A graph that is a useful summary...

    Incorrect

    • Identify the type of graph described below:

      A graph that is a useful summary of a set of bivariate data (two variables), usually drawn before working out a linear correlation coefficient or fitting a regression line.

      Your Answer:

      Correct Answer: Scatterplot

      Explanation:

      A scatterplot is a useful summary of a set of bivariate data (two variables), usually drawn before working out a linear correlation coefficient or fitting a regression line. It gives a good visual picture of the relationship between the two variables, and aids the interpretation of the correlation coefficient or regression model. Each unit contributes one point to the scatterplot, on which points are plotted but not joined. The resulting pattern indicates the type and strength of the relationship between the two variables.

    • This question is part of the following fields:

      • Evidence Based Medicine
      0
      Seconds
  • Question 27 - A 7-year-old presented to a GP with a history of headache, neck stiffness...

    Incorrect

    • A 7-year-old presented to a GP with a history of headache, neck stiffness and photophobia. On examination, HR is 122, BP is 87/42, RR is 28, SaO 2 is 95%, temperature is 39.4 o C. There is a recent non-blanching rash on legs and arms. The GP administered a dose of antibiotics before transferring child to the Emergency Department.

      Which of these is the most appropriate antibiotic to administer in this scenario from the choices available?

      Your Answer:

      Correct Answer: Give IM benzylpenicillin 600 mg

      Explanation:

      Meningococcal septicaemia should be suspected in a child with a non-blanching rash especially in the presence of:
      An ill-looking child
      Neck stiffness
      Lesions larger than 2 mm in diameter (purpura)
      Capillary refill time of>3 seconds

      The index child is very sick and shows signs of septic shock. In the prehospital setting, a single dose of benzylpenicillin should be given immediately. The correct dose for this childs age is IM benzylpenicillin 600 mg.

      The recommended doses of benzylpenicillin according to age are:
      Infants <1 year of age: IM or IV benzylpenicillin 300 mg
      Children 1 to 9 years of age: IM or IV benzylpenicillin 600mg
      Children and adults 10 years or older: IM or IV benzylpenicillin 1.2g

    • This question is part of the following fields:

      • Infections
      • Pharmacology
      0
      Seconds
  • Question 28 - You review a 37-year-old man with a history of intravenous drug abuse who...

    Incorrect

    • You review a 37-year-old man with a history of intravenous drug abuse who admits to sharing needles in the past. He has a flu-like illness and a rash. Concerned he may be experiencing an HIV seroconversion illness, you order a test.

      Which of these tests is most reliably used to diagnose HIV at this stage?

      Your Answer:

      Correct Answer: p24 antigen test

      Explanation:

      Serum concentrations of the p24 antigen are usually high in the first few weeks after human immunodeficiency virus (HIV) infection and testing for p24 antigen is therefore a useful way of diagnosing very early infection. P24 is the viral protein that makes up most of the core of the HIV.

      ELISA and other antibody tests, though a very sensitive way of detecting the presence of HIV, cannot be used in the early stages of the disease. This is because of the window period of 6-12 weeks before antibodies are produced. These tests will be negative during a seroconversion illness.

      The ‘rapid HIV test’ is an HIV antibody test. It will also be negative during the ‘window period’ since it takes time for antibodies to be produced. It is called the ‘rapid test’ as it can detect antibodies in blood or saliva much quicker than the other antibody tests and results are often back within 20 minutes.

      CD4 and CD8 counts are usually normal in the early stages of the HIV infection and cannot be used in this case.

    • This question is part of the following fields:

      • Microbiology
      • Specific Pathogen Groups
      0
      Seconds
  • Question 29 - In ventricular myocytes, the plateau phase of the action potential comes about through which...

    Incorrect

    • In ventricular myocytes, the plateau phase of the action potential comes about through which of the following:

      Your Answer:

      Correct Answer: Opening of voltage-gated Ca 2+ channels

      Explanation:

      After the intial upstroke of the action potential, Na+channels and currents rapidly inactivate, but in cardiac myocytes, the initial depolarisation activates voltage-gated Ca2+channels (slow L-type channels, threshold approximately – 45 mV) through which Ca2+floods into the cell. The resulting influx of Ca2+prevents the cell from repolarising and causes a plateau phase, that is maintained for about 250 ms until the L-type channels inactivate. The cardiac AP is thus much longer than that in nerve or skeletal muscle.

    • This question is part of the following fields:

      • Cardiovascular
      • Physiology
      0
      Seconds
  • Question 30 - A 26-year old female comes to the Emergency Room with complaints of bloody...

    Incorrect

    • A 26-year old female comes to the Emergency Room with complaints of bloody stools. She reports that prior to the passage of bloody stools, she experienced a sharp pain during defecation. Medical history reveals that she has been experiencing constipation for the past 2 weeks. After completing her medical history and physical examination, the attending physician gives an initial diagnosis of an anal fissure.

      Which of the following nerves transmit painful sensation from the anus, resulting in the pain associated with anal fissure?

      Your Answer:

      Correct Answer: Inferior rectal nerve

      Explanation:

      A fissure in ano is a tear in the anoderm distal to the dentate line. The pathophysiology of anal fissure is thought to be related to trauma from either the passage of hard stool or prolonged diarrhoea. A tear in the anoderm causes spasm of the internal anal sphincter, which results in pain, increased tearing, and decreased blood supply to the anoderm. The site of the anal fissure in the sensitive lower half of the anal canal, which is innervated by the inferior rectal nerve, results in reflex spasm of the external anal sphincter, aggravating the condition. Because of the intense pain, anal fissures may have to be examined under local anaesthesia.

      The inferior rectal nerve is a branch of the pudendal nerve. This nerve runs medially across the ischiorectal fossa and supplies the external anal sphincter, the mucous membrane of the lower half of the anal canal, and the perianal skin.

    • This question is part of the following fields:

      • Abdomen And Pelvis
      • Anatomy
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Anatomy (1/6) 17%
Lower Limb (1/1) 100%
Gastrointestinal (1/1) 100%
Physiology (3/3) 100%
Cardiovascular (3/3) 100%
Pharmacology (7/11) 64%
Central Nervous System (0/1) 0%
Cardiovascular Pharmacology (2/3) 67%
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Specific Pathogen Groups (1/2) 50%
Respiratory (1/1) 100%
Renal (1/1) 100%
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Cranial Nerve Lesions (0/1) 0%
Infections (2/4) 50%
Haematology (0/2) 0%
Abdomen And Pelvis (0/2) 0%
Head And Neck (0/1) 0%
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