00
Correct
00
Incorrect
00 : 00 : 0 00
Session Time
00 : 00
Average Question Time ( Secs)
Retry this test Dashboard

  • Question 1 - Where is the most erythropoietin produced? ...

    Incorrect

    • Where is the most erythropoietin produced?

      Your Answer: Bone marrow

      Correct Answer: Kidneys

      Explanation:

      Erythropoietin is produced by interstitial fibroblasts in the kidney in close association with peritubular capillary and proximal convoluted tubule. It is also produced in perisinusoidal cells in the liver. While liver production predominates in the fetal and perinatal period, renal production is predominant during adulthood.

    • This question is part of the following fields:

      • Haematology
      • Medicine
      6.1
      Seconds

  • Question 2 - Which of the following is matched correctly with regard to stem cells of...

    Incorrect

    • Which of the following is matched correctly with regard to stem cells of the bone marrow?

      Your Answer:

      Correct Answer: Hemopoietic stem cells - basophils

      Explanation:

      Hematopoietic stem cells (HSCs) or hemocytoblasts are the stem cells that give rise to all the other blood cells through the process of haematopoiesis. They give rise to both the myeloid and lymphoid lineages of blood cells. (Myeloid cells include monocytes, macrophages, neutrophils, basophils, eosinophils, erythrocytes, dendritic cells, and megakaryocytes or platelets. Lymphoid cells include T cells, B cells, and natural killer cells.)

    • This question is part of the following fields:

      • Haematology
      • Medicine
      0
      Seconds

  • Question 3 - The spleen underlies which ribs? ...

    Incorrect

    • The spleen underlies which ribs?

      Your Answer:

      Correct Answer: 9 through 11

      Explanation:

      The spleen lies between the 9th and 11th ribs on the left hand side.

    • This question is part of the following fields:

      • Haematology
      • Medicine
      0
      Seconds

  • Question 4 - All of the following are Vitamin K-dependent clotting factors except: ...

    Incorrect

    • All of the following are Vitamin K-dependent clotting factors except:

      Your Answer:

      Correct Answer: Factor XI

      Explanation:

      Activated Vitamin K is used to gamma carboxylate (and thus activate) certain enzymes involved in coagulation: Factors II, VII, IX, X, and protein C and protein S. Inability to activate the clotting cascade via these factors leads to the bleeding symptoms

    • This question is part of the following fields:

      • Haematology
      • Medicine
      0
      Seconds

  • Question 5 - 5-methyltetrahydrofolate (Methyl THF) is converted to THF with the help of which of...

    Incorrect

    • 5-methyltetrahydrofolate (Methyl THF) is converted to THF with the help of which of the following?

      Your Answer:

      Correct Answer: B 12

      Explanation:

      MTR, also known as methionine synthase, is a methyltransferase enzyme, which uses the Vitamin B12 to transfer a methyl group from 5-methyltetrahydrofolate to homocysteine, thereby generating tetrahydrofolate (THF) and methionine. This functionality is lost in vitamin B12 deficiency, resulting in an increased homocysteine level and the trapping of folate as 5-methyl-tetrahydrofolate, from which THF (the active form of folate) cannot be recovered. THF plays an important role in DNA synthesis so reduced availability of THF results in ineffective production of cells with rapid turnover, in particular red blood cells, and also intestinal wall cells which are responsible for absorption.

    • This question is part of the following fields:

      • Haematology
      • Medicine
      0
      Seconds

  • Question 6 - Which of the following is a precursor to the tissue macrophage? ...

    Incorrect

    • Which of the following is a precursor to the tissue macrophage?

      Your Answer:

      Correct Answer: Monocyte

      Explanation:

      Monocytes are a type of white blood cell, or leukocyte. They are the largest type of leukocyte and can differentiate into macrophages or dendritic cells.

    • This question is part of the following fields:

      • Haematology
      • Medicine
      0
      Seconds

  • Question 7 - Which vitamin is found in NAD and NADP? ...

    Incorrect

    • Which vitamin is found in NAD and NADP?

      Your Answer:

      Correct Answer: Vitamin B3

      Explanation:

      In organisms, NAD can be synthesized from simple building-blocks (de novo) from the amino acids tryptophan or aspartic acid. In an alternative fashion, more complex components of the coenzymes are taken up from food as the vitamin called niacin (vitamin B3)

    • This question is part of the following fields:

      • Haematology
      • Medicine
      0
      Seconds

  • Question 8 - What is the function of Activated protein C? ...

    Incorrect

    • What is the function of Activated protein C?

      Your Answer:

      Correct Answer: Inactivates factor Va

      Explanation:

      Activated Protein C (APC) is a crucial protein in the regulation of blood coagulation. Its primary functions include:

      1. Inactivating Factor Va: APC inactivates Factor Va, which is a cofactor for the conversion of prothrombin to thrombin by Factor Xa. By inactivating Factor Va, APC reduces thrombin formation, thereby acting as an anticoagulant.
      2. Inactivating Factor VIIIa: APC also inactivates Factor VIIIa, another cofactor that assists Factor IXa in the conversion of Factor X to Factor Xa. This further contributes to its anticoagulant effect.

      These actions help to regulate blood clotting and prevent excessive thrombosis.

    • This question is part of the following fields:

      • Haematology
      • Medicine
      0
      Seconds

  • Question 9 - Which of the following conditions is procoagulant? ...

    Incorrect

    • Which of the following conditions is procoagulant?

      Your Answer:

      Correct Answer: Factor V Leiden

      Explanation:

      Factor V Leiden is a genetic mutation of one of the clotting factors in the blood, Factor V. This mutation makes Factor V resistant to inactivation by activated Protein C, which normally helps to regulate clot formation. As a result, individuals with Factor V Leiden are at increased risk of developing abnormal blood clots (thrombophilia), making it a procoagulant condition.

      The other conditions listed are associated with bleeding tendencies rather than increased clotting:

      • Afibrinogenemia: A rare genetic disorder where there is a complete lack of fibrinogen, leading to bleeding problems.
      • Hemophilia: A group of inherited bleeding disorders where blood does not clot properly due to the lack of sufficient blood-clotting proteins (factors VIII or IX).
      • Hypothrombinemia: A condition characterized by low levels of prothrombin, leading to increased bleeding.
      • Christmas disease (Hemophilia B): A form of hemophilia caused by a deficiency of factor IX, resulting in a bleeding tendency.

    • This question is part of the following fields:

      • Haematology
      • Medicine
      0
      Seconds

  • Question 10 - Why is tissue plasminogen activator (tPa) a valuable treatment used in myocardial infarction...

    Incorrect

    • Why is tissue plasminogen activator (tPa) a valuable treatment used in myocardial infarction and stroke?

      Your Answer:

      Correct Answer: It forms plasmin from its inactive precursor

      Explanation:

      tPA is a serine protease involved in the breakdown of blood clots. It functions by converting plasminogen, an inactive precursor, into plasmin, an active enzyme. Plasmin then degrades fibrin, the main protein component of blood clots, leading to clot dissolution. This mechanism is particularly valuable in the treatment of myocardial infarction (heart attack) and ischemic stroke, where timely dissolution of the clot can restore blood flow to affected tissues and reduce damage.

      Therefore, the correct answer is:

      • It forms plasmin from its inactive precursor

    • This question is part of the following fields:

      • Haematology
      • Medicine
      0
      Seconds

SESSION STATS - PERFORMANCE PER SPECIALTY

Haematology (0/1) 0%
Medicine (0/1) 0%
Passmed
Retry this test Dashboard