-
Question 1
Correct
-
In the normal adult, haematopoiesis is present
Your Answer: Axial skeleton and proximal ends of long bones
Explanation:In children, haematopoiesis occurs in the marrow of the long bones such as the femur and tibia. In adults, it occurs mainly in the pelvis, cranium, vertebrae, and sternum.
-
This question is part of the following fields:
- Haematology
- Medicine
-
-
Question 2
Incorrect
-
Which statement about antithrombin III is true?
Your Answer: Its activity is inhibited by heparin.
Correct Answer: It inhibits particularly factor II and X
Explanation:Antithrombin inactivates its physiological target enzymes, Thrombin (Factor II), Factor Xa and Factor IXa. ATIII binds to thrombin and then forms the thrombin-anti thrombin complex or TAT complex. This is a major natural pathway of anticoagulation. This binding of thrombin to AT is greatly enhanced in the presence of heparin.
-
This question is part of the following fields:
- Haematology
- Medicine
-
-
Question 3
Incorrect
-
Regarding transportation of iron in the body, the process in which iron is transported from the enterocyte into the blood occurs using which transporter protein:
Your Answer: Transferrin
Correct Answer: Ferroportin
Explanation:Divalent metal transporter 1 (DMT1) transport several divalent metals including iron across the enterocyte’s cell membrane into the cell. The cell can then release it into the body via the only known iron exporter in mammals, ferroportin.
-
This question is part of the following fields:
- Haematology
- Medicine
-
-
Question 4
Correct
-
Question 5
Correct
-
Lymphoid stem cells give rise to the following cells:
Your Answer: T cells, b cells and natural killer cells
Explanation:T Cells, B Cells and NK Cells (and all other Innate lymphoid cells) are unique to the lymphocyte family, but dendritic cells are not. Dendritic cells of identical appearance but different markers are spread throughout the body, and come from either lymphoid and myeloid lineages.
Myeloid stem cells lead to myeloblasts, which evolve into macrophages, monocytes, neutrophils, basophils, and eosinophils.
-
This question is part of the following fields:
- Haematology
- Medicine
-
-
Question 6
Correct
-
What is the average life span of red blood cells?
Your Answer: 4 months
Explanation:Approximately 2.4 million new erythrocytes are produced per second in human adults. The cells develop in the bone marrow and circulate for about 100–120 days (4 months) in the body before their components are recycled by macrophages.
-
This question is part of the following fields:
- Haematology
- Medicine
-
-
Question 7
Correct
-
90% of erythropoietin necessary for haemopoesis is produced by the kidneys, the remainder is formed in the?
Your Answer: Liver
Explanation:Erythropoietin is produced by interstitial fibroblasts in the kidney in close association with peritubular capillary and proximal convoluted tubule. It is also produced in perisinusoidal cells in the liver. While liver production predominates in the fetal and perinatal period, renal production is predominant during adulthood.
-
This question is part of the following fields:
- Haematology
- Medicine
-
-
Question 8
Incorrect
-
von Willebrand factor stabilises which clotting factor?
Your Answer: Factor V
Correct Answer: Factor VIII
Explanation:Von Willebrand factor’s primary function is binding to other proteins, in particular factor VIII, and it is important in platelet adhesion to wound sites. It is not an enzyme and, thus, has no catalytic activity. Factor VIII degrades rapidly when not bound to vWF. Factor VIII is released from vWF by the action of thrombin.
-
This question is part of the following fields:
- Haematology
- Medicine
-
-
Question 9
Incorrect
-
Choose the most correct answer, what reduces affinity for oxygen in haemoglobin?
Your Answer: Presence of carbon monoxide in blood
Correct Answer: All the options are true
Explanation:The strength with which oxygen binds to haemoglobin is affected by several factors. These factors shift or reshape the oxyhaemoglobin dissociation curve. A rightward shift indicates that the haemoglobin under study has a decreased affinity for oxygen. The causes of shift to right can be remembered using the mnemonic, CADET, face Right! for CO2 and CO, Acid (H+), 2,3-DPG, Exercise and Temperature.
-
This question is part of the following fields:
- Haematology
- Medicine
-
-
Question 10
Incorrect
-
Which of the following is a function of Vitamin C?
Your Answer: Iron transport across the enterocytes
Correct Answer: Hydroxylation of proline to hydroxyproline for collagen synthesis
Explanation:Vitamin C acts as an electron donor for eight different enzymes: Three enzymes (prolyl-3-hydroxylase, prolyl-4-hydroxylase, and lysyl hydroxylase) that are required for the hydroxylation of proline and lysine in the synthesis of collagen.
-
This question is part of the following fields:
- Haematology
- Medicine
-
SESSION STATS - PERFORMANCE PER SPECIALTY
